European Respiratory Journal最新文献

{"title":"Why fan therapy does not yet demonstrate enhanced training benefits in people with chronic respiratory disease.","authors":"Tristan Bonnevie, William Poncin","doi":"10.1183/13993003.02658-2025","DOIUrl":"https://doi.org/10.1183/13993003.02658-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the case to highlight the burden of respiratory diseases in Europe.","authors":"Guy Joos, Judith Garcia-Aymerich, Silke Ryan, Monika Gappa, Joanna Chorostowska-Wynimko, Marc Humbert, Carlos Robalo Cordeiro, Kjeld Hansen, Anita Simonds, Brian Ward, Pippa Powell, Lauren Anderson, Amy Auer","doi":"10.1183/13993003.00053-2026","DOIUrl":"https://doi.org/10.1183/13993003.00053-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Why fan therapy does not yet demonstrate enhanced training benefits in people with chronic respiratory disease.","authors":"Rachelle Aucoin, Dan Nguyen, Bryan Ross, Jean Bourbeau, Hayley Lewthwaite, Magnus Ekström, Andreas von Leupoldt, Dennis Jensen","doi":"10.1183/13993003.00206-2026","DOIUrl":"https://doi.org/10.1183/13993003.00206-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward pre-emptive CLAD care: fibroblast activation protein as a clinically actionable signal.","authors":"Sarbjot Grewal, Neelam Redekar, Sean Agbor Enoh","doi":"10.1183/13993003.02715-2025","DOIUrl":"https://doi.org/10.1183/13993003.02715-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading the monocyte code in idiopathic pulmonary fibrosis.","authors":"Anna V Curioni, Bruno Crestani, Doumet Georges Helou","doi":"10.1183/13993003.00349-2026","DOIUrl":"https://doi.org/10.1183/13993003.00349-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory stimuli and the rescue of disease-causing CFTR nonsense variants.","authors":"Carlos M Farinha","doi":"10.1183/13993003.02740-2025","DOIUrl":"https://doi.org/10.1183/13993003.02740-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Is the role of eosinophils in refractory chronic cough truly dismissed? Mepolizumab reduced blood and sputum eosinophils, but not eosinophil-derived neurotoxin.","authors":"Christiane Whetstone, Nermin Diab, Danica Brister, Elena Kum, Mustafaa Wahab, Wafa Hassan, Sue Beaudin, Catie Obminski, Jennifer Wattie, Lesley Wiltshire, Karen Howie, Kieran Killian, Kimberley Holt, Roma Sehmi, Jaclyn A Smith, Paul M O'Byrne, Imran Satia, Gail M Gauvreau","doi":"10.1183/13993003.00143-2026","DOIUrl":"10.1183/13993003.00143-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 5","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Azithromycin enhances epithelial antiviral immunity in uncontrolled asthma: results from the AZIMUNE randomized controlled trial.","authors":"Muzhda Ghanizada, Sofia Malm Tillgren, Mandy Menzel, Louis Praeger-Jahnsen, Nihaya Mahmoud Said, Sisse Ditlev, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Therese Lapperre","doi":"10.1183/13993003.02441-2025","DOIUrl":"https://doi.org/10.1183/13993003.02441-2025","url":null,"abstract":"<p><strong>Background: </strong>Viral respiratory infections are the leading trigger of asthma exacerbations and impaired epithelial type I and III interferon responses may contribute to more severe exacerbations. Azithromycin reduces exacerbations clinically, but its effects on epithelial antiviral immunity remain unclear. This study investigated whether azithromycin treatment enhances airway epithelial antiviral responses and modulates alarmin concentration in patients with uncontrolled asthma.</p><p><strong>Methods: </strong>In the investigator-initiated, double-blind, placebo-controlled AZIMUNE trial, 40 adults with uncontrolled asthma were randomized (1:1) to azithromycin (500 mg, three times/week) or placebo (500 mg/week) for 12 weeks. Bronchial epithelial cells were obtained <i>via</i> bronchoscopy at baseline and after week 12, and cultured and infected ex vivo with rhinovirus. Protein levels of IFN-β, IFN-λ, alarmins (IL-33 and thymic stromal lymphopoietin (TSLP)), and proinflammatory cytokines were quantified.