Experimental Aging Research最新文献

{"title":"Cognitive Status is Better in Older Adults under Colchicine Treatment: A Case-Control Study.","authors":"Arzu Okyar Baş, Gözde Kübra Yardımcı, Merve Güner Oytun, Serdar Ceylan, Zeynep Kahyaoğlu, Yelda Öztürk, Süheyla Çöteli, Meltem Gülhan Halil, Mustafa Cankurtaran, Levent Kılıç, Burcu Balam Doğu Yavuz","doi":"10.1080/0361073X.2022.2145164","DOIUrl":"10.1080/0361073X.2022.2145164","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate the effects of colchicine, an important anti-inflammatory agent, on cognitive functions in a geriatric population diagnosed with gout or osteoarthritis by comparing it to non-colchicine users.</p><p><strong>Methods: </strong>138 geriatric patients (67 colchicine users and 71 non-users) were enrolled. Within comprehensive geriatric assessment (CGA), cognitive status assessment via Mini-Mental State Examination test (MMSE), Quick Mild Cognitive Impairment Screening test (Qmci), clock drowning test (CDT), and digit span tests were performed.</p><p><strong>Results: </strong>Median age was 68 (65-72), and there were 82 female (59.4%) patients. The scores of CDT, Backward Digit Span Test, MMSE-Total, MMSE-Attention, MMSE-Motor Function, Qmci-Total Score, Qmci-Clock drawing, and Qmci-Logical Memory were significantly higher in the colchicine user group (p < .005), showing better cognitive function. Adjusted model analysis showed that colchicine usage is independently correlated with higher Qmci-Total Score and Qmci-Logical Memory Score (For Qmci total score β = 7.87 95%CI = 5.48-10.27, p = <0.0001, and for Qmci Logical memory score β = 3.52, 95%CI = 2.12-4.91, p = <0.0001).</p><p><strong>Conclusion: </strong>To the best of our knowledge, this is the first study revealing that colchicine usage is associated with better cognitive performance in older adults. Further investigations with a prospective, larger-sampled and randomized design are needed to show the causal relationship between colchicine and cognition.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40701662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metamemory Mediates the Effects of Age on Episodic and Working Memory across the Adult Lifespan.","authors":"Selene Cansino, Frine Torres-Trejo, Cinthya Estrada-Manilla, Silvia Ruiz Velasco","doi":"10.1080/0361073X.2022.2158004","DOIUrl":"10.1080/0361073X.2022.2158004","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have examined the direct relationship between metamemory and memory performance in young and older adults, but the results of these studies have been inconsistent. Therefore, we examined whether metamemory mediates the effects of age on memory performance.</p><p><strong>Methods: </strong>We examined episodic memory and working memory through computerized tasks performed by a lifespan sample of 1554 healthy adults. Seven metamemory traits were measured with the Metamemory in Adulthood (MIA) questionnaire. Separate structural equation modeling analyses were conducted to investigate potential metamemory mediators that intervened between age and the accuracy and speed of accessing information from episodic and working memory.</p><p><strong>Results: </strong>The use of internal or external strategies mediated the effects of age on episodic memory and spatial working memory performance. The perception of one's own memory capacity and the experience of anxiety when using memory functions mediated the effects of age on working memory performance in both domains.</p><p><strong>Conclusions: </strong>Metamemory traits have the power to strengthen or weaken the course of episodic and working memory decline throughout adulthood.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10325586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Memory-Relevant versus Memory-Irrelevant Aging Stereotypes Differentially Affects Memory Self-Perceptions and Memory Test Scores of Young, Middle, and Older Age Adults.","authors":"Tara T Lineweaver, Annie C Wetli, Coty Nicoson, Ashley J Tucker, Christopher Hertzog","doi":"10.1080/0361073X.2023.2295202","DOIUrl":"https://doi.org/10.1080/0361073X.2023.2295202","url":null,"abstract":"<p><p>This study examined the combined influence of assimilation and contrast effects on the memory self-efficacy and objective memory of young (ages 18-25, <i>n</i> = 114), middle-age (ages 26-59, <i>n</i> = 48), and older (ages 60-98, <i>n</i> = 59) adults. We reminded participants that they matched positive, not negative, memory-relevant