欧洲呼吸学会成人支气管扩张管理临床实践指南。

IF 21 1区 医学 Q1 RESPIRATORY SYSTEM
James D Chalmers,Charles S Haworth,Patrick Flume,Merete B Long,Pierre Régis Burgel,Katerina Dimakou,Francesco Blasi,Beatriz Herrero-Cortina,Raja Dhar,Sanjay H Chotirmall,Felix C Ringshausen,Josje Altenburg,Lucy Morgan,Mattia Nigro,Megan L Crichton,Chayenne Van Meel,Oriol Sibila,Alan Timothy,Eliza Kompatsiari,Tanja Hedberg,Thomas Vandendriessche,Pamela J McShane,Thomy Tonia,Kevin Winthrop,Michael R Loebinger,Natalie Lorent,Pieter Goeminne,Michal Shteinberg,Eva Polverino,Stefano Aliberti
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引用次数: 0

摘要

背景:支气管扩张是一种常见的肺部疾病,与广泛的感染性、免疫性、自身免疫性、过敏性和遗传性疾病有关。病情恶化和日常症状对患者和卫生保健系统的影响最大,也是治疗的重点。目前的做法是异质的全球,支气管扩张一直是历史上被忽视的疾病。在这里,我们提出以证据为基础的管理成人支气管扩张的国际指南。方法欧洲呼吸学会(ERS)工作组由全球专家、一名方法学家和患者代表组成,根据ERS方法学和GRADE(分级推荐、评估、发展和评估)方法制定了临床实践指南。系统文献检索、数据提取和荟萃分析生成证据表,并使用证据-决策框架制定建议。共编制了8个PICO(患者、干预、比较者、结果)问题和3个叙述性问题。特别工作组的建议包括强烈建议对大多数支气管扩张患者采用气道清除技术,对运动能力受损患者采用肺康复。我们强烈建议急性加重高风险患者长期使用大环内酯类药物治疗,并强烈建议急性加重高风险慢性铜绿假单胞菌感染患者长期使用吸入抗生素。有条件的建议支持在特定情况下使用根除治疗或黏液活性药物。我们建议不要常规使用长期口服,非大环内酯类抗生素治疗或吸入皮质类固醇。还提供了关于检测根本原因、管理恶化和管理恶化患者的额外指导。结论ERS支气管扩张指南为成人支气管扩张的优化管理提供了循证框架,并可作为评估护理质量的基准。范围和目的欧洲呼吸学会(ERS)成人支气管扩张管理指南为临床显著支气管扩张患者的护理提供了循证建议,支气管扩张的定义是胸部CT扫描上明显存在永久性支气管扩张,并伴有特征性临床症状。b[1]本指南适用于所有参与成人支气管扩张护理的医疗保健专业人员,以及政策制定者、监管机构和制药公司。支气管扩张是一种复杂的异质性疾病;因此,没有任何指南可以完全全面或取代临床判断。所有指南建议必须在其应用的特定临床背景下进行解释。针对儿童支气管扩张的管理,存在单独的ERS指南[bbb]。囊性纤维化(CF)所致支气管扩张有明确的证据基础;因此,CF的管理指南在其他地方提供。一些与支气管扩张相关的疾病也有不同的调查和治疗指南,如原发性纤毛运动障碍(PCD)[4]、过敏性支气管肺曲霉病(ABPA)[5]和非结核分枝杆菌(NTM)肺病[6]。虽然本指南适用于这些情况,但应结合相关的综合征特异性建议对其进行解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
European Respiratory Society Clinical Practice Guideline for the Management of Adult Bronchiectasis.
BACKGROUND Bronchiectasis is a common lung condition associated with wide range of infectious, immunological, autoimmune, allergic and genetic conditions. Exacerbations and daily symptoms have the largest impact on patients and healthcare systems, and they are the key focus of treatments. Current practice is heterogeneous globally, and bronchiectasis has historically been a neglected disease. Here, we present evidence-based international guidelines for the management of adults with bronchiectasis. METHODS A European Respiratory Society (ERS) Task Force, comprising global experts, a methodologist, and patient representatives, developed clinical practice guidelines in accordance with ERS methodology and the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach. Systematic literature searches, data extraction, and meta-analysis were performed to generate evidence tables, and recommendations were formulated using the evidence-to-decision framework. A total of 8 PICO (Patient, Intervention, Comparator, Outcomes) questions and 3 narrative questions were developed. RECOMMENDATIONS The Task Force recommendations include strong recommendations in favour of airway clearance techniques for most patients with bronchiectasis and pulmonary rehabilitation for those with impaired exercise capacity. We issue a strong recommendation for the use of long-term macrolide treatment for patients at high risk of exacerbations and a strong recommendation in favour of long-term inhaled antibiotics in patients with chronic Pseudomonas aeruginosa infection at high risk of exacerbation. Conditional recommendations support the use of eradication treatment or mucoactive drugs in specific circumstances. We suggest not to routinely use long term oral, non-macrolide antibiotic treatment or inhaled corticosteroids. Additional guidance is also provided on testing for underlying causes, managing exacerbations, and managing the deteriorating patient. CONCLUSION The ERS bronchiectasis guidelines provide an evidence-based framework for optimal management of adults with bronchiectasis and serve as a benchmark for evaluating the quality of care. SCOPE AND OBJECTIVES The European Respiratory Society (ERS) guidelines for the management of bronchiectasis in adults provide evidence-based recommendations for the care of people with clinically significant bronchiectasis, defined by the presence of permanent dilatation of the bronchi evident on chest CT scan, along with characteristic clinical symptoms. [1] These guidelines are intended for all healthcare professionals involved in the care of adults with bronchiectasis, as well as for policymakers, regulatory authorities, and pharmaceutical companies. Bronchiectasis is a complex and heterogeneous disease; therefore, no guideline can be entirely comprehensive or replace clinical judgement. All guideline recommendations must be interpreted within the specific clinical context in which they are applied. Separate ERS guidelines for the management of bronchiectasis in children exist [2]. Bronchiectasis due to cystic fibrosis (CF) has a distinct evidence base; therefore, guidance for the management of CF is provided elsewhere. [3] Some bronchiectasis-associated conditions also have distinct guidelines for investigation and management, such as primary ciliary dyskinesia (PCD) [4], allergic bronchopulmonary aspergillosis (ABPA) [5] and non-tuberculous mycobacterial (NTM) pulmonary disease [6]. While the present guidelines apply for these conditions, they should be interpreted in conjunction with the relevant syndrome-specific recommendations.
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来源期刊
European Respiratory Journal
European Respiratory Journal 医学-呼吸系统
CiteScore
27.50
自引率
3.30%
发文量
345
审稿时长
2-4 weeks
期刊介绍: The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.
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