Food Hydrocolloids for Health最新文献_第5页

Effect of nanoemulsion-based sage seed gum coating containing cinnamon essential oil on shelf life extension of strawberry 肉桂精油纳米乳基鼠尾草籽胶包衣对草莓保质期的影响

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.fhfh.2025.100242

Parastoo Asadi Shizari , Fatemeh Davoodi , Dayana Hassani , Shahriyar Amiri , Bahram Hassani

{"title":"Effect of nanoemulsion-based sage seed gum coating containing cinnamon essential oil on shelf life extension of strawberry","authors":"Parastoo Asadi Shizari , Fatemeh Davoodi , Dayana Hassani , Shahriyar Amiri , Bahram Hassani","doi":"10.1016/j.fhfh.2025.100242","DOIUrl":"10.1016/j.fhfh.2025.100242","url":null,"abstract":"<div><div>In this study, the antimicrobial efficacy of a nanoemulsion (NE) based on sage seed gum (WSG) containing cinnamon essential oil (CEO) was evaluated as an edible coating to extend the shelf life of strawberries. CEO at a concentration of 400 ppm was used for NE preparation. The particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency of the NE were reported to be 148.5 nm, 0.27, –27.12 mV, and 86 %, respectively. Strawberries were coated with distilled water (control), CEO (400 ppm), WSG coating, and CEO-loaded NE coating, then stored at room temperature for 9 days. Evaluations were conducted on days 0, 3, 6, and 9 to assess mass loss, total soluble solids, total mesophilic bacteria count, total mold and yeast count, pH, titratable acidity, vitamin C content, firmness, and color parameters. The results showed that over time, mass loss, total soluble solids, total mesophilic bacteria, and total mold and yeast counts increased significantly (<em>p</em> < 0.05), with the highest values observed in the control sample and the lowest in the NE -coated samples. Conversely, pH, titratable acidity, vitamin C content, and firmness decreased significantly (<em>p</em> < 0.05) over time. The lowest total phenolic content was observed in the control group, while the highest was recorded in the NE -coated strawberries at the end of the storage period. Overall, the NE coating showed the most significant preservative effect among all treatments, followed by the conventional WSG coating. These findings highlight the potential of CEO NE as an effective edible coating to extend the shelf life of strawberries.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100242"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products 探索从朝鲜蓟、红辣椒、黄瓜和胡萝卜副产品中提取的膳食纤维浓缩物的益生元潜力

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-11-28 DOI: 10.1016/j.fhfh.2025.100257

Ana A. Vaz , Isabel Odriozola-Serrano , Gemma Oms-Oliu , Olga Martín-Belloso , Gemma Bellí

{"title":"Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products","authors":"Ana A. Vaz , Isabel Odriozola-Serrano , Gemma Oms-Oliu , Olga Martín-Belloso , Gemma Bellí","doi":"10.1016/j.fhfh.2025.100257","DOIUrl":"10.1016/j.fhfh.2025.100257","url":null,"abstract":"<div><div>The agri-food industry exerts a considerable environmental impact while contributing to substantial losses of functional nutrients, particularly dietary fibre. Developing dietary fibre concentrates (DFCs) as novel functional food ingredients offers a dual opportunity: reducing environmental impact and delivering health-promoting prebiotic ingredients. This study evaluated the prebiotic potential of DFCs from artichoke, carrot, cucumber, and red pepper by assessing their impact on targeted gut microbiota composition and short-chain fatty acid (SCFA) production during 48 h of <em>in vitro</em> colonic digestion.</div><div>All DFCs reduced the Firmicutes/Bacteroidetes ratio from 0.5 to 0.8 at 24 h to below 0.4 at 48 h, indicating shifts towards microbial profiles favoring fibre degradation. Artichoke DFC induced the most pronounced effect, markedly stimulating <em>Lactobacillus</em> populations (>100-fold at 24 h and 14-fold increase at 48 h), likely linked to its chlorogenic acid and inulin content. Carrot DFC also promoted <em>Lactobacillus spp</em>. growth at 24 h, while both artichoke and carrot DFCs enhanced <em>Bifidobacterium</em> abundance. SCFA analysis revealed acetic acid as the dominant metabolite, with peak concentrations in cucumber (35.85 mM), red pepper (32.18 mM), and carrot (22.85 mM) fermentations at 48 h. Remarkably, artichoke DFC yielded the highest butyric acid concentration (13.30 mM), a key metabolite for colonocyte energy supply and intestinal barrier integrity.</div><div>These findings establish vegetable-derived DFCs, particularly artichoke and carrot, as promising prebiotic ingredients that can be selectively utilised by microorganisms to confer health benefits, while also highlighting a sustainable strategy to transform agricultural by-products into valuable functional foods ingredients with possible impacts on gut health.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100257"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical nanogel of glutathione and coenzyme Q10 in sodium alginate for chronic and inflammatory skin conditions: A synergistic antioxidant and anti-inflammatory delivery platform 外用海藻酸钠谷胱甘肽和辅酶Q10纳米凝胶治疗慢性和炎症性皮肤疾病：一种协同抗氧化和抗炎的递送平台

