European Respiratory Journal最新文献

{"title":"European Respiratory Society Clinical Practice Guideline on Telemedicine in Home Mechanical Ventilation.","authors":"Marieke L Duiverman,Carla Ribeiro,Thomy Tonia,Anda Hazenberg,Stien van Meerloo,Hans van Meerloo,Stefanie Werther,Christopher Schöbel,Aylin Özsancak Uğurlu,Jean-Christian Borel,Christina Jácome,Maxime Patout,Karen Ward,Clare Williams,Begum Ergan,Chris Carlin,Patrick Murphy,Raphaela Dellacà,Michele Vitacca,Claudia Crimi","doi":"10.1183/13993003.00094-2025","DOIUrl":"https://doi.org/10.1183/13993003.00094-2025","url":null,"abstract":"BACKGROUNDWith the increasing prevalence of patients on home mechanical ventilation (HMV), changing indications, shortage of hospital resources, and rapidly evolving technology, there is an urgent need for evaluating the added value of telemedicine in initiation and follow-up of HMV. This European Respiratory Society (ERS) clinical practice guideline provides evidence-based recommendations on the use of telemedicine in HMV.METHODSThe ERS Task Force consisted of 20 members, including a patient representative and her caregiver. The Task Force addressed five PICO questions and three narrative questions. Systematic searches were performed in MEDLINE, EMBASE, Cochrane, CINAHL. Evidence was synthesized by conducting meta-analyses, when possible, or when not, narratively. Certainty of evidence was rated with GRADE (Grading of Recommendations Assessment, Development and Evaluation). The \"evidence-to-decision\" framework was used to decide on the direction and formulate strengths of recommendations.RESULTSThe panel makes a conditional recommendation for the initiation of HMV with telemedicine in patients with neuromuscular diseases and in patients with COPD. No recommendation could be made for obesity hypoventilation syndrome. The panel conditionally recommends the use of telemedicine for the follow-up of patients on HMV, although could not make recommendations on parameters to be monitored. Suggestions were mainly based on theoretical benefits and patient preferences, as our confidence in the evidence was low.CONCLUSIONSWith these guidelines, clinical practice recommendations are provided for the use of telemedicine in HMV. Technological advances and the use of advanced data processing algorithms and artificial intelligence were identified as drivers for future research and telemedicine use.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"59 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic associations between Serotonin Receptor 1F (<i>HTR1F</i>) regulatory variation and sleep apnea in non-obese individuals: Insights from GWAS and eQTL analyses.","authors":"Satu Strausz, Martin Broberg, Samuel E Jones, Jukka Koskela, Tuomo Kiiskinen, FinnGen, Aarno Palotie, Tuula Palotie, Adel Bachour, Richa Saxena, Samuli Ripatti, Erik Abner, Hanna M Ollila","doi":"10.1183/13993003.01778-2024","DOIUrl":"https://doi.org/10.1183/13993003.01778-2024","url":null,"abstract":"<p><strong>Background: </strong>Sleep apnea is a common sleep disorder affecting at least ten percent of the population. It is caused by lack of breathing during sleep, typically mediated by obstruction of airways or less frequently by misdirected central signals for breathing. The primary risk factor is a high body mass index (BMI), causing airway obstruction. However, understanding risk factors for sleep apnea in non-obese (BMI<30) individuals requires further exploration.</p><p><strong>Aim: </strong>Our goal was to elucidate genetic risk factors for sleep apnea in non-obese individuals.</p><p><strong>Methods: </strong>We performed genome-wide association testing in individuals with BMI<30 in FinnGen including 20 413 cases with sleep apnea diagnosis (ICD-10 G47.3 or ICD-9 3472) and 443 463 disease free controls. We replicated our analysis in Estonian Biobank.</p><p><strong>Results: </strong>We identified a significant association within the Serotonin receptor 1F (<i>HTR1F</i>) locus (rs1818163, beta=0.059, se=0.010, p<1.58e-8), and replicated the association in Estonian Biobank (beta =0.042, se=0.020, p=0.034). The association signal co-localized with <i>HTR1F</i> expression across multiple tissues (posterior probability>0.8), and single cell sequencing implicated <i>HTR1F</i> expression particularly in neurons. Analysis of eQTL data further supported a possible regulatory role in neurons (beta=-0.03, p=1.2e-4). Finally, PheWAS analysis of rs1818163 showed an association with objectively measured sleep-activity data, specifically with the number of awakenings during the night (p=5.6e-8).</p><p><strong>Conclusions: </strong>The findings indicate association of <i>HTR1F</i> in sleep apnea particularly in the patient population within the non-obese BMI range and provide insight into the growing evidence of serotonin signaling as a factor modulating liability to sleep apnea.