Food Science and Human Wellness最新文献

{"title":"Protective Effect of DHA Monoacylglyceride Algae Oil on Liver Injury and Gut Microbiota in Mice Induced by Acute Alcohol Intake","authors":"Youcai Zhou, Qinyong Li, Xu Guo, Han Sun, Kaimin Cheng, Bilian Chen, Yangmin Wen, Yongjin He","doi":"10.26599/fshw.2025.9250614","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250614","url":null,"abstract":"Monoacylglyceride rich in docosahexaenoic acid (DHA-MAG) as a novel structured lipid can be produced from <em>Schizochytrium </em>oil, which is conductive to accumulate DHA into tissues and perform its biological functions. In this study, the effects of different DHA dose on serum lipid composition, liver fatty acid profile and physiological change, and gut microbiota composition of acute alcoholic liver disease (ALD) mice were deeply investigated. The obtained results showed that the high dose of DHA-MAG promoted the accumulation of DHA in liver tissue and significantly alleviated alcohol-induced liver injury, as evidenced by decreasing serum levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and increasing the levels of total protein and albumin; meantime, the values of these recorded indexes were close to the ones by the positive control group treated with silymarin. Moreover, DHA-MAG treatment distinctly improved lipid metabolism, as indicated by reducing serum triglycerides, total cholesterol, and low-density lipoprotein levels, and increasing high-density lipoprotein level. Importantly, DHA-MAG normalized the disrupted composition of the gut microbiota caused by alcohol consumption, thereby leading to alterations in the release of metabolites into the systemic circulation. Additionally, DHA-MAG inhibited the TLR₄/NF-κB signaling pathway, thereby modified inflammatory responses in the liver. Overall, this study revealed that DHA-MAG could be potential as a novel therapeutic agent for the prevention and alleviation of ALD.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1966387945520238594.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucosinolates and Their Biotransformation: Metabolism, Plant Roles, and Human Health","authors":"Hao Sha, Ruiling Liu, Ben Niu, Huizhi Chen, Mohamed A. Farag, Hangjun Chen, Xiangjun Fang, Weijie Wu, Haiyan Gao","doi":"10.26599/fshw.2025.9250740","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250740","url":null,"abstract":"Glucosinolates (GLS), sulfur-rich phytochemicals found in <em>cruciferous</em> vegetables, have gained attention for their multifunctional roles in plant defense and human health. This review outlines the biosynthesis, transport, and hydrolysis pathways of GLS and their conversion into bioactive metabolites, especially isothiocyanates (ITC) like sulforaphane (SFN). We explore the genetic and environmental regulation of GLS, microbial-mediated transformations, and their biological functions in plants, including insect resistance and sulfur balance. In humans, ITC exhibit antioxidant, anti-inflammatory, anticancer, neuroprotective, and antimicrobial effects. The impact of food processing on GLS stability, along with encapsulation technologies, is also discussed. Emerging strategies include breeding for tailored GLS profiles, gut microbiota modulation to enhance ITC production, advanced delivery systems to improve bioavailability, and novel processing methods to optimize ITC yields. This comprehensive review provides insight into optimizing GLS utilization for plant resilience, functional food innovation, and chronic disease prevention through personalized nutrition and translational applications.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972866237697888258.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa isothiocyanate-1 modulates LPS-induced depressive-like behavior through the microbiota-gut-brain axis","authors":"Qi Wu, Hejiang Zhou, Le-Lan Gong, Jun Sheng, Ling-Yan Su, Yang Tian","doi":"10.26599/fshw.2025.9250775","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250775","url":null,"abstract":"The incidence of depressive disorders has steadily increased, with factors such as social stress, neuroinflammation, and gut dysbiosis contributing to the intricate pathogenesis of depression. Traditional antidepressants often exhibit limited efficacy and are accompanied by pharmacological side effects. Moringa isothiocyanate-1 (MITC-1), a food-medicinal active substance isolated from moringa seeds, has demonstrated anti-inflammatory and neuroprotective properties. However, the potential effects and the mechanism of MITC-1 on neuroinflammation associated with depression remain unclear. In this study, we characterized aberrant activation of microglia induced by lipopolysaccharides (LPS) and demonstrated that MITC-1 has a protective effect on gut dysbiosis and neuroinflammation. We found that in MITC-1 treated mice, neuroinflammation was attenuated, evidenced