Food Hydrocolloids for Health最新文献

{"title":"Application of yeast cell-wall derived from a potential probiotic yeast isolate as a controlled release agent in a triple-layer microcapsule with potent anti S. aureus activity","authors":"Sima Shams Shargh ,&nbsp;Alireza Sadeghi ,&nbsp;Mahmoud Shams Shargh ,&nbsp;Fahimeh Hajinia ,&nbsp;Ali Moayedi","doi":"10.1016/j.fhfh.2025.100241","DOIUrl":"10.1016/j.fhfh.2025.100241","url":null,"abstract":"<div><div>Application of postbiotics derived from characterized probiotics (Probio) as efficient controlled release agents of the entrapped bioactives is a promising progress in microencapsulation strategies. In the present study, phylogenetic evolutionary analysis led to the identification of <em>Pichia kudriavzevii</em> as the potential Probio yeast isolated from fermented sprouted soybeans with 82.70 % survivability under simulated gastrointestinal (SGI) conditions and potent <em>in vitro</em> inhibitory activity against <em>Staphylococcus aureus</em> (88.21 %), which was significantly (<em>p</em> &lt; 0.05) higher than those of the other foodborne bacteria tested. The yeast isolate also showed antifungal, antioxidant and suitable adhesion capabilities. Moreover, anti-ochratoxigenic activity of viable and heat-killed cells of the isolate was approved according to the HPLC-based analysis. <em>In vivo</em> safety of the isolate was also confirmed in accordance with the blood biochemistry parameters and liver enzymes activity of the fed-chicken compared to the control group. <em>In vivo</em> inhibitory activity of viable and heat-killed cells of the isolate against <em>S. aureus</em> was equal to 74.39 % and 89.71 %, respectively. Cross-linking of the yeast cell-wall derived from the isolate with the alginate-chitosan construct was also approved through FTIR and SEM analyses. In addition, antibacterial profile of the construct under SGI conditions confirmed targeted delivery and controlled release of the entrapped chitosan.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100241"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pea protein and p-coumaric acid conjugates: New evidence on in vitro digestion, modulation of gut microbiota, and anti-inflammatory activity","authors":"Xuxiao Gong ,&nbsp;Jie Lin ,&nbsp;Gwoncheol Park ,&nbsp;Saurabh Kadyan ,&nbsp;Quancai Sun ,&nbsp;Ravinder Nagpal ,&nbsp;Leqi Cui","doi":"10.1016/j.fhfh.2025.100245","DOIUrl":"10.1016/j.fhfh.2025.100245","url":null,"abstract":"<div><div>This study aimed to investigate the gut health benefits and anti-inflammatory property of pea protein isolates (PPI) as affected by conjugating with p-coumaric acid (p-CA). ¹³C NMR analysis confirmed the newly formed covalent bonds between PPI and p-CA occurred at the C8 position of p-CA. Results showed that after in vitro digestion, the conjugates exhibited higher protein digestibility compared to PPI. Dialysis was conducted to simulate small intestinal absorption and obtain non-absorbable fraction, which were utilized for human fecal fermentation and for the evaluation of anti-inflammatory activity in RAW 264.7 cells. Gut microbiota analysis revealed that PPI reduced the abundance of Bifidobacterium and increased Lactobacillus. However, after conjugation with p-CA, the inhibitory effect of PPI on Bifidobacterium was diminished, while its promotive effect on Lactobacillus was further strengthened. Meanwhile, PPI exhibited anti-inflammatory potential, as evidenced by the significant suppression of nitric oxide (NO) production and IL-6 expression. While the conjugates induced higher NO production compared to PPI, the levels remained lower than those induced by LPS alone, suggesting a partial reduction in anti-inflammatory potential after conjugation. Overall, this study provides new evidence that conjugation with phenolics can enhance pea protein's potential to positively influence gut microbiota composition, albeit with a reduced anti-inflammatory potential.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100245"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The action of Poria cocos polysaccharides against non-alcoholic fatty liver disease: A preliminary study","authors":"Rui Zhou ,&nbsp;Qinting Chen ,&nbsp;Jie Mo ,&nbsp;Meizhen Liu ,&nbsp;Ka Wu ,&nbsp;Chao Guo","doi":"10.1016/j.fhfh.2025.100234","DOIUrl":"10.1016/j.fhfh.2025.100234","url":null,"abstract":"<div><div>Non-alcoholic fatty liver disease (NAFLD) is a significant public health challenge owing to its current prevalence. Basic and clinical evidence indicates that pyroptosis is responsible for the development of NAFLD to non-alcoholic steatohepatitis. Our previous findings suggested that <em>Poria cocos</em> polysaccharides (PCP) exert promising anti-liver injury