FEMS microbiology reviews最新文献

Exploring Antiviral Strategies to Combat African Swine Fever. 探索对抗非洲猪瘟的抗病毒策略。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-09-08 DOI: 10.1093/femsre/fuaf044

Ana Catarina Urbano, Beatriz Melo, Fernando Ferreira

{"title":"Exploring Antiviral Strategies to Combat African Swine Fever.","authors":"Ana Catarina Urbano, Beatriz Melo, Fernando Ferreira","doi":"10.1093/femsre/fuaf044","DOIUrl":"https://doi.org/10.1093/femsre/fuaf044","url":null,"abstract":"African Swine Fever (ASF), caused by the highly contagious African swine fever virus (ASFV), poses a significant threat to domestic and wild pigs worldwide. Despite its limited host range and lack of zoonotic potential, ASF has severe socio-economic and environmental consequences. Current control strategies primarily rely on early detection and culling of infected animals, but these measures are insufficient given the rapid spread of the disease. Developing effective therapeutics against ASFV is crucial to prevent further spread and mitigate economic losses. Although vaccination remains critical, recent vaccine approvals in Vietnam have raised safety and efficacy concerns. Moreover, as challenges persist in vaccine development and deployment, particularly in complex field conditions, antiviral agents have emerged as a critical complementary approach. These agents have the potential to mitigate side effects and control viral spread when vaccines alone are insufficient or when animals face simultaneous exposure to vaccine strains and wild-type viruses. However, advancing them from proof-of-concept to widespread practical application entails a significant interdisciplinary effort, given the logistical and economic constraints of in vivo testing. In this review, we examine emerging antiviral approaches and highlight key ASFV replication mechanisms and therapeutic targets to guide rational drug design amidst an evolving viral landscape.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-translational Modifications of the Nucleoid Protein H-NS: Sites, Mechanisms, and Regulatory Cues. 类核蛋白H-NS的翻译后修饰：位点、机制和调控线索。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-09-05 DOI: 10.1093/femsre/fuaf045

Yabo Liu, Xiaoxue Wang

引用次数: 0

Exploring the multilayered response of TB bacterium Mycobacterial tuberculosis to lysosomal injury. 探讨结核分枝杆菌对溶酶体损伤的多层反应。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-09-02 DOI: 10.1093/femsre/fuaf040

Mohd Shariq, Javaid Ahmad Sheikh, Asrar Ahmad Malik, Anwar Alam, Peter N Monk, Seyed E Hasnain, Nasreen Z Ehtesham

{"title":"Exploring the multilayered response of TB bacterium Mycobacterial tuberculosis to lysosomal injury.","authors":"Mohd Shariq, Javaid Ahmad Sheikh, Asrar Ahmad Malik, Anwar Alam, Peter N Monk, Seyed E Hasnain, Nasreen Z Ehtesham","doi":"10.1093/femsre/fuaf040","DOIUrl":"https://doi.org/10.1093/femsre/fuaf040","url":null,"abstract":"Mtb subverts host immune surveillance by damaging phagolysosomal membranes, exploiting them as replication niches. In response, host cells initiate a coordinated LDR, integrating membrane repair, selective autophagy, and de novo biogenesis. This review delineates a systems-level model of lysosomal quality control governed by three critical regulatory axes: LGALS3/8/9, TRIM E3 ubiquitin ligases, and the AMPK-TFEB signaling pathway. LGALSs detect exposed glycans on ruptured membranes, triggering ESCRT-mediated repair and recruiting ARs. TRIM proteins mediate context-specific ubiquitination, enhancing cargo selection and facilitating transcriptional reprogramming via TFEB. Simultaneously, AMPK-TFEB signaling links metabolic stress to lysosomal regeneration, reinforcing immune defense and cellular adaptation. We highlight emerging mechanisms, including ATG8ylation, CASM, Ca2 + leakage, and SG formation, that refine this multilayered response. Mtb virulence factors selectively disrupt these pathways, revealing their relevance to pathogen persistence. Beyond infection, this triadic network maintains lysosomal integrity in neurodegeneration, inflammation, and lysosomal storage disorders. Understanding its modular design reveals novel therapeutic targets and HDTs for combatting drug-resistant TB. This review integrates recent advances into a coherent framework that redefines lysosomal function as a dynamic, immune-regulatory hub essential for cellular resilience under infectious and metabolic stress.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradation of synthetic organic pollutants: principles, progress, problems, and perspectives. 合成有机污染物的生物降解：原理、进展、问题与展望。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-08-29 DOI: 10.1093/femsre/fuaf043

