Food Science and Human Wellness最新文献

{"title":"Tailoring Casein Functionality via Protein Glutaminase-Mediated Deamidation: Insights from Recombinant Enzyme Production and Structural Analysis","authors":"Zheng Zhang, Lihui Zheng, Wenjing Zhao, Yuxi Li, Shuchao Jiao, Mingfei Jin, Yelin Wu, Shuo Zhang, Bing Ni, Zhongyi Chang, Hongliang Gao, Deming Jiang, Jing Huang","doi":"10.26599/fshw.2025.9250773","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250773","url":null,"abstract":"<p class=\"0000\" style=\"margin-top: 6.0pt;\"><span lang=\"EN-US\">Casein, a major milk protein, faces limited industrial applications due to its hydrophobicity. Traditional chemical modifications (e.g., sodium caseinate) often compromise nutritional value, while enzymatic deamidation using protein glutaminase (PG) is hindered by low enzyme yields and endotoxin risks from conventional <em>Escherichia coli</em> expression systems. Here, we developed a safe and efficient strategy by expressing PG in probiotic <em>E. coli</em> Nissle 1917 (EcN), eliminating endotoxin production. The recombinant PG yielded 8.69 U/mL (1.64-fold higher than control) and retained stability at ≤ 50 ℃ and pH 4-8. Casein was deamidated under mild conditions (50 ℃, pH 7, 180 min) with a low enzyme-to-substrate ratio (5 U/g protein), reaching a 54.4% degree of deamidation (DD). Deamidation induced structural reorganization: β-sheet content decreased by 44.1%, while α-helix and β-turn increased by 22.5% and 24.4%, respectively. This exposed hydrophobic residues (e.g., tyrosine), reduced particle size to 200 nm, and enhanced electrostatic repulsion (zeta potential: −27.4 mV vs. −21.4 mV for undeamidated casein). Consequently, solubility surged from 1.2% to 80.5% under neutral conditions, with 1.8-fold improved foaming, 1.4-fold and 7.3-fold higher emulsifying property and emulsifying stability compared to untreated casein, respectively. Deamidation improved in vitro digestibility (77.4% gastrointestinal digestibility) and amino acid balance, alleviating leucine limitation and increasing the essential amino acid index to 100.1. This study pioneers the use of EcN for endotoxin-free PG production and demonstrates that enzymatic deamidation outperforms chemical methods by avoiding hydrolysis and toxicity and preserving functionality. The modified casein is directly applicable to dairy products (e.g., yogurt, cheese) as a natural emulsifier or foaming agent, offering a sustainable alternative to synthetic additives.</span>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1986692048653717505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary supplements of algal polysaccharides promote ellagic acid biotransformation targeted on gut bacteria","authors":"Zhao‐Rong Li, Rui‐Bo Jia, Weipei Li, G.J. Shang, Donghui Luo, Lianzhu Lin, Mouming Zhao","doi":"10.26599/fshw.2025.9250820","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250820","url":null,"abstract":"Ellagic acid (EA) could be converted into urolithins to exert health-promoting effects by intestinal flora, but the biotransformation capacity varied among individuals. Strategies targeted on gut microflora modulation could be a novel method to obtain more urolithins beyond the inter-individual variability. The study aimed at investigating the impacts of four algal polysaccharides (APs) supplements on EA biotransformation. Results showed that simple APs supplements would increase certain urolithin productions, and APs-EA solid dispersions supplement improved urolithins contents from 4.25 μmol to 6.16-6.79 μmol. The enhancement was related to the proliferation of the EA-metabolic-related bacteria like <em>Gordonibacter</em>, <em>Faecalibacterium</em>, <em>Sutterella</em>, <em>Dialister</em>, <em>Enterocloster</em> and etc. and increasing the bioaccessibility of EA to the bacteria. Furthermore, mono-/co-culture fermentation further verified that <em>Gordonibacter urolithinfaciens</em> was greatly proliferated by simple APs and EA solid dispersions supplements. EA/UPP 1-1 showed the best performances in urolithins productions, and the total urolithins contents increased by 3.78 times compared to control EA group. These results showed dietary supplements could improve biotransformation ability by influencing the EA-metabolic-related bacteria and the access to substrates.&nbsp;","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/10.26599/FSHW.2025.9250820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics Interact with &amp;beta;-lactoglobulin: Implications for Protein Structure, Digestibility, and Allergenicity","authors":"Qiang Shi, Z.L. Wang, Xin Li, Jinyan Gao, Hongbing Chen","doi":"10.26599/fshw.2025.9250785","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250785","url":null,"abstract":"Microplastics are pervasive throughout the food system. Recent research indicates that millions of microplastics are released from baby bottles during infant formula preparation. In this context, microplastics are likely to interact with milk allergens, potentially affecting the structures and characteristics of allergens, which may pose risks to human health, particularly for infants with cow's milk allergy. This study analyzed the