Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats.

IF 1.4 4区 医学 Q4 GERIATRICS & GERONTOLOGY
Experimental Aging Research Pub Date : 2024-07-01 Epub Date: 2023-05-08 DOI:10.1080/0361073X.2023.2210240
Farimah Beheshti, Arefeh Vakilian, Mohsen Navari, Mostafa Zare Moghaddam, Hossein Dinpanah, S Mohammad Ahmadi-Soleimani
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引用次数: 0

Abstract

The present study was conducted to investigate the effects of Ocimum basilicum L. (OB) extract on learning and memory impairment in aged rats. Male rats were divided into the following experimental groups: Group 1 (control): including 2 months old rats, Group 2 (aged) including 2 years old rats, Groups 3-5 (aged-OB): including 2 years old rats received 50, 100, and 150 mg/kg OB for 8 weeks by oral gavage. Aging increased the delay to find the platform but, however, decreased the time spent in the target quadrant when tested by Morris water maze (MWM). Aging also reduced the latency to enter the dark chamber in the passive avoidance (PA) test compared to the control group. Moreover, interleukin-6 (IL-6) and malondialdehyde (MDA) levels were raised in the hippocampus and cortex of aged rats. In contrast, thiol levels and enzymatic activity of superoxide dismutase (SOD) and catalase (CAT) significantly reduced. In addition, aging significantly reduced BDNF expression. Finally, OB administration reversed the mentioned effects. The current research showed that OB administration improves learning/memory impairment induced by aging. It also found that this plant extract protects the brain tissues from oxidative damage and neuroinflammation.

欧鼠李提取物对失忆老年大鼠海马氧化应激、炎症和BDNF表达的影响
本研究旨在探讨欧加马罗勒提取物(Ocimum basilicum L.,OB)对老年大鼠学习和记忆损伤的影响。雄性大鼠被分为以下实验组:第1组(对照组):包括2个月大的大鼠;第2组(老龄组):包括2岁大的大鼠;第3-5组(老龄-OB组):包括2岁大的大鼠。在莫里斯水迷宫(MWM)测试中,衰老增加了大鼠找到平台的延迟时间,但减少了大鼠在目标象限的停留时间。与对照组相比,老龄化还降低了被动回避(PA)测试中进入暗室的延迟时间。此外,老龄大鼠海马和皮层中的白细胞介素-6(IL-6)和丙二醛(MDA)水平升高。相反,硫醇水平以及超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的酶活性明显降低。此外,衰老还明显降低了 BDNF 的表达。最后,服用 OB 可逆转上述影响。目前的研究表明,服用 OB 可以改善衰老引起的学习/记忆障碍。研究还发现,这种植物提取物能保护脑组织免受氧化损伤和神经炎症。
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来源期刊
Experimental Aging Research
Experimental Aging Research 医学-老年医学
CiteScore
3.60
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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