Food Science and Human Wellness最新文献

{"title":"Angoline inhibits breast cancer cell proliferation and induces autophagy related cell death via attenuating lactate dehydrogenase A activity","authors":"Tingting Xu, Yong Sun, Yin Zhao, Yuan Li, Jiaqi Li, Bin Zheng, Xujun Zhou, Huiliang Zou, Xuhui Zhang, Jing Liu, Zhi‐Ming Zheng, Guang‐Xiong Zhou, Shuang Liu, Jun Fan","doi":"10.26599/fshw.2025.9250749","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250749","url":null,"abstract":"Dysregulated metabolism is one of the major hallmarks of malignant tumors, which includes increased glycolysis even in the presence of ample oxygen, providing a metabolic advantage for cell proliferation and tumor growth. Recognition of metabolic reprogramming in oncogenesis has paved the way for developing novel therapeutic approaches and agents targeting the key enzymes involved in this process. The therapeutic potential of plant-derived natural bioactive compounds is promising, due to their diverse structures and multiple targets. Angoline, an isoquinoline alkaloid isolated, has been reported to inhibit cancer cell proliferation and tumor growth, but the underlying mechanisms remain largely unclear. Our results showed that Angoline effectively inhibits breast cancer cell proliferation and tumor growth. Mechanistically, angoline directly binds to LDHA and suppresses its activity, resulting in decreased glycolytic rates, less lactate production and increased oxygen consumption in breast cancer cells. Furthermore, the metabolic switch from aerobic glycolysis to oxidative phosphorylation by angoline treatment induces the accumulation of intracellular ROS, which in turn causes a decline in mitochondrial membrane potential and subsequently triggers autophagy. <em>In vivo</em> xenograft model further confirmed the efficacy and safety of angoline in breast cancer treatment. Together, these results suggested that Angoline is a promising natural compound to inhibit LDHA activity, leading to decreased glycolytic rate and increased autophagy related cell death in breast cancer cells. These data together reveal an underlying molecular mechanism of angoline to treat breast cancer.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972926143973036033.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poplar type propolis influences the remodeling of the extracellular matrix in 3T3-L1 cells to reduce its differentiation and fat accumulation by inhibiting Col1a1","authors":"Wenjie Yu, Zhuozhen Li, Jiaqi Zhao, Jie Zhu, Yifan Zhang, Qifang Sun, Lili Chen, Shuai Zhuang, Lei Hu, Tao Liu, Shengxiang Yi, Gaowei Zhang, Liping Luo","doi":"10.26599/fshw.2025.9250745","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250745","url":null,"abstract":"Obesity has become a significant public health issue worldwide, which is defined as the abnormal enlargement of adipose tissue. Inhibiting fat cell growth and accumulation has been a key strategy in anti-obesity treatments. Poplar type propolis has shown great anti-obesity effects, but its effect and mechanism of poplar type propolis on adipocyte differentiation and fat accumulation are still not fully understood. In this study, the main compounds in poplar type propolis extract (PPE) were identified and used to construct a pharmacological network, revealing that PPE has potential roles in cellular development, differentiation, and lipid synthesis. Furthermore, lipidomics analysis indicated that PPE could reduce the ability of 3T3-L1 cells to mature and differentiate into adipocytes, which was evidenced by decreased formation of large lipid droplets and reduced cell membrane fluidity, along with a significant decrease in glucose uptake (67.45%) and fat accumulation (83.60%). Moreover, transcriptomics revealed PPE suppressed glycolysis in cells by steroid biosynthesis and PPAR signaling pathway by affected extracellular matrix remodeling during cell differentiation with Col1a1 was identified as an essential target of PPE affecting these processes through protein-protein interaction network and molecular docking. Finally, western blotting and immunofluorescence analysis were performed to validate the regulatory effect of PPE on Col1a1 expression. In conclusion, this study reveals a novel anti-adipogenic mechanism of PPE by inhibiting Col1a1-dependent extracellular matrix remodeling, thereby suppressing 3T3-L1 adipocyte differentiation and lipid accumulation. This study provides robust experimental evidence and theoretical foundations for developing PPE as a functional food.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1970390210715394049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147967070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of carbon quantum dots on the growth of \u0000 <em>Lactobacillus plantarum</em> ATCC 8014 due to oxidative stress and cell integrity destruction","authors":"Sijuan Wang, Jingwen Xu, Kaiqiang Lv, Guangwen Luo, Ning Guo, Yijie Li, Jinyuan Sun, Guoliang Li","doi":"10.26599/fshw.2025.9250788","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250788","url":null,"abstract":"","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of astaxanthin in ameliorating primary sclerosing cholangitis-related liver-gut dysregulation in mice","authors":"Mengyao Wang, Ge Yu, Feng Zhang, Shengyuan Lu, Juan Zheng, Yanlu Han, Wentong Guo, Mengjie Chen, Yuanli Chen, Xiaoxiao Yang, Zequn Yin, Yajun Duan, Wenting Li, Shuang