interaction between commonly used baby bottle microplastics (polypropylene, polyethersulfone, polyphenylsulfone) and the major milk allergen β-lactoglobulin using multi-spectroscopy techniques and molecular simulation. Furthermore, microplastics-mediated alterations in protein digestibility and allergenicity were evaluated through <em>in vitro</em> gastrointestinal digestion, peptidomics, ELISA, and a KU812 cell degranulation model. The results indicated that microplastics adsorbed β-lactoglobulin through nonpolar interactions, with the surface chemistry of microplastics determining the binding affinity. Microplastics induced the unfolding of β-lactoglobulin tertiary structure, and β-lactoglobulin mixed with microplastics resulted in reduced digestibility. Moreover, β-lactoglobulin that interacted with microplastics showed enhanced IgE binding capacity and a greater ability to elicit KU812 cell degranulation. This effect was especially pronounced with polyphenylsulfone@β-lactoglobulin, whose IgE binding capacity increased by 3.7%, while the release of β-hexosaminidase and histamine increased by 9.4% and 65.5%, respectively. Collectively, these findings provide novel insights into the interactions between microplastics from baby bottles and milk allergens, highlighting potential implications for cow's milk allergy management and broader health risks associated with microplastics exposure in infant nutrition.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1986688547018051585.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural evolution of citrus peel polysaccharides during aging modulates the <em>in vitro</em> digestive stability of EGCG and its transmembrane transport across Caco-2 monolayers","authors":"Gang Xu, Jingyun Zhao, Tan H, Xu Yang, Xianghao Yuan, Siyi Pan","doi":"10.26599/fshw.2025.9250835","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250835","url":null,"abstract":"Aged citrus peel (Chenpi) is traditionally consumed with tea in Asian for synergistic flavor and health benefits. However, the structural evolution of citrus peel polysaccharides (Chenpi polysaccharides, CP) during aging and their regulatory role in the bioavailability of tea polyphenols remain poorly understood. In this study, CP from Chenpi aged 1–15 years were investigated for their impact on the digestive stability, epithelial transport, and delivery efficiency of epigallocatechin gallate (EGCG). Progressive depolymerization of CP altered their binding affinity toward EGCG (CP1 &gt; CP15 &gt; CP10 &gt; CP5). Stronger binding led to greater digestive retention; CP1 showed the highest affinity (<em>K_a</em>= 3.02 × 10³ M^-1), enhancing EGCG retentionto 92.4 μg/mL (+376% vs. control), along with improved antioxidant capacity. However, its tight complexation hindered transmembrane transport. In contrast, CP15 formed compact nanospherical structures that enabled sustained EGCG release via weak multivalent interactions. Western blotting, TEM, and immunofluorescence revealed that CP15 downregulated efflux transporters (P-gp, MRP2) and reversibly remodeled tight junction protein ZO-1, promoting paracellular transport (<em>P_app</em> = 97.5 × 10^-7 cm·s^-1, 22.7-fold increase). These findings suggest a functional transformation of CP during aging—from stabilizing agents to barrier-modulating carriers—offering novel insights into structure-function relationships and a promising strategy for natural polysaccharide-based polyphenol delivery systems.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1986701846304591874.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Insights into the Gut-Spinal Cord Axis: Paeoniflorin Mitigates Diabetic Neuropathic Pain in Rats through Microbial-Metabolic Crosstalk","authors":"Yuning Liu, Zhi Ming, Shuaiying Jia, Su Yao, Kun Wu, Wei Yan, Jingyan Lin","doi":"10.26599/fshw.2025.9250837","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250837","url":null,"abstract":"Painful Diabetic Neuropathy (PDN), a common chronic complication of diabetes, is closely associated with glymphatic system dysfunction and neuroinflammation. This study is the first to explore the mechanism of Paeoniflorin (PF) in treating PDN from the perspective of the gut-spinal cord axis. By establishing a streptozotocin (STZ)/high-fat diet-induced PDN rat model and integrating metagenomics, untargeted metabolomics, and microbial depletion techniques, we demonstrated that PF significantly improved mechanical paw withdrawal threshold (PWT), alleviated insulin resistance, and reduced spinal pro-inflammatory cytokine levels (IL-1β, IL-6, TNF-α) in PDN rats. Dynamic Magnetic resonance imaging (MRI)&nbsp; revealed that PF restored spinal glymphatic metabolic function, evidenced by enhanced gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) clearance and aquaporin-4 (AQP4) polarization remodeling. Immunofluorescence confirmed that PF suppressed astrocyte activation (total GFAP fluorescence intensity decreased by 61.86% in the PF group vs. PDN group) and restored AQP4 polarity at perivascular endfeet (polarization rate increased from 31.8% to 59.3%). These therapeutic effects were completely reversed by antibiotic intervention (ABX+PF group), highlighting