European Respiratory Journal最新文献

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Measures of OSA-specific intermittent hypoxaemia in obstructive sleep apnoea: how far is clinical routine? 阻塞性睡眠呼吸暂停中osa特异性间歇性低氧血症的测量:离临床常规有多远?
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.00399-2025
Matteo Bradicich,Esther Irene Schwarz
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引用次数: 0
Hypoxic markers of severity and precision predictive outcomes in paediatric obstructive sleep apnoea: the quest must go on! 儿童阻塞性睡眠呼吸暂停的严重程度和精确预测结果的缺氧标志物:探索必须继续!
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.00930-2025
David Gozal
{"title":"Hypoxic markers of severity and precision predictive outcomes in paediatric obstructive sleep apnoea: the quest must go on!","authors":"David Gozal","doi":"10.1183/13993003.00930-2025","DOIUrl":"https://doi.org/10.1183/13993003.00930-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"35 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement. 聚类分析确定了COPD患者肺动脉扩张的定量CT成像亚组。
IF 21 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 Print Date: 2025-08-01 DOI: 10.1183/13993003.00038-2025
Shelsey W Johnson, James C Ross, Pietro Nardelli, Bina Choi, Rebecca R Vanderpool, Carrie Pistenmaa, J Michael Wells, Raul San Jose Estépar, George Washko, Farbod N Rahaghi
{"title":"Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement.","authors":"Shelsey W Johnson, James C Ross, Pietro Nardelli, Bina Choi, Rebecca R Vanderpool, Carrie Pistenmaa, J Michael Wells, Raul San Jose Estépar, George Washko, Farbod N Rahaghi","doi":"10.1183/13993003.00038-2025","DOIUrl":"10.1183/13993003.00038-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ever tried. Ever failed. No matter. The CFMATTERS study and the future of microbiome-directed trials in cystic fibrosis. 试过。曾经失败了。不管。CFMATTERS研究和微生物组导向囊性纤维化试验的未来。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.01122-2025
Micheál Mac Aogáin
{"title":"Ever tried. Ever failed. No matter. The CFMATTERS study and the future of microbiome-directed trials in cystic fibrosis.","authors":"Micheál Mac Aogáin","doi":"10.1183/13993003.01122-2025","DOIUrl":"https://doi.org/10.1183/13993003.01122-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"13 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis preventive treatment in people living with HIV: to improve treatment completion, we need a simpler cascade of care. 艾滋病毒感染者的结核病预防治疗:为了提高治疗完成度,我们需要更简单的护理级联。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.00638-2025
Marcello Scopazzini,Dominik Zenner
{"title":"Tuberculosis preventive treatment in people living with HIV: to improve treatment completion, we need a simpler cascade of care.","authors":"Marcello Scopazzini,Dominik Zenner","doi":"10.1183/13993003.00638-2025","DOIUrl":"https://doi.org/10.1183/13993003.00638-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"17 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: In support for a rational and sustainable use of in-line filters for pulmonary function tests. 答复:支持合理和可持续地使用联机过滤器进行肺功能检查。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.01023-2025
Santiago C Arce,Javier C Brea Folco,Roque A Baldasaria
{"title":"Reply: In support for a rational and sustainable use of in-line filters for pulmonary function tests.","authors":"Santiago C Arce,Javier C Brea Folco,Roque A Baldasaria","doi":"10.1183/13993003.01023-2025","DOIUrl":"https://doi.org/10.1183/13993003.01023-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"737 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of oxygen desaturation burden index in enhancing treatment strategies for childhood sleep apnoea. 氧去饱和负荷指数在提高儿童睡眠呼吸暂停治疗策略中的作用。
IF 21 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 Print Date: 2025-08-01 DOI: 10.1183/13993003.00553-2025
Xin Zhang, Yuanyuan Li, Xueying Wu, Peipei Wang, Wei Zhang, Bingjiao Zhao, Yuehua Liu
{"title":"The role of oxygen desaturation burden index in enhancing treatment strategies for childhood sleep apnoea.","authors":"Xin Zhang, Yuanyuan Li, Xueying Wu, Peipei Wang, Wei Zhang, Bingjiao Zhao, Yuehua Liu","doi":"10.1183/13993003.00553-2025","DOIUrl":"10.1183/13993003.00553-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation. cGAS在系统性硬化症相关间质性肺疾病中表达增强,并刺激炎症性肌成纤维细胞活化。
IF 21 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 Print Date: 2025-08-01 DOI: 10.1183/13993003.01564-2024
