Frontiers in Endocrinology最新文献

{"title":"Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms.","authors":"Zheng Zhao, Yongjia Zhu, Dongfeng Wan","doi":"10.3389/fendo.2025.1557797","DOIUrl":"10.3389/fendo.2025.1557797","url":null,"abstract":"<p><p>Tissue fibrosis represents an aberrant repair process, occurring because of prolonged injury, sustained inflammatory response, or metabolic disorders. It is characterized by an excessive accumulation of extracellular matrix (ECM), resulting in tissue hardening, structural remodeling, and loss of function. This pathological phenomenon is a common feature in the end stage of numerous chronic diseases. Despite the advent of novel therapeutic modalities, including antifibrotic agents, these have only modest efficacy in reversing established fibrosis and are associated with adverse effects. In recent years, a growing body of research has demonstrated that exercise has significant benefits and potential in the treatment of tissue fibrosis. The anti-fibrotic effects of exercise are mediated by multiple mechanisms, including direct inhibition of fibroblast activation, reduction in the expression of pro-fibrotic factors such as transforming growth factor-β (TGF-β) and slowing of collagen deposition. Furthermore, exercise has been demonstrated to assist in maintaining the dynamic equilibrium of tissue repair, thereby indirectly reducing tissue damage and fibrosis. It can also help maintain the dynamic balance of tissue repair by improving metabolic disorders, exerting anti-inflammatory and antioxidant effects, regulating cellular autophagy, restoring mitochondrial function, activating stem cell activity, and reducing cell apoptosis, thereby indirectly alleviating tissue. This paper presents a review of the therapeutic potential of exercise and its underlying mechanisms for the treatment of a range of tissue fibrosis, including cardiac, pulmonary, renal, hepatic, and skeletal muscle. It offers a valuable reference point for non-pharmacological intervention strategies for the comprehensive treatment of fibrotic diseases.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1557797"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics.","authors":"Xun Huang, Yunhong Wang, Rong Wan, Zhigang You, Lin Huang","doi":"10.3389/fendo.2025.1525831","DOIUrl":"10.3389/fendo.2025.1525831","url":null,"abstract":"<p><strong>Background: </strong>Diabetic cardiomyopathy (DCM) is a heart disease caused by the metabolic disorders of glucose and lipids associated with diabetes, leading to heart failure and death in diabetic patients. Dapagliflozin (DAPA) serves as a treatment for managing blood glucose levels in individuals with type 2 diabetes mellitus (DM). However, the specific mechanisms by which DAPA treats DCM are not yet fully understood.</p><p><strong>Methods: </strong>Sprague-Dawley (SD) rats (n = 5/group) were randomly divided into control, model, and intervention groups. Lipid metabolism-related genes (LMRGs) were gotten from publicly available database. Differential expression analysis of model <i>vs.</i> control and intervention <i>vs.</i> model samples was performed to obtain differentially expressed genes (DEGs), and the result was recorded as DEGs-Model and DEGs-Intervention. The intersection of genes with opposing expression trends between DEGs-Model and DEGs-Intervention were considered as candidate genes. Subsequently, candidate genes and LMRGs were intersected to acquire hub genes, and the expression of hub genes was analyzed in each group of samples. Then, the mechanism of action of these hub genes were investigated through functional enrichment analysis, gene set enrichment analysis (GSEA), and predictive of m6A binding sites.</p><p><strong>Results: </strong>Ultimately, 68 candidate genes and 590 LMRGs were intersected to derive 2 hub genes (Acsbg1 and Etnppl). Acsbg1 was significantly increase in model group compared with control group. RT-qPCR results confirmed Acsbg1 was obviously higher expression in model group, while Etnppl was significantly lower expression in model group compare to control groups and intervention group. While the expression of Etnppl was significantly increase in intervention group compared with model group. Functional enrichment analyses indicated that Acsbg1 and Etnppl were associated with fatty acid metabolism. The findings of GSEA indicated that Acsbg1 and Etnppl might affect the occurrence and progression of DCM through lysosome. And the Acsbg1 and Etnppl were located at UCAGG in the RNA secondary structure.