FEMS microbiology reviews最新文献_第7页

Feeding the invaders: how metabolic imbalance shapes infection and biofilm development. 喂养入侵者：代谢不平衡如何影响感染和生物膜的发育。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag029

Sahil Mahajan, Sarah MacDowell, Cortney Mitchem, Evan Alexander, Daniel J Wozniak

{"title":"Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.","authors":"Sahil Mahajan, Sarah MacDowell, Cortney Mitchem, Evan Alexander, Daniel J Wozniak","doi":"10.1093/femsre/fuag029","DOIUrl":"10.1093/femsre/fuag029","url":null,"abstract":"Infectious and metabolic disorders have risen sharply and pose a significant threat to human populations worldwide. Despite being deemed unrelated, mounting evidence indicates that metabolic disorders markedly heightened both the likelihood and severity of infectious disease. The mechanism underlying this association is only beginning to be appreciated and involves a complex interaction between altered metabolic state, pathogen virulence mechanisms, and immune effector pathways. Here, we highlight that a dysregulated metabolic environment disrupts homeostasis, creating a nutrient-rich, immunocompromised milieu that promotes bacterial survival and replication in the host. Metabolic dysfunction is also discussed as a factor that promotes bacterial persistence by altering reactive oxygen species production and inducing tissue hypoxia, conditions that favor biofilm growth. We also examine how bacteria directly exploit nutrient surplus in metabolic diseases to boost their virulence programs and biofilm formation. Moreover, given the ever-increasing problem of antibiotic resistance, we discuss how metabolic diseases contribute to this challenge. Collectively, uncovering how metabolic disorders increase chronic or recurrent infections can guide the development of effective treatment strategies.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral receptors as host-pathogen control nodes linking entry, signalling, and system-level pathogenesis. 病毒受体作为宿主-病原体控制节点连接入口、信号传导和系统级发病机制。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag043

Salvatore Furnari, Guido Attilio Condorelli, Giorgio Gallinella, Virginia Fuochi, Pio Maria Furneri

{"title":"Viral receptors as host-pathogen control nodes linking entry, signalling, and system-level pathogenesis.","authors":"Salvatore Furnari, Guido Attilio Condorelli, Giorgio Gallinella, Virginia Fuochi, Pio Maria Furneri","doi":"10.1093/femsre/fuag043","DOIUrl":"10.1093/femsre/fuag043","url":null,"abstract":"Viral receptors have traditionally been viewed as docking sites that mediate viral attachment and entry. However, this perspective no longer captures the full complexity of receptor function during infection. Receptor engagement links viral binding to intracellular trafficking, signal transduction, barrier integrity, and ultimately disease outcome. Rather than acting solely as entry determinants, receptors influence endocytic routing, cellular permissiveness, tissue tropism, immune responses, and systemic dissemination. A functional distinction between attachment factors, entry receptors, co-receptors or accessory factors, and receptor-like immune sensors is essential for accurate mechanistic interpretation and translational applications. This review examines the events that follow receptor engagement, including intracellular routing, signalling, regulation of receptor availability, and host determinants of susceptibility. Particular emphasis is placed on the concept of receptor landscapes, defined as dynamic and spatially organized receptor topologies across epithelial and endothelial barriers that are shaped by development, ageing, inflammation, and comorbidities. In this view, systemic disease is viewed as the consequence of failures in receptor-defined barriers and interconnected feedback circuits across organs. Finally, we discuss the implications of this perspective for host-directed therapies, receptor decoys, and biomarker development. Reframing receptors as regulatory hubs helps explain differences in viral tropism and disease severity and highlights new opportunities for host-targeted intervention.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148790134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary mechanisms underlying bacterial adaptation to the plant environment. 细菌适应植物环境的进化机制。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag005

Zaki Saati-Santamaría, Daniel Pérez-Mendoza, Muhammad Khashi U Rahman, Bruna Fernanda Silva de Sousa, Maria Del Carmen Montero-Calasanz, Luis Rey, Sonali Roy, Juan Sanjuán, Paula García-Fraile

引用次数: 0

Stepping out of the dark: how metabolomics shed light on fungal biology. 走出黑暗：代谢组学如何揭示真菌生物学。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-06-14 DOI: 10.1093/femsre/fuaf028