Sheeline Yu, Buqu Hu, Ying Sun, Xue Yan Peng, Chris J Lee, Samuel Woo, John McGovern, Jana Zielonka, Tina Saber, Alexander Ghincea, Shifa Gandhi, Anjali Walia, Taylor Pivarnik, Genta Ishikawa, Shuai Shao, Huanxing Sun, Baran Ilayda Gunes, Sophia Kujawski, Stephanie Perez, William Odell, Monique Hinchcliff, John Varga, Carol Feghali-Bostwick, Maor Sauler, Jose L Gomez, Changwan Ryu, Erica L Herzog
{"title":"Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation.","authors":"Sheeline Yu, Buqu Hu, Ying Sun, Xue Yan Peng, Chris J Lee, Samuel Woo, John McGovern, Jana Zielonka, Tina Saber, Alexander Ghincea, Shifa Gandhi, Anjali Walia, Taylor Pivarnik, Genta Ishikawa, Shuai Shao, Huanxing Sun, Baran Ilayda Gunes, Sophia Kujawski, Stephanie Perez, William Odell, Monique Hinchcliff, John Varga, Carol Feghali-Bostwick, Maor Sauler, Jose L Gomez, Changwan Ryu, Erica L Herzog","doi":"10.1183/13993003.01564-2024","DOIUrl":"10.1183/13993003.01564-2024","url":null,"abstract":"<p><strong>Objective: </strong>The lungs of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) contain inflammatory myofibroblasts that arise in association with fibrotic stimuli and perturbed innate immunity. The cytosolic DNA-binding receptor cyclic GMP-AMP synthase (cGAS) is implicated in inflammation and fibrosis, but its involvement in SSc-ILD remains unknown. We examined cGAS expression, activity and therapeutic potential in SSc-ILD using human biospecimens, cultured fibroblasts, precision-cut lung slices and a well-accepted animal model.</p><p><strong>Methods: </strong>Expression and localisation of cGAS, cytokines and type 1 interferons were evaluated in SSc‑ILD lung tissues, bronchoalveolar lavage fluid and isolated lung fibroblasts. <i>CGAS</i> activation was assessed in a publicly available SSc-ILD single-cell RNA-sequencing dataset. Production of cytokines, type 1 interferons and α-smooth muscle actin elicited by transforming growth factor-β1 or local substrate stiffness was measured in normal human lung fibroblasts <i>via</i> quantitative reverse transcription PCR, ELISA and immunofluorescence. Small molecule cGAS inhibition was tested in cultured fibroblasts, human precision-cut lung slices and the bleomycin pulmonary fibrosis model.</p><p><strong>Results: </strong>SSc-ILD lung tissue and bronchoalveolar lavage fluid were enriched for cGAS, cytokines and type 1 interferons. The cGAS pathway showed constitutive activation in SSc-ILD fibroblasts and was inducible in normal human lung fibroblasts by transforming growth factor-β1 or mechanical stimuli. In these settings, and in precision-cut lung slices, cGAS expression was paralleled by the production of cytokines, type 1 interferons and α-smooth muscle actin, which was mitigated by a small molecule cGAS inhibitor. These findings were recapitulated in the bleomycin mouse model.</p><p><strong>Conclusion: </strong>cGAS signalling contributes to pathogenic inflammatory myofibroblast phenotypes in SSc‑ILD. Inhibiting cGAS or its downstream effectors represents a novel therapeutic approach.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal function dynamics in pulmonary hypertension trials: less than anticipated. 肺动脉高压试验中的肾功能动态:低于预期。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.01042-2025
Lars Harbaum,Thenappan Thenappan
{"title":"Renal function dynamics in pulmonary hypertension trials: less than anticipated.","authors":"Lars Harbaum,Thenappan Thenappan","doi":"10.1183/13993003.01042-2025","DOIUrl":"https://doi.org/10.1183/13993003.01042-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"113 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
cGAS: a novel therapeutic target in systemic sclerosis-associated interstitial lung disease. cGAS:系统性硬化症相关间质性肺疾病的新治疗靶点
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-08-08 DOI: 10.1183/13993003.00835-2025
Theodoros Karampitsakos,Jose D Herazo-Maya
{"title":"cGAS: a novel therapeutic target in systemic sclerosis-associated interstitial lung disease.","authors":"Theodoros Karampitsakos,Jose D Herazo-Maya","doi":"10.1183/13993003.00835-2025","DOIUrl":"https://doi.org/10.1183/13993003.00835-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"12 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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