European Respiratory Journal最新文献

{"title":"The risk of hypoventilation during bronchoscopy under oxygen and procedural sedation.","authors":"Jens Gottlieb,Thomas Fuehner","doi":"10.1183/13993003.00532-2025","DOIUrl":"https://doi.org/10.1183/13993003.00532-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"27 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The altered gait of COPD: are we giving enough attention to how patients walk?","authors":"Renata G Mendes,Naiara T Leonardi","doi":"10.1183/13993003.01015-2025","DOIUrl":"https://doi.org/10.1183/13993003.01015-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"115 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soteria: deliverance from harm?","authors":"Christopher J Mullin, Corey E Ventetuolo","doi":"10.1183/13993003.00697-2025","DOIUrl":"https://doi.org/10.1183/13993003.00697-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"66 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Type 2 inflammatory biomarkers in asthma and COPD: what we think we know.","authors":"Carlos Celis-Preciado,Samuel Lemaire-Paquette,Philippe Lachapelle,Simon Couillard","doi":"10.1183/13993003.00949-2025","DOIUrl":"https://doi.org/10.1183/13993003.00949-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"706 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long-term follow-up study of sotatercept for treatment of pulmonary arterial hypertension: interim results of SOTERIA.","authors":"Ioana R Preston, David Badesch, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, Mardi Gomberg-Maitland, Marius M Hoeper, Marc Humbert, Vallerie V McLaughlin, Aaron B Waxman, Solaiappan Manimaran, Elina Mikhailova, Madhavi Reddy, Anna Lau, Janethe de Oliveira Pena, Rogerio Souza","doi":"10.1183/13993003.01435-2024","DOIUrl":"10.1183/13993003.01435-2024","url":null,"abstract":"<p><strong>Background: </strong>SOTERIA (ClinicalTrials.gov: NCT04796337) is an ongoing open-label study evaluating long-term safety, tolerability and efficacy of sotatercept in participants with pulmonary arterial hypertension (PAH).</p><p><strong>Methods: </strong>Eligible adults with PAH on stable background therapy who completed a prior sotatercept study without early discontinuation were enrolled. Participants received subcutaneous sotatercept (≤0.7 mg·kg^-1 once every 21 days). Safety and tolerability (primary objective) were assessed by adverse events (AEs), vital signs and laboratory assessments. Efficacy (secondary objective) was assessed by 6-min walk distance (6MWD), N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, World Health Organization (WHO) Functional Class, clinical worsening events and simplified French risk score (SFRS). The data cut-off date was 8 November 2023.</p><p><strong>Results: </strong>Altogether, 426 participants were included in the analyses. Mean±sd duration of exposure to sotatercept and follow-up in SOTERIA was 448.6±172.93 days (range 21-923 days; 523 patient-years). Of 426 participants, 387 (90.8%) experienced AEs, 15 (3.5%) discontinued treatment, 129 (30.3%) had serious AEs and 11 (2.6%) had serious AEs related to treatment. There were 12 deaths (2.8%). Among AEs of interest, epistaxis (22.1%) and telangiectasia (16.9%) were the most frequently reported individual events. 22 (5.2%) participants had serious bleeding events, including two (0.5%) with serious bleeding leading to death (not related to treatment by investigator judgement). Improvements in 6MWD, NT-proBNP, WHO Functional Class and SFRS achieved from baseline of SOTERIA were largely maintained at 1 year, including in the placebo-crossed group.</p><p><strong>Conclusion: </strong>Interim results of SOTERIA support the favourable benefit-risk of add-on sotatercept treatment in adults with PAH. Follow-up reports from this study will provide additional information on benefit-risk.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of continuous positive airway pressure on blood pressure in normotensive individuals with obstructive sleep apnoea: a randomised trial.","authors":"Adriano D S Targa, Gerard Torres, Iván D Benítez, Mario Henríquez-Beltrán, Rafaela Vaca, Lidia Pascual Arnó, Olga Mínguez, Maria Aguilà, Dolores Martínez, Lucía Pinilla, Anna Galan Gonzalez, Sergi Balsells Garriga, Manuel Sánchez-de-la-Torre, Ferran Barbé","doi":"10.1183/13993003.01954-2024","DOIUrl":"10.1183/13993003.01954-2024","url":null,"abstract":"<p><strong>Background: </strong>The effects of continuous positive airway pressure (CPAP) on blood pressure (BP) in normotensive subjects, particularly among those with a dipping BP pattern, remain uncertain, raising questions about its indication for this group of patients. We assessed the impact of CPAP on BP in normotensive subjects with a dipping BP pattern and severe obstructive sleep apnoea (OSA).</p><p><strong>Methods: </strong>This was a randomised, parallel, prospective, controlled trial. Inclusion criteria were: age ≥18 years, apnoea-hypopnoea index ≥30 events·h^-1, mean 24-h BP <130/80 mmHg and daytime to night-time BP reduction ≥10%. Patients were randomly assigned to receive either CPAP treatment or usual care for 12 weeks. The primary outcome was the change in ambulatory BP monitoring (ABPM) parameters from baseline to the 3-month follow-up.</p><p><strong>Results: </strong>The 60 patients who completed the follow-up had a mean±sd age of 52.2±10.8 years and 40 (66.7%) were male. The intention-to-treat analysis showed no significant changes with CPAP, whereas the usual care group experienced increases in ABPM parameters. This resulted in a mean difference of -3.4 mmHg (95% CI -6.124- -0.676; p=0.015) in night-time diastolic BP between the groups. The per-protocol analysis indicated significant differences between the CPAP and usual care groups for all primary end-points, except for daytime systolic BP. For night-time systolic BP, the mean difference was -6.052 mmHg (95% CI -10.895- -1.208; p=0.016).</p><p><strong>Conclusion: </strong>These findings suggest a protective effect of CPAP, highlighting the importance of CPAP prescription for this population to control potential increases in BP and possibly prevent the onset of hypertension.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 inflammatory biomarkers in asthma and COPD: what we think we know.","authors":"Lalitha Menon,John Blakey,Sanjay Ramakrishnan","doi":"10.1183/13993003.00685-2025","DOIUrl":"https://doi.org/10.1183/13993003.00685-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"265 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CPAP's impact on blood pressure: is there a preventive effect in normotensives?","authors":"Gonzalo Labarca,Martino F Pengo,Ali Azarbarzin","doi":"10.1183/13993003.00450-2025","DOIUrl":"https://doi.org/10.1183/13993003.00450-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"52 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: The risk of hypoventilation during bronchoscopy under oxygen and procedural sedation.","authors":"Andrei M Darie,Leticia Grize,Kathleen Jahn,Anna Salina,Jonathan Röcken,Matthias J Herrmann,Maria Pascarella,Vivian Suarez,Werner Strobel,Michael Tamm,Daiana Stolz","doi":"10.1183/13993003.00834-2025","DOIUrl":"https://doi.org/10.1183/13993003.00834-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"23 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three birds with one stone: screening of migrants for pulmonary TB, extrapulmonary TB and TB infection.","authors":"Ineke Spruijt,Edine Tiemersma","doi":"10.1183/13993003.00750-2025","DOIUrl":"https://doi.org/10.1183/13993003.00750-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"25 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}