Frontiers in Endocrinology最新文献

{"title":"Association between atherogenic index of plasma and future cardiovascular disease risk in middle-aged and elderly individuals with cardiovascular-kidney-metabolic syndrome stage 0-3.","authors":"Ya Lin, Xiaodong Lv, Ce Shi, Ting Wang, Zehao Jin, Qiangsong Jin, Chao Gu","doi":"10.3389/fendo.2025.1540241","DOIUrl":"10.3389/fendo.2025.1540241","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is strongly correlated with plasma atherogenic index (AIP); however, there is limited literature exploring the association between trajectories of change in AIP and the risk of CVD. This study aimed to investigate whether changes in AIP are associated with CVD in individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0-3.</p><p><strong>Methods: </strong>Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), aimed to compile high-quality microdata on individuals and households aged 45 and older in China. Change in AIP from 2012 to 2015 were classified employing K-means clustering analysis. Logistic regressions were employed to assess the association between different AIP change clusters and cumulative AIP and CVD incidence. Additionally, restricted cubic spline (RCS) regression was conducted to further evaluate the underlying linear relationship between cumulative AIP and CVD. Subgroup analyses were applied to verify the influence of confounding variables on the relationship between AIP and CVD. Weighted quantile sum (WGS) regressions were utilized to offer a comprehensive assessment of the overall effect.</p><p><strong>Results: </strong>Out of 4,525 participants, 578 (12.77%) ultimately developed CVD within three years. Compared to cluster 1, which served as the best control for AIP, the odds ratio (OR) was 1.29 (1.02-1.62) for cluster 2, 1.33 (1.04-1.71) for cluster 3 and 1.35 (0.98-1.85) for cluster 4 after adjusting for several confounding variables. Categorizing the cumulative AIP into quartiles revealed an ascending trend (P for trend = 0.014). RCS regression disclosed a linear relationship between cumulative AIP and CVD. Further subgroup analyses revealed variations in these correlations modified by gender and Hukou status. WQS regression analysis highlighted the significance of triglyceride in the pathogenesis of CVD.</p><p><strong>Conclusions: </strong>Significant changes in AIP are independently associated with the elevated risk of CVD in adults aged > 45 with CKM syndrome stage 0-3. Monitoring long-term fluctuations in AIP may aid in the early identification of individuals at high risk for CVD.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1540241"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of radioactive iodine therapy on hematological parameters in patients with thyroid cancer: systematic review and meta-analysis.","authors":"Dereje Mengesha Berta, Bisrat Birke Teketelew, Negesse Cherie, Mebratu Tamir, Zufan Yiheyis Abriham, Abiy Ayele Angelo, Amare Mekuanint Tarekegne, Elias Chane, Zewudu Mulatie, Muluken Walle","doi":"10.3389/fendo.2025.1562851","DOIUrl":"10.3389/fendo.2025.1562851","url":null,"abstract":"<p><strong>Background: </strong>Patients with thyroid cancer (TC) are commonly treated with radioactive iodine therapy (RIA) to prevent neoplastic transformation and the re-emergence of cancer cells. However, it has major side effects on blood cells. However, the degree of change in hematological parameters reported varies across studies. Therefore, the aim of this review was to assesses the mean differences in hematological parameters after RAI therapy.</p><p><strong>Methods: </strong>The relevant articles for this review were identified through extensive searches of databases and the Google search engine. The identified articles were subsequently selected using predetermined eligibility criteria. All relevant information from the screened articles was extracted. The pooled standardized mean differences (SMDs) of the parameters were assessed via a random effects model. The heterogeneity was determined by I² statistics test. Funnel plots and Egger's test were utilized to assess publication bias.</p><p><strong>Results: </strong>A total of 17 studies including 4,112 and 3,766 study participants before and after RAI therapy, respectively, were included. The pooled SMDs of the total leucocyte count (TLC) (*10⁹/L) at one, three, six and 12 months and the last follow-up period were 2.39, 2.46, 5.84, 3.19, and 0.53, respectively. Changes in the TLC after one, three and six months of therapy were statistically significant. In terms of the absolute neutrophil count (ANC; *10⁹/L) and absolute lymphocyte count (ALC; *10⁹/L), the pooled SMDs at the last follow-up period were 6.32 and 7.37, respectively. In addition, statistically significant changes in the platelet count (PLT; *10⁹/L) were observed at one, three, six and 12 months and at the last follow-up, with pooled SMDs of 7.01, 0.22, 2.63, 6.61, and 8.76, respectively. Furthermore, statistically significant changes in red blood cells (RBCs; *10¹²/L) and hemoglobin (Hgb; g/dl) were detected after three and six months of therapy, with pooled SMDs of -1.088 and 2.4, respectively.</p><p><strong>Conclusion: </strong>According to the current systematic review and meta-analysis, radioiodine therapy had a significant effect on hematological parameters. Thus, early screening and correction of hematological toxicity may be helpful for improving quality of life in thyroid cancer patients receiving radioiodine therapy.