European Respiratory Journal最新文献

{"title":"Decreased Pulmonary Exacerbations and Lower IV Antibiotic Usage Following Vanzacaftor/Tezacaftor/Deutivacaftor Treatment in People with Cystic Fibrosis with F508del-Minimal Function Genotypes.","authors":"Alexander Horsley,Emilio Arteaga-Solis,Claire Keating,Marcus A Mall,Bonnie Ramsey,Nitin Nair,Teja Thorat,Patrick Sosnay","doi":"10.1183/13993003.02538-2025","DOIUrl":"https://doi.org/10.1183/13993003.02538-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"33 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GOLD Stage 1 COPD pharmacotherapy: big question, few answers.","authors":"Helen O'Brien,Cormac McCarthy,Alessandro N Franciosi","doi":"10.1183/13993003.01948-2025","DOIUrl":"https://doi.org/10.1183/13993003.01948-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"18 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy is indicated and beneficial in patients with symptomatic GOLD Stage I COPD.","authors":"Ophir Freund,Amir Bar-Shai,Shawn D Aaron","doi":"10.1183/13993003.00417-2026","DOIUrl":"https://doi.org/10.1183/13993003.00417-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"1 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3).","authors":"Julia Y Chu,Samuel Hollins,Alguili Elsheikh,Stephen Gerry,Nikita Manoharan,Tryfon Zarganes-Tzitzikas,Yinzhou Feng,Elie Antoun,Eihab O Bedawi,John P Corcoran,Amy Gilmour,Federico Mei,Federica Monaco,Marco Tomasetti,Argyrios Tzouvelekis,Electra Koulousousa,Fotios Sampsonas,Malvika Bhatnagar,Ellice Z Chen,Paul E Brennan,Tao Dong,Ian D Pavord,Yuanlin Song,James D Chalmers,Julian C Knight,Najib M Rahman,Nikolaos I Kanellakis","doi":"10.1183/13993003.00113-2026","DOIUrl":"https://doi.org/10.1183/13993003.00113-2026","url":null,"abstract":"BACKGROUNDInflux of large numbers of neutrophils is characteristic of pleural infection; however, neutrophil behaviour is understudied. We designed an observational multicohort study with the aims to discover and validate the association between neutrophil extracellular traps (NETs), disease severity, one-year survival, and the extent of sonographic septations.METHODSWe analysed five independent datasets across three countries. The PILOT cohort (UK, n=215) was used as a discovery cohort for the association of NETs with disease severity with validation in four independent cohorts across three countries (UK, Greece, Italy, n=100). The PILOT cohort was further analysed to assess the association of NETs with one-year survival and the development and extent of sonographic septations. A separate cohort (the Oxford-Osler cohort, UK, n=30) was used to assess the relationship between NETs and the need for intrapleural enzyme therapy (IET) as rescue treatment.RESULTSA ten-unit increase in NETs was associated with 13% higher odds of being into a higher RAPID Score group (OR=1.13, 95% CI: 1.02-1.27, p=0.02), and this association remained robust in the independent validation cohort (OR=1.29, 95% CI: 1.11-1.40, p=0.0005). A ten-unit increase in NETs was also associated with a 15% higher risk of one-year mortality (HR=1.15, 95% CI: 1.01-1.32, p=0.04) independent of the RAPID Score, and a 17% higher likelihood of sonographic septations (OR=1.17, 95% CI: 1.01-1.37, p=0.04). Citrullinated fibrin was associated with septation severity (OR=1.10, 95% CI: 1.04-1.16, p=0.00005).CONCLUSIONSPleural fluid NETs are a biomarker of disease severity and one-year mortality, in pleural infection. Future studies are required to assess the combination of NET-targeting strategies in combination with existing treatments.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"136 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature hair graying in patients with pulmonary fibrosis and relatives is suggestive of pathogenic variants in telomere related genes.","authors":"Raphael Borie,Arthur Mageau,Cécile Guérin,Morgane Weiss,Mathilde Le Brun,Bruno Crestani,Quentin Philippot,Flore Sicre de Fontbrune,Aurélie Plessier,Diane Bouvry,Andrew Courtwright,John Mackintosh,Emmanuelle Bourrat,Clément R Massonnaud,Ibrahima Ba,Caroline Kannengiesser","doi":"10.1183/13993003.00093-2026","DOIUrl":"https://doi.org/10.1183/13993003.00093-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"45 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic rhinitis in home noninvasive ventilation interface selection.","authors":"Catarina La Cueva Couto,Joana Almeida Borges,Marta Drummond","doi":"10.1183/13993003.02018-2025","DOIUrl":"https://doi.org/10.1183/13993003.02018-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"440 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the Multimarker Calculator for predicting short-term deterioration and mortality in a Chinese prospective multicentre pulmonary embolism cohort.","authors":"Yizhuo Gao, Zhichun Gu, Xuejiao Wei, Shibo Wei, Yuchen Liu, Shu Wang, Dong Jia","doi":"10.1183/13993003.02124-2025","DOIUrl":"10.1183/13993003.02124-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic elastography-guided pleural biopsy: robustness, mechanisms and technical validity.","authors":"Fang Li,Liqun Zhang","doi":"10.1183/13993003.00098-2026","DOIUrl":"https://doi.org/10.1183/13993003.00098-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"3 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer.","authors":"Kristofer Hedman, Karolina Kristenson","doi":"10.1183/13993003.02480-2025","DOIUrl":"10.1183/13993003.02480-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"67 4","pages":""},"PeriodicalIF":21.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply regarding the European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer.","authors":"Alessandro Brunelli,Georgia Hardavella,Rudolf M Huber,Thierry Berghmans,Armin Frille,Maria Rodriguez,Ilona Tietzova,Lieven Depypere,Riccardo Asteggiano,Tim Batchelor,Adrien Costantini,Dirk De Ruysscher,Corinne Faivre-Finn,Mark Ferguson,Daniel Langer,Nandor Marczin,Nuria Novoa,Cecilia Pompili,Janette Rawlinson,Annemiek Snoeckx,Wouter H van Geffen,Clare Williams,Torsten Gerriet Blum","doi":"10.1183/13993003.02601-2025","DOIUrl":"https://doi.org/10.1183/13993003.02601-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"52 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}