Early-life exposure to mixture of phenols and respiratory health in pre-school children.

IF 21 1区 医学 Q1 RESPIRATORY SYSTEM
Alicia Guillien, Sam Bayat, Inès Amine, Anne Boudier, Sarah Lyon-Caen, Joane Quentin, Zoltán Hantos, Séverine Valmary-Degano, Amrit K Sakhi, Cathrine Thomsen, Claire Philippat, Rémy Slama, Valérie Siroux
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Abstract

Introduction: Exposure to synthetic phenols is suspected of affecting child respiratory health, but epidemiological findings are not consistent and studies on exposure during infancy are lacking. We aimed to investigate the association between exposure to a mixture of phenols in pregnancy and in infancy and children's respiratory health.

Methods: Among 363 mother-child pairs from the SEPAGES cohort, twelve phenols were measured in weekly-pooled urine samples collected twice during pregnancy (second (T2) and third (T3) trimesters) and in infancy (2 months (M2) and 1 year (Y1)). Children's lung function was assessed through tidal breathing flow-volume loops and nitrogen multiple-breath washout at M2, and standard and intra-breath oscillometry at 3 years. Time-specific phenol exposure profiles were identified through cluster analysis and then studied in association with respiratory health using adjusted regression models.

Results: Two exposure profiles were identified at each point in time, characterized by low versus high levels of several phenol compounds. Overall, high exposure profiles were associated with altered oscillometry parameters at 3 years, particularly between high exposure profile at T2 and higher frequency-dependence of resistance (R7-19) and lower volume-dependence of reactance (ΔX); high exposure profile at M2 and lower reactance at 7 Hz (X7), and high exposure at Y1 and higher area of the reactance curve (AX), resistance at 7 Hz (R7), and volume-dependence of resistance (ΔR).

Conclusion: This study relying on repeated and accurate assessments of phenols exposure provides evidence of the deleterious effects of early-life exposures to a mixture of phenols on lung function in pre-school children.

学龄前儿童早期接触酚类混合物与呼吸系统健康。
人们怀疑暴露于合成酚类物质会影响儿童呼吸系统健康,但流行病学调查结果并不一致,而且缺乏关于婴儿期暴露的研究。我们的目的是调查在妊娠期和婴儿期接触混合酚类物质与儿童呼吸健康之间的关系。方法:在来自SEPAGES队列的363对母婴中,在妊娠中期(T2)和晚期(T3)以及婴儿期(2个月(M2)和1年(Y1)期间每周收集两次尿液样本,对12种酚类物质进行检测。通过M2时的潮汐式呼吸流量-容积循环和氮多次呼吸冲洗,以及3岁时的标准和呼吸内振荡测量来评估儿童的肺功能。通过聚类分析确定时间特异性苯酚暴露概况,然后使用调整后的回归模型研究与呼吸健康的关系。结果:在每个时间点确定了两种暴露概况,其特征是几种酚化合物的低水平与高水平。总体而言,高暴露谱与3年时振荡参数的改变有关,特别是T2时的高暴露谱与更高频率依赖性的电阻(R7-19)和更低体积依赖性的电抗(ΔX)之间的关系。M2处的高曝光曲线和7hz时的低电抗(X7),以及Y1处的高曝光和电抗曲线(AX)的较高区域,7 Hz时的电阻(R7),以及电阻的体积依赖性(ΔR)。结论:这项研究依赖于对酚暴露的重复和准确评估,为早期暴露于混合酚对学龄前儿童肺功能的有害影响提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Respiratory Journal
European Respiratory Journal 医学-呼吸系统
CiteScore
27.50
自引率
3.30%
发文量
345
审稿时长
2-4 weeks
期刊介绍: The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.
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