Hypothyroidism monitoring and control during the first trimester of pregnancy in Catalonia.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1445977

Glòria Tena Vivó, Oriol Cunillera Puértolas, Mercè Albareda Riera, Neus Parellada Esquius, Mònica Isidro Albaladejo, Gemma Rodríguez Palomar, Silvia Palmero Aliste, Lluís Vila

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Abstract

Objective: This study aims to describe hypothyroidism monitoring and control during the first trimester of pregnancy in women with known hypothyroidism in Catalonia.

Materials and methods: Pregnancies registered in primary care in Catalonia between 2014 and 2016 were retrospectively studied. Women with hypothyroidism were selected for the study. Hypothyroidism was defined if, on the date of the last menstrual period (LMP), there was an updated thyroid hormone prescription (code ATC H03AA -levothyroxine) or any of the following active diagnostic codes: ICD-10: E02, E03, E89.0. To evaluate hypothyroidism monitoring and control, thyrotropin (TSH) tests during the first trimester of pregnancy were considered and categorized according to the reference values of each laboratory.

Results: Out of 111,811 pregnancies, 5,574 had known hypothyroidism. TSH was evaluated in 3,158 (56.65%) of them. The TSH values were within the recommended ranges in 1,146 (36.3%) of the cases, being low abnormal in 53 of them (1.7%) and high abnormal in 1,959 (62%).

Conclusion: TSH testing was not evaluated in almost half of the pregnant women with known hypothyroidism in primary care services in Catalonia during the pregnancy first trimester. Among those tested, more than two-thirds had TSH levels outside the target range. This means that it is essential to improve the management of hypothyroidism during the first trimester of pregnancy in Catalonia.

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加泰罗尼亚妊娠前三个月甲状腺功能减退的监测和控制。

目的：本研究旨在描述加泰罗尼亚已知甲状腺功能减退的妇女妊娠前三个月甲状腺功能减退监测和控制。材料和方法：回顾性研究2014年至2016年在加泰罗尼亚初级保健机构登记的妊娠。患有甲状腺功能减退症的妇女被选为研究对象。如果在最后一次月经（LMP）日期有更新的甲状腺激素处方（代码ATC H03AA -左旋甲状腺素）或以下任何有效诊断代码：ICD-10: E02， E03, E89.0，则定义为甲状腺功能减退。为了评估甲状腺功能减退的监测和控制，考虑妊娠前三个月的促甲状腺素（TSH）检测结果，并根据各实验室的参考值进行分类。结果：111811例妊娠中，5574例已知甲状腺功能减退。其中3158人（56.65%）进行了TSH检测。TSH值在推荐范围内的1146例（36.3%），低异常53例（1.7%），高异常1959例（62%）。结论：在加泰罗尼亚的初级保健服务中，几乎有一半的已知甲状腺功能减退的孕妇在怀孕的前三个月没有进行TSH检测。在接受测试的人中，超过三分之二的人的TSH水平超出了目标范围。这意味着，它是必不可少的，以改善管理甲状腺功能减退症在怀孕的前三个月在加泰罗尼亚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.