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024586449.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1562851"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between chronic kidney disease and all-cause mortality in diabetic foot ulcers: evidence from the 1999-2004 national health and nutrition examination survey (NHANES).","authors":"Jiaru Liang, Hang An, Xuyang Hu, Yuling Gao, Jiaqi Zhou, Xiaoyang Gong, Junwei Zong, Yong Liu","doi":"10.3389/fendo.2025.1533087","DOIUrl":"10.3389/fendo.2025.1533087","url":null,"abstract":"<p><strong>Background: </strong>The poor prognosis of diabetic foot ulcers (DFUs) often leads to amputation and high mortality rates, becoming a heavy economic burden on the healthcare system. Several clinical studies have been conducted to investigate the risk factors for DFU mortality and to provide clinical guidance for better prevention and control of DFU mortality.</p><p><strong>Methods: </strong>We used R to organize the mortality data of patients with DFU, collected from the NHANES database during the 1994-2004 period, along with three kidney function indicators including Albumin-to-Creatinine Ratio (ACR), estimated Glomerular Filtration Rate (eGFR) and cystatin C, used to assess chronic kidney disease (CKD). We explored the relationship between CKD and the risk of death in DFU patients through multiple kidney function indicators. Baseline characteristics of the surviving group and the mortality group of patients with DFU were analyzed using the 'svyby' function in the 'survey' package. We used Kaplan-Meier curves, multivariable logistic regression models, Cox proportional risk regression models, and time-dependent ROC curves to analyze the relationship between CKD and the risk of death in patients with DFU.</p><p><strong>Results: </strong>This study included a total of 112 patients with DFU. The overall sample had an average age of 65 years, with 43 females (38.39%) and 69 males (61.61%). During the follow-up time, 29 survived and 89 died. All-cause mortality in DFU patients was analyzed based on clinical classifications of ACR, eGFR, and cystatin C, with Kaplan-Meier curves illustrating survival variability. Multivariable logistic regression analysis showed no significant correlation between the risk of death in patients with DFU and CKD. However, analysis of Cox proportional risk regression model that accounted for time effects found a significant association between all-cause mortality and cystatin C levels in patients with DFU. Time-dependent ROC curve analysis demonstrated that cystatin C had superior diagnostic accuracy and stability for predicting all-cause mortality in DFU patients.</p><p><strong>Conclusions: </strong>In this study, we found that cystatin C demonstrated greater stability and accuracy in assessing the risk of death and predicting mortality in patients with DFU.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1533087"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between urinary albumin-to-creatinine ratio within normal range and kidney stones in U.S. adults: a cross-sectional observational study.","authors":"Yuan-Zhuo Du, Chi-Teng Zhang, De-Ming Zeng, Yong Li, Yi-Fu Liu","doi":"10.3389/fendo.2025.1526694","DOIUrl":"10.3389/fendo.2025.1526694","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are a major public health concern, and their prevalence has increased significantly in recent decades. While urinary albumin-to-creatinine ratio (UACR) is a recognized marker for kidney disease, its relationship with kidney stones, especially within the normal UACR range, remains unclear. The purpose of this study was to investigate the association between UACR levels within the normal range and the risk of developing kidney stones.</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2009 to 2018, focusing on adults aged 20 years and older with available UACR data. Using weighted multivariable logistic regression and restricted cubic spline (RCS) models, we assessed the relationship between UACR levels and the prevalence of kidney stones, adjusting for relevant covariates. Subgroup analyses were also performed to evaluate the consistency of this association across demographic and health-related factors.</p><p><strong>Results: </strong>The study found that higher UACR levels within the normal range were significantly associated with an increased likelihood of developing kidney stones. Specifically, individuals in the highest quartile of UACR had a 36% higher odds of kidney stones compared to those in the lowest quartile (OR: 1.36, 95% CI: 1.04-1.77). A non-linear, dose-response relationship was observed between UACR levels and kidney stone risk (P < 0.001), with the association remaining consistent across various demographic subgroups.</p><p><strong>Conclusion: </strong>Elevated UACR levels, even within the normal range, are strongly associated with a higher risk of kidney stones. This finding highlights the potential of UACR as a valuable biomarker for assessing kidney stone risk in clinical practice.