European Respiratory Journal最新文献

{"title":"Epigenetic Age among U.S. Adults with Chronic Respiratory Diseases: Results from NHANES 1999-2002.","authors":"Javier Perez-Garcia, Dennis Khodasevich, Sara De Matteis, Mary B Rice, Belinda L Needham, David H Rehkopf, Andres Cardenas","doi":"10.1183/13993003.00293-2025","DOIUrl":"https://doi.org/10.1183/13993003.00293-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ERJ</i> Podcast May 2025: Efficacy and safety of the activin signalling inhibitor sotatercept.","authors":"","doi":"10.1183/13993003.E6505-2025","DOIUrl":"https://doi.org/10.1183/13993003.E6505-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"65 5","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are systemic corticosteroids needed for all asthma exacerbations?","authors":"William W Busse,Paul M O'Byrne","doi":"10.1183/13993003.00370-2025","DOIUrl":"https://doi.org/10.1183/13993003.00370-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"33 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of chronic obstructive pulmonary disease through JNK-dependent and JNK-independent signaling.","authors":"Sheng-Ming Wu,Kuan-Yuan Chen,Hsiao-Chi Chuang,Shu-Chuan Ho,Cheng-Wei Lin,Chia-Li Han,Wei-Lun Sun,Po-Hao Feng,Shiou-Fu Lin,Yueh-Hsi Chen,Tzu-Tao Chen,Chien-Hua Tseng,Wen-Te Liu,Kang-Yun Lee","doi":"10.1183/13993003.01610-2024","DOIUrl":"https://doi.org/10.1183/13993003.01610-2024","url":null,"abstract":"RATIONALE: Prolonged exposure to airborne particulate matter (PM) is associated with emphysema and chronic obstructive pulmonary disease (COPD); however, the precise underlying mechanism remains unclear.OBJECTIVESIn a previous high-throughput screen, we identified inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) as a biomarker of long-term PM exposure. We hypothesized that ITIH4 is implicated in PM-related emphysema.METHODSWe investigated the association between ITIH4 expression and ambient PM exposure through a clinical cohort analysis (220 patients with COPD and 61 healthy participants) and in vitro studies.MEASUREMENTS AND MAIN RESULTSThe COPD cohort studies revealed significant correlations between emphysema severity, ambient PM exposure, and serum ITIH4 levels. In primary small airway epithelial cells from COPD patients with low basal levels of ITIH4, exposure to PM and oxidative stress led to increased apoptosis. However, ITIH4 overexpression significantly inhibited oxidative stress-induced apoptosis in normal and COPD airway epithelial cells. Acute exposure to hydrogen peroxide resulted in the rapid degradation of ITIH4 protein with no effect on transcriptional level, although ITIH4 gene expression is downregulated in the lung tissue of patients with COPD. A human apoptosis antibody array revealed that ITIH4 overexpression attenuated hydrogen peroxide-induced apoptotic signaling. Furthermore, extracellular ITIH4 protein confers cytoprotective functions in cells exposed to PM or oxidative stress. Mechanistically, ITIH4 attenuated oxidative stress-induced JNK activation and β-catenin decrease. A deficiency of ITIH4 exacerbated the effects of oxidative stress.CONCLUSIONSWe identified a novel pathogenetic mechanism involving ITIH4, where chronic exposure to air pollution induces or promotes emphysema.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"57 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal dysfunction and outcomes in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: an individual participant data meta-analysis.","authors":"Amber Meservey,Nadine Al-Naamani,Jasleen Minhas,Jason S Fritz,Dina Appleby,Guillaume Baudry,Nicolas Girerd,Rui Feng,Steven M Kawut,Jude Moutchia","doi":"10.1183/13993003.02400-2024","DOIUrl":"https://doi.org/10.1183/13993003.02400-2024","url":null,"abstract":"BACKGROUNDPulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) cause right ventricular dysfunction with extrapulmonary sequalae including renal dysfunction. We sought to characterize renal dysfunction in PAH and CTEPH and to assess the effect of pulmonary hypertension treatment on renal function.METHODSWe performed an individual participant data meta-analysis of 6694 participants from 18 phase III randomized clinical trials of pulmonary hypertension therapies. We calculated estimated glomerular filtration rate (eGFR) using the race-agnostic 2021 CKD-EPI equation.RESULTSThe mean age was 49.6±15.5 years, 78% were female and 58% had idiopathic PAH. A total of 907 participants (13.5%) had a baseline eGFR<60 mL·min-1·1.73 m-2. Lower baseline eGFR correlated with higher mean right atrial pressure (mRAP) and lower cardiac index. At 12-16 weeks, a 10 mmHg decrease in mRAP from baseline or a 1 L·min-1·m-2 increase in cardiac index was associated with only a 1.7 mL·min-1·1.73 m-2 (95% CI: -2.9, -0.5; p=0.006) or a 1.4 mL·min-1·1.73 m-2 (95% CI: 0.5, 2.4; p=0.003) increase in eGFR, respectively. A 10 mL·min-1·1.73 m-2 lower baseline eGFR was associated with an increased risk of all-cause mortality (aHR: 1.16 [95% CI:1.08, 1.23]; p<0.001). Interestingly, pulmonary hypertension treatment was associated with only a small improvement in eGFR at 12-16 weeks (aβ: 2.0 mL·min-1·1.73 m-2 [95% CI: 1.4, 2.6]; p<0.001).CONCLUSIONRenal dysfunction remains highly prevalent in PAH and CTEPH and is associated with worse hemodynamics and worse clinical outcomes. In this cohort with relatively preserved renal function, pulmonary hypertension treatment was associated with only a minimal improvement in eGFR.