European Respiratory Journal最新文献

{"title":"\"Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation.\" K. Jankowski, S.E. Lemay, D. Lozano-Ojalvo, <i>et al</i>. <i>Eur Respir J</i> 2025; 66: 2402250.","authors":"","doi":"10.1183/13993003.52250-2024","DOIUrl":"10.1183/13993003.52250-2024","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 3","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Has obstructive sleep apnoea been prematurely removed from group 3 pulmonary hypertension?","authors":"Babak Mokhlesi, Juan Fernando Masa, Gonzalo Labarca, Atul Malhotra","doi":"10.1183/13993003.01401-2026","DOIUrl":"https://doi.org/10.1183/13993003.01401-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 3","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal hypoxaemia in sleep disordered breathing as a driver of precapillary pulmonary hypertension: reappraising clinical relevance.","authors":"Esther Irene Schwarz, Silvia Ulrich","doi":"10.1183/13993003.00915-2026","DOIUrl":"https://doi.org/10.1183/13993003.00915-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 3","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small airway dysfunction may mediate the association between body mass index and severe asthma exacerbations.","authors":"Andrea Portacci, Laura Ventura, Francesco Menzella, Remo Poto, Alvise Berti, Carlo Lombardi, Pasquale Comberiati, Giovanna Elisiana Carpagnano, Zuzana Diamant, Ian M Adcock, Brian Lipworth, Omar Usmani, Marcello Cottini, Rory Chan","doi":"10.1183/13993003.00150-2026","DOIUrl":"10.1183/13993003.00150-2026","url":null,"abstract":"<p><strong>Background: </strong>Obesity is associated with poorer asthma outcomes and an increased risk of exacerbations, but the underlying mechanisms remain incompletely understood. Small airway dysfunction (SAD) may represent a key mechanistic link between excess body weight and adverse asthma outcomes.</p><p><strong>Methods: </strong>In this multicentre observational study, adult patients with asthma underwent clinical characterisation, spirometry and impulse oscillometry (IOS). SAD was defined using a composite criterion based on small airway resistance (frequency dependence of resistance between 5 and 20 Hz (<i>R</i> _5-20)), reactance area (A<i>X</i>) and ratio of peripheral airway to total airway resistance ((<i>R</i> _5-20)/<i>R</i> ₅). Associations between body mass index (BMI), SAD and severe asthma exacerbations were assessed using multivariable regression models. Non-linear relationships were explored using generalised additive models, and mediation analyses quantified the contribution of SAD to the obesity-exacerbation association.</p><p><strong>Results: </strong>Among 1169 patients, IOS-defined SAD was significantly more prevalent in individuals with BMI ≥30 kg·m^-2. Increasing BMI was associated with worse IOS parameters (p<0.0001), following a non-linear pattern with steeper deterioration beyond BMI values of ∼28-30 kg·m^-2. SAD was independently associated with obesity (adjusted OR 2.11, 95% CI 1.56-2.86) and with severe asthma exacerbations in the previous year (adjusted OR 2.01, 95% CI 1.53-2.65) (both p<0.0001). Mediation analyses showed that SAD accounted for 26-41% of the association between obesity and exacerbation risk (p=0.004 and p=0.03). Spirometry indices provided limited additional information.</p><p><strong>Conclusion: </strong>Oscillometry-defined SAD represents a non-linear functional trait underlying the association between obesity and severe asthma exacerbations, supporting its clinical relevance in obese patients with asthma and identifying SAD as a potential treatable trait.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating emphysema with hepatocyte growth factor mRNA lipid nanoparticles.","authors":"Darrell N Kotton","doi":"10.1183/13993003.01318-2026","DOIUrl":"https://doi.org/10.1183/13993003.01318-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 3","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New therapeutic targets for restrictive allograft syndrome?","authors":"Veronika Grau","doi":"10.1183/13993003.00991-2026","DOIUrl":"https://doi.org/10.1183/13993003.00991-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"68 3","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent respiratory, psychological and quality-of-life impairments 2 years post-tuberculosis: evidence from a cohort study in Cambodia.","authors":"Sothearith Eng, Kiesha Prem, Sovannary Tuot, Chamroen Pall, Sovanvorleak Tep, Graeme Hoddinott, Masao Ichikawa, Siyan Yi, Alvin Kuo Jing Teo","doi":"10.1183/13993003.00858-2026","DOIUrl":"10.1183/13993003.00858-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung-targeted hepatocyte growth factor mRNA restores alveolar structure in experimental emphysema.","authors":"Dian Chen, Jeffrey L Curtis, Weijing Kong, Lanhe Chu, Yixia Jiang, Tongxinwei Sun, Huanyu Long, Zihang Pan, Qiyang Yao, Dayan Li, Yun Zhao, Simin Jiang, Rongbing Yi, Guangliang Qiang, Yongchang Sun, Ping Jiang, Aihong Meng, Xiaojuan Liu, Yahong Chen, Kai Wang","doi":"10.1183/13993003.02323-2025","DOIUrl":"10.1183/13993003.02323-2025","url":null,"abstract":"<p><strong>Background: </strong>Emphysema, a major component of COPD characterised by progressive alveolar destruction, lacks effective medical therapies. Hepatocyte growth factor (HGF) possesses potent regenerative functions, but its therapeutic potential remains unrealised due to challenges in achieving targeted delivery and sustained lung expression.