John Adejor, Elisabeth Tumukunde, Guoqi Li, Tanimu Alhaji Shehu, Lihan Wu, Zhiwei Jiang, Shihua Wang

{"title":"Stepping out of the dark: how metabolomics shed light on fungal biology.","authors":"John Adejor, Elisabeth Tumukunde, Guoqi Li, Tanimu Alhaji Shehu, Lihan Wu, Zhiwei Jiang, Shihua Wang","doi":"10.1093/femsre/fuaf028","DOIUrl":"10.1093/femsre/fuaf028","url":null,"abstract":"Metabolomics, a critical tool for analyzing small-molecule metabolites, integrates with genomics, transcriptomics, and proteomics to provide a systems-level understanding of fungal biology. By mapping metabolic networks, it elucidates regulatory mechanisms driving physiological and ecological adaptations. In fungal pathogenesis, metabolomics reveals host-pathogen dynamics, identifying virulence factors like gliotoxin in Aspergillus fumigatus and metabolic shifts, such as glyoxylate cycle upregulation in Candida albicans. Ecologically, it highlights fungal responses to abiotic stressors, including osmolyte production like trehalose, enhancing survival in extreme environments. These insights highlight metabolomics' role in decoding fungal persistence and niche colonization. In drug discovery, it aids target identification by profiling biosynthetic pathways, supporting novel antifungal and nanostructured therapy development. Combined with multi-omics, metabolomics advances insights into fungal pathogenesis, ecological interactions, and therapeutic innovation, offering translational potential for addressing antifungal resistance and improving treatment outcomes for fungal infections. Its progress shed light on complex fungal molecular profiles, advancing discovery and innovation in fungal biology.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back. 糖酵解途径从自养起源到糖原再返回的早期进化。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf049

Luca D Modjewski, Ulrike Johnsen, Peter Schönheit, William F Martin

{"title":"The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back.","authors":"Luca D Modjewski, Ulrike Johnsen, Peter Schönheit, William F Martin","doi":"10.1093/femsre/fuaf049","DOIUrl":"10.1093/femsre/fuaf049","url":null,"abstract":"Glycolysis stops where gluconeogenesis starts-at pyruvate, the central metabolite of biosynthesis. The early history of carbon metabolism is preserved in archaeal and bacterial enzymes for glucose synthesis and breakdown. Here, we summarize the distribution and phylogeny of enzymes involved in glycolysis, gluconeogenesis, and glycogen metabolism from genomes of cultured prokaryotes. The presence of glycolytic pathways in H2-dependent chemolithoautotrophs, including methanogens, which cannot grow on exogenous glucose, correlates with their use of glycogen for intracellular carbon storage. Glycogen synthesis and gluconeogenesis are universal among prokaryotes, but glycolysis is not, indicating that the enzymatic conversions of glycolysis arose in the gluconeogenic direction encompassing three phases: (1) an autotrophic origin from H2 and CO2 to pyruvate and triosephosphate (trunk glycolysis) fulfilling basic amino acid and cofactor synthesis in the last universal common ancestor, (2) from triosephosphate to glucose supplying cell wall (murein and pseudomurein) and nucleic acid biosynthetic requirements in the first free-living autotrophs, also giving rise to intracellular carbon reserves (glycogen), followed by (3) diversification and transfer of enzymes for glycogen-mobilizing glycolytic routes. An autotrophic origin of trunk glycolysis followed by glycogen-dependent origin of glucose utilization account for conservation, distribution, and diversity of enzymes observed in microbial sugar phosphate pathways.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12525153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defective but tumorigenic: the evolutionary and functional roles of mutated oncoviruses. 缺陷但致瘤性：突变癌病毒的进化和功能作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf048

