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Bendopnoea in pleural effusion: a dynamic symptom of clinical relevance. 胸膜积液弯曲腔：一种与临床相关的动态症状。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.00876-2026
José M Porcel
{"title":"Bendopnoea in pleural effusion: a dynamic symptom of clinical relevance.","authors":"José M Porcel","doi":"10.1183/13993003.00876-2026","DOIUrl":"https://doi.org/10.1183/13993003.00876-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: When can a negative endosonographic examination be trusted? 什么时候可以相信超声阴性检查？
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 DOI: 10.1183/13993003.01778-2026
Daniël A Korevaar, Frank J C van den Broek, Jouke T Annema
{"title":"Reply to: When can a negative endosonographic examination be trusted?","authors":"Daniël A Korevaar, Frank J C van den Broek, Jouke T Annema","doi":"10.1183/13993003.01778-2026","DOIUrl":"https://doi.org/10.1183/13993003.01778-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways." R.M. Mroz, R.P.F. Schins, H. Li, L.A. Jimenez, E.M. Drost, A. Holownia, W. MacNee and K. Donaldson. Eur Respir J 2008; 31: 241-251. “纳米颗粒驱动的DNA损伤模拟了辐射相关的致癌途径。”R.M. Mroz， R.P.F. Schins， H. Li， L.A. Jimenez， E.M. Drost， A. Holownia， W. MacNee和K. Donaldson。中华呼吸病学杂志2008;31日:241 - 251。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.50067-2007
{"title":"\"Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways.\" R.M. Mroz, R.P.F. Schins, H. Li, L.A. Jimenez, E.M. Drost, A. Holownia, W. MacNee and K. Donaldson. <i>Eur Respir J</i> 2008; 31: 241-251.","authors":"","doi":"10.1183/13993003.50067-2007","DOIUrl":"https://doi.org/10.1183/13993003.50067-2007","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical models of COPD: a state of the art review. 慢性阻塞性肺病的临床前模型：最先进的状态。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.00289-2026
Francesca Polverino, Kambez H Benam, Suzanne M Cloonan, Jeffrey L Curtis, Amit Gaggar, Farrah Kheradmand, Mareike Lehmann, Enid Neptune, S Vamsee Raju, Joselyn Rojas-Quintero, Maor Sauler, Yohannes Tesfaigzi, Ali Önder Yildirim, Anny Xiaobo Zhou, Don D Sin
{"title":"Preclinical models of COPD: a state of the art review.","authors":"Francesca Polverino, Kambez H Benam, Suzanne M Cloonan, Jeffrey L Curtis, Amit Gaggar, Farrah Kheradmand, Mareike Lehmann, Enid Neptune, S Vamsee Raju, Joselyn Rojas-Quintero, Maor Sauler, Yohannes Tesfaigzi, Ali Önder Yildirim, Anny Xiaobo Zhou, Don D Sin","doi":"10.1183/13993003.00289-2026","DOIUrl":"10.1183/13993003.00289-2026","url":null,"abstract":"<p><p>COPD is a progressive and heterogeneous condition characterised by varying combinations of emphysema, small airway disease, chronic bronchitis and exacerbations. Although multiple symptomatic therapies exist, no disease-modifying treatments are available. This gap highlights the need for improved preclinical models with greater translational relevance. Large human cohorts and single-cell/multi-omics studies have informed the development of current COPD models. We provide a state of the art review of the major experimental platforms: <i>in vivo</i> (small and large animals, genetic and injury models, environmental exposures), <i>ex vivo</i> (precision-cut lung slices, organoids, co-cultures, lung-on-a-chip systems) and <i>in silico</i> (aerosol dispersion and computational tools). While each approach has yielded important mechanistic insights, none fully captures the complexity of COPD progression, comorbidities, gene-environment interactions or heterogeneous clinical endotypes. Future progress will depend on the development of more integrated, human-relevant modelling systems, alongside advanced exposure platforms and artificial intelligence-driven multi-omics integration to identify biologically meaningful endotypes and speed the creation of phenotype-specific therapies. We propose a phenotype-driven, cross-platform framework in which hypotheses emerging from human clinical and omics data are validated in <i>in vitro</i> and <i>ex vivo</i> systems, evaluated in phenotype-specific <i>in vivo</i> models, and ultimately confirmed through clinical studies.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of HDAC2 and HDAC8 in the airways of COPD patients is associated with responsiveness to ICS: insights from the HISTORIC study. 慢性阻塞性肺病患者气道中HDAC2和HDAC8的表达与对ICS的反应性相关：来自HISTORIC研究的见解
