Food Science and Human Wellness最新文献_第7页

Maternal dietary patterns associated with bone density in Chinese lactating women and infants at 6 months postpartum: a prospective study using data from 2018–2019 母亲膳食模式与中国哺乳期妇女和产后6个月婴儿骨密度的相关性：利用2018-2019年数据进行的前瞻性研究

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250214

{"title":"Maternal dietary patterns associated with bone density in Chinese lactating women and infants at 6 months postpartum: a prospective study using data from 2018–2019","authors":"","doi":"10.26599/FSHW.2022.9250214","DOIUrl":"10.26599/FSHW.2022.9250214","url":null,"abstract":"<div><div>This cohort study was designed to explore the relationship between maternal dietary patterns (DPs) and bone health in Chinese lactating mothers and infants. We recruited 150 lactating women at 1-month postpartum. The estimated bone mineral density (eBMD) of subjects’ calcanei and the information on dietary intake were collected. After 5-month follow-up, the eBMD of mothers and their infants were measured again. Factor analysis was applied to determine maternal DPs. General linear models were used to evaluate the association between maternal DPs and maternal eBMD loss or infants’ eBMD. With all potential covariates adjusted, Factor 2 (high intake of whole grains, tubers, mixed beans, soybeans and soybean products, seaweeds, and nuts) showed a positive association with the changes of maternal eBMD (<em>β</em> = 0.16, 95 % CI: 0.005, 0.310). Factor 3 (high intake of soft drinks, fried foods, and puffed foods) was inversely correlated with the changes of maternal eBMD (<em>β</em> = –0. 22, 95 % CI: -0.44, 0.00). The changes of maternal eBMD were positively associated with 6-month infants’ eBMD (<em>β</em> = 0.34, 95 % CI: 0.017, 0.652). In conclusion, Factor 2 might contribute to the maintenance of eBMD in lactating women, while Factor 3 could exacerbate maternal eBMD loss. Additionally, the changes of maternal eBMD presented a positive correlation with 6-month infants’ eBMD.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2668-2676"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a xylitol-casein complex on insulin resistance and gut microbiota composition in high-fat-diet + streptozotocin-induced type 2 diabetes mellitus mice 木糖醇-酪蛋白复合物对高脂饮食+链脲佐菌素诱导的 2 型糖尿病小鼠胰岛素抵抗和肠道微生物群组成的影响

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250221

{"title":"Effects of a xylitol-casein complex on insulin resistance and gut microbiota composition in high-fat-diet + streptozotocin-induced type 2 diabetes mellitus mice","authors":"","doi":"10.26599/FSHW.2022.9250221","DOIUrl":"10.26599/FSHW.2022.9250221","url":null,"abstract":"<div><div>This study investigated the effects of a xylitol-casein non-covalent complex (XC) on parameters related to type 2 diabetes mellitus (T2DM), in addition to related changes in gut microbiome composition and functions. High-fat-diet (HFD) + streptozotocin (STZ)-induced T2DM mice were treated with xylitol (XY), casein (CN), and XC, after which fecal samples were collected for gut microbiota composition and diversity analyses based on 16S rRNA high-throughput sequencing and multivariate statistics. XC decreased body weight and improved glucose tolerance, insulin sensitivity, pancreas impairment, blood lipid levels, and liver function in T2DM mice compared to XY- and CN-treated mice. Furthermore, XC modulated the <em>α</em>-diversity, <em>β</em>-diversity and gut microbiota composition. Based on Spearman’s correlation analysis, the relative abundances of <em>Alistipes</em>, <em>Bacteroides</em>, and <em>Faecalibaculum</em> were positively correlated and those of <em>Akkermansia</em>, <em>Lactobacillus</em>, <em>Bifidobacterium</em>, and <em>Turicibacter</em> were negatively correlated with the phenotypes related to the improvement of T2DM. In conclusion, we found that XC alleviated insulin resistance by restoring the gut microbiota of T2DM mice. Our results provide strong evidence for the beneficial effects of XC on T2DM and motivation for further investigation in animal models and, eventually, human trials.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2741-2753"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of glucose metabolism in middle-aged mice on a high-fat diet by whole-grain highland barley is related to low methionine levels 全麦高原大麦对高脂饮食中年小鼠糖代谢的改善与低蛋氨酸水平有关