Yoshitaka Sato, Yusuke Okuno, Takayuki Murata, Hiroshi Kimura

{"title":"Defective but tumorigenic: the evolutionary and functional roles of mutated oncoviruses.","authors":"Yoshitaka Sato, Yusuke Okuno, Takayuki Murata, Hiroshi Kimura","doi":"10.1093/femsre/fuaf048","DOIUrl":"10.1093/femsre/fuaf048","url":null,"abstract":"Human oncogenic viruses contribute significantly to the global health burden and include seven types: Epstein-Barr virus, hepatitis B virus, human T-cell leukemia virus type 1, human papillomavirus, hepatitis C virus, Kaposi's sarcoma-associated herpesvirus, and Merkel cell polyomavirus. While the roles of latent or integrated viral genomes in cancer have been documented, emerging evidence highlights the contribution of defective viruses-those carrying intragenic deletions or loss-of-function mutations-in promoting viral oncogenesis. These altered genomes often lack genes essential for lytic replication or immune recognition, which enhances their persistence and immune evasion. In virus-associated diseases, specific patterns of gene retention and deletion suggest that host-driven selective pressures drive the emergence of these altered genomes. This review examines the generation, prevalence, and functional impact of these viruses, reframing them as active participants in disease development and progression. Recognizing their role offers new insights into viral tumor evolution and creates opportunities for applications in viral diagnostics and targeted intervention strategies.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Forging new paths in bacterial motility and sensory transduction: highlights from BLAST XVIII. 修正：细菌运动和感觉转导的新途径：BLAST XVIII的亮点。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf050

引用次数: 0

Multidisciplinary methodologies used in the study of cable bacteria. 电缆细菌研究中使用的多学科方法。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuae030

Michaela M H Wawryk, Philip Ley, Diana Vasquez-Cardenas, Rico F Tabor, Perran L M Cook

引用次数: 0

Electrical signaling in fungi: past and present challenges. 真菌中的电信号：过去和现在的挑战。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf009

Matteo Buffi, Julia M Kelliher, Aaron J Robinson, Diego Gonzalez, Guillaume Cailleau, Justine A Macalindong, Eleonora Frau, Silvia Schintke, Patrick S G Chain, Claire E Stanley, Markus Künzler, Saskia Bindschedler, Pilar Junier

{"title":"Electrical signaling in fungi: past and present challenges.","authors":"Matteo Buffi, Julia M Kelliher, Aaron J Robinson, Diego Gonzalez, Guillaume Cailleau, Justine A Macalindong, Eleonora Frau, Silvia Schintke, Patrick S G Chain, Claire E Stanley, Markus Künzler, Saskia Bindschedler, Pilar Junier","doi":"10.1093/femsre/fuaf009","DOIUrl":"10.1093/femsre/fuaf009","url":null,"abstract":"Electrical signaling is a fundamental mechanism for integrating environmental stimuli and coordinating responses in living organisms. While extensively studied in animals and plants, the role of electrical signaling in fungi remains a largely underexplored field. Early studies suggested that filamentous fungi generate action potential-like signals and electrical currents at hyphal tips, yet their function in intracellular communication remained unclear. Renewed interest in fungal electrical activity has fueled developments such as the hypothesis that mycorrhizal networks facilitate electrical communication between plants and the emerging field of fungal-based electronic materials. Given their continuous plasma membrane, specialized septal pores, and insulating cell wall structures, filamentous fungi possess architectural features that could support electrical signaling over long distances. However, studying electrical phenomena in fungal networks presents unique challenges due to the microscopic dimensions of hyphae, the structural complexity of highly modular mycelial networks, and the limitations of traditional electrophysiological methods. This review synthesizes current evidence for electrical signaling in filamentous fungi, evaluates methodological approaches, and highlights experimental challenges. By addressing these challenges and identifying best practices, we aim to advance research in this field and provide a foundation for future studies exploring the role of electrical signaling in fungal biology.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helminth infections affect host immune responses to viral infections and vaccines. 蠕虫感染影响宿主对病毒感染和疫苗的免疫反应。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf036

Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert

{"title":"Helminth infections affect host immune responses to viral infections and vaccines.","authors":"Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert","doi":"10.1093/femsre/fuaf036","DOIUrl":"10.1093/femsre/fuaf036","url":null,"abstract":"Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficient immunomodulators of their hosts. This modulation often leads to skewed or even impaired immune responses against unrelated antigens, such as viruses and vaccines, which can be both beneficial and detrimental for the host. The extent of these effects and the impact on the outcomes of viral infection depends on a variety of factors including timing and tropism of both infections, pathological mechanisms, genetic background, and environmental factors. In this review, we dissect these complex interactions between virus and helminths in the context of coinfection and the impact of helminth infection on antiviral vaccine efficacy. We characterize the key contributing mechanisms that have been defined in preclinical models and human trials and describe the immune actors involved in the modulation of the antiviral and vaccine immune response by helminths. Finally, we address the limitations of our current understanding of helminth-virus interactions.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0