Yue Huang, Yu Deng, Ke Yu, Bing Li, Tong Zhang

引用次数: 0

Hallmarks of DNA replication stress responses in Escherichia coli and Bacillus subtilis. 大肠杆菌和枯草芽孢杆菌DNA复制应激反应的特征。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-08-28 DOI: 10.1093/femsre/fuaf041

Rubén Torres, Begoña Carrasco, Silvia Ayora, Juan C Alonso

{"title":"Hallmarks of DNA replication stress responses in Escherichia coli and Bacillus subtilis.","authors":"Rubén Torres, Begoña Carrasco, Silvia Ayora, Juan C Alonso","doi":"10.1093/femsre/fuaf041","DOIUrl":"https://doi.org/10.1093/femsre/fuaf041","url":null,"abstract":"Escherichia coli and Bacillus subtilis provide well-studied models for understanding how bacteria manage DNA replication stress (RS). These bacteria employ various strategies to detect and stabilize stalled replication forks (RFs), circumvent or bypass lesions, resolve replication-transcription conflicts (RTCs), and resume replication. While central features of responses to RS are broadly conserved, distinct mechanisms have evolved to adapt to their complex environments. In this review, we compare the RS sensors, regulators, and molecular players of these two phylogenetically distant bacteria. The differing roles of the RecA recombinase are used as the touchstone of the distinct strategies each bacterium employs to overcome RS, provided that the fork does not collapse. In E. coli, RecA mainly assembles at locations distal from replisomes, promotes global responses, and contributes to circumvent or bypass lesions. RecA assembles less frequently at stalled RFs, and its role in lesion skipping, fork remodeling, RTC resolution, and replication restart remains poorly defined. In contrast, in B. subtilis, RecA assembles at stalled forks, fine-tunes damage signaling, and, in concert with RecA-interacting proteins, may facilitate fork remodeling or lesion bypass, overcome RTCs, and contribute to replication restart.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stepping out of the dark: how metabolomics shed light on fungal biology. 走出黑暗：代谢组学如何揭示真菌生物学。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-06-14 DOI: 10.1093/femsre/fuaf028

John Adejor, Elisabeth Tumukunde, Guoqi Li, Tanimu Alhaji Shehu, Lihan Wu, Zhiwei Jiang, Shihua Wang

{"title":"Stepping out of the dark: how metabolomics shed light on fungal biology.","authors":"John Adejor, Elisabeth Tumukunde, Guoqi Li, Tanimu Alhaji Shehu, Lihan Wu, Zhiwei Jiang, Shihua Wang","doi":"10.1093/femsre/fuaf028","DOIUrl":"10.1093/femsre/fuaf028","url":null,"abstract":"Metabolomics, a critical tool for analyzing small-molecule metabolites, integrates with genomics, transcriptomics, and proteomics to provide a systems-level understanding of fungal biology. By mapping metabolic networks, it elucidates regulatory mechanisms driving physiological and ecological adaptations. In fungal pathogenesis, metabolomics reveals host-pathogen dynamics, identifying virulence factors like gliotoxin in Aspergillus fumigatus and metabolic shifts, such as glyoxylate cycle upregulation in Candida albicans. Ecologically, it highlights fungal responses to abiotic stressors, including osmolyte production like trehalose, enhancing survival in extreme environments. These insights highlight metabolomics' role in decoding fungal persistence and niche colonization. In drug discovery, it aids target identification by profiling biosynthetic pathways, supporting novel antifungal and nanostructured therapy development. Combined with multi-omics, metabolomics advances insights into fungal pathogenesis, ecological interactions, and therapeutic innovation, offering translational potential for addressing antifungal resistance and improving treatment outcomes for fungal infections. Its progress shed light on complex fungal molecular profiles, advancing discovery and innovation in fungal biology.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrical signaling in fungi: past and present challenges. 真菌中的电信号：过去和现在的挑战。

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf009

Matteo Buffi, Julia M Kelliher, Aaron J Robinson, Diego Gonzalez, Guillaume Cailleau, Justine A Macalindong, Eleonora Frau, Silvia Schintke, Patrick S G Chain, Claire E Stanley, Markus Künzler, Saskia Bindschedler, Pilar Junier

