法医学杂志最新文献_第7页

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2023.430502

晨光杨, 慧讷刘, 美辰潘, 玮玮朱, 飞李, 成海李, 红梅董

引用次数: 0

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2023.331001

乾亚邓, 永生陈, 思阳何, 文娟孙, 春芳倪, 芳琦曹, 水庆郑, 晨梁

引用次数: 0

Construction and Evaluation of Intimate Partner Homicide Prediction Model. 亲密伴侣凶杀预测模型的构建与评价。

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2023.431005

Wei-Ping Lü, Xin-Biao Liao, Li-Ju Ren, Xiao-Ping Kong, Yan-Chang Chen, Ya-Fei Chang, Bin Luo

{"title":"Construction and Evaluation of Intimate Partner Homicide Prediction Model.","authors":"Wei-Ping Lü, Xin-Biao Liao, Li-Ju Ren, Xiao-Ping Kong, Yan-Chang Chen, Ya-Fei Chang, Bin Luo","doi":"10.12116/j.issn.1004-5619.2023.431005","DOIUrl":"10.12116/j.issn.1004-5619.2023.431005","url":null,"abstract":"Objectives: To analyze the independent influencing factors of intimate partner homicide (IPH) cases, construct an IPH prediction model, and provide a basis for criminal profiling.Methods: A total of 476 convicted homicide cases in Guangdong Province from January 1, 2014, to December 31, 2020, were collected as modeling dataset. They were divided into the IPH group (n=180) and the non-intimate partner homicide (N-IPH) group (n=296) based on whether the offender and victim were intimate partners. Logistic regression was used to build the model, the model was evaluated through the receiver operating characteristic (ROC) curve analysis and a nomogram was drawn. Internal validation was conducted using ten-fold cross-validation method. A total of 126 court judgments from outside Guangdong Province from January 1, 2011, to December 31, 2020, were randomly collected for external validation.Results: Through multi-factor Logistic regression analysis, 7 variables were ultimately selected for inclusion in the model. The Hosmer-Lemeshow goodness of fit test result of the model was χ2=13.158, P=0.068. The ROC area under the curve (AUC) of the model was 0.939 (95% CI: 0.919-0.959), the cut-off value was 0.292, the sensitivity was 0.900, and the specificity was 0.865. The calibration curve was close to the ideal curve. The ten-fold cross-validation showed the accuracy of 0.863 and a Kappa value of 0.708. The external validation results showed an AUC of 0.922 (95% CI: 0.872-0.971), a cut-off value of 0.292, a sensitivity of 0.890, and a specificity of 0.886. The calibration curve tended to the ideal curve.Conclusions: The IPH prediction model based on forensic field indicators has good predictive ability, reliable accuracy and stability, and can provide a scientific method for criminal profiling.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 6","pages":"582-588"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340603

学虎王, 仿敏徐

引用次数: 0

High Resolution Mass Spectrometry Fragmentation Rules of Etomidate and Its Structural Analogues. 依托咪酯及其结构类似物的高分辨质谱破碎规律。

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340602

Xian-Yu Fan, Xue-Yan Zhu, Xin Wang, Ping Xiang, Jun-Bo Zhao

{"title":"High Resolution Mass Spectrometry Fragmentation Rules of Etomidate and Its Structural Analogues.","authors":"Xian-Yu Fan, Xue-Yan Zhu, Xin Wang, Ping Xiang, Jun-Bo Zhao","doi":"10.12116/j.issn.1004-5619.2024.340602","DOIUrl":"10.12116/j.issn.1004-5619.2024.340602","url":null,"abstract":"Objectives: To explore the characteristic fragment ions, ion abundance ratios and mass spectrometry fragmentation rules of etomidate and its structural analogues by using gas chromatography-quadrupole/orbitrap mass spectrometry (GC-Q/Orbitrap MS) and liquid chromatography-linear ion trap quadrupole-orbitrap mass spectrometry (LC-LTQ-Orbitrap MS) techniques, providing important data support for the identification and prediction of etomidate structural analogues.Methods: GC-Q/Orbitrap MS and LC-LTQ-Orbitrap MS were used to analyze metomidate, etomidate, isopropoxate and propoxate, to obtain their GC high resolution mass spectra and LC high resolution mass spectra.Results: Under the electron impact (EI) ion source mode, etomidate, metomidate and the other two analogues all produced their molecular ions and seven identical fragment ions (m/z 77.038 6, 79.054 2, 95.024 0, 105.069 9, 143.073 0, 172.099 5 and 199.086 6), among which isopropoxate and propoxate also produced characteristic fragment ions m/z 216.089 3. In the collision cell of the electrospray ionization (ESI) source mode, etomidate, metomidate and the other two analogues all produced three identical fragment ions (m/z 95.024 0, 105.069 9 and 113.034 6). Meanwhile, each substance produced one characteristic fragment ion (metomidate: m/z 127.050 2; etomidate: m/z 141.065 9; isopropoxate and propoxate: m/z 155.081 5).Conclusions: Common fragment ions exist among etomidate and its structural analogues, and characteristic ion fragments are generated based on the different carbon numbers of their side chains. The structure of side chains can affect the abundance ratio of each fragment ion, providing a basis for the structural identification and prediction of such compounds.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 6","pages":"557-563"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Application of MALDI-MSI in Hair Analysis. MALDI-MSI在毛发分析中的应用研究进展。