benefits. However, the anti-NAFLD action of PCP via the modulation of pyroptosis remains untested. In this study, a network pharmacology- and molecular docking-based approach was used to determine the anti-NAFLD activities and mechanisms of PCP prior to <em>in vitro</em> or <em>in vivo</em>. Based on these bioinformatics data, 31 intersecting genes in PCP (483 target genes), NAFLD (1445 target genes), and pyroptosis (905 target genes) were identified via network pharmacology analysis, and a total of 16 key genes in PCP against NAFLD through the modulation of pyroptosis were determined. Further enrichment analysis revealed the detailed anti-NAFLD functions and molecular mechanisms of PCP. Molecular docking simulations were used to identify the spatial binding features between PCP and the target proteins related to pyroptosis. This study determined the pyroptosis-related cluster genes that act with PCP against NAFLD, thereby offering preliminary evidence to support PCP’s potential in treating NAFLD. Additionally, we identified the possible underlying pyroptotic mechanisms for future experimental validations.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100234"},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical fish scale collagen cream: Formulation, skin permeation, and biocompatibility for cosmetic and therapeutic use","authors":"Ismail Zainol ,&nbsp;Ayah Rebhi Hilles ,&nbsp;Wan Rusmawati Wan Mahamod ,&nbsp;Hasnor Izzati Che Razali ,&nbsp;Haniza Hanim Mohd Zain","doi":"10.1016/j.fhfh.2025.100253","DOIUrl":"10.1016/j.fhfh.2025.100253","url":null,"abstract":"<div><div>This study aims to develop and characterise fish scale-collagen cream (CoC) intended for topical application. The development of CoC consists of hydrolysed collagen (molecular weight ≈ 1 kDa) dispersed into the aqueous phase of a water-in-oil (w/o) emulsion of Span 60: Tween 60/water/virgin coconut oil (VCO) system. Collagen used in this study has been extracted from Tilapia fish scales using hydrothermal extraction combined with enzymatic hydrolysis treatment. The CoC was developed using a water-in-VCO emulsion medium at water volume fractions (φ_w) of 0.74, 0.83, and 0.94. Up to 20 wt.% of hydrolysed collagen was successfully loaded into the emulsion system via the high shear homogenisation technique. The characterisation of the CoC involved a complex microscopic analysis, including optical polarising microscopy (OPM) and scanning electron microscopy (SEM), complemented by droplet size analysis, differential scanning calorimetry, and rheological evaluation. The physical characteristics of CoC were investigated to evaluate its suitability for administration on the skin. The potential of CoC to be applied on the skin was evaluated using analysis of <em>ex vivo</em> rat skin permeation using the Franz diffusion cell, <em>in vitro</em> fibroblast cell viability and <em>in vivo</em> toxicity to the mice. Franz diffusion cell studies revealed 3466.46 ± 21.70 μg/cm² cumulative collagen permeation over 6 h (vs. 1750 ± 319.67 μg/cm² control; <em>p</em> &lt; 0.001, 95 % CI: 1580–1850 μg/cm²), with 94–97 % retention in skin layers. <em>In vitro</em>, 0.02 mg/mL hydrolysed collagen increased fibroblast viability by 34 % (<em>p</em> &lt; 0.01, <em>n</em> = 3). Furthermore, Sub-acute toxicity tests of 25–50 mg/kg body weight of hydrolysed collagen for 7 days showed no significant weight changes (<em>p</em> &gt; 0.05, 95 % CI: −0.5 % to +1.2 %) or mortality. It was observed that the hydrolysed collagen could pass through the rat skin easily and successfully stimulate the fibroblast cell viability. In conclusion, CoC is a suitable carrier for hydrolysed collagen in topical applications. The use of the designed emulsion-based creams can safely enhance the delivery of the hydrolysed collagen in the skin layers with additional benefits for cosmetic and therapeutic applications.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100253"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nanoemulsion-based sage seed gum coating containing cinnamon essential oil on shelf life extension of strawberry","authors":"Parastoo Asadi Shizari ,&nbsp;Fatemeh Davoodi ,&nbsp;Dayana Hassani ,&nbsp;Shahriyar Amiri ,&nbsp;Bahram Hassani","doi":"10.1016/j.fhfh.2025.100242","DOIUrl":"10.1016/j.fhfh.2025.100242","url":null,"abstract":"<div><div>In this study, the antimicrobial efficacy of a nanoemulsion (NE) based on sage seed gum (WSG) containing cinnamon essential oil (CEO) was evaluated as an edible coating to extend the shelf life of strawberries. CEO at a concentration of 400 ppm was used for NE preparation. The particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency of the NE were reported to be 148.5 nm, 0.27, –27.12 mV, and 86 %, respectively. Strawberries were coated with distilled water (control), CEO (400 ppm), WSG coating, and CEO-loaded NE coating, then stored at room temperature for 9 days. Evaluations were conducted on days 0, 3, 6, and 9 to assess mass loss, total soluble solids, total mesophilic bacteria count, total mold and yeast count, pH, titratable acidity, vitamin C content, firmness, and color parameters. The results showed that over time, mass loss, total soluble solids, total mesophilic bacteria, and total mold and yeast counts increased significantly (<em>p</em> &lt; 0.05), with the highest values observed in the control sample and the lowest in the NE -coated samples. Conversely, pH, titratable acidity, vitamin C content, and firmness decreased significantly (<em>p</em> &lt; 0.05) over time. The lowest total phenolic content was observed in the control group, while the highest was recorded in the NE -coated strawberries at the end of the storage period. Overall, the NE coating showed the most significant preservative effect among all treatments, followed by the conventional WSG coating. These findings highlight the potential of CEO NE as an effective edible coating to extend the shelf life of strawberries.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100242"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products","authors":"Ana A. Vaz ,&nbsp;Isabel Odriozola-Serrano ,&nbsp;Gemma Oms-Oliu ,&nbsp;Olga Martín-Belloso ,&nbsp;Gemma Bellí","doi":"10.1016/j.fhfh.2025.100257","DOIUrl":"10.1016/j.fhfh.2025.100257","url":null,"abstract":"<div><div>The agri-food industry exerts a considerable environmental impact while contributing to substantial losses of functional nutrients, particularly dietary fibre. Developing dietary fibre concentrates (DFCs) as novel functional food ingredients offers a dual opportunity: reducing environmental impact and delivering health-promoting prebiotic ingredients. This study evaluated the prebiotic potential of DFCs from artichoke, carrot, cucumber, and red pepper by assessing their impact on targeted gut microbiota composition and short-chain fatty acid (SCFA) production during 48 h of <em>in vitro</em> colonic digestion.</div><div>All DFCs reduced the Firmicutes/Bacteroidetes ratio from 0.5 to 0.8 at 24 h to below 0.4 at 48 h, indicating shifts towards microbial profiles favoring fibre degradation. Artichoke DFC induced the most pronounced effect, markedly stimulating <em>Lactobacillus</em> populations (&gt;100-fold at 24 h and 14-fold increase at 48 h), likely linked to its chlorogenic acid and inulin content. Carrot DFC also promoted <em>Lactobacillus spp</em>. growth at 24 h, while both artichoke and carrot DFCs enhanced <em>Bifidobacterium</em> abundance. SCFA analysis revealed acetic acid as the dominant metabolite, with peak concentrations in cucumber (35.85 mM), red pepper (32.18 mM), and carrot (22.85 mM) fermentations at 48 h. Remarkably, artichoke DFC yielded the highest butyric acid concentration (13.30 mM), a key metabolite for colonocyte energy supply and intestinal barrier integrity.</div><div>These findings establish vegetable-derived DFCs, particularly artichoke and carrot, as promising prebiotic ingredients that can be selectively utilised by microorganisms to confer health benefits, while also highlighting a sustainable strategy to transform agricultural by-products into valuable functional foods ingredients with possible impacts on gut health.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100257"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical nanogel of glutathione and coenzyme Q10 in sodium alginate for chronic and inflammatory skin conditions: A synergistic antioxidant and anti-inflammatory delivery platform","authors":"Samaa Abdullah ,&nbsp;Samar Thiab ,&nbsp;Alaa A. Al-Masud ,&nbsp;Sarah Fahmi Faludah ,&nbsp;Abeer A. Altamimi","doi":"10.1016/j.fhfh.2025.100258","DOIUrl":"10.1016/j.fhfh.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>Chronic wounds and oxidative stress–related skin disorders, such as diabetic ulcers, burns, surgical wounds, and inflammatory dermatoses, require sustained topical delivery of antioxidant and anti-inflammatory agents. Glutathione (GSH) and Coenzyme Q10 (CoQ10) offer synergistic therapeutic effects but suffer from poor stability and limited skin permeability. This study developed and evaluated a sodium alginate (SA)-based nanogel co-delivering GSH and CoQ10 for enhanced wound healing.