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Food and Agricultural Immunology最新文献

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A SERS-based immunochromatographic assay for ultrasensitive and quantitative detection of florfenicol using long wavelength absorption of Au nanocubes 基于SERS的金纳米立方体长波长吸收免疫色谱法超灵敏定量检测氟苯尼考
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-10-04 DOI: 10.1080/09540105.2022.2120852
Ying Liu, Ting Zhou, Penghui Zhou, Hanwen Liu, Jianguo Li, Anping Deng
{"title":"A SERS-based immunochromatographic assay for ultrasensitive and quantitative detection of florfenicol using long wavelength absorption of Au nanocubes","authors":"Ying Liu, Ting Zhou, Penghui Zhou, Hanwen Liu, Jianguo Li, Anping Deng","doi":"10.1080/09540105.2022.2120852","DOIUrl":"https://doi.org/10.1080/09540105.2022.2120852","url":null,"abstract":"ABSTRACT An immunochromatographic assay (ICA) based on surface-enhanced Raman scattering (SERS) for ultrasensitive and quantitative detection of florfenicol (FF) in food samples was developed. Au nanocubers (AuNCs) with long wavelength absorption were synthesised, characterised and used as the substrate in SERS-ICA. Immunoprobe was prepared by linking Raman reporter and the antibody against FF on AuNCs. The SERS-ICA was completed in 15 min. By measuring the Raman intensities on T lines, quantitative detection of FF was achieved. The IC50 and limit of detection (LOD) of the assay for FF were 0.027 ng mL−1 and 0.12 pg mL−1, respectively. The cross-reactivity (CR) of the assay with thiamphenicol, chloramphenicol and other four drugs were examined. The recoveries of FF in spiked samples were 88.5% ∼ 102.4% with RSD of 2.3% ∼ 7.4%. It was proven that SERS-ICA was able to rapidly detect FF in food samples with high sensitivity, accuracy and precision.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"752 - 767"},"PeriodicalIF":3.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43131208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of fermented oat milk and evaluation of its modulatory effect on antigen-specific immune responses in ovalbumin-sensitized mice 发酵燕麦乳的制备及其对卵清蛋白致敏小鼠抗原特异性免疫反应的调节作用
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-09-21 DOI: 10.1080/09540105.2022.2120851
F. Liu, Chien-Li Chen, Chung-Hsiung Huang
{"title":"Preparation of fermented oat milk and evaluation of its modulatory effect on antigen-specific immune responses in ovalbumin-sensitized mice","authors":"F. Liu, Chien-Li Chen, Chung-Hsiung Huang","doi":"10.1080/09540105.2022.2120851","DOIUrl":"https://doi.org/10.1080/09540105.2022.2120851","url":null,"abstract":"ABSTRACT A growing number of people choose plant-based milk products to replace dairy for health reasons or veganism. Since fermentation is a promising method to improve the nutritional value of plant-based milk, this study aimed to establish the process of oat milk fermentation and to evaluate the effect of fermented oat milk (FOM) on modulating antigen-specific immune response in ovalbumin (OVA)-sensitized mice. The FOM was prepared by fermentation of oat milk with Streptococcus thermophilus, Lactobacillus bulgaricus and proteolytic L. rhamnosus. Addition of 1% glucose improved the process of fermentation. FOM was stable while stored at 4°C within seven days. Oral administration with FOM (0.4 and 2 g/kg body weight) did not alter the serum level of OVA-specific IgG and spleen index. However, FOM had comparable potency with commercial dairy yogurt to lower stimulation index, IL-2, IFN-γ and IL-4 production and to promote TGF-β and IL-10 secretion by OVA-stimulated splenocytes.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"722 - 735"},"PeriodicalIF":3.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47508325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rapid screening of 15 highly toxic pesticide residues in Angelica sinensis decoctions by thermal desorption electrospray ionization mass spectrometry 热解吸电喷雾质谱法快速筛选当归煎液中15种剧毒农药残留
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-09-20 DOI: 10.1080/09540105.2022.2119942
Hongyan Zhang, Qiaoying Chang, Xingzhi Wang, Jian Li, Guoyu Qiu, F. Wu, Renyuan Zhu, M. Su