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"60 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of tofacitinib <i>versus</i> calcineurin inhibitor in interstitial lung disease secondary to anti-MDA5-positive dermatomyositis: a multicentre cohort study.","authors":"Wanlong Wu, Bingpeng Guo, Wenjia Sun, Dan Chen, Wenwen Xu, Zhiwei Chen, Yakai Fu, Yan Ye, Xia Lyu, Zhixin Xue, Kaiwen Wang, Jiangfeng Zhao, Cuiying Xie, Yi Chen, Chunhua Ye, Min Dai, Wei Fan, Jia Li, Xiaodong Wang, Yu Xue, Weiguo Wan, Li Sun, Huaxiang Wu, Qun Luo, Qian Han, Qiong Fu, Shuang Ye","doi":"10.1183/13993003.01488-2024","DOIUrl":"10.1183/13993003.01488-2024","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness and safety of tofacitinib <i>versus</i> calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5⁺DM-ILD).</p><p><strong>Methods: </strong>Adult Chinese patients with newly diagnosed MDA5⁺DM-ILD (ILD course <3 months) from five tertiary referral centres between April 2014 and January 2023 were included in this retrospective cohort study. The primary effectiveness end-point was lung transplantation-free survival within 1 year. Propensity score-based inverse probability of treatment weighting (IPTW) was applied for adjustment in this real-world study.</p><p><strong>Results: </strong>In the eligible cohort, a total of 94 (32.4%) and 105 (46.7%) patients died or underwent lung transplantation within 1 year in the tofacitinib group (n=290) and the CNI group (n=225), respectively. After adjustment by IPTW, patients' lung transplantation-free survival rate within 1 year was significantly higher in the tofacitinib group compared to the CNI group (log-rank p=0.013). Multivariable Cox analysis performed in the IPTW dataset revealed that the hazard ratio of tofacitinib <i>versus</i> CNI for 1-year survival was 0.72 (95% CI 0.56-0.94; p=0.013). The adjusted difference of survival rate was 9.3% (95% CI 2.8-15.8%). Alternative analytic strategies yielded consistent results in sensitivity analyses. Patients aged <60 years, without rapidly progressive ILD, or with baseline arterial oxygen tension/inspiratory oxygen fraction ≥300 mmHg might benefit more from tofacitinib. Opportunistic infection was the major treatment-related serious adverse event, with generally comparable incidence (42.4% <i>versus</i> 45.3%).</p><p><strong>Conclusion: </strong>In this large multicentre cohort study, tofacitinib showed significantly more benefits for 1-year lung transplantation-free survival than calcineurin inhibitors in MDA5⁺DM-ILD.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the complexity: mechanistic insights into comorbidities in idiopathic pulmonary fibrosis.","authors":"Moisés Selman, Ivette Buendia-Roldan, Annie Pardo","doi":"10.1183/13993003.02418-2024","DOIUrl":"10.1183/13993003.02418-2024","url":null,"abstract":"<p><p>The complex pathogenic relationships between idiopathic pulmonary fibrosis (IPF) and its usually associated comorbidities remain poorly understood. While evidence suggests that some comorbidities may directly influence the development or progression of IPF, or <i>vice versa</i>, whether these associations are causal or arise independently due to shared risk factors, such as ageing, smoking, lifestyle and genetic susceptibility, is still uncertain. Some comorbidities, such as metabolic syndromes, gastro-oesophageal reflux disease and obstructive sleep apnoea, precede the development of IPF. In contrast, others, such as pulmonary hypertension and lung cancer, often become apparent after IPF onset or during its progression. These timing patterns suggest a directional relationship in their associations. The issue is further complicated by the fact that patients often have multiple comorbidities, which may interact and exacerbate one another, creating a vicious cycle. To clarify these correlations, some studies have used causal inference methods (<i>e.g.</i> Mendelian randomisation) and exploration of underlying mechanisms; however, these efforts have not yet generated conclusive insights. In this review, we provide a general overview of the relationship between IPF and its comorbidities, emphasising the pathogenic mechanisms underlying each comorbidity, potential shared pathobiology with IPF and, when available, causal insights from Mendelian randomisation studies.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clean air prescriptions: investing in healthy lungs and a healthier future.","authors":"José Luis Castro,Maria Neira,Sarah Rylance,Marit Viktoria Pettersen,Samantha Pegoraro","doi":"10.1183/13993003.00186-2025","DOIUrl":"https://doi.org/10.1183/13993003.00186-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"18 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation for persons with long COVID beyond the recovery phase of SARS-CoV-2 infection.","authors":"Milo A Puhan,Kaba Dalla Lana","doi":"10.1183/13993003.00239-2025","DOIUrl":"https://doi.org/10.1183/13993003.00239-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"33 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equity in research: a global consensus statement on the urgency of including children in long COVID clinical trials.","authors":"Lael M Yonker,Binita Kane,Etheresia Pretorius,David Putrino,Sammie McFarland,Petter Brodin,Kanecia O Zimmerman,Daniel Munblit,Peter C Rowe,Theo Vos,David Warburton,Terence Stephenson,Danilo Buonsenso,","doi":"10.1183/13993003.00092-2025","DOIUrl":"https://doi.org/10.1183/13993003.00092-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"137 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}