by increased interest in sucrose and food rewards, reduced ingestion latency, enhanced novel object recognition, and improved voluntary activity and social behaviors. Subsequently, fecal microbiota transplantation (FMT) models were also established in mice, primarily focusing on behavioral aspects and intestinal function evaluations. We found fecal microbiota transplantation from MITC-1 treated mice facilitated the reconstruction of gut microbiota in LPS-induced mice. Ultimately, integrative approaches utilizing gut microbiome and metabolomics technology analyses, coupled with neuroglial morphology assessments, were employed to uncover the preventive mechanisms of MITC-1 against inflammatory depression. Our results revealed that oral administration of MITC-1 significantly altered the fecal microbiota composition, up-regulated the tryptophan (Trp) metabolic pathway, and inhibited neuronal loss and microglial activation, thereby, ameliorating mood, cognition function, and behaviors. In summary, MITC-1 mediated the microbiota-gut-brain axis through the Trp metabolic pathway, restructuring gut microbes and reducing neuroinflammation.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972192967537463298.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects of aloenin against oxidative stress in HepG2 cells and acute liver injury in mice","authors":"Yue-Zhu Zhao, Yi-Lun Wang, Yang Yu","doi":"10.26599/fshw.2025.9250746","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250746","url":null,"abstract":"<p class=\"0000\" style=\"margin-top: 6.0pt;\"><span lang=\"EN-US\">The antioxidant effects alonenin, the main active ingredient of <em>Aloe vera</em> were investigated <em>in vitro</em> and <em>in vivo</em>. Aloenin increased the survival rate of oxidatively damaged cells and reduced cellular MDA production. It also increased cellular SOD, CAT, and GPx enzyme activities. An acute liver injury mouse model was constructed using CCl₄, and aloenin downregulated the liver index, enhanced the total antioxidant capacity of liver tissue, and alleviated oxidative stress injury. In addition, aloenin upregulated the expression of Nrf2, HO-1, and GCLC genes and proteins, and reduced the expression of Keap1 genes and proteins in mouse liver tissues. Overall, aloenin showed protective effects against oxidative stress in HepG2 cells and liver injury in mice. This may be related to the activation of the Keap1/Nrf2/HO-1 and PI3K/Akt signaling pathways.</span>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1970387235326468098.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fermentation by lactic acid bacteria enhances the flavor, bioactivity, and metabolic profile of guava juice","authors":"Xiaolu Zhou, Huixian Wang, Ziqian Zhu, Zihan Sun, Ruimin Wang, Fang Chen, Xiaosong Hu, Jiachao Zhang","doi":"10.26599/fshw.2025.9250686","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250686","url":null,"abstract":"Four strains of lactic acid bacteria (LAB) isolated from diverse sources were used to ferment guava juice, revealing strain-specific characteristics. Systematic analysis revealed LAB fermentation significantly altered physicochemical properties, bioactive compounds, and metabolic profiles.<em> Lactobacillus plantarum</em> strains notably increased organic acids, polyphenols and flavonoids while reducing sugars in fermented guava juice (FGJ), enhancing its antioxidant capacity and α-glucosidase inhibitory activity. Sensory evaluation and flavoromics analysis identified 55 distinct volatile metabolites that collectively improved juice flavor profiles through increased beneficial flavor compounds (acetoin and acetophenone), and decreased off-flavor substances (caryophyllene and humulene). Non-targeted metabolomics revealed 289 significantly altered metabolites primarily enriched in amino acid metabolism (e.g., DL-glutamate and indolelactic acid) and lipid oxidation pathways (e.g., 6-hydroxyhexanoic acid and dihydroxyacetone), which correlated with both flavor enhancement and antioxidant accumulation. These results demonstrated LAB reshaped guava juice metabolism at both volatile and non-volatile levels, as well as established a theoretical foundation for developing FGJ as a novel functional beverage with health-promoting properties.