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250235

{"title":"Improvement of glucose metabolism in middle-aged mice on a high-fat diet by whole-grain highland barley is related to low methionine levels","authors":"","doi":"10.26599/FSHW.2022.9250235","DOIUrl":"10.26599/FSHW.2022.9250235","url":null,"abstract":"<div><div>Methionine restriction (MR) is an effective dietary strategy to regulate energy metabolism and alleviate oxidative stress and inflammation in the body, especially in the middle-aged and elderly population. However, the high methionine content of meat products makes this dietary strategy impossible to combine with protein supplementation and MR. Highland barley (HB), a low-methionine cereal, not only provides the body with protein but also has improved glucose metabolism and antioxidant and anti-inflammatory properties. Therefore, this study evaluated the feasibility of HB as a source of methionine-restricted dietary protein and the potential mechanisms. Middle-aged C57BL/6J mice were fed a control diet (CON), a high-fat diet (HFD), a whole-grain HB high-fat diet (HBHF), or a HBHF + methionine diet (HBHFmet) for 25 weeks. The results showed that the HBHF could keep the body weight, fasting glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, inflammation, and oxidative stress of HFD mice at normal levels. Compared with the HFD groups, HBHF inhibited pancreatic cell apoptosis and improved insulin secretion while improving hepatic and skeletal muscle glucose metabolism. However, these efficacies were attenuated in HBHFmet group mice. These findings suggest that HBHF has an MR strategy.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2906-2916"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of salt and rice flour concentration on microbial diversity and the quality of sour meat, a Chinese traditional meat 盐和米粉浓度对中国传统肉类--酸肉的微生物多样性和质量的影响

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250226

引用次数: 0

Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization 绿藻素通过 KLF4 介导的巨噬细胞 M2 极化改善非酒精性脂肪性肝炎

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250220

{"title":"Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization","authors":"","doi":"10.26599/FSHW.2022.9250220","DOIUrl":"10.26599/FSHW.2022.9250220","url":null,"abstract":"<div><div>Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public health. However, to date, no approved therapeutic drugs have been developed. Dietary interventions with natural products have shown promise in preventing and treating NAFLD. Sulforaphane (SFN) is a phytocompound with antioxidant and anti-inflammatory properties, and previous research has demonstrated that SFN can ameliorate hepatic lipid accumulation and inflammation. However, the molecular mechanisms underlying these beneficial effects remain unclear. In this study, we confirmed the protective effects of SFN on excessive lipid accumulation and inflammatory injury in a high-fat, high-fructose diet-induced non-alcoholic steatohepatitis (NASH) mouse model. We found that SFN attenuates the inflammatory injury in a macrophage cell line and the liver of NASH mice, owing to the promotion of M1-type macrophage polarization toward the M2-type and the regulation of inflammatory mediators. Further analysis demonstrated that this SFN-induced macrophage M2-type polarization occurs in a Krüppel-like factor 4 (KLF4)-dependent manner. In summary, we uncovered a new mechanism of action underlying SFN activity and provide evidence that dietary intervention with SFN might be protective against NASH.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2727-2740"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer 槲皮素可抑制多巴胺和 cAMP 调节磷酸蛋白的截短异构体，作为曲妥珠单抗治疗 HER2 阳性乳腺癌耐药性的辅助疗法

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250213

{"title":"Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer","authors":"","doi":"10.26599/FSHW.2022.9250213","DOIUrl":"10.26599/FSHW.2022.9250213","url":null,"abstract":"<div><div>Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer (BC). The truncated isoform of dopamine- and cAMP-regulated phosphoprotein (t-DARPP) has been reported to be involved in trastuzumab therapy resistance and promoting tumor progression. To evaluate the t-DARPP expression in BC, paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+ BC tumor tissues. We established 2 patient-derived xenografts (PDX) mice models to test the efficacy of trastuzumab, named model 1 (non-responder) and model 2 (responder). t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer assays. Instead, there is no response from the responder. Furthermore, mechanistic studies using transwell and Western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins, enhance p95-HER2 expression and promote cell migration. We found that quercetin effectively reduced t-DARPP expression in HER2+ BC cells. In t-DARPP ShRNA-suppressed cells, quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase arrest. In conclusion, the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+ BC patients has the potential as a biomarker for mitigating drug resistance.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2653-2667"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High β-sitosterol-D-glucoside content in sweet potato varieties and its anti-breast cancer potential through multiple metastasis-associated signals 甘薯品种中的高β-谷甾醇-D-葡萄糖苷含量及其通过多种转移相关信号抗乳腺癌的潜力

