European Respiratory Journal最新文献

{"title":"Adaptive servo-ventilation for central sleep apnoea in heart failure: where are we?","authors":"Patrick Lévy","doi":"10.1183/13993003.00976-2025","DOIUrl":"https://doi.org/10.1183/13993003.00976-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"4 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just like good wine, European bronchiectasis deserves regional denominations.","authors":"Keshav Mangalick,Leopoldo N Segal","doi":"10.1183/13993003.01020-2025","DOIUrl":"https://doi.org/10.1183/13993003.01020-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"16 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of Interstitial Lung Diseases: A State-of-the-Art Review.","authors":"Nicole Ng,Maria Molina-Molina,Ayodeji Adegunsoye,Raphael Borie,Chad A Newton,Benjamin Raby,David Zhang,Maria Padilla,Bruno Crestani,Marshall S Horwitz,Siobán Keel,Michael F Murray,Andrew B Stergachis,Shandra Knight,Christine K Garcia,Louise V Wain,Ganesh Raghu","doi":"10.1183/13993003.00788-2025","DOIUrl":"https://doi.org/10.1183/13993003.00788-2025","url":null,"abstract":"Advancements in genetics and genomics continue to further our understanding of their contributions to the development of interstitial lung diseases. This state-of-the-art clinical review synthesizes current knowledge of the contribution of genetics when evaluating patients suspected to have ILD. We consider highly penetrant Mendelian disorders as well as common variants conferring smaller risk that act in concert with other genetic and acquired risk factors. Additionally, gene-by-environment and pharmacogenomic interactions are discussed to highlight their impact on disease course. Lastly, the approach to genetic ILDs is reviewed from available testing to future directions.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"8 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of oral anticoagulants on idiopathic pulmonary fibrosis risk and prognosis: a population study.","authors":"Francesca Gonnelli,Heath Heatley,Ursie Smith,Neva Eleangovan,Vidya Navarantam,John Townend,Tamera J Corte,David B Price,Victoria Carter,Martina Bonifazi,Caitlin C Fermoyle,Richard Hubbard","doi":"10.1183/13993003.00432-2025","DOIUrl":"https://doi.org/10.1183/13993003.00432-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"17 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CompEx Asthma: is it time for a change in clinical trials?","authors":"Tom M A Wilkinson,Praveen Akuthota","doi":"10.1183/13993003.00470-2025","DOIUrl":"https://doi.org/10.1183/13993003.00470-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"31 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MACE or Death Risk in Obstructive Sleep Apnoea and the Effect of Positive Airway Pressure.","authors":"Miguel J Divo,Miguel A Martinez-Garcia,Monica Gonzalez,Francisco Campos-Rodriguez,Patricia Lloberes,Marta Marin-Oto,Marta Forner,David Sanz-Rubio,David Nieto,Bartolome R Celli,Jose M Marin, ","doi":"10.1183/13993003.00519-2025","DOIUrl":"https://doi.org/10.1183/13993003.00519-2025","url":null,"abstract":"RATIONALEEvidence regarding the efficacy of positive airway pressure (PAP) therapy in reducing the risks of non-fatal major cardiovascular events (NF-MACE) and mortality in patients with obstructive sleep apnoea (OSA) remains controversial.OBJECTIVESThis study aims to quantify the impact of PAP therapy on these risks and develop a predictive risk estimator.METHODSWe conducted a multicentre, observational, prospective study involving 5358 individuals diagnosed with OSA, with a median follow-up of 14 years (IQR 10-15 years). We derived and validated a risk estimator of NF-MACE (including myocardial infarction, stroke, revascularisation procedures, and congestive heart failure) and all-cause mortality, incorporating PAP adherence alongside clinical and sleep-related data.RESULTSThe cohort's mean (sd) for age was 55±11 years, the Body Mass Index 32.0±5.4 Kg·m-2, and an apnoea-hypopnea index (AHI) of 35 (±22) events/hour; 26% were females, and 1467 (37%) were PAP adherent. Over the follow-up period, 754 participants experienced NF-MACE, while 858 deaths were recorded. Significant predictors included prior cardiovascular events, non-HDL cholesterol ≥200 mg·dL-1, COPD diagnosis, AHI >30 events/hr, and age >60 years. PAP adherence was protective (OR 0.46; 95% CI: 0.38 to 0.56), and the absolute risk reduction varied depending on the baseline risk (median of 16%, IQR 12-18). The risk estimator yielded an AUROC of 0.75 and a Brier score of 0.17, with 64% sensitivity and 75% specificity.CONCLUSIONSPAP therapy is associated with long-term risk reduction of NF-MACE and mortality in OSA patients, while the developed risk estimator enhances clinical decision-making regarding therapy initiation.