{"title":"Rapid screening of 15 highly toxic pesticide residues in Angelica sinensis decoctions by thermal desorption electrospray ionization mass spectrometry","authors":"Hongyan Zhang, Qiaoying Chang, Xingzhi Wang, Jian Li, Guoyu Qiu, F. Wu, Renyuan Zhu, M. Su","doi":"10.1080/09540105.2022.2119942","DOIUrl":"https://doi.org/10.1080/09540105.2022.2119942","url":null,"abstract":"ABSTRACT A decoction is the most common form of Chinese herbal medicine dosing. An Angelica sinensis decoction was qualitatively and semi-quantitatively analyzed for 15 highly toxic pesticide residues by thermal desorption electrospray ionization mass spectrometry (TD-ESI/MS) with a triple quadrupole mass spectrometer in multiple reaction monitoring mode without pretreatment. The instrument response was optimal and sensitivity was highest with the following parameters: thermal desorption temperature, 300 °C; 0.1% formic acid aqueous solution-methanol (1:1,V:V) solvent; syringe pump flow rate, 150 μL/h; and sampler length, 5 cm. Good linearity was attained within the appropriate linear range with the detection limits ranging from 0.01–0.05 mg/L. The same positive sample was verified for QuEChERS pretreatment coupled with liquid chromatography tandem mass spectrometry, showing good agreement with TD-ESI/MS. The newly developed method was demonstrated to be a rapid, green, and efficient analytical method for screening 15 highly toxic pesticide residues in Angelica sinensis decoctions.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"709 - 721"},"PeriodicalIF":3.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43523789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea 蜜环菌转化天麻制品抗皮肤肿瘤和UVB损伤作用的研究
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-09-19 DOI: 10.1080/09540105.2022.2120853
Tong Zheng, Yugang Gao, Zhilong Zhang, Xinyue Li, P. Zang, Yan Zhao, Zhongmei He
{"title":"A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea","authors":"Tong Zheng, Yugang Gao, Zhilong Zhang, Xinyue Li, P. Zang, Yan Zhao, Zhongmei He","doi":"10.1080/09540105.2022.2120853","DOIUrl":"https://doi.org/10.1080/09540105.2022.2120853","url":null,"abstract":"ABSTRACT Skin cancer is a malignant tumour that can spread in the skin and is a serious threat to human health. Excessive ultraviolet radiation is one of the most common factors that leads to skin cancer. The purpose of this study was to evaluate the anti-skin tumour and anti-UVB damage effects of Armillaria mellea (Vahl) P. Kumm transformed Gastrodia elata Bl products (ATGP). Gastrodia elata Blume f.glauca S. Chows from Changbai Mountain and 4 Armillaria mellea (Vahl) P. Kumm strains were used as experimental materials. First, the optimum fungal strains of Armillaria mellea used to transform gastrodin were screened. Then, the MTT assay and scratch test proved that ATGP had anti-B16 melanoma cell activity in vitro. Furthermore, the anti-UVB damage effect of ATGP was proven by a UVB damage mouse skin model and HaCat photoaging model, and its mechanism was preliminarily discussed. GRAPHICAL ABSTRACT","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"736 - 751"},"PeriodicalIF":3.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42575816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics and water migration analysis provides valuable insights into nutrient generation in Tartary buckwheat (Fagopyrum tataricum) seed germination 代谢组学和水分迁移分析为苦麦种子发芽过程中的营养生成提供了有价值的见解
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-09-19 DOI: 10.1080/09540105.2022.2117797
Bai Yongliang, Xin Meiguo, Lin Roumin, He Weijun, He Shuyan, Z. Rong, Guo Yiping
{"title":"Metabolomics and water migration analysis provides valuable insights into nutrient generation in Tartary buckwheat (Fagopyrum tataricum) seed germination","authors":"Bai Yongliang, Xin Meiguo, Lin Roumin, He Weijun, He Shuyan, Z. Rong, Guo Yiping","doi":"10.1080/09540105.2022.2117797","DOIUrl":"https://doi.org/10.1080/09540105.2022.2117797","url":null,"abstract":"ABSTRACT Seed germination of Tartary buckwheat is important for its biological generation of various nutrients. To investigate the nutrient differences during seed germination, the metabolic profiling and moisture status of Tartary buckwheat seed germination were quantitatively measured by ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) and NMR, respectively. The results showed water was predominantly in free status during the three stages of seed germination divided. Statistical analysis (PCA, OPLS-DA, KEGG) of 53 metabolites at different germination stages revealed the key metabolites of linoleic, flavonoid and phenylalanine biosynthesis during the seed germination. Furthermore, flavonoids biosynthesis was identified as the pathway with the largest difference significance at the second and third stages, while linoleic and phenylalanine metabolisms were screened out as the major pathways with most impact factors in the first and second and the third stage, respectively. The analysis provided valuable insights into the nutrient generation during Tartary buckwheat seeds germination.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"692 - 708"},"PeriodicalIF":3.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44024267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid enzyme-linked immunosorbent assay and colloidal gold immunoassay for assessing okadaic acid and its derivatives in shellfish 快速酶联免疫吸附法和胶体金免疫测定法测定贝类中冈田酸及其衍生物
