FEMS microbiology reviews最新文献

Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species. 经典博德特菌中c-二- gmp信号的结构和调控功能。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuaf065

Denisa Vondrova, Sabrina Laura Mugni, Jan Blumenstein, Clara Kasiztky, Federico Sisti, Julieta Fernández, Jana Kamanova

{"title":"Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species.","authors":"Denisa Vondrova, Sabrina Laura Mugni, Jan Blumenstein, Clara Kasiztky, Federico Sisti, Julieta Fernández, Jana Kamanova","doi":"10.1093/femsre/fuaf065","DOIUrl":"10.1093/femsre/fuaf065","url":null,"abstract":"Cyclic di-GMP (c-di-GMP) is a highly conserved bacterial second messenger that regulates important processes such as motility, biofilm formation and virulence. In this review, we investigate the architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species, including B. bronchiseptica, B. parapertussis and B. pertussis. We examine how the c-di-GMP signaling pathway interacts with the BvgAS two-component system and other signaling pathways to coordinate virulence gene expression and surface-associated behaviors in these respiratory pathogens. In particular, we highlight the functions of characterized diguanylate cyclases (DGCs), phosphodiesterases (PDEs) and dual-domain proteins, focusing on regulatory modules such as the BdcA-DdpA scaffold complex, the oxygen-sensing DGC BpeGReg and the LapD-LapG proteolytic switch that controls BrtA adhesin. We also propose a model for the function of BvgR, a PDE-like protein lacking catalytic residues, and discuss how c-di-GMP suppresses the type III secretion system. Importantly, we highlight the diversity of the c-di-GMP network in classical Bordetella species, likely reflecting their evolutionary specialization. To conclude, we outline important open questions and suggest future research directions, including the identification of sensory ligands and c-di-GMP effectors. Overall, our review illustrates the importance of c-di-GMP as a critical, but still incompletely understood, regulatory hub in Bordetella pathogenesis.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":12.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of myeloid cells expressing CD169/Siglec-1 in host-pathogen interactions. 表达CD169/ siglec1的骨髓细胞在宿主-病原体相互作用中的作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag013

Ilona Ronco, Branka Horvat

{"title":"Role of myeloid cells expressing CD169/Siglec-1 in host-pathogen interactions.","authors":"Ilona Ronco, Branka Horvat","doi":"10.1093/femsre/fuag013","DOIUrl":"10.1093/femsre/fuag013","url":null,"abstract":"CD169/Siglec-1 is a type-I transmembrane lectin receptor expressed on subcapsular sinus macrophages and activated monocytes, which plays a key role in innate immune surveillance and orchestration of adaptive immunity. As a sialic acid-binding immunoglobulin-like lectin (Siglec), CD169 recognizes sialylated gangliosides and glycoconjugates present on surface of several viral envelopes, including HIV-1, SARS-CoV-2, and Ebola virus as well as sialylated bacterial capsules such as those of Neisseria meningitidis and Campylobacter jejuni. Moreover, different viruses were shown to be captured by CD169+ cells which could play distinctive role during infections: they could enhance efficient immune responses, but also facilitate pathogen dissemination through viral capture and transfer to permissive cells. This last mechanism has been well documented for HIV-1, where CD169 mediates viral trans-infection of CD4⁺ T-cells. CD169 expression is rapidly induced by type-I interferons during acute viral infections and has emerged as a valuable biomarker to distinguish viral from bacterial infection, particularly for COVID-19 and influenza. Detectable by flow cytometry, CD169 represents a solid biomarker in clinical settings and possible target in the development of novel prophylactic and therapeutic strategies. Its dual role, protective in host defence yet exploitable by certain pathogens, highlights the need for careful consideration in future therapeutic approaches.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From microbes to animals: a review on prey choice and prey-predator dynamics across organismal scales. 从微生物到动物：跨生物尺度的猎物选择和捕食动力学研究综述。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag004