Zhang","doi":"10.26599/fshw.2025.9250748","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250748","url":null,"abstract":"Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder primarily resulting from various etiologies that impair bile acids production, secretion and excretion. This impairment leads to the accumulation of toxic bile acids in the liver, causing bile duct obstruction and ultimately resulting in liver fibrosis, cirrhosis, and eventually liver failure. Currently, ursodeoxycholic acid and obeticholic acid are used for PSC treatment approved by the Food and Drug Administration with side effects unfortunately. Astaxanthin (AX), a natural antioxidant, plays a crucial role in many diseases. Nevertheless, the therapeutic effects and underlying mechanisms of AX in PSC remain to be investigated. In this study, we initially employed bioinformatics to analyze common targets between AX and cholestasis, revealing a correlation between them. Subsequently, we aimed to explore the effects of AX on 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced PSC in mice. AX treatment substantially ameliorated liver injury in mice, including liver histological morphology, fibrosis and ductular reaction. Simultaneously, AX restored the homeostasis of bile acid metabolism while inhibited inflammation, oxidative stress and apoptosis in mice. <em>In vitro</em> studies also demonstrated that AX markedly alleviated taurocholic acid (TCA)-induced cellular damage and inflammation. 16S rRNA gene sequencing was used to further examine the gut microbiota composition of DDC group and AX group mice. AX reduced the relative abundance of potentially pathogenic bacteria and increased the relative abundance of probiotics. Furthermore, correlation analysis suggested that an increase in harmful gut bacteria corresponded with impaired liver function. Mechanistically, Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed significant involvement of these common targets of AX and cholestasis within the HIF-1 signaling pathway encompassing NF-kB/IL-6/STAT3/HIF-1a axis. Consistently, we determined that AX inhibited NF-kB/IL-6/STAT3/HIF-1a signaling pathway in DDC-fed mice and TCA-treated cells. Phorbol 12-myristate 13-acetate, an NF-kB agonist, reversed AX-suppressed cellular inflammation and NF-kB downstream signaling. Furthermore, AX can also ameliorate the disruption of the intestinal barrier caused by PSC, reducing intestinal permeability, thereby alleviating hepatocyte inflammation. In summary, our study demonstrated that AX synergistically ameliorated PSC through modulation of gut microbiota alongside targeting hepatic NF-kB/IL-6/STAT3/HIF-1a axis.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972869671557795841.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <em>Opuntia ficus-indica</em>fruit juice <em>-</em>fermented by <em>Lactiplantibacillus plantarum</em>HNU082 on kidney injury, gut microbiota and metabolites in hyperuricemia mice based on multi-omics techniques","authors":"Huixian Wang, Xinhui Liu, Yi Huang, Jintao Wu, Yuyi Liu, R. Wang","doi":"10.26599/fshw.2025.9250680","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250680","url":null,"abstract":"Hyperuricemia (HUA), as a disease of purine metabolic disorder, seriously affects human health, mainly manifested in kidney injury, gut microbiota dysbiosis, and metabolic disorders. In this study, C57BL/6J mice were used to establish a HUA model by a combination of potassium oxonate and adenine to investigate the effect of fermented<em> Opuntia ficus-indica juice-</em>based<em> Lactiplantibacillus plantarum </em>HNU082 (OFIBP) on HUA. The results showed that OFIBP alleviated kidney inflammation and gut damage in HUA mice and regulate uric acid (UA) homeostasis in HUA mice through modulating UA production and excretion, which was evidenced by enhancing the expression of UA excretory protein and gene and decreasing the activity of key enzymes of UA synthesis. In addition, OFIBP supplementation restored HUA-induced gut microbiota disturbance, as well as increased metabolites of short-chain fatty acids (SCFAs) levels. Importantly, OFIBP supplementation modulated intestinal metabolic dysbiosis and mediated amino acid metabolism to ameliorate HUA in mice. Therefore, probiotic fermented juice could play a positive role in improving HUA as a novel and efficient functional food.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1966391482039930882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephroprotective effects and antioxidant mechanisms of a novel polysaccharide from <em>Poria cocos</em> sclerotia in chemotherapy-induced kidney injury","authors":"Daolun Yu, Kai Ge, Naidong Chen, Zhiqiang He, Yinuo Gong, Zongmeng Zhang","doi":"10.26599/fshw.2025.9250728","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250728","url":null,"abstract":"Kidney injury is one of the common side effects in cancer patients receiving chemotherapy. Enhancement of renal antioxidant and anti-inflammation function are important strategies to combat chemotherapy-induced kidney injury. In this study, we successfully isolated a novel water-soluble polysaccharide (PCP, Mw: 55.245 kDa) from <em>Poria cocos</em> sclerotia, which features an α-1,4-D-Glcp backbone with branches linked at the O-6 positions. <em>In vitro</em>, PCP significantly relieved oxidative damage and apoptosis caused by the chemotherapeutic agent cisplatin in renal tubular epithelial cells (RTECs). <em>In vivo</em>, pretreatment with PCP attenuated cisplatin-induced kidney injury by mitigating oxidative stress, apoptosis, and inflammation. Furthermore, post-treatment with PCP facilitated the recovery of renal function following kidney injury. In chronic kidney injury model, PCP exhibited a persistent nephroprotective effect in inhibiting the progression of chronic kidney disease and fibrosis. Mechanistically, PCP protected RTECs from cisplatin by activating the Nrf2 signaling pathway. Importantly, PKCζ was identified as the upstream kinase responsible for initiating the phosphorylation activation of Nrf2. Taken together, PCP confers protection against cisplatin-induced kidney injury by activating the PKCζ-Nrf2 signaling pathway, suggesting that PCP may be a promising clinical candidate for the treatment of chemotherapy-induced kidney injury.