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-11-28 DOI: 10.1016/j.fhfh.2025.100258

Samaa Abdullah , Samar Thiab , Alaa A. Al-Masud , Sarah Fahmi Faludah , Abeer A. Altamimi

{"title":"Topical nanogel of glutathione and coenzyme Q10 in sodium alginate for chronic and inflammatory skin conditions: A synergistic antioxidant and anti-inflammatory delivery platform","authors":"Samaa Abdullah , Samar Thiab , Alaa A. Al-Masud , Sarah Fahmi Faludah , Abeer A. Altamimi","doi":"10.1016/j.fhfh.2025.100258","DOIUrl":"10.1016/j.fhfh.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>Chronic wounds and oxidative stress–related skin disorders, such as diabetic ulcers, burns, surgical wounds, and inflammatory dermatoses, require sustained topical delivery of antioxidant and anti-inflammatory agents. Glutathione (GSH) and Coenzyme Q10 (CoQ10) offer synergistic therapeutic effects but suffer from poor stability and limited skin permeability. This study developed and evaluated a sodium alginate (SA)-based nanogel co-delivering GSH and CoQ10 for enhanced wound healing.</div></div><div><h3>Methods</h3><div>A GSH–CoQ10 complex was prepared via adsorption and characterised using FT-IR, DSC, XRD, and SEM. The complex was incorporated into SA gels at varying concentrations (1.5%, 2.5%, 3.5%), and formulations were analysed for particle size, polydispersity index (PDI), and zeta potential using dynamic light scattering. GSH release was measured using a DTNB assay and fitted to kinetic models. Rheological behaviour, long-term stability (12 months), and morphology (SEM/TEM) were examined. <em>In vivo</em> efficacy was tested in a rat excisional wound model (<em>n</em> = 36), with ELISA quantification of VEGF, TGF-β1, Collagen I, and IL-6.</div></div><div><h3>Results</h3><div>The optimal 2.5% SA nanogel exhibited 122.0 ± 4.9 nm particle size, −40.0 ± 1.3 mV zeta potential, and PDI 0.25 ± 0.02. GSH release reached 72% over 24 h, following Korsmeyer–Peppas kinetics. Rheological analysis indicated pseudoplastic behaviour. The formulation remained stable for 12 months (f₂ = 81.04). <em>In vivo</em>, the nanogel achieved 98.6% wound closure at day 14 and significantly improved collagen synthesis while reducing IL-6 levels.</div></div><div><h3>Conclusion</h3><div>The GSH–CoQ10-loaded SA nanogel offers a stable and effective platform for treating chronic and acute skin injuries through synergistic antioxidant and anti-inflammatory mechanisms.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100258"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citrus flavonoid-pectin conjugates: Towards broad scope therapeutic agents 柑橘类黄酮-果胶缀合物：面向广泛用途的治疗剂

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.fhfh.2025.100246

Caterina Di Sano , Claudia D’Anna , Giovanna Li Petri , Giuseppe Angellotti , Francesco Meneguzzo , Rosaria Ciriminna , Mario Pagliaro

引用次数: 0

Development of a new self-nanoemulsifying Narcissus tazetta L. oil delivery system and study of its anti-breast and anti-pancreas cancers activities in vitro 新型自纳米乳化水仙油传递体系的研制及其体外抗乳腺癌、抗胰腺癌活性研究

