Evolving global trends in PCOS burden: a three-decade analysis (1990-2021) with projections to 2036 among adolescents and young adults.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1569694

Jiameng Wang, Boyu Wang, Chengjia Li, Tianwei Meng, Changxing Liu, Jia Chen, Ying Guo

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引用次数: 0

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting adolescent and young adult females, yet global data on its burden and trends remains limited.

Methods: We analyzed data from the Global Burden of Disease Study 2021 for females aged 10-24 years in 204 countries (1990-2021). Metrics included cases, age-standardized incidence (ASIR), prevalence (ASPR), disability-adjusted life years (ASDR), and average annual percentage changes (AAPCs). Future trends (2022-2036) and disease reduction gaps were assessed.

Results: From 1990 to 2021, global PCOS cases increased by 56% (incidence), 59% (prevalence), and 58% (DALYs). ASIR rose from 49.45 to 63.26 per 100,000, with an AAPC of 0.8. Southeast Asia, East Asia, and Oceania had the fastest growth, while high-SDI regions bore the highest burden. Girls aged 10-14 showed the steepest age-specific increase. Nationally, the largest increases occurred in Equatorial Guinea, Maldives, and Myanmar, while Italy saw a decline. Forecasts through 2036 indicate continued increases in ASIR (+8.32%), ASPR (+10.87%), and ASDR (+10.39%). Frontier analysis highlighted unachieved reduction potential, especially in high-SDI countries.

Conclusions: PCOS burden among adolescents and young adults has significantly risen globally with disparities by region, SDI, and age, warranting urgent and equitable public health strategies.

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多囊卵巢综合征（PCOS）负担不断变化的全球趋势：三十年分析（1990-2021年），并预测到2036年的青少年和年轻人。

背景：多囊卵巢综合征（PCOS）是一种影响青少年和年轻成年女性的常见内分泌疾病，但关于其负担和趋势的全球数据仍然有限。方法：我们分析了全球疾病负担研究2021中204个国家10-24岁女性（1990-2021）的数据。指标包括病例数、年龄标准化发病率（ASIR）、患病率（ASPR）、残疾调整生命年（ASDR）和平均年百分比变化（AAPCs）。评估了未来趋势（2022-2036）和减少疾病差距。结果：从1990年到2021年，全球PCOS病例增加了56%（发病率），59%（患病率）和58% （DALYs）。ASIR从49.45 / 10万上升到63.26 / 10万，AAPC为0.8。东南亚、东亚和大洋洲增长最快，而高sdi地区负担最重。10-14岁女孩的年龄增幅最大。从全国来看，增幅最大的是赤道几内亚、马尔代夫和缅甸，而意大利则出现了下降。预测显示，到2036年，ASIR（+8.32%）、ASPR（+10.87%）和ASDR（+10.39%）将继续增长。前沿分析强调了未实现的减排潜力，特别是在高sdi国家。结论：在全球范围内，青少年和年轻人的多囊卵巢综合征负担显著增加，且存在地区、SDI和年龄的差异，需要采取紧急和公平的公共卫生战略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.