</p><p><strong>Results: </strong>Azithromycin significantly increased rhinovirus-induced concentration of IFN-β (p=0.047) and IFN-λ (p=0.013) in azithromycin group (n=16) compared with baseline, whereas no change was seen in the placebo group (n=16). Azithromycin treatment also reduced IL-33 concentration (p=0.001), while TSLP levels were unaffected. Clinical outcomes improved numerically in the azithromycin group, but differences <i>versus</i> placebo were not statistically significant.</p><p><strong>Conclusions: </strong>Azithromycin enhances epithelial antiviral immunity and attenuates IL-33 concentration in response to rhinoviral infection in asthma. The dual immunomodulatory effect of azithromycin supports its role as adjunctive therapy to prevent virus-induced exacerbations.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Adaptation after Pulmonary Endarterectomy and Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension: A comparative Cardiac MRI-Based Study.","authors":"Tamara C Rodenburg, Satoshi Higuchi, Stine Andersen, Elisa Stilling, Natalia J Braams, Azar Kianzad, Esther J Nossent, Jurjan Aman, Morten K Jensen, Won Y Kim, Marcel A M Beijk, Rutger J Lely, Jacobus A Winkelman, Lars B Ilkjær, Frances S de Man, Anton Vonk Noordegraaf, Mads J Andersen, Asger Andersen, Lilian J Meijboom, Harm Jan Bogaard","doi":"10.1183/13993003.02314-2025","DOIUrl":"https://doi.org/10.1183/13993003.02314-2025","url":null,"abstract":"<p><strong>Background: </strong>Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with elevated right ventricular (RV) afterload and progressive RV remodeling. Balloon pulmonary angioplasty (BPA) has emerged as an established and increasingly used alternative to pulmonary endarterectomy (PEA). This study aimed to evaluate hemodynamic, functional and structural cardiac responses to PEA and BPA, with specific focus on RV reverse remodeling.</p><p><strong>Methods: </strong>In this prospective, multicenter cohort study, 93 patients with CTEPH (PEA; n=50, BPA; n=43) from the Netherlands and Denmark underwent cardiac magnetic resonance imaging, right heart catheterization, exercise testing and biomarker assessment at baseline and 6-months post-intervention. Longitudinal changes were assessed with repeated-measures ANOVA. A subgroup underwent analysis at 18 months.</p><p><strong>Results: </strong>BPA patients were older (68.9±10.1 <i>versus</i> 62.4±11.1 years, p<i>=</i>0.004), and used more PH medication. PEA-treated patients had higher RV mass index at baseline (40.1±13.5 <i>versus</i> 32.9±12.2 g·m^-2; p=0.017), and consistently higher relative RV wall thickness at baseline and follow-up (both 0.4±0.1 <i>versus</i> 0.3±0.1; <i>p</i><0.001). Both interventions improved RV afterload, function and exercise capacity (all <i>p</i><0.05). Larger hemodynamic improvement after PEA (mPAP and PVR; p-interaction≤0.001) was accompanied by more pronounced RV reverse remodeling, including lower follow-up indexed RV volumes (RVEDVi; 76.2±16.8 <i>versus</i> 92.2±20.2 mL·m^-2; <i>p</i><0.001 and RVESVi; 39.0±15.6 <i>versus</i> 49.0±18.8 mL·m^-2; p=0.014).</p><p><strong>Conclusions: </strong>In this multicenter European study, both therapies resulted in significant RV reverse remodeling. PEA was associated with larger absolute reductions in indexed RV mass and volumes than BPA. However, remodeling sensitivity to unloading appeared broadly similar across treatments. Despite favorable outcomes following both treatments, our findings emphasize the need for randomized controlled studies, to optimize treatment strategies for operable and inoperable patients.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sotatercept improves small airway disease and hyperinflation in patients with pulmonary hypertension.","authors":"Hooman D Poor, Jimmy Zhang, Simone Hannah-Clark, Shyla Saini, Elliot Eisenberg, Jing Wang, Alison G Lee, Gregory Serrao, Helena Schotland, Linda Rogers, Benjamin M Smith, Mary Beth Beasley, Michelle Li, Charles A Powell, Corey E Ventetuolo, Maria Padilla","doi":"10.1183/13993003.02731-2025","DOIUrl":"10.1183/13993003.02731-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}