or memory-irrelevant stereotypes of aging either before (experimental conditions) or after (control condition) they completed a memory self-efficacy questionnaire and took a memory test. Participants exposed to memory-relevant aging stereotypes prior to other measures reported higher memory self-efficacy than those exposed to memory-irrelevant stereotypes; this effect did not depend on age group. In contrast, the effect of stereotype exposure on memory performance differed with age. Young and older, but not middle-aged, adults showed differences in their memory scores depending on whether they were exposed to memory-relevant, memory-irrelevant or no aging stereotypes. In general, exposure to stereotypes (particularly those relevant to memory) had a negative influence on memory that contrasted with its positive effect on memory self-efficacy. Together, these results indicate that exposure to aging stereotypes can have opposing effects on the memory self-efficacy and objective test performance of adults of various ages and that the relevance of the stereotypes to the cognitive domain being assessed matters.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congruent Prosody Reduces Cognitive Effort in Memory for Spoken Sentences: A Pupillometric Study with Young and Older Adults","authors":"Ryan M. O’Leary, Nicole M. Amichetti, Zoe Brown, Alexander J. Kinney, Arthur Wingfield","doi":"10.1080/0361073x.2023.2286872","DOIUrl":"https://doi.org/10.1080/0361073x.2023.2286872","url":null,"abstract":"In spite of declines in working memory and other processes, older adults generally maintain good ability to understand and remember spoken sentences. In part this is due to preserved knowledge of l...","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD, Dietary Fiber Intake, and Cognitive Performance in Older Adults: A Cross-Sectional Study from NHANES 2011-2014.","authors":"Songlan Liang, Xu Han, Shuang Diao, Hui Li","doi":"10.1080/0361073X.2023.2286874","DOIUrl":"https://doi.org/10.1080/0361073X.2023.2286874","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the modifying role of dietary fiber intake in the relationship between COPD and cognitive performance.</p><p><strong>Methods: </strong>Data of adults aged ≥60 years were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Participants with information on cognitive function measures were included. Dietary fiber intake, identified using participants' 24-h recall surveys, was grouped into high (>25 g/day) and low (≤25 g/day) levels. COPD was identified through self-reported physician diagnoses. Associations between dietary fiber intake, cognitive function and COPD were evaluated using the regression analysis.</p><p><strong>Results: </strong>Data of 2,189 participants were analyzed. Multivariate analysis revealed that COPD was significantly associated with lowered CERAD (adjusted beta [aBeta]: -0.17, 95% confidence interval [CI]: -0.33 to -0.002, <i>p</i> = .047) and DSST (aBeta: -2.23, 95% CI: -4.25 to -0.2, <i>p</i> = .032) scores in older adults. The analysis on the association between COPD and cognitive function stratified by dietary fiber intake revealed that COPD remained significantly associated with lowered CREAD among individuals with a high fiber intake (aBeta: -0.54, 95% CI: -1.00 to -0.08, <i>p</i> = .024).</p><p><strong>Conclusions: </strong>In US older adults, COPD is associated with reduced cognitive function. However, the findings do not support that high dietary fiber intake may modify the association between COPD and cognitive impairment.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Quality of Life and Depressive Symptoms Among Jordanian Community-Dwelling Older Adults.","authors":"Malakeh Z Malak, Anas H Khalifeh","doi":"10.1080/0361073X.2023.2286873","DOIUrl":"https://doi.org/10.1080/0361073X.2023.2286873","url":null,"abstract":"<p><strong>Objective: </strong>The current study aimed to examine the relationship between depressive symptoms and quality of life among Jordanian community-dwelling older adults.</p><p><strong>Methods: </strong>A cross-sectional, descriptive correlational design was used. A convenience sample (<i>N</i> = 602) was selected to recruit the participants in the Amman governorate during the period from August to November 2021.