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-08-31 DOI: 10.1080/09540105.2022.2115466
Ruirui Wang, Hong-bo Qi, Miao Liang, Guoxiang Liao, Fan Yang
{"title":"Rapid enzyme-linked immunosorbent assay and colloidal gold immunoassay for assessing okadaic acid and its derivatives in shellfish","authors":"Ruirui Wang, Hong-bo Qi, Miao Liang, Guoxiang Liao, Fan Yang","doi":"10.1080/09540105.2022.2115466","DOIUrl":"https://doi.org/10.1080/09540105.2022.2115466","url":null,"abstract":"ABSTRACT Okadaic acid (OA) and the analogs of dinophysistoxin (DTX) are important members of diarrhetic shellfish poisoning (DSP) toxins. In this study, five OA-specific mAbs (monoclonal antibodies) were developed from five stable cells of hybridoma. The anti-OA mAb-2D7 showed high sensitivity to OA, the IC50 of the antibody was 0.24 ng/mL, and its cross-reactivity was 91.6% with DTX-1 and 110.5% with DTX-2., In dcELISA, the IC50 was set at 0.182 ng/mL, and the detection limit was set at 0.023 ng/mL by using the anti-OA mAb-2D7. The level of OA recovered from spiked mussel samples was 2–50 ng/g, ranging from 97.6 ± 7.2% to 106.4 ± 9.8%. In contrast, the immunostrip assay with a limit of 5 ng/mL, conducted for detecting OA, was completed in 10 min. The mAb-based dcELISA and immunostrip assay developed were precise and sensitive enough to quickly assess OA, DTX-1, and DTX-2 in shellfish specimens.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"677 - 691"},"PeriodicalIF":3.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46487863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Curcumin inhibits invasion and metastasis of human hepatoma cells through Bclaf1-mediated Wnt/β-catenin signalling 姜黄素通过bclaf1介导的Wnt/β-catenin信号传导抑制人肝癌细胞的侵袭和转移
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-08-28 DOI: 10.1080/09540105.2022.2113864
Zhongwei Zhao, Jielin Su, Jiaqi Zhao, Jiaxin Chen, Xinmu Cui, Manqing Sun, Xuewu Zhang
{"title":"Curcumin inhibits invasion and metastasis of human hepatoma cells through Bclaf1-mediated Wnt/β-catenin signalling","authors":"Zhongwei Zhao, Jielin Su, Jiaqi Zhao, Jiaxin Chen, Xinmu Cui, Manqing Sun, Xuewu Zhang","doi":"10.1080/09540105.2022.2113864","DOIUrl":"https://doi.org/10.1080/09540105.2022.2113864","url":null,"abstract":"ABSTRACT Curcumin, a kind of natural compound extracted from the rhizome of Zingiberaceae such as turmeric, has many pharmacological effects such as anti-cancer effects. This study investigated the effect of curcumin on the invasion and metastasis of hepatocellular carcinoma (HCC) cell lines HepG2 and SK-Hep-1 through the Wnt/β-catenin signalling pathway and the regulatory mechanism of Bcl-2-associated transcription factor 1 (Bclaf1). Curcumin significantly inhibited the migration and invasion of HepG2 and SK-Hep-1 cells and inhibited the Wnt/β-catenin signalling pathway and reduced Bclaf1 expression in human hepatoma cells. In nude mice, intraperitoneal injection of curcumin significantly inhibited the growth of subcutaneously transplanted tumours and reduced lung metastasis of the tumour cells, downregulated the expression of Bclaf1, and inhibited the Wnt/β-catenin pathway. This study suggests that curcumin is a novel candidate drug to prevent cancer metastasis and that Bclaf1 is a new gene target related to the proliferation, invasion, and metastasis of hepatocellular carcinoma.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"664 - 676"},"PeriodicalIF":3.0,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45563165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification and characterization of MicroRNAs in pig liver after the LPS challenge using RNA-seq 利用RNA-seq技术鉴定和表征LPS攻毒后猪肝中的microrna
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-08-22 DOI: 10.1080/09540105.2022.2109602
Yang Yang, Qingqing Lv, Xingfa Huang, Jiajun Fan, Pei Li, Huijuan Zhu, P. Kang, Yulan Liu