the critical role of gut microbiota. Metagenomic analysis showed that PF enriched short-chain fatty acid (SCFA)-producing genera (<em>Bifidobacterium </em>and<em> Faecalibacterium</em>), activating the tricarboxylic acid (TCA) cycle and arginine metabolism. Metabolomics identified PF-mediated upregulation of anti-inflammatory metabolites (e.g., MGMG 18:2 and N-Acetyl-4-O-acetylneuraminic acid) and suppression of dehydroepiandrosterone sulfate (DHEA-S) synthesis. Our findings demonstrate that PF alleviates PDN by remodeling the gut microbiota-metabolite network, repairing intestinal barrier integrity, and regulating AQP4-dependent waste clearance in the spinal glymphatic system, providing novel therapeutic targets. This study elucidates the regulatory role of the gut-spinal cord axis in PDN and offers a paradigm for investigating \"microbiota-host\" interactions of low-bioavailability herbal components.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1990314336473153538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of synergistic antioxidant interactions of lutein and cyanidin-3-O-glucoside and their roles in age-related macular degeneration","authors":"Fengqin Lu, Zhongyuan Zhang, Yan Li, Dajing Li, Cunshan Zhou, Weiwei He, Yayuan Xu, Cheng Yang, Yongjin Chang, Lianfu Zhang, Yamamoto Yamamoto","doi":"10.26599/fshw.2025.9250719","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250719","url":null,"abstract":"This study aimed to evaluate the effects of lutein (LUT) combined with cyanidin-3-O-glucoside (C3G) on age-related macular degeneration (AMD). Three complementary models were used to investigate the antioxidant effects, including free radical scavenging models, a cell model, and a mouse gavage assay. The results revealed that LUT combined with C3G at ratios ranging from 1:2 to 1:5 exhibited synergistic antioxidant effects <em>in vitro</em>. Compared with LUT/C3G alone, LUT:C3G (1:5) increased SOD and CAT activities by 50.22%, 33.73% and 86.21%, 30.77%, respectively, increased GSH levels by 79.31% and 36.82%, and decreased MDA levels by 50.04% and 31.11%. The combination treatment increased the mRNA and protein expression levels of Nrf2, HO-1 and NQO1 and decreased the level of Keap1. Furthermore, Nrf2 knockdown in ARPE-19 cells significantly inhibited combination treatment-induced Nrf2 protein expression and nuclear translocation, as well as HO-1 and NQO1 expression. A mouse model of AMD demonstrated that LUT combined with C3G activated the Keap1/Nrf2/HO-1/NQO1 signalling pathway, thereby preventing retinal oxidative stress.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1978368609001934849.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anti-central fatigue effects of tartary buckwheat polyphenols <i>via</i> the microbiota-gut-brain axis","authors":"Tong Wu, Baosong Wang, Fu Long, Z.-H. Liu, Hong Zeng, Yanbo Wanga","doi":"10.26599/fshw.2025.9250792","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250792","url":null,"abstract":"Central fatigue is closely linked to disruptions in the microbiota–gut–brain axis (MGBA), yet the molecular mechanisms involved remain largely unclear, and effective nutritional interventions are still limited. Tartary buckwheat polyphenols (TBP) have demonstrated potential in modulating the gut microbiota and supporting neuronal function. However, the specific pathways through which TBP exert their anti-fatigue effects are not fully understood. Clarifying these mechanisms is crucial for the development of precision dietary strategies to alleviate central fatigue. In this work, we established a mouse model of overexercise-induced central fatigue to systematically evaluate the effects of TBP through behavioral assessments, histological examination, neurotransmitter profiling, and inflammatory and oxidative stress marker analysis. The results showed that TBP significantly improved fatigue-related behaviors, alleviated intestinal and brain tissue damage, and modulated the expression of various neurotransmitters. Furthermore, TBP significantly reduced serum levels of pro-inflammatory cytokines (e.g., IL-1β and TNF-α), and mitigated oxidative stress by enhancing GSH-Px and CAT activity and reducing MDA levels. 16S rRNA sequencing revealed that TBP altered gut microbiota composition, promoting the abundance of beneficial taxa such as <em>Lachnospiraceae</em>, <em>Lactobacillus</em>, and <em>Roseburia</em>, while suppressing potentially harmful microbes. Short-chain fatty acids analysis further demonstrated that TBP modulated levels of acetic, propionic, and butyric acids, contributing to intestinal barrier integrity and energy homeostasis. Metabolomics analysis revealed that TBP influenced several key pathways, including alanine, aspartate, and glutamate metabolism, as well as neuroactive ligand-receptor interactions, thereby restoring the metabolic balance under central fatigue. Collectively, this work provides supportive evidence that TBP alleviates central fatigue through modulating the MGBA.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"15 3","pages":"9250792-9250792"},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://file.sciopen.com/sciopen_public/1977998400399347713.