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1964928095888080898.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviation of excessive intestinal reactive oxygen species induced by circadian rhythm disruption through the Astaxanthin@ <em>Spirulina platensis</em> complex","authors":"Xiaoting Yu, Yannan Chen, Wentao Su, Haitao Wang, Jia-lin Miao, Y. Bai, Xunyu Song, Mingqian Tan","doi":"10.26599/fshw.2025.9250695","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250695","url":null,"abstract":"Circadian rhythm plays a crucial role in maintaining intestinal homeostasis, and conversely, the remodeling of gut microbiota can help regulate circadian rhythm. Although traditional therapeutic strategies involving oral small-molecule drugs can modulate the intestinal health in circadian rhythm disruption (CRD), they are limited by restricted efficacy, dependence, and side effects. Herein, astaxanthin (AXT) and <em>Spirulina platensis </em>(SP) were used to prepare an innovative complex (AXT@SP) by a simple one-step synthesis method to alleviate the excessive intestinal reactive oxygen species (ROS) in CRD. The AXT@SP successfully achieved efficient loading of AXT with the drug loading efficiency of 34.56% and extended the retention time of AXT in the intestine for more than 12 h. As expected, AXT@SP reduced the intestinal ROS generation by 40.7%, restored the circadian oscillation of antioxidant-related indicators, protected the intestinal immune barrier, and reshaped the gut microbiota composition in the intestine of CRD mice. Importantly, AXT@SP restored the circadian peak of γ-aminobutyric acid during the physiological sleeping phase and regulated the phase advance of cortisol at ZT12. Our results suggested that AXT@SP could be exploited as a promising strategy for regulating CRD-related intestinal homeostasis <em>via</em> the gut-brain axis.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1963419381821603842.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Hyperuricemic Effects of <em>Ampelopsis grossedentata</em> Extract and Its Major Component Dihydromyricetin via Targeted Regulation of Uric Acid Metabolism","authors":"Ruilong Li, Huimin Xue, Guanghe Fan, Fang Liu, Xiping Kang, Wei Lan, Yilin You","doi":"10.26599/fshw.2025.9250754","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250754","url":null,"abstract":"","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk mechanism exploration of the medical food homology compound β-ecdysterone with sympathetic overactivation-induced cardiac hypertrophy","authors":"Yu Duan, Xin Li, Runze Li, Ming Jiang, Qinhao Zhou, Yu Jiao, Siqi Peng, Yan Lin, Hui Li, Dan Xiao","doi":"10.26599/fshw.2025.9250725","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250725","url":null,"abstract":"β-ecdysterone, a functional component derived from medicine and food homologous herb <em>Achyranthes bidentata</em>, has shown potential in cardiovascular protection according to our previous studies. This study aims to further investigate its neuromodulatory mechanism in cardiac hypertrophy. The anti-hypertrophic effects of β-ecdysterone were validated both <em>in vivo</em> and <em>in vitro</em>. Transcriptomic analysis of cardiac and medullary tissues revealed the involvement of neuroregulatory pathways, including modulation of sympathetic acitivity. β-ecdysterone significantly reduced norepinephrine (NE) levels and its metabolites, which correlated with hypertrophic markers. Weighted Gene Co-Expression Network Analysis (WGCNA) identified <em>Dhx37</em> as a key gene associated with cardiac hypertrophy. In a co-culture model of sympathetic neurons (PC-12) and cardiomyocytes (H9C2), β-ecdysterone suppressed NE secretion and calcium influx in PC-12 cells under Angiotensin II (AngII) stimulation, an effect abolished by .<em>Dhx37</em> knockdown in cardiomyocytes. These findings suggest that β-ecdysterone alleviates cardiac hypertrophy by modulating cardiac-sympathetic neuron interaction via the Dhx37 pathway, offering a novel neurocardiac regulatory target for MFH-based therapies.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1962793795621224450.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of complement C3/C3aR pathway by paeoniflorin, a major constituent of Paeoniae Radix Alba, ameliorates vascular cognitive impairment under the theory of medicinal food homology","authors":"Jin Wang, Jingwen Wu, Minjie Sun, Yuejie Zhang, Ying Xu, Xiang Li, Boran Zhu, Xin Gu","doi":"10.26599/fshw.2025.9250690","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250690","url":null,"abstract":"","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}