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.00950-2026
Eleni Papakonstantinou, Marta Nowak, Spasenija Savic Prince, Daniel Soriano, Leticia Grize, Björn Christian Frye, Sebastian Fähndrich, Viktor H Koelzer, Daiana Stolz
{"title":"Expression of HDAC2 and HDAC8 in the airways of COPD patients is associated with responsiveness to ICS: insights from the HISTORIC study.","authors":"Eleni Papakonstantinou, Marta Nowak, Spasenija Savic Prince, Daniel Soriano, Leticia Grize, Björn Christian Frye, Sebastian Fähndrich, Viktor H Koelzer, Daiana Stolz","doi":"10.1183/13993003.00950-2026","DOIUrl":"10.1183/13993003.00950-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating mean pulmonary arterial pressure in the machine learning era. 估计机器学习时代的平均肺动脉压。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.01466-2026
Denis Chemla, Philippe Hervé, Marc Humbert, David Montani
{"title":"Estimating mean pulmonary arterial pressure in the machine learning era.","authors":"Denis Chemla, Philippe Hervé, Marc Humbert, David Montani","doi":"10.1183/13993003.01466-2026","DOIUrl":"https://doi.org/10.1183/13993003.01466-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal nitric oxide as a gateway, not a gatekeeper, to primary ciliary dyskinesia diagnosis in bronchiectasis. 鼻腔一氧化氮作为支气管扩张中原发性纤毛运动障碍诊断的一个关口，而不是一个守门人。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.01080-2026
Takanori Asakura, Hayoung Choi
{"title":"Nasal nitric oxide as a gateway, not a gatekeeper, to primary ciliary dyskinesia diagnosis in bronchiectasis.","authors":"Takanori Asakura, Hayoung Choi","doi":"10.1183/13993003.01080-2026","DOIUrl":"https://doi.org/10.1183/13993003.01080-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissolving the candy clouds: flavour restrictions for a tobacco-free future. 溶解糖果云：为无烟未来的口味限制。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.01323-2026
Frank Vandenbroucke, Katrien Eger, Lena Boons, Pieter Goeminne
{"title":"Dissolving the candy clouds: flavour restrictions for a tobacco-free future.","authors":"Frank Vandenbroucke, Katrien Eger, Lena Boons, Pieter Goeminne","doi":"10.1183/13993003.01323-2026","DOIUrl":"https://doi.org/10.1183/13993003.01323-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When can a negative endosonographic examination be trusted? 什么时候可以相信阴性的超声检查？
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 DOI: 10.1183/13993003.01423-2026
Sergi Call, Carme Obiols, Ramón Rami-Porta
{"title":"When can a negative endosonographic examination be trusted?","authors":"Sergi Call, Carme Obiols, Ramón Rami-Porta","doi":"10.1183/13993003.01423-2026","DOIUrl":"https://doi.org/10.1183/13993003.01423-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward molecular endotypes of CLAD: dancing around the truth hidden in the tissue. 论分子内型的覆层：围绕隐藏在组织中的真相跳舞。
IF 23.8 1区 医学
European Respiratory Journal Pub Date : 2026-10-09 Print Date: 2026-10-01 DOI: 10.1183/13993003.01141-2026
Stephen Juvet
{"title":"Toward molecular endotypes of CLAD: dancing around the truth hidden in the tissue.","authors":"Stephen Juvet","doi":"10.1183/13993003.01141-2026","DOIUrl":"https://doi.org/10.1183/13993003.01141-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 4","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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