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CPAP's impact on blood pressure: is there a preventive effect in normotensives? CPAP对血压的影响：对血压正常者有预防作用吗？
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-24 DOI: 10.1183/13993003.00450-2025
Gonzalo Labarca,Martino F Pengo,Ali Azarbarzin
{"title":"CPAP's impact on blood pressure: is there a preventive effect in normotensives?","authors":"Gonzalo Labarca,Martino F Pengo,Ali Azarbarzin","doi":"10.1183/13993003.00450-2025","DOIUrl":"https://doi.org/10.1183/13993003.00450-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"52 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: The risk of hypoventilation during bronchoscopy under oxygen and procedural sedation. 回复：在吸氧和程序性镇静下支气管镜检查时低通气的风险。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-24 DOI: 10.1183/13993003.00834-2025
Andrei M Darie,Leticia Grize,Kathleen Jahn,Anna Salina,Jonathan Röcken,Matthias J Herrmann,Maria Pascarella,Vivian Suarez,Werner Strobel,Michael Tamm,Daiana Stolz
{"title":"Reply to: The risk of hypoventilation during bronchoscopy under oxygen and procedural sedation.","authors":"Andrei M Darie,Leticia Grize,Kathleen Jahn,Anna Salina,Jonathan Röcken,Matthias J Herrmann,Maria Pascarella,Vivian Suarez,Werner Strobel,Michael Tamm,Daiana Stolz","doi":"10.1183/13993003.00834-2025","DOIUrl":"https://doi.org/10.1183/13993003.00834-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"23 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three birds with one stone: screening of migrants for pulmonary TB, extrapulmonary TB and TB infection. 一石三鸟：筛查肺结核、肺外结核和结核感染。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-24 DOI: 10.1183/13993003.00750-2025
Ineke Spruijt,Edine Tiemersma
{"title":"Three birds with one stone: screening of migrants for pulmonary TB, extrapulmonary TB and TB infection.","authors":"Ineke Spruijt,Edine Tiemersma","doi":"10.1183/13993003.00750-2025","DOIUrl":"https://doi.org/10.1183/13993003.00750-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"25 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small extracellular vesicles and induction of epithelial to mesenchymal transition in lymphangioleiomyomatosis. 淋巴管平滑肌瘤病中细胞外小泡和上皮向间质转化的诱导。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-17 DOI: 10.1183/13993003.02455-2024
Amina Jouida,Lucas Souza Dantas,Donal O'Malley,Evelyn Lynn,Marissa O'Callaghan,Minzhe Guo,Patrick McFadden,Grace Buckley,Michael P Keane,Cormac McCarthy
{"title":"Small extracellular vesicles and induction of epithelial to mesenchymal transition in lymphangioleiomyomatosis.","authors":"Amina Jouida,Lucas Souza Dantas,Donal O'Malley,Evelyn Lynn,Marissa O'Callaghan,Minzhe Guo,Patrick McFadden,Grace Buckley,Michael P Keane,Cormac McCarthy","doi":"10.1183/13993003.02455-2024","DOIUrl":"https://doi.org/10.1183/13993003.02455-2024","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"109 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of IPF. 综合空间和单细胞转录组学显示PAK激酶是IPF成纤维细胞灶和致密纤维化的治疗靶点。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-17 DOI: 10.1183/13993003.00022-2025
Naoaki Watanabe,Masahiro Yoshida,Yuta Hirano,Shota Fujimoto,Sachi Matsubayashi,Takashi Ishiguro,Nobumasa Takahashi,Yoshihiko Shimizu,Noboru Takayanagi,Yoshinori Kawabata,Yutaro Mori,Koji Okamoto,Shunsuke Minagawa,Kazuyoshi Kuwano,Jun Araya,Yusuke Yamamoto,Yu Fujita