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-11-14 DOI: 10.1016/j.fhfh.2025.100255

R. Nazari-Vanani , S.R. Rasouli Nasrabadi , S.A. Dastgheib , H. Heli

{"title":"Development of a new self-nanoemulsifying Narcissus tazetta L. oil delivery system and study of its anti-breast and anti-pancreas cancers activities in vitro","authors":"R. Nazari-Vanani , S.R. Rasouli Nasrabadi , S.A. Dastgheib , H. Heli","doi":"10.1016/j.fhfh.2025.100255","DOIUrl":"10.1016/j.fhfh.2025.100255","url":null,"abstract":"<div><div>Administration of natural oil extracts suffers from low oral bioavailability and anti-proliferative activity. Self-nanoemulsifying drug delivery systems (SNEDDSs) are novel formulations to improvement of the efficacy of poorly water-soluble compounds. In this study, a novel <em>Narcissus Tazetta</em> L. oil-loaded SNEDDS (NT-SNEDDS) was used to improve the antitumor effect of the oil against MCF-7 and PANC-1 cells. 30% tween 80, 55 % PEG 600, and 15 % ethyl oleate were considered as surfactant, cosurfactant, and oil, respectively, to form a SNEDDS. When combined with water, NT-SNEDDS created a nanoemulsion consisting of oil nanodroplets of 40±8 nm. Field emission scanning electron microscopy was also utilized to examine the structure of the nanodroplets. The formulations exhibited no indications of precipitation or phase separation throughout the storage duration. Toxicity of NT-SNEDDS was evaluated, and the results suggested that it had potential as an anticancer with IC50 values of 0.17 and 0.21 % (V/V, <em>Narcissus Tazetta</em> L. oil content of NT-SNEDDS) against MCF-7 and PANC-1 cells, respectively. The enhanced cytotoxicity was due to the induction of DNA fragmentation and apoptosis. Further investigations through in vitro mechanistic endpoint as well as in vivo experimentations would clarify the efficacy of NT-SNEDDS.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100255"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives 真菌生物聚合物纳米颗粒用于伤口愈合：机制、应用和未来展望

IF 4.6

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-06-27 DOI: 10.1016/j.fhfh.2025.100229

Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari

{"title":"Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives","authors":"Kaakarlu Shivakumar Vinanthi Rajalakshmi , Balamuralikrishnan Balasubramanian , Hemanth Hinnakki , Arun Meyyazhagan , Wen-Chao Liu , Manikantan Pappuswamy , Hesam Kamyab , Daniel Simancas-Racines , Kuppusamy Alagesan Paari","doi":"10.1016/j.fhfh.2025.100229","DOIUrl":"10.1016/j.fhfh.2025.100229","url":null,"abstract":"<div><div>Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100229"},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and innovative applications of persian gum as a native hydrocolloid: Physicochemical properties, biopolymer compatibility, and encapsulation technologies 作为天然水胶体的波斯胶的进展和创新应用：物理化学性质、生物聚合物相容性和封装技术

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.fhfh.2025.100250

Zahra Khoshdouni Farahani , Mohammad ali Ebrahimzadeh Mousavi , Abdorreza Mohammadi Nafchi

{"title":"Advances and innovative applications of persian gum as a native hydrocolloid: Physicochemical properties, biopolymer compatibility, and encapsulation technologies","authors":"Zahra Khoshdouni Farahani , Mohammad ali Ebrahimzadeh Mousavi , Abdorreza Mohammadi Nafchi","doi":"10.1016/j.fhfh.2025.100250","DOIUrl":"10.1016/j.fhfh.2025.100250","url":null,"abstract":"<div><div>This mini review focuses on Persian gum, a native Iranian hydrocolloid derived from the mountain almond tree (<em>Amygdalus</em> species), which has attracted significant interest due to its unique structural properties and potential applications across various industries, especially in food and pharmaceuticals. Despite its promising characteristics, the use of Persian gum in coating and encapsulation technologies within the food industry remains limited. This paper highlights recent advances in the development of Persian gum-based beads and capsules for encapsulation purposes. Utilizing this native gum as a cost-effective coating material not only offers a sustainable alternative to expensive imported hydrocolloids but also provides comparable quality in food formulations. Moreover, Persian gum demonstrates excellent compatibility with other biopolymers and proteins, broadening its potential applications. The review summarizes experimental findings on Persian gum’s encapsulation efficiency, interactions with other gums and proteins, and its role in various coating methods. These insights underscore Persian gum’s promising role as a versatile and economical encapsulating agent, with significant potential for broader industrial application.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100250"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pectins mitigate Candidalysin-induced gut barrier disruption and inflammation in vitro in a degree of methyl-esterification-dependent manner 果胶在体外以一定程度的甲基酯化依赖方式减轻念珠菌素诱导的肠道屏障破坏和炎症

