PDX1 in early pregnancy is associated with decreased risks of gestational diabetes mellitus and adverse pregnancy outcomes.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1486197

Qian Zhang, Qing-Qing Zhang, Shu-Qin Dong, Xia Liu, Jing Wei, Kai Li, Yu Lu

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引用次数: 0

Abstract

Aim: To investigate the association of pancreatic duodenal homeobox-1 (PDX1) in early pregnancy with the risks of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.

Methods: A total of 231 pregnant women were recruited at their initial antenatal care visit during 8-12 gestational weeks in this study. The 75g OGTT was performed during 24-28 gestational weeks. Blood samples were collected to measure PDX1 levels. Participants were followed throughout their pregnancy to monitor for the development of GDM and adverse pregnancy outcomes. The odds ratio (OR) was used to assess the risks of GDM and adverse pregnancy outcomes.

Results: Pregnant women in the GDM group had higher levels of HOMA-IR and TyG index, and lower PDX1 levels both in early and mid-pregnancy (P<0.05), but had lower HOMA-β levels only in mid-pregnancy (P<0.05). PDX1 in early pregnancy was negatively correlated with FPG, 2h PG, HOMA-IR, and TyG, while positively correlated with HOMA-β in mid-pregnancy (P<0.05). The adjusted analysis showed that elevated PDX1 levels in early pregnancy were associated with reduced risks of GDM (aOR 0.287, 95%CI 0.130-0.636, P=0.002), macrosomia (aOR 0.249, 95%CI 0.076-0.811, P=0.021) and composite adverse pregnancy outcomes (aOR 0.496, 95%CI 0.256-0.960, P=0.037).

Conclusion: Elevated PDX1 in early pregnancy was associated with decreased risks of GDM and adverse pregnancy outcomes.

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妊娠早期PDX1与妊娠期糖尿病风险降低和不良妊娠结局相关。

目的：探讨妊娠早期胰十二指肠同型盒-1 （PDX1）与妊娠期糖尿病（GDM）风险及不良妊娠结局的关系。方法：在本研究中，共有231名孕妇在8-12孕周的初次产前保健访问中被招募。75g OGTT于妊娠24-28周进行。采集血液样本测量PDX1水平。参与者在整个怀孕期间都被跟踪，以监测GDM的发展和不良妊娠结局。比值比（OR）用于评估GDM的风险和不良妊娠结局。结果：妊娠早期和妊娠中期，GDM组孕妇的HOMA-IR和TyG指数水平较高，PDX1水平较低（结论：妊娠早期PDX1升高与GDM风险降低和不良妊娠结局相关）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.