</p><p><strong>Conclusion: </strong>This study identified 2 hub genes (Acsbg1 and Etnppl) as potential new focal points for diagnosing and treating DCM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1525831"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating bone mineral density in osteoporotic vertebral compression fractures: the clinical utility of anterior column Hounsfield units.","authors":"Jiabao Chen, Han Zheng, Haotian Li, Qingsong Yu, Yanhong Li, Huangda An, Lei Ma","doi":"10.3389/fendo.2025.1552780","DOIUrl":"10.3389/fendo.2025.1552780","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective radiological analysis.</p><p><strong>Objective: </strong>This study aimed to evaluate the clinical utility of anterior column Hounsfield units (HU) in assessing bone mineral density (BMD) in patients with osteoporotic vertebral compression fractures (OVCFs) and to investigate its potential advantages over traditional measurement methods.</p><p><strong>Method: </strong>In this retrospective study, we analyzed data from 106 patients with acute OVCFs treated between January 2020 and June 2024. Inclusion criteria encompassed single-segment fractures from T10 to L2, with clear imaging results. HU values were measured from computed tomography (CT) scans, specifically targeting the anterior column of the vertebral body. Interobserver reliability was assessed via intraclass correlation coefficients (ICCs). Correlations between HU values, dual-energy X-ray absorptiometry (DEXA) results, and vertebral compression degrees were analyzed using Pearson correlation and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The average HU values were significantly lower in the anterior column (50.39 ± 21.62 HU) compared to the middle column (63.12 ± 25.14 HU). The anterior column HU values showed a strong positive correlation with DEXA T-scores (r = 0.643) and BMD (r = 0.656). The degree of vertebral compression also correlated positively with both HU values and DEXA results, with the anterior column HU demonstrating the highest correlation (r = 0.727). ROC analysis indicated that the anterior column HU value had the largest area under the curve (AUC = 0.913) for predicting severe OVCFs, with an optimal cutoff of 59.07 HU.</p><p><strong>Conclusion: </strong>The anterior column HU value serves as a superior predictor of BMD in patients with OVCFs compared to traditional methods. This study highlights the potential of using anterior column HU measurements to guide clinical decision-making regarding treatment options for OVCF patients, suggesting a shift towards more nuanced assessment strategies in osteoporosis management. Further research with larger sample sizes is warranted to validate these findings and explore the comprehensive application of HU values in osteoporosis evaluation.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1552780"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Effect of probiotics at different intervention time on glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.","authors":"Shanshan Wu, Yanhai Wang","doi":"10.3389/fendo.2025.1514969","DOIUrl":"10.3389/fendo.2025.1514969","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1514969"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell sequencing in non-obstructive azoospermia: insights from primary and re-analysis studies.","authors":"Zesong Jiang, Junwen Zhang, Zhongjian Qiu, Yufei Zhang, Nan Li, Jianmeng Hu, Zhiguo Zhu","doi":"10.3389/fendo.2025.1539063","DOIUrl":"10.3389/fendo.2025.1539063","url":null,"abstract":"<p><p>Non-obstructive azoospermia (NOA) constitutes one of the most severe forms of male infertility. Recent advancements in single-cell sequencing have significantly contributed to understanding the molecular landscape of NOA in human testicular tissues, elucidating the factors that underpin spermatogenic dysfunction. This technology has improved our understanding of the condition at a cellular level. Concurrently, bioinformatics developments have facilitated the re-analysis of publicly available single-cell datasets, offering novel insights into the disorder. Nevertheless, a comprehensive review integrating primary and re-analysis studies of single-cell sequencing in NOA is lacking. This review systematically evaluates 10 primary studies reporting original single-cell sequencing data of human NOA testicular samples and 22 secondary studies that re-analyzed these published data. We explore single-cell sequencing