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1526694"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes.","authors":"Jielin Song, Chuanfu Wang, Tong Zhao, Yu Zhang, Jixiang Xing, Xuelian Zhao, Yunsha Zhang, Zhaohui Zhang","doi":"10.3389/fendo.2025.1520436","DOIUrl":"10.3389/fendo.2025.1520436","url":null,"abstract":"<p><p>Recent advancements in multi-omics technologies have provided unprecedented opportunities to identify biomarkers associated with prediabetes, offering novel insights into its diagnosis and management. This review synthesizes the latest findings on prediabetes from multiple omics domains, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, and radiomics. We explore how these technologies elucidate the molecular and cellular mechanisms underlying prediabetes and analyze potential biomarkers with predictive value in disease progression. Integrating multi-omics data helps address the limitations of traditional diagnostic methods, enabling early detection, personalized interventions, and improved patient outcomes. However, challenges such as data integration, standardization, and clinical validation and translation remain to be resolved. Future research leveraging artificial intelligence and machine learning is expected to further enhance the predictive power of multi-omics technologies, contributing to the precision diagnosis and tailored management of prediabetes.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1520436"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Erratum: High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.","authors":"","doi":"10.3389/fendo.2025.1589509","DOIUrl":"https://doi.org/10.3389/fendo.2025.1589509","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fendo.2023.1200774.].</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1589509"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018.","authors":"Qihui Chu, Bin Wu, Zhaofu Zhang","doi":"10.3389/fendo.2025.1537403","DOIUrl":"10.3389/fendo.2025.1537403","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and all-cause as well as cause-specific mortality among patients with kidney stones, and to evaluate the capability of NLR as a predictor of mortality.</p><p><strong>Methods: </strong>This study included 2,995 patients with kidney stones from the NHANES database during the period from 2007 to 2018, and subsequently linked this data with the National Death Index. The relationship between NLR and mortality was analyzed using the Cox proportional hazards model and Kaplan-Meier survival curves. Additionally, restricted cubic spline (RCS) curves were employed to explore the dose-response relationship between NLR and mortality, while time-dependent ROC curves were utilized to assess the predictive capability of NLR for mortality. Finally, the mediating effect of estimated glomerular filtration rate (eGFR) on the relationship between NLR and mortality was also analyzed.</p><p><strong>Results: </strong>This study ultimately included 2,995 patients with kidney stones, with a median follow-up period of 74 months. A total of 395 deaths were recorded, of which 87 were attributed to cardiovascular diseases. An NLR cut-off of 3.62 was identified as significantly associated with survival outcomes using the 'maxstat' package and the principle of maximum rank statistics. The restricted cubic spline plot indicates a non-linear relationship between NLR and both all-cause mortality and cardiovascular mortality. After adjusting for relevant covariates, the Cox regression analysis demonstrated that, in comparison to the lower NLR group, the higher NLR group exhibited a 1.05-fold (HR 2.05, 95% CI 1.51-2.78, <i>P</i> < 0.001) increased risk of all-cause mortality and a 1.99-fold (HR 2.99, 95% CI 1.89-4.72, <i>P</i> < 0.001) increased risk of cardiovascular mortality. Furthermore, eGFR exhibited a significant mediating effect on the relationship between NLR and mortality.</p><p><strong>Conclusion: </strong>This study found that patients with kidney stones exhibiting a high NLR have a significantly increased risk of mortality in the U.S. population. Therefore, monitoring NLR may be important for the prognosis of patients with kidney stones.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1537403"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inverse relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and testosterone in adult males in the United States: a cross-sectional study based on the NHANES database.","authors":"Yangyang Mei, Yiming Chen, Xiaogang Wang, Renfang Xu, Rui Xu, Xingliang Feng","doi":"10.3389/fendo.2025.1478124","DOIUrl":"10.3389/fendo.2025.1478124","url":null,"abstract":"<p><strong>Background: </strong>Testosterone is a crucial hormone for male health, influencing metabolism, cardiovascular function, bone density, and cognitive abilities. Elevated non-HDL cholesterol to HDL cholesterol ratio (NHHR) has been implicated in lipid metabolism disorders, which may adversely affect testosterone levels. This study investigates the association between NHHR and testosterone levels in adult males, utilizing data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 2,859 adult males from the NHANES cycles 2011-2016. Total testosterone levels were measured using isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS). NHHR was calculated and analyzed as both a continuous variable and in quartiles. Multivariable linear and logistic regression models, adjusted for demographic, biochemical, lifestyle factors, and medical comorbidities, were used to assess the relationship between NHHR and total testosterone levels and the risk of testosterone deficiency (TD).