European Respiratory Journal最新文献

{"title":"Early-life exposure to a mixture of phenols and respiratory health in preschool children.","authors":"Alicia Guillien, Sam Bayat, Ines Amine, Anne Boudier, Sarah Lyon-Caen, Joane Quentin, Zoltán Hantos, Séverine Valmary-Degano, Amrit K Sakhi, Cathrine Thomsen, Claire Philippat, Rémy Slama, Valérie Siroux","doi":"10.1183/13993003.02265-2024","DOIUrl":"10.1183/13993003.02265-2024","url":null,"abstract":"<p><strong>Introduction: </strong>Exposure to synthetic phenols is suspected to affect child respiratory health, but epidemiological findings are not consistent and studies on exposure during infancy are lacking. We aimed to investigate the association between exposure to a mixture of phenols in pregnancy and infancy and children's respiratory health.</p><p><strong>Methods: </strong>Among 363 mother-child pairs from the Suivi de l'Exposition à la Pollution Atmosphérique durant la Grossesse et Effets sur la Santé cohort, 12 phenols were measured in weekly-pooled urine samples collected twice during pregnancy (second and third trimesters) and in infancy (2 months and 1 year). Children's lung function was assessed through tidal breathing flow-volume loops and nitrogen multiple-breath washout at 2 months, and standard and intra-breath oscillometry at 3 years. Time-specific phenol exposure profiles were identified through cluster analysis and then studied in association with respiratory health using adjusted regression models.</p><p><strong>Results: </strong>Two exposure profiles were identified at each point in time, characterised by low <i>versus</i> high levels of several phenol compounds. Overall, high exposure profiles were associated with altered oscillometry parameters at 3 years, particularly a high profile in the second trimester with higher frequency dependence of resistance and lower volume dependence of reactance, between a high profile at 2 months and lower reactance at 7 Hz, and between a high profile at 1 year and higher area of the reactance curve, resistance at 7 Hz and volume dependence of resistance.</p><p><strong>Conclusion: </strong>Using repeated and accurate assessments of phenol exposure, this study provides evidence of the deleterious effects of early-life exposure to a mixture of phenols on lung function in preschool children.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollution-induced ITIH4 deficiency: a gateway to novel targeted antioxidant therapy in COPD?","authors":"Carolyn J Wang,Don D Sin","doi":"10.1183/13993003.01097-2025","DOIUrl":"https://doi.org/10.1183/13993003.01097-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"9 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using human genetics to explore pathogenesis and future treatment targets in primary spontaneous pneumothorax.","authors":"Shoaib Afzal","doi":"10.1183/13993003.01044-2025","DOIUrl":"https://doi.org/10.1183/13993003.01044-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"37 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pirfenidone and lung cancer in idiopathic pulmonary fibrosis: mind the index date, detection bias and competing risks.","authors":"Ryosuke Imai,Sho Fukui,Kosuke Inoue","doi":"10.1183/13993003.00453-2025","DOIUrl":"https://doi.org/10.1183/13993003.00453-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"10 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pirfenidone in post-COVID-19 pulmonary fibrosis.","authors":"Raùl H Sansores, Mario Cazzola, Jorge Luis Poo","doi":"10.1183/13993003.01271-2025","DOIUrl":"10.1183/13993003.01271-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"66 3","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study reveals <i>CBX7</i> as a novel susceptibility gene associated with primary spontaneous pneumothorax in the Chinese Han population.","authors":"Leilei Xu, Dehua Ma, Bingjian Wang, Mengru Cai, Zhichong Wu, Shuwen Cheng, Minghui Cai, Yibing Ding, Xinxin Zhang, Qi Sun, Fengnan Niu, Hongyan Wu, Zhicheng Dai, Haiyan Min, Yanting Wen, Shiyu Song, Wei Zou, Chao Wang, Sufen Li, Jiaochen Wang, Jianfei Shen, Xinxin Wang, Aifen Lin, Xingbing Cao, Xinxin Yuan, Chao Xia, Zhongying Guo, Zhenhua Feng, Ronghui Du, Jun Qiao, Qi Gao, Benlong Shi, Saihu Mao, Tianming Chen, Haozhen Ren, Minhua Ye, Xiaowen Hu, Ping Hu, Zhengfeng Xu, Shilin Chen, Yong Qiu, Yong Wang, Qian Gao, Chengchu Zhu, Zezhang Zhu, Long Yi","doi":"10.1183/13993003.02110-2024","DOIUrl":"10.1183/13993003.02110-2024","url":null,"abstract":"<p><strong>Background: </strong>Primary spontaneous pneumothorax is a rare disease commonly found in young adults, with unknown aetiology. We aimed to investigate the susceptibility genes and the downstream signalling involved in the development of primary spontaneous pneumothorax.</p><p><strong>Methods: </strong>We conducted the first large-scale genome-wide association study (GWAS) composed of 2223 patients and 3838 controls. The functional role of the novel susceptibility loci was investigated by both <i>in vivo</i> and <i>in vitro</i> assays. Gene expression profiling in lung epithelial cell lines was performed, and conditional gene knockout mice were generated.</p><p><strong>Results: </strong>We identified four novel susceptibility loci at 14q32.2 near <i>C14orf177</i>, at 15q26.3 near <i>CHSY1</i>, at 16q23.1 near <i>CFDP1</i> and at 22q13.1 near <i>CBX7</i>. The fine-mapping of 22q13.1 revealed a functional variant which regulated <i>CBX7</i> expression by disrupting the binding activity of transcription factor CREB1. Conditional knockout of <i>Cbx7</i> in mouse lung epithelial cells resulted in lung cyst formation. Meanwhile, downregulation of the <i>CBX7</i> elevated the expression of <i>MMP9</i> and <i>MMP16</i>, which are part of extracellular matrix regulators and may lead to lung injury.</p><p><strong>Conclusions: </strong>Our GWAS discovered four novel susceptibility loci of primary spontaneous pneumothorax and presented a mechanistic basis for the genetic association with primary spontaneous pneumothorax. The novel susceptibility gene <i>CBX7</i> and downstream <i>MMP</i> signalling give a new clue to the pathogenesis of primary spontaneous pneumothorax.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No exposure left behind: time to pay attention to children's chemical environment in lung development.","authors":"Stefano Guerra,Erik Melén,Enrico Lombardi","doi":"10.1183/13993003.00952-2025","DOIUrl":"https://doi.org/10.1183/13993003.00952-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"70 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Pirfenidone and lung cancer in idiopathic pulmonary fibrosis: mind the index date, detection bias and competing risks.","authors":"Hee-Young Yoon,Jin Woo Song","doi":"10.1183/13993003.01350-2025","DOIUrl":"https://doi.org/10.1183/13993003.01350-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"71 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics profiling in severe pneumonia: the importance of robust study design.","authors":"Benjamin D Singer","doi":"10.1183/13993003.00760-2025","DOIUrl":"https://doi.org/10.1183/13993003.00760-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"78 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERJ Podcast August 2025: Treatment of central sleep apnoea with adaptive servo-ventilation.","authors":"","doi":"10.1183/13993003.e6602-2025","DOIUrl":"https://doi.org/10.1183/13993003.e6602-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"28 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}