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250225

{"title":"High β-sitosterol-D-glucoside content in sweet potato varieties and its anti-breast cancer potential through multiple metastasis-associated signals","authors":"","doi":"10.26599/FSHW.2022.9250225","DOIUrl":"10.26599/FSHW.2022.9250225","url":null,"abstract":"<div><div><em>β</em>-Sitosterol-<em>D</em>-glucoside (<em>β</em>-SDG) is a phytosterol compound whose antitumor activity has been confirmed by previous studies. However, its suppression on breast cancer remains unclear. To that purpose, we isolated <em>β</em>-SDG from sweet potato and investigated the breast-cancer-inhibiting mechanism using proteomic analysis. The sweet potato species S6 with high <em>β</em>-SDG content were chosen form 36 species and <em>β</em>-SDG was isolated by HPLC. Afterwards, an <em>in situ</em> animal model of breast cancer was established, and <em>β</em>-SDG significantly reduced the tumor volume of MCF-7 xenograft mice. Proteomic analysis of tumor tissues revealed that 127 of these proteins were upregulated and 80 were downregulated. Gene ontology and network analysis showed that regulatory proteins were mainly associated with epithelial-mesenchymal transition (EMT), myogenesis, cholesterol homeostasis, oxidative phosphorylation and reactive oxygen pathways, while <em>Vimentin</em>, <em>NDUF</em>, <em>VDAC1</em>, <em>PPP2CA</em> and <em>SNX9</em> were the most significant 5 node degree genes. Meanwhile, <em>in vitro</em> and <em>in vivo</em> results showed that the protein expression of PPP2CA and Vimentin, which are markers of EMT, were involved in breast cancer cell metastasis and could be reversed by <em>β</em>-SDG. This work highlights <em>β</em>-SDG as a bioactive compound in sweet potato and the potential therapeutic effect of β-SDG for the treatment of breast cancer by inhibiting metastasis.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2779-2789"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maillard reaction affecting immunobinding activity and digestibility of tropomyosin in Alectryonella plicatula food matrix 马氏反应影响栉水母食物基质中肌球蛋白的免疫结合活性和消化率

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250239

引用次数: 0

Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota 通过恢复口腔微生物群，辅助使用后益生菌可改善龋齿预后

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250217

{"title":"Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota","authors":"","doi":"10.26599/FSHW.2022.9250217","DOIUrl":"10.26599/FSHW.2022.9250217","url":null,"abstract":"<div><div>Conventional filling therapy fails to fundamentally reduce oral cariogenic bacteria. Thus, oral microbiota follow-up intervention after filling would be necessary for improving dental caries prognosis. We recruited 9 caries-free individuals, and 89 dental caries subjects (5 dropouts). Eighty-nine patients were randomized into three groups: caries (<em>n</em> = 8; no treatment), control (<em>n</em> = 40; filling), and postbiotics (<em>n</em> = 41; filling and 14-day Probio-Eco® intervention). Salivary samples were collected at 0 day (after filling) and 14 days. Our results showed that the diversity of dental caries oral microbiota was significantly increased compared with healthy subjects, and filling could restore a healthier oral microbiota partially and temporarily. Thepostbiotics intervention keeps a low alpha-diversity. Co-occurrence network analysis showed that a more stable oral microbiota structure after postbiotics intervention. Taxonomic and functional annotation of the microbiota revealed that postbiotics co-treatment significantly: increased the relative abundance of <em>Pseudomonas</em> and <em>P. reactans</em>, decreased the relative abundance of <em>Prevotella shahii</em>, and enriched the energy metabolism-related pathways. BugBase-predicted phenotypes inferred to an oral microbiota with decreased potential pathogenic bacteria and increased oxidative stress-tolerant bacteria after postbiotics intervention. Collectively, it suggested that postbiotics co-treatment could be a promising strategy that restores the oral microecological balance for dental caries.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 5","pages":"Pages 2690-2702"},"PeriodicalIF":5.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents 大蒜及其生物活性成分的信号转导级联调控作用概述

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250196

引用次数: 0