{"title":"Identification and characterization of MicroRNAs in pig liver after the LPS challenge using RNA-seq","authors":"Yang Yang, Qingqing Lv, Xingfa Huang, Jiajun Fan, Pei Li, Huijuan Zhu, P. Kang, Yulan Liu","doi":"10.1080/09540105.2022.2109602","DOIUrl":"https://doi.org/10.1080/09540105.2022.2109602","url":null,"abstract":"ABSTRACT This study was conducted to test the expression profiles of miRNAs in the liver in piglets after the LPS challenge using sequencing technology. Twelve barrows were assigned to two groups, including the saline group and the LPS group. Six small RNA (sRNA) libraries were constructed, and novel miRNAs were identified using mirevo and mirdeep2 software and validated by quantitative real-time PCR (qRT-PCR). The results showed the mRNA expression of IL-1β, IL-6 and TNF-α in the liver increased after the LPS challenge (P < .05). A total of 29 differentially expressed miRNAs were identified in the liver after the LPS challenge. And 11 miRNAs were validated by qRT-PCR. In addition, the results of statistics of pathway enrichment showed that these miRNAs could be related to lipid metabolism response. This study provides the first miRNA expression profiles of LPS-mediated changes in the liver, which might provide potential insights into miRNAs involved in regulating lipid metabolism in pigs challenged by LPS.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"652 - 663"},"PeriodicalIF":3.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48546669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK 龙葵通过TLR4介导的JNK活化诱导巨噬细胞活化，并通过TLR4中介导的p38和JNK活化介导巨噬细胞自噬
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-08-16 DOI: 10.1080/09540105.2022.2113507
Julia Yu, Min Yeong Choi, So-Jung Park, Na Gyeong Geum, Jae Won Lee, G. Park, H. Eo, J. Jeong
{"title":"Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK","authors":"Julia Yu, Min Yeong Choi, So-Jung Park, Na Gyeong Geum, Jae Won Lee, G. Park, H. Eo, J. Jeong","doi":"10.1080/09540105.2022.2113507","DOIUrl":"https://doi.org/10.1080/09540105.2022.2113507","url":null,"abstract":"ABSTRACT In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells. TLR4 inhibition blocked SNAP-mediated production of immunostimulatory factors. In addition, the JNK inhibition reduced the SNAP-mediated production of immunostimulatory factors, and the SNAP-mediated JNK activation was blocked by the TLR4 inhibition. SNAP activated macrophage autophagy. TLR4 inhibition blocked SNAP-mediated macrophage autophagy and inhibition of p38 and JNK attenuated SNAP-mediated macrophage autophagy. These findings indicate that SNAP may induce TLR4/JNK-mediated macrophage activation and TLR4/p38 and JNK-mediated macrophage autophagy.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"641 - 651"},"PeriodicalIF":3.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44820149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-enhancing effects of Hibiscus syriacus roots in RAW264.7 macrcophages 木槿根对RAW264.7巨噬细胞的免疫增强作用
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-08-16 DOI: 10.1080/09540105.2022.2107621
H. Eo, Yunmi Park, H. Kwon, G. Park
{"title":"Immune-enhancing effects of Hibiscus syriacus roots in RAW264.7 macrcophages","authors":"H. Eo, Yunmi Park, H. Kwon, G. Park","doi":"10.1080/09540105.2022.2107621","DOIUrl":"https://doi.org/10.1080/09540105.2022.2107621","url":null,"abstract":"ABSTRACT In this study, we evaluated whether extracts of the roots of Hibiscus syriacus (HSR) exert immune activation activities and elucidated its potential mechanism in macrophages. The HSR dose-dependently increased the production of immunomodulators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor (TNF-α) activated phagocytosis in macrophages. Inhibition of toll-like receptors 4 (TLR4) reduced the production of immunomodulators induced by HSR. Inhibition of mitogen-activated protein kinase (MAPKs), nuclear factor-κB (NF-κB) and phosphoinositide-3 kinase (PI3K) signaling attenuated the production of immunomodulators induced by HSR. Based on the results of this study, HSR was thought to activate macrophages through the production of immunomodulators and phagocytosis activation through TLR4-dependent MAPKs, NF-κB and PI3K signaling pathways. Therefore, it is thought that the HSR has the potential to be used as agents for enhancing immunity.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"617 - 626"},"PeriodicalIF":3.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48567130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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