IF 5.1

Food Hydrocolloids for Health Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1016/j.fhfh.2025.100232

Naschla Gasaly , Xiaochen Chen , Luis Silva-Lagos , Isaura Beatriz Borges Silva , Marcela A. Hermoso , Paul de Vos

{"title":"Pectins mitigate Candidalysin-induced gut barrier disruption and inflammation in vitro in a degree of methyl-esterification-dependent manner","authors":"Naschla Gasaly , Xiaochen Chen , Luis Silva-Lagos , Isaura Beatriz Borges Silva , Marcela A. Hermoso , Paul de Vos","doi":"10.1016/j.fhfh.2025.100232","DOIUrl":"10.1016/j.fhfh.2025.100232","url":null,"abstract":"<div><div>Pectin, a dietary fiber, exhibits anti-inflammatory properties influenced by its degree of methyl-esterification (DM). Inflammatory bowel disease (IBD) is characterized by chronic inflammation due to a compromised epithelial barrier, dysregulated microbiota, and an overactive immune response. Beyond bacterial dysbiosis, recent research emphasizes the gut mycobiota, particularly <em>Candida albicans</em>, in IBD progression. <em>C. albicans</em> is frequently elevated in IBD patients and secretes candidalysin (CaLysin), a cytolytic toxin that disrupts epithelial barrier integrity. This study evaluates the protective effects of lemon-derived pectins with low (DM18) and high (DM88) DM against CaLysin-induced epithelial-stress <em>in vitro</em>. T84 cell monolayers were pre-treated with pectins prior to CaLysin challenge. CaLysin impaired barrier function, increased lactate dehydrogenase (LDH) release, and pro-inflammatory cytokines (e.g., IL-8, IL-33), while downregulating tight junction proteins (Claudin-1, Occludin) and tissue repair markers such as Retinaldehyde dehydrogenase 1 (<em>ALDH1A1</em>) and Amphiregulin (<em>AREG</em>). Both pectins mitigated these effects, preserving barrier integrity, reducing LDH release, and cytokine expression (e.g., IL-8, IL-13, IL-18, CCL20). Pectins also upregulated tight junction proteins (Claudin-1, Occludin, Zonula Occludens-1) at mRNA and protein levels in a DM-dependent manner and enhanced tissue repair genes. These findings highlight the potential of pectins, particularly those with low-DM (DM18), in protecting against CaLysin-induced gut epithelial damage.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100232"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation 枣渣多糖包封硒纳米粒子：生物合成、优化、理化表征、生物活性、稳定性和肠道菌群调节

IF 4.6

Food Hydrocolloids for Health Pub Date : 2025-06-01 Epub Date: 2025-01-20 DOI: 10.1016/j.fhfh.2025.100198

Gafar Babatunde Bamigbade , Athira Subhash , Mohammed Abdin , Hebah Jarusheh , Basim Abu-Jdayil , Shao-Quan Liu , Giovanni Palmisano , Abdelmoneim Ali , Afaf Kamal Eldin , Mutamed Ayyash

