特应性皮炎患者对螨虫分子成分的致敏

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED

Food and Agricultural Immunology Pub Date : 2022-08-04 DOI:10.1080/09540105.2022.2100323

J. Čelakovská, E. Čermáková, R. Vankova, P. Boudková, C. Andrys, J. Krejsek

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引用次数: 0

摘要

摘要背景和目的：应用ALEX2过敏探索者试验分析特应性皮炎（AD）患者对螨类过敏原分子成分的致敏情况。方法：进行完整的皮肤科和变态反应学检查，包括用ALEX2 Allergy Explorer测试对分子成分的敏感性。对于统计分析，我们使用了Fisher精确。结果和结论：对螨虫的敏感性随着AD的严重程度而增加。特应性进行曲的核心作用可能是分子组分Der f2和Der p23。我们的研究结果证实了Der p 5和Der p 7在支气管哮喘患者亚组中的重要作用。特异性免疫治疗应关注AD患者的NPC2家族和Der p 23的成分。我们的研究结果可能有助于规划减敏、治疗和免疫治疗。

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Sensitisation to molecular components of mites in atopic dermatitis patients

ABSTRACT Background and aim: To analyse the sensitisation profile to molecular components of mites allergens with the use of ALEX2 Allergy Explorer test in Atopic dermatitis (AD) patients. Method: The complete dermatological and allergological examination including the examination of the sensitisation to molecular components with ALEX2 Allergy Explorer testing was performed. For the statistical analysis, we used Fisher's Exact. Results and conclusion: The sensitisation to mites increases with AD severity. The central role in atopic march may play the molecular component Der f 2 and Der p 23. The results of our study confirm the important role of Der p 5 and Der p 7 in subgroup of patients suffering from bronchial asthma. The specific immunotherapy should focus on the components of NPC2 family and Der p 23 in AD patients. Our results may be helpful in planning hyposensitisation, treatment and immunotherapy.

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.