</p><p><strong>Results: </strong>Findings demonstrated that the mean (SD) age of older adults was 67.5 (7.0) years and 51.5% of participants were females. Also, 54.1% of the participants experienced moderate to severe depressive symptoms with a total mean (SD) score was 8.57 on a scale of 0 to 15, while the mean (SD) for the quality of life scale was 12.12 (3.85) on a scale of 4 to 20. Significant differences existed in quality of life and depressive symptoms based on marital status (<i>p</i> < .001), educational level (<i>p</i> < .001), working status (<i>p</i> < .01), income (<i>p</i> < .001), and chronic disease (<i>p</i> < .01). Quality of life and its domains were negatively associated with depressive symptoms (B= - 0.596, <i>p</i> < .001). Also, marital status, working, educational level, income, and chronic disease were associated with depressive symptoms.</p><p><strong>Conclusion: </strong>Strategies to improve quality of life should be promoted to minimize depressive symptoms among older adults and consider significant demographic factors.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older Adults Show Intraindividual Variation in the Use of Predictive Processing.","authors":"Suzanne R Jongman, Allyson Copeland, Yaqi Xu, Brennan R Payne, Kara D Federmeier","doi":"10.1080/0361073X.2022.2137358","DOIUrl":"10.1080/0361073X.2022.2137358","url":null,"abstract":"<p><strong>Background: </strong>The use of prediction can aid language comprehension through preactivation of relevant word features. However, predictions can be wrong, and it has been proposed that resolving the mismatch between the predicted and presented item requires cognitive resources. Older adults tend not to predict and instead rely more on passive comprehension. Here, we tested, using an intraindividual approach, whether older adults consistently use this less demanding processing strategy while reading or whether they attempt to predict on some trials.</p><p><strong>Methods: </strong>We used a cross-task conflict paradigm. Younger and older participants self-paced to read sentences that ended with either an expected or unexpected word. Each sentence was then followed by a flanker stimulus that could be congruent or incongruent. We examined responses within and across the two tasks.</p><p><strong>Results: </strong>Unexpected words were in general read as quickly as expected words, indicating that typical processing of these words was similar. However, for both younger and older adults, there was a greater proportion of very slow trials for unexpected words, revealing different processing on a subset of trials. Critically, in older adults, these slowly read unexpected words engaged control, as seen in speeded responses to incongruent flanker stimuli.</p><p><strong>Conclusion: </strong>Using a cross-task conflict paradigm, we showed that older adults are able to predict and engage cognitive resources to cope with prediction violations, but do not opt to use these processes consistently.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10024197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of whole-course nutrition management on accelerated recovery in elderly patients with bladder cancer","authors":"Wenwen Fu, Lina Zhang","doi":"10.26599/agr.2023.9340014","DOIUrl":"https://doi.org/10.26599/agr.2023.9340014","url":null,"abstract":"<sec><strong>Objective</strong> The purpose of this article is to explore the effect of whole-course nutrition management on accelerated recovery in elderly patients with bladder cancer. </sec><sec><strong>Results</strong> 126 elderly patients with bladder cancer completed the study (<i>N</i>_{accelerated rehabilitation} = 63; <i>N</i>_control = 63). The levels of albumin, prealbumin, and hemoglobin accelerated rehabilitation group were significantly higher than those in control group (<i>P</i> < 0.05), the albumin supplementation amount, intensive care unit (ICU) monitoring time, and hospitalization cost in the accelerated rehabilitation group were lower than those in the control group, with statistically significant differences (<i>P</i> < 0.05). The postoperative complication rate of patients in the accelerated rehabilitation group was lower than that of the control group. There was no significant difference between the two groups in body composition body mass index (BMI), actual weight, body fat volume, body fat percentage, fat free weight, visceral fat area Basal metabolic rate, ratio of total body water to protein weight, waist circumference, phase angle (<i>P</i> > 0.05), The degree of loss of skeletal muscle, body water, intracellular water, protein, and body cell mass in accelerated rehabilitation group was lower than that in control group (<i>P</i> < 