Nicole Ng,Maria Molina-Molina,Ayodeji Adegunsoye,Raphael Borie,Chad A Newton,Benjamin Raby,David Zhang,Maria Padilla,Bruno Crestani,Marshall S Horwitz,Siobán Keel,Michael F Murray,Andrew B Stergachis,Shandra Knight,Christine K Garcia,Louise V Wain,Ganesh Raghu
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Genetics of Interstitial Lung Diseases: A State-of-the-Art Review.
Advancements in genetics and genomics continue to further our understanding of their contributions to the development of interstitial lung diseases. This state-of-the-art clinical review synthesizes current knowledge of the contribution of genetics when evaluating patients suspected to have ILD. We consider highly penetrant Mendelian disorders as well as common variants conferring smaller risk that act in concert with other genetic and acquired risk factors. Additionally, gene-by-environment and pharmacogenomic interactions are discussed to highlight their impact on disease course. Lastly, the approach to genetic ILDs is reviewed from available testing to future directions.
期刊介绍:
The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.