法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.521001

Wen-Jing Hu, Ting-Ting Yang, Ya-Ya Wang, Jiang-Wei Yan

引用次数: 0

[Bicuspid aoritc valve with rupture of aorta dissection： A case report]. [二尖瓣伴主动脉夹层破裂：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.420410

碧宇徐, 晨阳吴, 艳琦姬, 莹莹李, 旭东宋

引用次数: 0

[Forensic identification of vocal cord paralysis and dysphonia caused by chest crush injury： A case report]. [胸部挤压伤所致声带麻痹和发音障碍的法医鉴定：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.220306

洪松虢, 晓贺刘, 红红韦, 长征李

引用次数: 0

[Identification of labor capacity of fracture of the polydactyly thumb： A case report]. [多指畸形拇指骨折的劳动能力鉴定：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.221202

怀君任

引用次数: 0

Pathological Characteristics and Classification of Unstable Coronary Atherosclerotic Plaques. 不稳定冠状动脉粥样硬化斑块的病理特征和分类。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.421203

Yun-Hong Xing, Yang Li, Wen-Zheng Wang, Liang-Liang Wang, Le-le Sun, Qiu-Xiang DU, Jie Cao, Guang-Long He, Jun-Hong Sun

{"title":"Pathological Characteristics and Classification of Unstable Coronary Atherosclerotic Plaques.","authors":"Yun-Hong Xing, Yang Li, Wen-Zheng Wang, Liang-Liang Wang, Le-le Sun, Qiu-Xiang DU, Jie Cao, Guang-Long He, Jun-Hong Sun","doi":"10.12116/j.issn.1004-5619.2022.421203","DOIUrl":"10.12116/j.issn.1004-5619.2022.421203","url":null,"abstract":"Important forensic diagnostic indicators of sudden death in coronary atherosclerotic heart disease, such as acute or chronic myocardial ischemic changes, sometimes make it difficult to locate the ischemic site due to the short death process, the lack of tissue reaction time. In some cases, the deceased died of sudden death on the first-episode, resulting in difficulty for medical examiners to make an accurate diagnosis. However, clinical studies on coronary instability plaque revealed the key role of coronary spasm and thrombosis caused by their lesions in sudden coronary death process. This paper mainly summarizes the pathological characteristics of unstable coronary plaque based on clinical medical research, including plaque rupture, plaque erosion and calcified nodules, as well as the influencing factors leading to plaque instability, and briefly describes the research progress and technique of the atherosclerotic plaques, in order to improve the study on the mechanism of sudden coronary death and improve the accuracy of the forensic diagnosis of sudden coronary death by diagnosing different pathologic states of coronary atherosclerotic plaques.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 1","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Screening of 34 Emerging Contaminants in Surface Water by UHPLC-Q-TOF-MS. 利用超高效液相色谱-Q-TOF-MS 快速筛查地表水中的 34 种新污染物。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.320301

Chen-Shan Lü, Yi-Xuan Cao, Xiao-Xi Mu, Hai-Yan Cui, Tao Wang, Zhi-Wen Wei, Ke-Ming Yun, Meng Hu

{"title":"Rapid Screening of 34 Emerging Contaminants in Surface Water by UHPLC-Q-TOF-MS.","authors":"Chen-Shan Lü, Yi-Xuan Cao, Xiao-Xi Mu, Hai-Yan Cui, Tao Wang, Zhi-Wen Wei, Ke-Ming Yun, Meng Hu","doi":"10.12116/j.issn.1004-5619.2022.320301","DOIUrl":"10.12116/j.issn.1004-5619.2022.320301","url":null,"abstract":"Objectives: To establish a rapid screening method for 34 emerging contaminants in surface water by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF-MS).Methods: The pretreatment conditions of solid phase extraction (SPE) were optimized by orthogonal experimental design and the surface water samples were concentrated and extracted by Oasis® HLB and Oasis® MCX SPE columns in series. The extracts were separated by Kinetex® EVO C18 column, with gradient elution of 0.1% formic acid aqueous solution and 0.1% formic acid methanol solution. Q-TOF-MS 'fullscan' and 'targeted MS/MS' modes were used to detect 34 emerging contaminants and to establish a database with 34 emerging contaminants precursor ion, product ion and retention times.Results: The 34 emerging contaminants exhibited good linearity in the concentration range respectively and the correlation coefficients (r) were higher than 0.97. The limit of detection was 0.2-10 ng/L and the recoveries were 81.2%-119.2%. The intra-day precision was 0.78%-18.70%. The method was applied to analyze multiple surface water samples and 6 emerging contaminants were detected, with a concentration range of 1.93-157.71 ng/L.Conclusions: The method is simple and rapid for screening various emerging contaminants at the trace level in surface water.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment and Application of a 42-plex Microhaplotype Assay in Forensic Genetics. 在法医遗传学中建立和应用 42 复式微单体型检测。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2023.530803

Peng Yun, An-Qi Chen, Li-Qin Chen, Cheng-Tao Li

{"title":"Establishment and Application of a 42-plex Microhaplotype Assay in Forensic Genetics.","authors":"Peng Yun, An-Qi Chen, Li-Qin Chen, Cheng-Tao Li","doi":"10.12116/j.issn.1004-5619.2023.530803","DOIUrl":"10.12116/j.issn.1004-5619.2023.530803","url":null,"abstract":"Objectives: To establish and forensically verify a 42 microhaplotypes (mircohaps, MHs) multiplex assay system based on next-generation sequencing (NGS), and to explore the application value of this system in the practice of forensic genetics.Methods: A total of 42 highly polymorphic MHs were selected from previous studies, and sequenced by the MiSeq FGxTM platform to verify the repeata-bility, sensitivity, specificity, stability, and mixture analysis ability of the detection system. Through population genetic investigation of 102 unrelated Chinese Han individuals in Liyang City, Jiangsu Province, China, the application value of this system in forensic genetics was evaluated.Results: The sequencing repeatability of the 42-plex MHs assay was 100% and the sensitivity was as low as 0.062 5 ng. The system had the ability to withstand the interference of indigo (≤2 500 ng/μL), humic acid (≤9 ng/μL), hemoglobin(≤20 μmol), and urea (≤200 ng/μL) and to detect mixtures of 2 people (1∶19), 3 people (1∶1∶9) and 4 people (1∶1∶1∶9). Based on 102 individual data, the combined power of discrimination and the combined power of exclusion were 1-3.45×10-30 and 1-3.77×10-11, respectively, and the average effect value of alleles was 2.899.Conclusions: The 42-plex MHs assay was successfully established in this study and this system has high repeatability and sensitivity, good anti-jamming ability and mixture analysis ability. The 42 MHs are highly polymorphism and have good application value in individual identification and paternity testing.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 1","pages":"50-58"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Forensic identification of death from status epilepticus： A case report]. [癫痫状态致死的法医鉴定：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2022.420413

茜茜靳, 雅琴白, 念念陈, 祎铭董, 学慧高, 修强孙, 君丽王, 洁曹, 新华梁, 相杰郭

引用次数: 0

[Assessment of disability for exaggerated visual impairment after traumatic brain injury： A case report]. [脑外伤后夸大性视力损伤的残疾评估：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2021.210702

陨石李, 炜高, 艳琴张, 强徐, 晓林沈

引用次数: 0

[Paterning identification of twins with differnet fathers using multiple genetic markers： A case report]. [利用多重遗传标记对不同父亲的双胞胎进行父子鉴定：病例报告]。

法医学杂志 Pub Date : 2024-02-25 DOI: 10.12116/j.issn.1004-5619.2023.530702

光渊刘

引用次数: 0

法医学杂志最新文献