{"title":"Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation","authors":"Gafar Babatunde Bamigbade , Athira Subhash , Mohammed Abdin , Hebah Jarusheh , Basim Abu-Jdayil , Shao-Quan Liu , Giovanni Palmisano , Abdelmoneim Ali , Afaf Kamal Eldin , Mutamed Ayyash","doi":"10.1016/j.fhfh.2025.100198","DOIUrl":"10.1016/j.fhfh.2025.100198","url":null,"abstract":"<div><div>Selenium nanoparticles (Se-NP<sub>S</sub>) are recognized for their bioavailability and low toxicity, though their inherent instability limits broader applications. This study explored the biosynthesis and functional properties of selenium nanoparticles (Se-NPS) stabilized with date pomace polysaccharides (MPS-NP<sub>S</sub>). The MPS-NP<sub>S</sub> characteristics, digestibility and impact on human gut microbiota were investigated. The MPS-NP<sub>S</sub> were well-stabilized, spherical particles averaging 65.4 nm in size, with PDI (0.032), zeta potential (–21.07 mV) and notable antioxidant activity (82.7 % DPPH, 68.9 % ABTS, 491.0 µg/mL FRAP, and 961.2 µg/mL TAC at 100 mg/L). They also showed concentration-dependent enzyme inhibition: 86.8 % α-amylase, 53.9 % α-glucosidase, and 42.4 % ACE inhibition at 100 mg/L, along with anticancer effects against Caco-2 (32.3 %) and MCF-7 (11.3 %) at 50 mg/L. MPS-NP<sub>S</sub> demonstrated broad antimicrobial activity against <em>E. coli</em> O 157:H7 (84.2 %), <em>S</em>. Typhimurium (82.5 %), <em>S. aureus</em> (77.2 %), and L. <em>monocytogenes</em> (89.24 %) and supported probiotic growth, indicating prebiotic potential. During fecal fermentation, they boosted short-chain fatty acid (SCFA) production and the abundance of SCFA-producing bacteria, including G<em>emmiger formicilis</em> and <em>Bifidobacterium</em> species. These findings suggest MPS-NP<sub>S</sub> as a promising functional ingredient for gut health and dietary supplementation.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100198"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emulsion-enhanced synergy of walnut-derived hexapeptide (EPEVLR) and DHA in mitigating D-galactose-induced cognitive decline in mice 乳剂增强核桃衍生六肽（EPEVLR）和DHA在减轻d -半乳糖诱导的小鼠认知能力下降中的协同作用

IF 4.6

Food Hydrocolloids for Health Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1016/j.fhfh.2025.100215

Like Lin , Li Zhang , Cong Li , Lihua Jin , Rui Wang , Yu Shu , Bang Chen , Yehua Shen

{"title":"Emulsion-enhanced synergy of walnut-derived hexapeptide (EPEVLR) and DHA in mitigating D-galactose-induced cognitive decline in mice","authors":"Like Lin , Li Zhang , Cong Li , Lihua Jin , Rui Wang , Yu Shu , Bang Chen , Yehua Shen","doi":"10.1016/j.fhfh.2025.100215","DOIUrl":"10.1016/j.fhfh.2025.100215","url":null,"abstract":"<div><div>This study explored the synergistic effects of walnut-derived peptide (Glu-Pro-Glu-Val-Leu-Arg, EPEVLR) and docosahexaenoic acid (DHA) on ameliorating D-galactose (D-gal) induced cognitive dysfunction in mice. EPEVLR and DHA were integrated using ultrasonic mixing at a 2:1 molar ratio, resulting in a stable water-in-oil (W/O) emulsion labeled DHA@EP. DHA@EP was more effective than DHA or EPEVLR alone in alleviating D-gal-induced mice cognitive deficits. The underlying mechanisms included reducing oxidative stress, mitigating neuroinflammation, and stabilizing the cholinergic system. Structural characterization and theoretical calculations confirmed that EPEVLR and DHA formed a stable emulsion with droplet diameters below 10 μm, driven by hydrogen bonding between the nitrogen (N) and oxygen (O) atoms of EPEVLR and the hydrogen (H) atoms of DHA. <em>In vitro</em> digestion simulation experiments indicated that the W/O emulsion structure of DHA@EP significantly enhanced the intestinal stability of EPEVLR, likely due to the protective effect of the oil phase against enzymatic degradation in the gastrointestinal tract. These findings highlight the potential of DHA@EP as a functional food ingredient for cognitive improvement and provide insights into the synergistic use of bioactive peptides and fatty acids.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100215"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0