Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population.

IF 4.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-07-14 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1616907

Yu Gong, Guojuan Wang, Qianqian Zhang, Xu Jiang, Zhangxiang Zhu, Ying Li

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引用次数: 0

Abstract

Background: We aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.

Methods: A total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured. Central TH sensitivity was evaluated using the thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI) and thyrotropin thyroxine resistance index (TT4RI). We analyzed the relationship between central TH sensitivity and triglyceride (TG) level using smooth curve fitting and threshold effect analysis and trend tests in multiple regression equations..

Results: TSHI (β=0.158, P=0.0443) was positively correlated with TG, while TT4RI (β=0.018, P=0.0112, inflection point: 25.809) and TFQI (β=0.798, P=0.0066, inflection point: -0.194) were both positively correlated with TG before the inflection points. Subgroup analyses revealed these relationships were particularly pronounced in females (TT4RI β=0.026, P=0.0205, inflection point: 22.487; TFQI β=0.780, P=0.0133, inflection point: -0.142), males (TFQI β=1.954, P=0.0100, inflection point: -0.395), individuals with age <65 years (TT4RI β=0.019, P=0.0119, inflection point: 25.809; TFQI β=0.878, P=0.0060, inflection point: -0.206), and individuals with BMI<28kg/m² (TT4RI β=0.026, P=0.0090, inflection point: 21.515; TFQI β=0.735, P=0.0132, inflection point: -0.173), all showing positive correlations before the point correlations. Tests for trend in multiple regression equations showed that with the increased quartiles of TT4RI (OR=1.321, P=0.00118) and TSHI (OR=1.253, P=0.00784), the risk of HTG increased correspondingly. For per SD increase in TT4RI, the odds of HTG increased by 36.5% (OR=1.365, P=0.00703). For per SD increase in TSHI, the odds of HTG increased by 19.1% (OR=1.191, P=0.06648).

Conclusion: Impaired central thyroid hormone sensitivity is associated with increased triglyceride in euthyroid population, this association is more pronounced in individuals with aged<65 years and BMI<28kg/m². Impaired central thyroid hormone sensitivity may be an independent risk factor for hypertriglyceridemia.

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甲状腺功能正常人群中甲状腺激素中枢敏感性受损与高甘油三酯血症相关。

背景：我们旨在研究甲状腺功能正常人群中枢性甲状腺激素敏感性与高甘油三酯血症（HTG）的相关性。方法：随机抽取体检对象833人。测定甲状腺激素（THs）、肝肾功能、血糖、血脂等生化指标。采用甲状腺反馈分位数指数（TFQI）、促甲状腺激素指数（TSHI）和促甲状腺素甲状腺素抵抗指数（TT4RI）评价中央甲状腺激素敏感性。我们采用平滑曲线拟合、阈值效应分析和多元回归方程趋势检验分析了中心TH敏感性与甘油三酯（TG）水平的关系。结果：TSHI （β=0.158， P=0.0443）与TG呈正相关，TT4RI （β=0.018， P=0.0112，拐点：25.809）和TFQI （β=0.798， P=0.0066，拐点：-0.194）与TG在拐点前均呈正相关。亚组分析显示，这些关系在女性中尤为明显(TT4RI β=0.026， P=0.0205，拐点：22.487；TFQI β=0.780， P=0.0133，拐点：-0.142)，男性（TFQI β=1.954， P=0.0100，拐点：-0.395），年龄个体P=0.0119，拐点：25.809；TFQI β=0.878， P=0.0060，拐点：-0.206)，BMIP=0.0090，拐点：21.515；TFQI β=0.735， P=0.0132，拐点：-0.173)，点相关前均为正相关。多元回归方程趋势检验显示，TT4RI （OR=1.321， P=0.00118）和TSHI （OR=1.253， P=0.00784）的四分位数增加，HTG的风险相应增加。TT4RI每增加SD， HTG的几率增加36.5% （OR=1.365， P=0.00703）。TSHI每增加一个SD， HTG的发生率增加19.1% （OR=1.191， P=0.06648）。结论：甲状腺功能正常的人群中，中枢甲状腺激素敏感性受损与甘油三酯升高有关，这种关联在年龄较大的人群中更为明显。中枢甲状腺激素敏感性受损可能是高甘油三酯血症的独立危险因素。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.