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ergothioneine Alleviates Motor Dysfunction in Parkinson&amp;rsquo;s Disease Mouse Model by Restoring Neural Oscillations","authors":"Xinyu Zhu, Wentai Zhang, Xinyue Sheng, Yixin Feng, Ningning Lin, Longfei Li, Chi Man KOON, Fan Hu","doi":"10.26599/fshw.2025.9250721","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250721","url":null,"abstract":"Ergothioneine (EGT), an active compound in many edible mushrooms, has considerable potential for therapeutic intervention in neurodegenerative diseases. However, whether EGT can safely alleviate symptoms of Parkinson’s disease (PD) and its neurophysiological mechanisms remain unclear. In this study, 6-hydroxydopamine (6-OHDA) mouse model of PD was chosen to mimic the pathological progression observed in the early stages of PD patients. After four weeks of EGT treatment (8 mg/kg/d), there was a significant improvement in motor impairments of 6-OHDA mice with a reduction in dopaminergic neuronal loss in the substantia nigra pars compacta (SNc). Using <em>in vivo </em>multi-electrophysiological recordings, we found that EGT treatment increased the firing rates of neurons in the primary motor cortex (M1) of 6-OHDA mice. In addition, EGT treatment notably reduced pathological beta oscillations (β, 13-30 Hz) and beta-gamma phase-amplitude coupling (β-γ PAC) in both the M1 and the subthalamic nucleus (STN) of 6-OHDA mice. These physiological recoveries after EGT treatment were accompanied by increased spine density of pyramidal neurons and upregulated expression of glutamate receptors in the M1. Our findings suggest that EGT is a promising natural neuroprotective agent for slowing or preventing PD progression.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1978374092723064834.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An antibody-aptamer sandwich-based isothermal amplification fluorescence biosensor for the detection of <em>Salmonella</em> Typhimurium","authors":"Kai Dong, Zaihui Du, Yongxia Yu, Wentao Xu, Xiaohong Wang","doi":"10.26599/fshw.2025.9250798","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250798","url":null,"abstract":"<em>Salmonella </em>Typhimurium (<em>S. </em>Typhimurium) is an important foodborne pathogen, its harm is mainly reflected in high pathogenicity, clinical manifestations, and drug resistance. The detection technology for this pathogen is gradually shifting from traditional methods to rapid and highly sensitive molecular biological methods. In order to solve the sensitivity and specificity of Salmonella detection, we built a fluorescent biosensor with an antibody-target-aptamer sandwich structure based on immune recognition and aptamer technology for quantitative detection of<em> S. </em>Typhimurium<em>.</em> By integrating the heterogeneous recognition mode composed of antibody and aptamer with isothermal hybridization chain reaction (HCR), this approach enables highly specific detection of <em>Salmonella</em> while significantly enhancing detection sensitivity through signal amplification. In the HCR hairpin structure, site-specific labeling of the fluorophore and quencher enables fluorescence signal generation via fluorescence resonance energy transfer (FRET), thereby achieving efficient optical signal output. The results show that the proposed enzyme-free heterogeneous recognition mode sensor has a detection limit of 9 CFU/mL and a 10-10⁴ CFU/mL detection range under optimized conditions. It also has good detection performance in milk and drinking water, which are common sources of <em>S. </em>Typhimurium contamination.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1981188860198637570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A holistic study to evaluate the degradation of zearalenone in corn and its impact on quality using dielectric barrier discharge cold plasma","authors":"Fei Shen, Ai Zhi, Shuo Zhu, Yuxin Zhang, Qiuhui Hu, Xihua Ding, Xirong Huang, Jianwei Chen","doi":"10.26599/fshw.2025.9250797","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250797","url":null,"abstract":"Zearalenone (ZEN), an extensively prevalent mycotoxin, severely endangers human health and causes economic losses. In this study, we introduced a novel method employing dielectric barrier discharge cold plasma (DBD-CP) to efficiently reduce ZEN levels in corn. We not only investigated the influence of plasma parameters and sample properties on degradation rates but also comprehensively evaluated the quality of treated corn and explored the degradation mechanism through product identification. The results demonstrate an impressive 63.71% reduction in ZEN levels in corn. Notably, structural analysis indicated that the oxy-lactone ring of degradation products found in this study, namely the estrogenic toxicity site of ZEN, had been destroyed. Furthermore, sensory properties and nutritional value of corn were minimally affected by this technique except for a slight promotion of lipid oxidation. Overall,, this work verified that DBD-CP holds great promise for application in product detoxification in the future agricultural and food industries.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}