{"title":"Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of IPF.","authors":"Naoaki Watanabe,Masahiro Yoshida,Yuta Hirano,Shota Fujimoto,Sachi Matsubayashi,Takashi Ishiguro,Nobumasa Takahashi,Yoshihiko Shimizu,Noboru Takayanagi,Yoshinori Kawabata,Yutaro Mori,Koji Okamoto,Shunsuke Minagawa,Kazuyoshi Kuwano,Jun Araya,Yusuke Yamamoto,Yu Fujita","doi":"10.1183/13993003.00022-2025","DOIUrl":"https://doi.org/10.1183/13993003.00022-2025","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive fibrosis of lung parenchyma. The histopathology of IPF exhibits temporal and spatial heterogeneity, including immature fibroblastic foci (FF) and densely collagenized fibrosis. FF serve as dynamic niches of profibrotic fibroblasts and play a pivotal role in fibrosis progression and transition into dense fibrosis (DF). Here, we integrated single-cell RNA sequencing (scRNA-seq) with spatial transcriptomics to elucidate cellular heterogeneity and the novel cell type involved not only in FF formation but also in DF development. We identified a novel myofibroblast population, WNT5A+ CTHRC1+ myofibroblasts, enriched in both FF and DF regions, underscoring their pivotal role in fibrosis progression. Differential gene expression analysis revealed the activation of p21-activated kinase 2 (PAK2) in these fibrotic areas, including WNT5A+ CTHRC1+ myofibroblasts. PAK inhibition significantly suppressed TGF-β-induced myofibroblast differentiation and collagen production in IPF-derived fibroblasts. Furthermore, in a bleomycin-induced lung fibrosis mouse model, intraperitoneal administration of the PAK inhibitor significantly attenuated fibrotic progression. This study highlights the therapeutic potential of PAK inhibition for IPF, particularly targeting pathogenic fibroblasts within both FF and DF regions. By leveraging spatial transcriptomics and scRNA-seq, we provide a comprehensive molecular and cellular atlas of FF and DF in IPF lung tissue, offering new insights into fibrosis progression and therapeutic intervention.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"677 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal dosing and duration of linezolid for the treatment of multidrug-resistant and rifampicin-resistant tuberculosis: An individual patient data meta-analysis. 利奈唑胺治疗耐多药和利福平耐药结核病的最佳剂量和持续时间：一项个体患者数据荟萃分析。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-17 DOI: 10.1183/13993003.00315-2025
Nakwon Kwak,Joong-Yub Kim,Areum Han,Catherine Berry,Maria Beumont,Tweed Conor,Angela Crook,Keertan Dheda,Stella Fabiane,Muse O Fadeyi,Salah Foraida,Tinne Gils,Thi Thanh,Thuy Hoang,Menal A Jham,Richard A Murphy,Binh Hoa Nguyen,Thi Mai,Phuong Nguyen,Bern Thomas Nyang'wa,Suzette Oelofse,Seokyung Hahn,Jae-Joon Yim
{"title":"Optimal dosing and duration of linezolid for the treatment of multidrug-resistant and rifampicin-resistant tuberculosis: An individual patient data meta-analysis.","authors":"Nakwon Kwak,Joong-Yub Kim,Areum Han,Catherine Berry,Maria Beumont,Tweed Conor,Angela Crook,Keertan Dheda,Stella Fabiane,Muse O Fadeyi,Salah Foraida,Tinne Gils,Thi Thanh,Thuy Hoang,Menal A Jham,Richard A Murphy,Binh Hoa Nguyen,Thi Mai,Phuong Nguyen,Bern Thomas Nyang'wa,Suzette Oelofse,Seokyung Hahn,Jae-Joon Yim","doi":"10.1183/13993003.00315-2025","DOIUrl":"https://doi.org/10.1183/13993003.00315-2025","url":null,"abstract":"BACKGROUNDThe optimal dosing strategy of linezolid for treating multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) remains unclear. We conducted an individual patient data (IPD) meta-analysis to determine the optimal linezolid dosing strategy.METHODSWe searched PubMed, Embase, and Scopus for randomised controlled trials (RCTs) and prospective cohort studies on short-course, all-oral regimens containing linezolid for treating MDR/RR-TB through 31 August 2023. Patients were grouped according to linezolid dosing patterns. Time to treatment success and adverse events≥grade 3 were analysed using the Fine-Gray sub-distribution hazard model.RESULTSOf 12 eligible