Alicia Guillien, Sam Bayat, Inès Amine, Anne Boudier, Sarah Lyon-Caen, Joane Quentin, Zoltán Hantos, Séverine Valmary-Degano, Amrit K Sakhi, Cathrine Thomsen, Claire Philippat, Rémy Slama, Valérie Siroux
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引用次数: 0
Abstract
Introduction: Exposure to synthetic phenols is suspected of affecting child respiratory health, but epidemiological findings are not consistent and studies on exposure during infancy are lacking. We aimed to investigate the association between exposure to a mixture of phenols in pregnancy and in infancy and children's respiratory health.
Methods: Among 363 mother-child pairs from the SEPAGES cohort, twelve phenols were measured in weekly-pooled urine samples collected twice during pregnancy (second (T2) and third (T3) trimesters) and in infancy (2 months (M2) and 1 year (Y1)). Children's lung function was assessed through tidal breathing flow-volume loops and nitrogen multiple-breath washout at M2, and standard and intra-breath oscillometry at 3 years. Time-specific phenol exposure profiles were identified through cluster analysis and then studied in association with respiratory health using adjusted regression models.
Results: Two exposure profiles were identified at each point in time, characterized by low versus high levels of several phenol compounds. Overall, high exposure profiles were associated with altered oscillometry parameters at 3 years, particularly between high exposure profile at T2 and higher frequency-dependence of resistance (R7-19) and lower volume-dependence of reactance (ΔX); high exposure profile at M2 and lower reactance at 7 Hz (X7), and high exposure at Y1 and higher area of the reactance curve (AX), resistance at 7 Hz (R7), and volume-dependence of resistance (ΔR).
Conclusion: This study relying on repeated and accurate assessments of phenols exposure provides evidence of the deleterious effects of early-life exposures to a mixture of phenols on lung function in pre-school children.
期刊介绍:
The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.