Mohor Mitra, Sajan, Shrutarshi Paul, Amit Huppert, Edouard Jurkevitch

{"title":"From microbes to animals: a review on prey choice and prey-predator dynamics across organismal scales.","authors":"Mohor Mitra, Sajan, Shrutarshi Paul, Amit Huppert, Edouard Jurkevitch","doi":"10.1093/femsre/fuag004","DOIUrl":"10.1093/femsre/fuag004","url":null,"abstract":"Predator-prey interactions are intricately linked to ecological systems, from micro-organisms to large animals. Most predator-prey studies use simplified pairwise interactions, constraining our ability to identify general principles. Here, predator-prey choices are examined across scales and levels of environmental complexity. We review current knowledge and emphasize the diversity and complexity of predator-prey systems, point to challenges in integrating them, and propose a framework that could benefit predictive modeling for ecosystem functioning and resilience. To do so, we compare the tools, mechanisms, and strategies deployed by micro- and macro- predators and prey defenses to show that commonalities become identifiable, and suggest structural and functional links between micro- and macro-scales. This provides arguments for both descriptive, and mathematical models. We propose that the use of microbial predators like the Bdellovibrio and like organisms can greatly advance the integration of experimental and mathematical modeling research, as they can provide robust empirical observations of predator-prey interactions tested under multiple conditions and levels of complexity. This facilitates model development, in turn leading to new hypotheses. We conclude by showing examples of current developments, that predator-prey interaction-based knowledge has the potential to provide novel medical tools and to improve environmental and agricultural management.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation quality control in Pseudomonas aeruginosa: current knowledge and perspectives. 铜绿假单胞菌翻译质量控制：目前的知识和观点。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag018

Bastien L'Hermitte, Reynald Gillet, Christine Baysse

引用次数: 0

Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms. 秀丽隐杆线虫作为非模式变温动物中增强弹性的微生物群干预的实验模型。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag031

Charlotte Sprason, Philip Donkersley, Jason P Chin, Alexandre Benedetto

{"title":"Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.","authors":"Charlotte Sprason, Philip Donkersley, Jason P Chin, Alexandre Benedetto","doi":"10.1093/femsre/fuag031","DOIUrl":"10.1093/femsre/fuag031","url":null,"abstract":"Ectotherms make up most animal species and deliver essential services to ecosystems and human food supply chains but are highly vulnerable to environmental perturbations. Being vastly underrepresented in laboratory-based studies, we also critically lack knowledge and approaches to improve their resilience to emerging threats from climate change and anthropogenic activities. With the gut microbiota critically modulating animal health, including stress tolerance, gut microbial interventions may offer opportunities to improve nonmodel ectotherm resilience to such pressures. Developing such interventions requires knowledge of host-gut microbiota-environment interactions that is critically lacking for most species and needs establishing. The roundworm Caenorhabditis elegans is emerging as a powerful ectotherm model to study host-gut microbiota interactions. Extensively utilized across research fields, C. elegans offers a breadth of resources and methodologies, including bioengineering technologies, defined microbiotas, and host and microbial isolate collections. In this review, we recapitulate C. elegans uses in gut microbiota studies, highlighting strengths and limitations and how it may accelerate mechanistic study of nonmodel ectotherm microbiotas. We notably propose a C. elegans-based strategy to identify, isolate, and study isolates from nonmodel ectotherm species to design microbial interventions that may promote climate resilience in nonmodel species.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria. 掌握细菌中star相关脂质转移（START）结构域蛋白。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag042

Ece Aslan, Ksenia I Lubova, Alex Speer, Wilbert Bitter

{"title":"Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria.","authors":"Ece Aslan, Ksenia I Lubova, Alex Speer, Wilbert Bitter","doi":"10.1093/femsre/fuag042","DOIUrl":"10.1093/femsre/fuag042","url":null,"abstract":"StAR-related lipid transfer (START) domain proteins comprise a conserved superfamily defined by a characteristic helix-grip fold that enables the binding of hydrophobic ligands. In mammals, START domain proteins have been extensively characterized as key mediators of nonvesicular lipid transport and lipid-dependent signalling pathways. In contrast, the prevalence, structural diversity, and functional roles of START domain proteins in bacteria remain underexplored and for those that are characterized, experimental findings are occasionally conflicting. While bacterial START domains preserve the core helix-grip fold for lipid binding, they are typically smaller and exhibit more limited conformational flexibility than their eukaryotic counterparts. Despite these apparent constraints, available experimental data suggest that bacterial START domains participate in a remarkably broad range of biological processes-including small-molecule binding, metabolic regulation, enzymatic catalysis, and stress adaptation-rather than traditional lipid transport. Bacteria within the phylum Actinomycetota, in particular, have evolved a prolific repertoire of START-domain proteins. As an example, we will discuss the START domain proteins of Mycobacterium tuberculosis in detail, one of which has emerged as a promising drug target. Collectively, this synthesis underscores the functional versatility of the START domain across the domains of life and identifies critical knowledge gaps that warrant further investigation.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148790177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage cocktails: state-of-the-art technologies and strategies for effective design. 噬菌体鸡尾酒：最先进的技术和有效设计策略。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuaf061