studies, 8 (4 RCTs, 4 prospective) were included. Overall, 945 patients were grouped as follows: group 1 (600 mg linezolid for 8 weeks), group 2 (600 mg for 16 weeks, then 300 mg for 8 weeks), group 3 (600 mg for 39 weeks), and group 4 (1200 mg for 25 weeks). Proportions of patients achieving treatment success were 59·1%, 90·4%, 91·3%, and 96·0%, respectively. Compared with group 2, groups 1 (adjusted sub-distribution hazard ratio [aSHR], 0·24, 95% confidence interval [CI], 0·08-0·71) and 3 (aSHR, 0·36, 95% CI, 0·16-0·81) had lower success rates. While group 4 showed no significant difference in treatment success versus group 2 (aSHR, 0·57, 95% CI, 0·23-1·43), it had a higher rate of adverse events≥grade 3 (aSHR, 2·29, 95% CI, 1·37-3·83).CONCLUSIONA dosing strategy of 600 mg linezolid daily for 16 weeks, then 300 mg for 8 weeks, could be optimal for treating MDR/RR-TB when considering effectiveness and safety.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"29 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Tofacitinib is a step forward for management of patients with interstitial lung disease associated with anti-MDA5-positive dermatomyositis. 答复：托法替尼是治疗与抗mda5阳性皮肌炎相关的间质性肺疾病患者的又一进步。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-14 DOI: 10.1183/13993003.00699-2025
Wanlong Wu,Shuang Ye
{"title":"Reply: Tofacitinib is a step forward for management of patients with interstitial lung disease associated with anti-MDA5-positive dermatomyositis.","authors":"Wanlong Wu,Shuang Ye","doi":"10.1183/13993003.00699-2025","DOIUrl":"https://doi.org/10.1183/13993003.00699-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"9 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to treat patients with MDA5-associated rapidly progressive interstitial lung disease? Which immunosuppressive therapy for which patients? 如何治疗与mda5相关的快速进展性间质性肺病患者？哪种免疫抑制疗法适用于哪些患者？
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-14 DOI: 10.1183/13993003.00446-2025
Yurdagül Uzunhan,Baptiste Hervier
{"title":"How to treat patients with MDA5-associated rapidly progressive interstitial lung disease? Which immunosuppressive therapy for which patients?","authors":"Yurdagül Uzunhan,Baptiste Hervier","doi":"10.1183/13993003.00446-2025","DOIUrl":"https://doi.org/10.1183/13993003.00446-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"37 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reason to celebrate: multimodal treatments and recent improvements in the long-term outcomes of patients with chronic thromboembolic pulmonary hypertension. 值得庆祝的理由：多模式治疗和慢性血栓栓塞性肺动脉高压患者长期预后的近期改善。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-14 DOI: 10.1183/13993003.00562-2025
Irene M Lang
{"title":"A reason to celebrate: multimodal treatments and recent improvements in the long-term outcomes of patients with chronic thromboembolic pulmonary hypertension.","authors":"Irene M Lang","doi":"10.1183/13993003.00562-2025","DOIUrl":"https://doi.org/10.1183/13993003.00562-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"15 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils in pleural infection: untapped potential for targeted therapeutics. 中性粒细胞在胸膜感染：未开发的潜力靶向治疗。
IF 24.3 1区 医学
European Respiratory Journal Pub Date : 2025-07-14 DOI: 10.1183/13993003.00861-2025
Amy Gilmour,James D Chalmers
{"title":"Neutrophils in pleural infection: untapped potential for targeted therapeutics.","authors":"Amy Gilmour,James D Chalmers","doi":"10.1183/13993003.00861-2025","DOIUrl":"https://doi.org/10.1183/13993003.00861-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"16 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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