</p><p><strong>Methods: </strong>We first assessed associations between HGF expression and emphysema severity using human datasets, lung tissue, and both elastase-induced and cigarette-smoke-induced murine models. We repurposed a clinical-stage SM102 lipid nanoparticles platform to deliver human HGF mRNA in murine models, evaluating therapeutic efficacy <i>via</i> intratracheal instillation in the elastase model. After optimising nebulisation, we assessed efficacy in the cigarette-smoke model. We investigated underlying mechanisms <i>via</i> single-cell RNA sequencing (scRNA-seq), which we validated in patient-derived lung organoids.</p><p><strong>Results: </strong>HGF expression displayed a biphasic pattern across the emphysema spectrum, with upregulation in milder disease states and marked reduction in advanced emphysema. Intratracheal delivery of HGF mRNA lipid nanoparticles restored lung function and attenuated alveolar destruction in the elastase model. Nebulised delivery achieved efficient pulmonary distribution and demonstrated comparable therapeutic efficacy in the cigarette-smoke model, including improved lung function, reduced inflammation, and decreased apoptosis. scRNA-seq analysis detected enhanced alveolar type II (AT2) cell proliferation and differentiation in the elastase model and human organoids.</p><p><strong>Conclusion: </strong>This study provides proof-of-concept evidence for a therapeutic strategy for emphysema. Using a clinical-stage lipid nanoparticle platform, we demonstrate that HGF mRNA therapy is effective <i>via</i> both direct instillation and optimised nebulisation, prompting structural and functional recovery by activating endogenous repair pathways in AT2 cells.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive pulmonary fibrosis: a state-of-the-art review.","authors":"Vincent Cottin, Kevin Brown, Kevin R Flaherty, Martin Kolb, David A Lynch, Justin Oldham, Claudia Valenzuela, Marlies Wijsenbeek, Athol U Wells","doi":"10.1183/13993003.01557-2025","DOIUrl":"10.1183/13993003.01557-2025","url":null,"abstract":"<p><p>Fibrosing interstitial lung disease encompasses a large number of diverse conditions, the prototype being idiopathic pulmonary fibrosis (IPF). IPF is characterised by irreversible progression and accounts for loss of lung function, exercise intolerance and complications, especially acute exacerbation and respiratory failure leading to early mortality. A significant proportion of patients with fibrosing interstitial lung diseases other than IPF will develop a progressive phenotype comparable to IPF. Progression occurs despite conventional treatment, which, depending on the underlying condition, may include close monitoring, antigen eviction, glucocorticoids, immunosuppressive therapy and pulmonary rehabilitation. Progressive pulmonary fibrosis (PPF) has a disease course similar to IPF, with worsening respiratory symptoms, decline in lung function, impairment of quality of life and premature death. In 2019, a phase 3 trial demonstrated that treatment with the tyrosine kinase inhibitor nintedanib halves disease progression as measured by a decline in forced vital capacity over 1 year, and contributed to the validation of the PPF concept. In the 2022 international clinical practice guideline, nintedanib received a conditional recommendation for treating patients with PPF. In 2025, it was demonstrated that the phosphodiesterase 4B inhibitor nerandomilast further reduces disease progression in patients with PPF. Other smaller trials have suggested that pirfenidone may also benefit patients with PPF. Several newer compounds are currently being developed for both IPF and PPF. Because a diagnosis of PPF identifies patients with fibrotic disease progression, early identification is warranted for the timely initiation of antifibrotic therapy, consideration of lung transplantation if eligible, and holistic care.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148224171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserved terminal bronchiole density in PAH revealed by micro-CT imaging.","authors":"Gitte Aerts, Emanuele Muscogiuri, Laura Hardy, Pieterjan Kerckhof, Vincent Geudens, Xin Jin, Charlotte Hooft, Marta Zapata-Ortega, Stephanie Everaerts, Marion Delcroix, Rozenn Quarck, Bart M Vanaudenaerde, Laurent Godinas","doi":"10.1183/13993003.01230-2026","DOIUrl":"https://doi.org/10.1183/13993003.01230-2026","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":23.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}