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"32 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cure for Alpha-1? Novel Therapeutics in Alpha-1 Antitrypsin Deficiency.","authors":"Reem Alluhibi,Aileen Marshall,David A Lomas,John R Hurst","doi":"10.1183/13993003.01101-2025","DOIUrl":"https://doi.org/10.1183/13993003.01101-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"44 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of different inhaled corticosteroid and long-acting bronchodilator combinations on the airway microbiome in patients with severe chronic obstructive pulmonary disease: A randomized trial (MUSIC).","authors":"Hollian Richardson,Daniela Alferes De Lima Headley,Clare Clarke,Abirami Veluchamy,Petra Rauchhaus,Jennifer Pollock,Thomas Pembridge,Diane Cassidy,Holly R Keir,Simon Finch,Furrah Hussain,Margaret Band,Andrew Smith,Manish Patel,Mohammad Paracha,Gourab Choudhury,Devesh Dhasmana,Rekha Chaudhuri,Philip M Short,James D Chalmers","doi":"10.1183/13993003.00287-2025","DOIUrl":"https://doi.org/10.1183/13993003.00287-2025","url":null,"abstract":"INTRODUCTIONThe microbiome is associated with exacerbation risk, quality of life and mortality in COPD. Inhaled corticosteroid (ICS) treatment has been reported to alter the microbiome through modulating host defence. How ICS alters the microbiome and whether effects are equal between different ICS preparations is debated. The aim of the MUSIC trial was to investigate whether commonly used ICS therapies have different effects on the airway microbiome in COPD.METHODSMulticentre randomized controlled trial. After a four-week washout period during which they withdrew from ICS, patients with COPD (FEV1 <50% predicted at baseline and/or a history of 2 or more exacerbations per year) were randomized to one of 4 treatments (budesonide/formoterol 400/12 mcg, fluticasone/salmeterol 500 mcg, fluticasone/salmeterol 250 mcg or aclidinium/formoterol 340/12 mcg, twice daily). Patients were followed-up for 3 months with monthly induced sputum, oropharyngeal and nasopharyngeal swabs for bacterial load and 16S rRNA sequencing to characterise the microbiome. Inflammatory markers were measured in sputum and blood. The primary outcome was bacterial load in oropharyngeal swabs comparing budesonide/formoterol versus fluticasone/salmeterol 500, with sputum bacterial load the key secondary endpoint.RESULTS122 participants started the washout period. ICS withdrawal was poorly tolerated, 61 participants withdrew before randomization with 45 experiencing an exacerbation. 61 patients were randomized. No statistically significant differences were observed for the primary comparison of budesonide/formoterol versus fluticasone/salmeterol 500 in oropharyngeal bacterial load. There was however a significant increase in sputum bacterial load with fluticasone/salmeterol 500 compared to budesonide/formoterol by month 3. This difference was not seen with fluticasone/salmeterol 250. No significant differences in microbiome alpha diversity were observed over time. Adverse events were similar between the groups.CONCLUSIONFluticasone/salmeterol 500 increased sputum but not upper airway bacterial loads. ICS withdrawal was poorly tolerated in severe COPD.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"32 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between a known diagnosis of tuberculosis and symptom reporting: implications for case detection strategies.","authors":"Alvin Kuo Jing Teo, Khanh Boi Luu, Frances Garden, Cuong Duc Pham, Jennifer Ho, Thu-Anh Nguyen, Guy B Marks, Greg J Fox","doi":"10.1183/13993003.02521-2024","DOIUrl":"10.1183/13993003.02521-2024","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filters used for pulmonary function testing.","authors":"Roy T McKay","doi":"10.1183/13993003.00812-2025","DOIUrl":"https://doi.org/10.1183/13993003.00812-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"27 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}