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1966400383795859458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fermentation of moso bamboo ( <em>Phyllostachys edulis</em>) shoots by giant panda-derived <em>Bacillus altitudinis</em> ICBR-C01 induces release of multifunctional bioactive peptides","authors":"Yuan Yang, Hang Xun, Dongli Ma, Jie Wang, Xuefeng Liu, Haihua Yuan, Feng Tang","doi":"10.26599/fshw.2025.9250787","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250787","url":null,"abstract":"The therapeutic potential of multifunctional bioactive peptide derived from food fermentation to alleviate chronic diseases has attracted considerable research interest. The objective of this study was to investigate the biological activities of peptides produced by the fermentation of moso bamboo (<em>Phyllostachys edulis</em>) shoots with <em>Bacillus altitudinis</em>&nbsp;ICBR-C01, a microbial strain isolated from the feces of giant pandas (<em>Ailuropoda</em>&nbsp;<em>melanoleuca</em>). The peptidomics profiles were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS), and the potential biological activities of the newly generated peptides after the fermentation were predicted with the aid of bioinformatics tools. The angiotensin-I-converting enzyme (ACE) inhibitory, dipeptidyl peptidase-IV&nbsp;(DPP-IV) inhibitory, and antioxidant activities were validated <em>in vitro</em>, and their mechanisms of action were further studied through the use of molecular docking simulations. The stability of the peptides was assessed by hydrothermal treatment and simulated gastrointestinal digestion. The yield of peptides was (16.93 ± 0.19) mg/g bamboo shoot (raw material, RM) by the fermentation of moso bamboo shoots with <em>Bacillus altitudinis </em>ICBR-C01, and the process resulted in a notable alteration of the peptide composition. Among the 53 peptides identified in the fermented moso bamboo shoots, 30 were newly formed, of which six were predicted to possess multifunctional bioactivities.&nbsp;The<em>&nbsp;in vitro</em>&nbsp;experiments and <em>in silico</em>&nbsp;analysis demonstrated that the peptides GGLAGPPGS (IC₅₀: 13.52 μmol/L), SIHKVPL (IC₅₀: 11.48 μmol/L), and EEHPVLL (IC₅₀: 11.79 μmol/L) exhibited potent ACE inhibitory activity. All three peptides were observed to bind to the key amino residues in the S1 active pocket of the ACE protein via multiple interaction forces. Peptides FAGDDAPR, GFAGDDAPR, GGLAGPPGS, and GLAGPPGS were shown to exhibit DPP-IV inhibitory activity, with IC₅₀&nbsp;values of 495.17 μmol/L, 541.79 μmol/L, 305.19 μmol/L, and 367.24 μmol/L, respectively. Moreover, EEHPVLL exhibited a moderate 1,1-Diphenyl-2-picrylhydrazyl&nbsp;(DPPH) radical scavenging activity, with an IC₅₀&nbsp;value of 4.33 mmol/L. The percentage of SIHKVPL and GGLAGPPGS remaining exceeded 90% after being heated for up to 2 h in a water bath at 100 ℃. The percentage remaining after simulated gastrointestinal digestion was over 85% for all four peptides tested. The results of this study provide a basis for the utilization of the giant panda-derived <em>Bacillus altitudinis</em>&nbsp;ICBR-C01 in the fermentation of bamboo shoots, with the aim of preparing multifunctional bioactive peptide.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972957704634241026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<em>Chrysanthemum</em>&amp;lsquo;Honglian&amp;rsquo; extract (CM-HLE) alleviates colitis by inhibiting ferroptosis in intestinal epithelial cells","authors":"Kai-Yue He, Jin-Rong Guo, Hai-Hui Lu, Wang An, Yuan Zhao, Ji-Yun Zhao, Jun-Qi Li, Xin-Yuan Lei, Huai Liu, Zhen-Hua Yan, Peng-Hui Ai, Yong-Ping Jian, Zi-Cheng Wang, Zhi-Xiang Xu","doi":"10.26599/fshw.2025.9250777","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250777","url":null,"abstract":"<em>Chrysanthemum</em>, a traditional Chinese medicinal herb, exhibits various biological activities, including anti-inflammatory, anti-tumor, and antiviral effects. However, its potential role in preventing inflammatory bowel disease (IBD) and the underlying mechanisms remain unclear. In this study, we cultivated and identified a chrysanthemum variety, Hong Lian, with a high content of flavonoid. We extracted components from the plant and applied <em>Chrysanthemum</em> ‘Honglian’ extract (CM-HLE) to DSS-induced colitis C57BL6 mice. We found that CM-HLE pretreatment could significantly alleviate symptoms of intestinal inflammation in mice, including weight loss, colon shortening, intestinal epithelial injury, and immune cell infiltration. Further, we found that CM-HLE treatment effectively prevented intestinal epithelial CCD841 cells from DSS-induced ferroptosis, a programmed cell death triggered by iron accumulation and lipid peroxidation in cells. Mechanistically, we validated the enrichment of ferroptosis-related signaling pathways in intestinal epithelial cells of mice treated with CM-HLE in the RNA-seq analysis and demonstrated that CM-HLE inhibited ferroptosis in intestinal epithelial cells by upregulating SLC7A11. The untargeted metabolomics analysis of CM-HLE revealed that its main components, apigenin-7-glucuronide and apigenin-7-glucoside, both inhibit ferroptosis via the ATF3/SLC7A11 axis. In conclusion, our study reveals a novel medicinal value of <em>chrysanthemum</em>, offering a new strategy for the prevention and treatment of IBD.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1972182538048245762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}