applications in germ cells, Sertoli cells, and Leydig cells, offering a comprehensive overview of molecular insights into spermatogenic dysfunction. Our review highlights novel findings in secondary studies, including the roles of transcriptional regulators, RNA transcription, endocrine disruptors, and microtubular cytoskeleton, thereby bridging primary studies and re-analysis studies. Additionally, we discussed future research directions and the challenges of translating single-cell research findings into clinical applications. In summary, single-cell sequencing offers a high-resolution, single-cell perspective of NOA testicular tissue, paving the way for innovative therapeutic strategies in male infertility.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1539063"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism monitoring and control during the first trimester of pregnancy in Catalonia.","authors":"Glòria Tena Vivó, Oriol Cunillera Puértolas, Mercè Albareda Riera, Neus Parellada Esquius, Mònica Isidro Albaladejo, Gemma Rodríguez Palomar, Silvia Palmero Aliste, Lluís Vila","doi":"10.3389/fendo.2025.1445977","DOIUrl":"10.3389/fendo.2025.1445977","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to describe hypothyroidism monitoring and control during the first trimester of pregnancy in women with known hypothyroidism in Catalonia.</p><p><strong>Materials and methods: </strong>Pregnancies registered in primary care in Catalonia between 2014 and 2016 were retrospectively studied. Women with hypothyroidism were selected for the study. Hypothyroidism was defined if, on the date of the last menstrual period (LMP), there was an updated thyroid hormone prescription (code ATC H03AA -levothyroxine) or any of the following active diagnostic codes: ICD-10: E02, E03, E89.0. To evaluate hypothyroidism monitoring and control, thyrotropin (TSH) tests during the first trimester of pregnancy were considered and categorized according to the reference values of each laboratory.</p><p><strong>Results: </strong>Out of 111,811 pregnancies, 5,574 had known hypothyroidism. TSH was evaluated in 3,158 (56.65%) of them. The TSH values were within the recommended ranges in 1,146 (36.3%) of the cases, being low abnormal in 53 of them (1.7%) and high abnormal in 1,959 (62%).</p><p><strong>Conclusion: </strong>TSH testing was not evaluated in almost half of the pregnant women with known hypothyroidism in primary care services in Catalonia during the pregnancy first trimester. Among those tested, more than two-thirds had TSH levels outside the target range. This means that it is essential to improve the management of hypothyroidism during the first trimester of pregnancy in Catalonia.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1445977"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mendelian randomization study reveals a causal association between NASH and the risk of atrial fibrillation.","authors":"Biwei Cheng, Xuekang Su, Jue He, Yanghui Gu, Mingtai Chen, Yi Wei, Yumeng Yi, Peiying Chen, Xiaojuan Lin, Tao Li, Chong Xu, Qiang Liu, Biao Li","doi":"10.3389/fendo.2025.1390259","DOIUrl":"10.3389/fendo.2025.1390259","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological evidence suggests that non-alcoholic fatty liver disease (NAFLD) may increase the risk of atrial fibrillation (AF). However, the findings are inconsistent, and the causality remains to be established.</p><p><strong>Methods: </strong>We conducted two-step, two-sample Mendelian randomization (MR) analysis to assess the association between genetically predicted NAFLD (i.e. chronically elevated serum alanine aminotransferase levels [cALT], imaging-based and biopsy-confirmed NAFLD) and AF. Subsequently, we further performed Mendelian randomization to investigate the causal relationship between non-alcoholic steatohepatitis (NASH), a subtype of NAFLD, and AF. The inverse variance weighted (IVW) method was used as the primary approach to reveal the potential causation between the exposure and outcome.</p><p><strong>Results: </strong>There was no significant causal association between NAFLD diagnosed based on cALT, confirmed by imaging, or verified by biopsy, and an increased risk of atrial fibrillation. Furthermore, the results of the IVW method revealed a positive causal effect of NASH on AF (OR=1.113, 95% CI=1.025-1.209, P = 0.011). In the reverse analysis, however, no evidence supported a significant genetic association between AF and NASH (OR=0.974, 95% CI=0.934-1.016, P = 0.214).