0.05). </sec><sec><strong>Conclusion</strong> The whole-course nutrition management had a positive effect on accelerated recovery in elderly bladder cancer patients. </sec><sec><strong>Methods</strong> 126 elderly patients with bladder cancer were randomly divided into an accelerated rehabilitation group (accelerated recovery surgery group) and a control group (traditional treatment group). The baseline values were registered. After admission, the postoperative hematological indicators (albumin, prealbumin, and hemoglobin), and postoperative related indicators (albumin supplementation, postoperative complication rate, ICU monitoring time, and total hospitalization costs) were recorded to simultaneously measure the differences in body composition between two groups of patients. </sec>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136010253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The connotation and path of sports promoting \"proactive health\" strategy","authors":"Huiru Wang, Jiachen Liu","doi":"10.26599/agr.2023.9340011","DOIUrl":"https://doi.org/10.26599/agr.2023.9340011","url":null,"abstract":"In response to an aging population and the accelerated transition from a disease-centered approach to a people's health-centered approach, proactive health has become an essential component of China's future health security system. Sports are a significant part of the proactive health strategy. Using Citespace 6.2.2 visualization analysis software, 211 effective documents were visually analyzed. It is believed that the focal points for implementing the \"proactive health\" strategy include: 1. Insisting on \"moving the focus upstream\" to curb diseases at their budding stage; 2. Dialectically viewing the aging population, regarding the elderly from a \"positive perspective\"; 3. Creating a proactive health environment and improve the proactive health security system; 4. Popularizing health knowledge scientifically, promoting the health literacy and health behaviors of the elderly.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of aging-related genes in <i>Helicobacter pylori</i> infection","authors":"Honghao Li, Yuanyuan Deng, Honglie Zeng, Shaowei Cai, Ming Xu, Hongli Zhao","doi":"10.26599/agr.2023.9340013","DOIUrl":"https://doi.org/10.26599/agr.2023.9340013","url":null,"abstract":"<sec><strong>Background</strong> <i> Helicobacter pylori</i> (HP) infection is common worldwide, leading to many systemic diseases. The reasons for aging have been explored, but there is no unified conclusion. The aim of this study was to explore aging-related genes involved in HP infection. </sec><sec><strong>Results</strong> A total of 70 aging-related differentially expressed genes (DEGs) were identified between HP infection and control groups, including 64 upregulated genes and 6 downregulated genes. Functional enrichment analysis revealed that multiple signaling pathways are closely linked to HP infection. In addition, the cytoHubba plugin identified 10 important hub genes, namely, ITGB2, PTPRC, HCLS1, LAPTM5, CD53, LYN, HLA-DRA, HLA-DPA1, HLA-DQB1, and CXCL8. Additionally, the correlation analysis of immune cell fractions revealed that immune infiltration plays an important role in HP infection. The nomogram containing CD53, ITGB2, and CXCL8 confirmed the favorable prediction ability of HP infection. </sec><sec><strong>Conclusion</strong> Ten aging-related hub genes involved in HP infection were identified. This study revealed an association between aging and HP infection, and they may have a causal relationship. </sec><sec><strong>Methods</strong> Microarray data for HP infection were obtained from the Gene Expression Omnibus (GEO) database. Aging-related genes were obtained from the Molecular Signature Database (<a ext-link-type=\"uri\" href=\"https://www.gsea-msigdb.org\">https://www.gsea-msigdb.org</a>). Differential gene expression analysis was analysed using R software and the limma package to find DEGs. In addition, functional enrichment analysis of DEGs by using GO and KEGG and construction of protein‒protein interactions (PPIs) and hub genes were determined by using the STRING database and Cytoscape software. Additionally, immune infiltration and difference analysis between HP infection and control groups were performed with R software. A nomogram was constructed to predict the risk of infection with HP by using some hub genes that were strongly correlated with neutrophils. </sec>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}