</p>","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement.","authors":"Shelsey W Johnson, James C Ross, Pietro Nardelli, Bina Choi, Rebecca R Vanderpool, Carrie Pistenmaa, J Michael Wells, Raul San Jose Estépar, George Washko, Farbod N Rahaghi","doi":"10.1183/13993003.00038-2025","DOIUrl":"https://doi.org/10.1183/13993003.00038-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study.","authors":"Peter G J Burney, Tracey Nguyen, Dhiraj Agarwal, Christer Janson, Rune Nielsen, Padukudru Anand Mahesh, Rain Jögi, Gregory Erhabor, Meriam Denguezli, Karima El Rhazi, James Potts, Asaad A Nafees, Parvaiz Koul, Stefanni N Paraguas, André F S D Amaral","doi":"10.1183/13993003.00690-2025","DOIUrl":"https://doi.org/10.1183/13993003.00690-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement.","authors":"Shelsey W Johnson,James C Ross,Pietro Nardelli,Bina Choi,Rebecca R Vanderpool,Carrie Pistenmaa,J Michael Wells,Raul San Jose Estépar,George Washko,Farbod N Rahaghi","doi":"10.1183/13993003.00038-2025","DOIUrl":"https://doi.org/10.1183/13993003.00038-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"51 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxygen-desaturation burden index in enhancing treatment strategies for childhood sleep apnea.","authors":"Xin Zhang,Yuanyuan Li,Xueying Wu,Peipei Wang,Wei Zhang,Bingjiao Zhao,Yuehua Liu","doi":"10.1183/13993003.00553-2025","DOIUrl":"https://doi.org/10.1183/13993003.00553-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"11 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Respiratory Society and European Sleep Research Society Statement on the treatment of central sleep apnoea with adaptive servo-ventilation.","authors":"Winfried J Randerath,Sophia E Schiza,Michael Arzt,Maria Rosaria Bonsignore,Raphael Heinzer,Carolina Lombardi,Robert Lyssens,Gianfranco Parati,Thomas Penzel,Jean Louis Pepin,Dirk Pevernagie,Silke Ryan,Luca Vignatelli,Esther I Schwarz","doi":"10.1183/13993003.00263-2025","DOIUrl":"https://doi.org/10.1183/13993003.00263-2025","url":null,"abstract":"Adaptive servo-ventilation (ASV) has been considered effective in controlling various forms of central sleep apnoea (CSA) and also any additional obstructive sleep apnoea (OSA) component. However, after the publication of the SERVE-HF study, its use was restricted in patients with systolic heart failure and prevalent CSA and was withheld from many patients with symptomatic CSA. In the meantime, the devices have been further developed and the algorithms adapted, and there is new evidence from randomised controlled trials and observational studies that makes it necessary to re-evaluate some societies' statements on the use of ASV, especially in patients with heart failure and CSA and with the current ASV devices. This short statement is based on a review of the effect of ASV on hard cardiovascular endpoints, echocardiographic parameters and exercise capacity as well as on sleep architecture and sleep quality, symptoms and quality of life (QoL) in patients with CHF. The expert group concludes that ASV has positive effects on CSA and quality of life in various forms of CSA that current ASV devices have no negative effect on hard cardiovascular endpoints and that ASV has positive effects on patient-reported outcomes. Moreover, it is used by TF members after optimal treatment of the underlying disease and after an unsuccessful CPAP trial in patients with heart failure with preserved ejection fraction, but also in patients with LVEF 30-45%. In the latter group, however, initiation is performed in expert centres only. In severe systolic heart failure, ASV is sometimes evaluated in a palliative therapy concept for severely symptomatic patients with CSA.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"91 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study.","authors":"Peter G J Burney,Tracey Nguyen,Dhiraj Agarwal,Christer Janson,Rune Nielsen,Padukudru Anand Mahesh,Rain Jögi,Gregory Erhabor,Meriam Denguezli,Karima El Rhazi,James Potts,Asaad A Nafees,Parvaiz Koul,Stefanni N Paraguas,André F S D Amaral,","doi":"10.1183/13993003.00690-2025","DOIUrl":"https://doi.org/10.1183/13993003.00690-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"18 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between a known diagnosis of tuberculosis and symptom reporting: implications for case detection strategies.","authors":"Alvin Kuo Jing Teo,Khanh Boi Luu,Frances Garden,Cuong Duc Pham,Jennifer Ho,Thu-Anh Nguyen,Guy B Marks,Greg J Fox","doi":"10.1183/13993003.02521-2024","DOIUrl":"https://doi.org/10.1183/13993003.02521-2024","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"23 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxygen-desaturation burden index in enhancing treatment strategies for childhood sleep apnea.","authors":"Xin Zhang, Yuanyuan Li, Xueying Wu, Peipei Wang, Wei Zhang, Bingjiao Zhao, Yuehua Liu","doi":"10.1183/13993003.00553-2025","DOIUrl":"https://doi.org/10.1183/13993003.00553-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}