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340405

Jiao-Jiao Ji, Xin Wang, Jia-Man Lin, Duo-Qi Xu, Hui Yan, Min Shen

引用次数: 0

Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS. LC-HRMS法分析人肝微粒体中米氮平代谢物。

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340606

Ying Zhang, Wen-Fang Zhang, Duo-Qi Xu, Shi-Yang Qin, Shi-Yun Yang, Jing Qiao

{"title":"Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS.","authors":"Ying Zhang, Wen-Fang Zhang, Duo-Qi Xu, Shi-Yang Qin, Shi-Yun Yang, Jing Qiao","doi":"10.12116/j.issn.1004-5619.2024.340606","DOIUrl":"10.12116/j.issn.1004-5619.2024.340606","url":null,"abstract":"Objectives: To establish and optimize an in vitro incubation system with human liver microsomes and investigate the in vitro metabolites and possible metabolic pathways of mirtazapine.Methods: Three major metabolites of mirtazapine were selected to optimize the incubation conditions of liver microsomes. The metabolites of mirtazapine were analyzed by liquid chromatography-high resolution mass spectrometry (LC-HRMS) to identify the in vitro metabolites and metabolic pathways of mirtazapine.Results: Ten metabolites, including nine phase Ⅰ metabolites and one phase Ⅱ metabolite, were identified in the in vitro liver microsome incubation. Among them, five new metabolites and one new metabolic pathway were discovered. The pathways involved in phase Ⅰ metabolic included methylation, hydroxylation, oxidation, reduction, etc., while the phase Ⅱ biotransformation was mainly glucuronidation.Conclusions: The metabolites discovered in this study are consistent with the main metabolites of mirtazapine reported in literature, which are N-desmethylmetazapine, 8-hydroxy mirtazapine and mirtazapine-N-oxide. The results can provide basis for the confirmation of mirtazapine cases and provide reference for the study of other substances.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 6","pages":"569-574"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a Novel Synthetic Cathinone CMMP. 一种新型合成卡西酮CMMP的鉴定。

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340103

Si-Yang He, Qian-Ya Deng, Shui-Qing Zheng, Chun-Fang Ni, Wen-Juan Sun, Fang-Qi Cao, Chen Liang, Fei-Jun Gong

{"title":"Identification of a Novel Synthetic Cathinone CMMP.","authors":"Si-Yang He, Qian-Ya Deng, Shui-Qing Zheng, Chun-Fang Ni, Wen-Juan Sun, Fang-Qi Cao, Chen Liang, Fei-Jun Gong","doi":"10.12116/j.issn.1004-5619.2024.340103","DOIUrl":"10.12116/j.issn.1004-5619.2024.340103","url":null,"abstract":"Objectives: To establish a method to identify an unknown substance based on the combined use of gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-MS), ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q/Orbitrap HRMS)and nuclear magnetic resonance (NMR) techniques.Methods: The unknown substance was dissolved in methanol and was detected by GC-QTOF-MS and UPLC-Q/Orbitrap HRMS, and was dissolved in methanol-d4 to be detected by NMR.Results: The main characteristics ion peaks of components with retention time of 9.67 min in GC-QTOF-MS measured were 84.080 8, 110.999 7, 128.107 0 (base peak), 138.994 7, etc. The protonated molecular ion peak m/z in UPLC-Q/Orbitrap HRMS was 268.109 3. It was inferred that the unknown substance was an analog of the synthetic cathinone substance 2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one (MTMP) by comparing the mass spectrum information and molecular structure of MTMP. NMR analysis confirmed it as a novel N-morpholine substituted synthetic cathinone substance 1-(4-chlorophenyl)-2-methyl-2-morpholinopropan-1-one (CMMP).Conclusions: The method established in this study can be used for structural confirmation of CMMP.","PeriodicalId":12317,"journal":{"name":"法医学杂志","volume":"40 6","pages":"550-556"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.340605

慧严

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法医学杂志 Pub Date : 2024-12-25 DOI: 10.12116/j.issn.1004-5619.2024.240909

志华冯, 路遥刘, 宇铭刘, 亦斌程

引用次数: 0