</div></div><div><h3>Methods</h3><div>A GSH–CoQ10 complex was prepared via adsorption and characterised using FT-IR, DSC, XRD, and SEM. The complex was incorporated into SA gels at varying concentrations (1.5%, 2.5%, 3.5%), and formulations were analysed for particle size, polydispersity index (PDI), and zeta potential using dynamic light scattering. GSH release was measured using a DTNB assay and fitted to kinetic models. Rheological behaviour, long-term stability (12 months), and morphology (SEM/TEM) were examined. <em>In vivo</em> efficacy was tested in a rat excisional wound model (<em>n</em> = 36), with ELISA quantification of VEGF, TGF-β1, Collagen I, and IL-6.</div></div><div><h3>Results</h3><div>The optimal 2.5% SA nanogel exhibited 122.0 ± 4.9 nm particle size, −40.0 ± 1.3 mV zeta potential, and PDI 0.25 ± 0.02. GSH release reached 72% over 24 h, following Korsmeyer–Peppas kinetics. Rheological analysis indicated pseudoplastic behaviour. The formulation remained stable for 12 months (f₂ = 81.04). <em>In vivo</em>, the nanogel achieved 98.6% wound closure at day 14 and significantly improved collagen synthesis while reducing IL-6 levels.</div></div><div><h3>Conclusion</h3><div>The GSH–CoQ10-loaded SA nanogel offers a stable and effective platform for treating chronic and acute skin injuries through synergistic antioxidant and anti-inflammatory mechanisms.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100258"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citrus flavonoid-pectin conjugates: Towards broad scope therapeutic agents","authors":"Caterina Di Sano ,&nbsp;Claudia D’Anna ,&nbsp;Giovanna Li Petri ,&nbsp;Giuseppe Angellotti ,&nbsp;Francesco Meneguzzo ,&nbsp;Rosaria Ciriminna ,&nbsp;Mario Pagliaro","doi":"10.1016/j.fhfh.2025.100246","DOIUrl":"10.1016/j.fhfh.2025.100246","url":null,"abstract":"<div><div>Obtained via synthetic organic chemistry, enzymatic, free radical or cavitation-based routes, citrus flavonoid-pectin conjugates are bioconjugates showing substantial bioactivity. Reviewing research achievements concerning the biological activity of citrus flavonoid-pectin conjugates since their recent introduction, this study suggests that the use of water-soluble and biocompatible citrus pectin to chemically bind and deliver citrus flavonoids offers a synergistic solution to the poor bioavailability of flavonoids that so far limited their uptake. Merging the powerful and broad scope bioactivity of citrus flavonoids with that of pectin, the approach is promising towards the development of new pharmaceutical and nutraceutical products for the treatment and prevention of numerous diseases.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100246"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a new self-nanoemulsifying Narcissus tazetta L. oil delivery system and study of its anti-breast and anti-pancreas cancers activities in vitro","authors":"R. Nazari-Vanani ,&nbsp;S.R. Rasouli Nasrabadi ,&nbsp;S.A. Dastgheib ,&nbsp;H. Heli","doi":"10.1016/j.fhfh.2025.100255","DOIUrl":"10.1016/j.fhfh.2025.100255","url":null,"abstract":"<div><div>Administration of natural oil extracts suffers from low oral bioavailability and anti-proliferative activity. Self-nanoemulsifying drug delivery systems (SNEDDSs) are novel formulations to improvement of the efficacy of poorly water-soluble compounds. In this study, a novel <em>Narcissus Tazetta</em> L. oil-loaded SNEDDS (NT-SNEDDS) was used to improve the antitumor effect of the oil against MCF-7 and PANC-1 cells. 30% tween 80, 55 % PEG 600, and 15 % ethyl oleate were considered as surfactant, cosurfactant, and oil, respectively, to form a SNEDDS. When combined with water, NT-SNEDDS created a nanoemulsion consisting of oil nanodroplets of 40±8 nm. Field emission scanning electron microscopy was also utilized to examine the structure of the nanodroplets. The formulations exhibited no indications of precipitation or phase separation throughout the storage duration. Toxicity of NT-SNEDDS was evaluated, and the results suggested that it had potential as an anticancer with IC50 values of 0.17 and 0.21 % (V/V, <em>Narcissus Tazetta</em> L. oil content of NT-SNEDDS) against MCF-7 and PANC-1 cells, respectively. The enhanced cytotoxicity was due to the induction of DNA fragmentation and apoptosis. Further investigations through in vitro mechanistic endpoint as well as in vivo experimentations would clarify the efficacy of NT-SNEDDS.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100255"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives","authors":"Kaakarlu Shivakumar Vinanthi Rajalakshmi ,&nbsp;Balamuralikrishnan Balasubramanian ,&nbsp;Hemanth Hinnakki ,&nbsp;Arun Meyyazhagan ,&nbsp;Wen-Chao Liu ,&nbsp;Manikantan Pappuswamy ,&nbsp;Hesam Kamyab ,&nbsp;Daniel Simancas-Racines ,&nbsp;Kuppusamy Alagesan Paari","doi":"10.1016/j.fhfh.2025.100229","DOIUrl":"10.1016/j.fhfh.2025.100229","url":null,"abstract":"<div><div>Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100229"},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}