Tomoyoshi Kaneko, Kanata Nakatsuka, Satoshi Tsuneda

引用次数: 0

Bacterial extracellular vesicles as players in biofilm dynamics and community interactions. 细菌胞外囊泡在生物膜动力学和群落相互作用中的作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag047

Victoria Namiganda, Jeffrey W Schertzer

引用次数: 0

Metabolic and regulatory adaptations of Staphylococcus epidermidis to host stresses. 表皮葡萄球菌对宿主胁迫的代谢和调节适应。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag008

Sandra M Carvalho, Lígia M Saraiva

{"title":"Metabolic and regulatory adaptations of Staphylococcus epidermidis to host stresses.","authors":"Sandra M Carvalho, Lígia M Saraiva","doi":"10.1093/femsre/fuag008","DOIUrl":"10.1093/femsre/fuag008","url":null,"abstract":"Staphylococcus epidermidis is a highly adapted commensal of the human skin. However, it can also cause severe infections by exploiting skin fissures to establish antibiotic-resistant biofilms on implanted medical devices, which may subsequently release bacteria into the bloodstream. Emerging studies increasingly highlight the critical role of metabolic status and regulatory mechanisms in governing biofilm formation and, consequently, the pathogenic potential of S. epidermidis. This review examines its metabolic adaptability across different environments, emphasizing how environmental factors such as nutrient availability, oxygen levels, pH, and temperature, shape central metabolic pathways. It covers sugar, amino acid, and fatty acid utilization, regulatory networks controlling respiration, fermentation, and polysaccharide intercellular adhesin (PIA)-mediated biofilm formation, and strategies for surviving host-derived oxidative and nitrosative stresses. Comparisons with S. aureus further reveal species-specific differences in metabolism, nutrient acquisition, and regulation. Altogether, the mechanistic insights provide a comprehensive overview of S. epidermidis physiology in both commensal and infection-associated contexts.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the role of extracellular vesicles in HIV infection: molecular mechanisms, viral persistence, and therapeutic opportunities. 揭示细胞外囊泡在HIV感染中的作用：分子机制、病毒持久性和治疗机会。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag046

Flora Salzano, Nicoletta Capuano, Francesco Giordano, Emanuela De Bellis, Valeria Conti, Pasquale Pagliano, Gianluigi Franci

{"title":"Unveiling the role of extracellular vesicles in HIV infection: molecular mechanisms, viral persistence, and therapeutic opportunities.","authors":"Flora Salzano, Nicoletta Capuano, Francesco Giordano, Emanuela De Bellis, Valeria Conti, Pasquale Pagliano, Gianluigi Franci","doi":"10.1093/femsre/fuag046","DOIUrl":"10.1093/femsre/fuag046","url":null,"abstract":"Human immunodeficiency virus (HIV) infection remains a major global health challenge despite the success of antiretroviral therapy, largely due to the persistence of viral reservoirs and chronic immune dysregulation. Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication during viral infection, operating at the interface between viral and host cellular pathways. Depending on their cellular origin and molecular cargo, EVs can exert context-dependent effects, with studies suggesting roles in both viral dissemination and persistence, as well as in the modulation of antiviral immune responses. This review examines the molecular mechanisms through which EVs have been proposed to contribute to HIV infection, focusing on host-virus interactions, immune regulation, chronic inflammation, and viral latency. We further discuss emerging therapeutic strategies targeting EV biology, including approaches aimed at modulating EV biogenesis and cargo composition, as well as the development of engineered EVs as platforms for drug delivery, gene editing, and immune modulation. Overall, this study highlights the emerging roles of EVs in HIV infection, emphasizing both their potential relevance and the limitations that currently complicate the interpretation of EV-associated effects.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0