{"title":"Electrical signaling in fungi: past and present challenges.","authors":"Matteo Buffi, Julia M Kelliher, Aaron J Robinson, Diego Gonzalez, Guillaume Cailleau, Justine A Macalindong, Eleonora Frau, Silvia Schintke, Patrick S G Chain, Claire E Stanley, Markus Künzler, Saskia Bindschedler, Pilar Junier","doi":"10.1093/femsre/fuaf009","DOIUrl":"10.1093/femsre/fuaf009","url":null,"abstract":"Electrical signaling is a fundamental mechanism for integrating environmental stimuli and coordinating responses in living organisms. While extensively studied in animals and plants, the role of electrical signaling in fungi remains a largely underexplored field. Early studies suggested that filamentous fungi generate action potential-like signals and electrical currents at hyphal tips, yet their function in intracellular communication remained unclear. Renewed interest in fungal electrical activity has fueled developments such as the hypothesis that mycorrhizal networks facilitate electrical communication between plants and the emerging field of fungal-based electronic materials. Given their continuous plasma membrane, specialized septal pores, and insulating cell wall structures, filamentous fungi possess architectural features that could support electrical signaling over long distances. However, studying electrical phenomena in fungal networks presents unique challenges due to the microscopic dimensions of hyphae, the structural complexity of highly modular mycelial networks, and the limitations of traditional electrophysiological methods. This review synthesizes current evidence for electrical signaling in filamentous fungi, evaluates methodological approaches, and highlights experimental challenges. By addressing these challenges and identifying best practices, we aim to advance research in this field and provide a foundation for future studies exploring the role of electrical signaling in fungal biology.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals. 基于嘌呤的信息化学物质和免疫代谢物：植物和动物中新出现的信号通路的比较综述。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf029

Nick Dunken, Tim Thomsen, Alga Zuccaro

{"title":"Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals.","authors":"Nick Dunken, Tim Thomsen, Alga Zuccaro","doi":"10.1093/femsre/fuaf029","DOIUrl":"10.1093/femsre/fuaf029","url":null,"abstract":"Purine-based metabolites serve as essential mediators of signaling, immunity, and host-microbe interactions across biological kingdoms. This review explores their extracellular and intracellular functions, focusing on well-characterized molecules as well as emerging players, and examines the conserved and divergent mechanisms underlying purine-mediated responses in plants and animals, with comparative insights into microbial strategies that influence or exploit these pathways. Key topics include the role of extracellular adenosine triphosphate in immune responses, the dual function of NAD+ as both a metabolic cofactor and signaling molecule, and the emerging roles of deoxynucleosides and cyclic nucleotides in stress and immunity regulation. Special emphasis is placed on Toll/interleukin-1 receptor (TIR) domain-containing proteins, which generate novel purine-derived infochemicals-bioactive signaling metabolites that regulate immune responses and cell death while modulating host-microbe interactions. By integrating insights across biological kingdoms, this review underscores the potential of purine-based signaling molecules and their natural and chemically modified functional derivatives as targets for therapeutic and agricultural innovation, bridging fundamental discoveries with practical applications. Finally, moving beyond purine-based metabolites, we offer a new perspective on immunometabolism and infochemicals as fundamental regulators of host-microbe interactions, shaping defense, modulating metabolism, facilitating symbiosis, and driving broader evolutionary dynamics.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helminth infections affect host immune responses to viral infections and vaccines. 蠕虫感染影响宿主对病毒感染和疫苗的免疫反应。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf036

Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert

{"title":"Helminth infections affect host immune responses to viral infections and vaccines.","authors":"Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert","doi":"10.1093/femsre/fuaf036","DOIUrl":"10.1093/femsre/fuaf036","url":null,"abstract":"Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficient immunomodulators of their hosts. This modulation often leads to skewed or even impaired immune responses against unrelated antigens, such as viruses and vaccines, which can be both beneficial and detrimental for the host. The extent of these effects and the impact on the outcomes of viral infection depends on a variety of factors including timing and tropism of both infections, pathological mechanisms, genetic background, and environmental factors. In this review, we dissect these complex interactions between virus and helminths in the context of coinfection and the impact of helminth infection on antiviral vaccine efficacy. We characterize the key contributing mechanisms that have been defined in preclinical models and human trials and describe the immune actors involved in the modulation of the antiviral and vaccine immune response by helminths. Finally, we address the limitations of our current understanding of helminth-virus interactions.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary methodologies used in the study of cable bacteria. 电缆细菌研究中使用的多学科方法。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuae030

Michaela M H Wawryk, Philip Ley, Diana Vasquez-Cardenas, Rico F Tabor, Perran L M Cook

引用次数: 0