</p><p><strong>Conclusion: </strong>A causal relationship existed between NASH and the risk of AF. However, no significant genetic association has been observed between NAFLD and AF risk. This suggests that managing the progression of NAFLD may hold potential value in preventing the onset of AF.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1390259"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the stress hyperglycemia ratio and all-cause mortality in critically ill patients with T2DM: a retrospective study.","authors":"Yuanyuan Rui, Bing Wu, Changbao Huang, Qian Li","doi":"10.3389/fendo.2025.1487496","DOIUrl":"10.3389/fendo.2025.1487496","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown a significant correlation between the stress-hyperglycemia ratio (SHR) and mortality. However, it is unknown whether the SHR has the same predictive value in severely ill patients. The main purpose of this research was to investigate the association between the SHR and all-cause mortality in critically ill patients with T2DM.</p><p><strong>Methods: </strong>The data used in this study were derived from the Medical Information Mart for Intensive Care (MIMIC-IV) database. The primary outcome was 180-day mortality and the secondary outcomes were 28-day, 90-day and 365-day mortality. The main analytical methods included: Kaplan-Meier survival analysis, the COX proportional hazards model and restricted cubic splines.</p><p><strong>Results: </strong>A total of 993 patients were included. The 28-day, 90-day, 180-day, and 365-day mortalities reached 10.4%, 14.4%, 16.7% and 19.0%, respectively. Multivariate Cox proportional hazards analysis revealed that the elevated SHR was significantly related to 28-day, 90-day and 180-day all-cause mortality even after cofounder adjustment. Restricted cubic spline analysis revealed a nonlinear association between the SHR and the risk of 28-day (p for nonlinear=0.014), 90-day (p for nonlinear=0.007), 180-day (p for nonlinear=0.001) and 365-day (p for nonlinear=0.003) all-cause mortality.</p><p><strong>Conclusion: </strong>SHR is significantly associated with 28-day, 90-day and 180-day all-cause mortality in critically ill patients with T2DM. This may help us identify patients at higher risk of death early.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1487496"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Pre-natal and post-natal environmental impacts on metabolic control.","authors":"David J Hill, Daniel B Hardy, Luis Sobrevia, Gernot Desoye","doi":"10.3389/fendo.2025.1583915","DOIUrl":"https://doi.org/10.3389/fendo.2025.1583915","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1583915"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodopa induces thyroid function regulation in a patient with thyroid hormone resistance and Parkinson's disease: a case report.","authors":"Gabriela Rozo-Paz, Clara Maria Ruiz-Forero, José David Suárez-Mera, Guillermo Monsalve Duarte, William Kattah Calderón","doi":"10.3389/fendo.2025.1536372","DOIUrl":"10.3389/fendo.2025.1536372","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid hormone resistance (THR) is a rare genetic syndrome characterized by reduced sensitivity to thyroid hormones. Patients may be asymptomatic, although clinical manifestations depend on the THR subtype. This entity commonly has abnormal thyroid function tests and can be confirmed by molecular analyses.</p><p><strong>Case presentation: </strong>The present study describes a 55 year-old female diagnosed with surgically resected papillary thyroid carcinoma. During the endocrinology consults, elevated thyroid hormone levels were detected without an adequate TSH response, and THR was suspected. Moreover, Parkinson's disease was diagnosed, and treatment with levodopa/carbidopa was initiated. Following this regimen, her TSH and total T3 levels were subsequently normalized, which suggests a potential effect of this agent on the normalization of these hormone levels in the blood. In this case, the role of levodopa was crucial to regulate the TSH concentration which was required to carry out the resection of a tumoral remnant.</p><p><strong>Conclusion: </strong>The influence of dopamine in the endocrine system, specifically in the thyroid gland, is beneficial in conditions such as THR where abnormal TSH levels can be lowered, helping to balance the thyroid and hormones function.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1536372"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}