</p><p><strong>Results: </strong>Higher NHHR was significantly associated with lower total testosterone levels and increased risk of TD. In fully adjusted models, each unit increase in NHHR was associated with a decrease in total testosterone levels (β = -16.31, 95% CI: -26.58 to -6.04, P = 0.003) and an increased risk of TD (OR = 1.24, 95% CI: 1.07 to 1.44, P = 0.01). When NHHR was analyzed in quartiles, participants in the highest quartile (Q4) had significantly lower testosterone levels (β = -54.98, 95% CI: -86.21 to -23.74, P = 0.001) and a higher risk of TD (OR = 2.04, 95% CI: 1.20 to 3.49, P = 0.01) compared to those in the lowest quartile (Q1). Subgroup analyses confirmed these findings across different age groups, BMI categories, smoking status, and presence of comorbidities. Smooth curve fitting demonstrated a linear relationship among them.</p><p><strong>Conclusion: </strong>Our study is the first to identify a significant association between elevated NHHR and both reduced total testosterone levels and increased risk of TD in a large, representative sample of adult American males. These findings suggest that NHHR could serve as a valuable marker for early identification of individuals at risk for testosterone decline and TD, enabling timely and targeted clinical interventions.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1478124"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the association between visceral adiposity index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus in China.","authors":"Xin Zhao, Jianbin Sun, Sixu Xin, Xiaomei Zhang","doi":"10.3389/fendo.2025.1549954","DOIUrl":"10.3389/fendo.2025.1549954","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the correlation between visceral adiposity index (VAI) and diabetes kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM), so as to provide a clinical basis for the prevention and treatment of DKD.</p><p><strong>Methods: </strong>This study retrospectively analyzed 1817 patients with T2DM hospitalized in the department of Endocrinology, Peking University International Hospital from January 2017 to August 2021, including 1053 males and 764 females. According the level of VAI, subjects were divided into three groups.</p><p><strong>Results: </strong>(1) The results showed that with the increase of VAI level, the proportion of DKD gradually increased, and there was a statistical difference (p < 0.05). With the increase of VAI levels, there is an increasing trend in males, age, WC, BMI, WHtR, WHR, VAI, LAP, ABSI, C-Index, CUN-BAE, SBP, DBP, HbA1c, FBG, PBG, UACR, TG, while HDL-C levels show a decreasing trend (p all <0.05). (2)Logistic regression showed that after adjusting age, sex, diabetic duration, smoking, drinking, BP, blood glucose and blood lipids, high level of VAI was an independent risk factor for DKD (HR=1.38, 95% CI 1.18, 1.63). (3)The model to predict the risk of DKD using anthropometric indicators, showed that the AUC of the models ranked VAI>ABSI>C-index>WHR>AVI=BRI>BMI>CUN-BAE>LAP>WHtR.(4)The predictive ability for DKD of Model 1 with VAI was higher than that of Model 2 with BMI.</p><p><strong>Conclusion: </strong>The increase of VAI is an independent predictor of DKD occurrence in patients with T2DM, which provides a certain clinical basis for preventing the development of DKD in patients with T2DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1549954"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel target genes in exaggerated cardiac remodeling following myocardial infarction in diabetes.","authors":"Yanru Duan, Shihan Zhang, Yihua Xia, Huili Li, Demin Liu, Yunhui Du","doi":"10.3389/fendo.2025.1536639","DOIUrl":"10.3389/fendo.2025.1536639","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus is a major risk factor for myocardial infarction (MI), yet its molecular mechanisms exacerbating post-MI cardiac remodeling remain unclear.</p><p><strong>Methods: </strong>Type 2 diabetes mellitus mouse model was developed through a high-sugar and high-fat diet (HFD), followed by MI surgery. Four weeks post-surgery, cardiac function was evaluated via echocardiography, and cardiac pathology was examined using Masson's trichrome and wheat germ agglutinin staining. High-throughput sequencing identified differentially expressed mRNAs and long non-coding RNAs (LncRNAs) in diabetic mice with MI. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, along with LncRNA-target-gene analysis, were performed. Validation in human samples of diabetic patients with STEMI confirmed the influence of HFD on the expression of specific genes.</p><p><strong>Results: </strong>The results demonstrate that diabetes significantly impairs cardiac function, exacerbates cardiac fibrosis and hypertrophy. In addition, our extensive examination of human samples has conclusively demonstrated that diabetes significantly modulates the expression of genes (Rapgef5 and Ing1) within the cardiac tissue of individuals afflicted with STEMI, underscoring the intricate interplay between these conditions. In addition, we have found that Rapgef5 and Ing1 are involved in diabetes-mediated cardiomyocyte apoptosis and proliferation following myocardial infarction.</p><p><strong>Discussion: </strong>Diabetes aggravates post-MI remodeling via Rapgef5/Ing1-mediated apoptosis and proliferation, these findings highlight novel therapeutic targets for diabetic cardiovascular complications.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1536639"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}