FEMS microbiology reviews最新文献_第10页

Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential. 通过可溶性肽聚糖片段感知和反应的细菌毒力调节:知识差距和治疗潜力。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad010

María Escobar-Salom, Isabel María Barceló, Elena Jordana-Lluch, Gabriel Torrens, Antonio Oliver, Carlos Juan

{"title":"Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential.","authors":"María Escobar-Salom, Isabel María Barceló, Elena Jordana-Lluch, Gabriel Torrens, Antonio Oliver, Carlos Juan","doi":"10.1093/femsre/fuad010","DOIUrl":"https://doi.org/10.1093/femsre/fuad010","url":null,"abstract":"Given the growing clinical-epidemiological threat posed by the phenomenon of antibiotic resistance, new therapeutic options are urgently needed, especially against top nosocomial pathogens such as those within the ESKAPE group. In this scenario, research is pushed to explore therapeutic alternatives and, among these, those oriented toward reducing bacterial pathogenic power could pose encouraging options. However, the first step in developing these antivirulence weapons is to find weak points in the bacterial biology to be attacked with the goal of dampening pathogenesis. In this regard, during the last decades some studies have directly/indirectly suggested that certain soluble peptidoglycan-derived fragments display virulence-regulatory capacities, likely through similar mechanisms to those followed to regulate the production of several β-lactamases: binding to specific transcriptional regulators and/or sensing/activation of two-component systems. These data suggest the existence of intra- and also intercellular peptidoglycan-derived signaling capable of impacting bacterial behavior, and hence likely exploitable from the therapeutic perspective. Using the well-known phenomenon of peptidoglycan metabolism-linked β-lactamase regulation as a starting point, we gather and integrate the studies connecting soluble peptidoglycan sensing with fitness/virulence regulation in Gram-negatives, dissecting the gaps in current knowledge that need filling to enable potential therapeutic strategy development, a topic which is also finally discussed.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/4d/fuad010.PMC10039701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10660914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Manipulation of plant metabolism by pathogen effectors: more than just food. 病原体效应物对植物代谢的操纵:不仅仅是食物。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad007

Jun Cai, Yuxin Jiang, Erin S Ritchie, Alberto P Macho, Feng Yu, Dousheng Wu

引用次数: 3

The molecular basis and downstream immune consequences of mycobacteria-host cell interactions. 分枝杆菌-宿主细胞相互作用的分子基础和下游免疫后果。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad009

Wassim Daher, Virginia Pichler, Jona Karam, Olivier Neyrolles, Laurent Kremer

{"title":"The molecular basis and downstream immune consequences of mycobacteria-host cell interactions.","authors":"Wassim Daher, Virginia Pichler, Jona Karam, Olivier Neyrolles, Laurent Kremer","doi":"10.1093/femsre/fuad009","DOIUrl":"https://doi.org/10.1093/femsre/fuad009","url":null,"abstract":"Pathogenic mycobacteria gain entry to their hosts by inhalation or ingestion where they adhere to different cell types and are subsequently internalized by professional phagocytic cells, such as macrophages or dendritic cells. Multiple pathogen-associated molecular patterns present on the mycobacterial surface are recognized by and interact with a diverse panel of phagocytic pattern recognition receptors, representing the first step of the infection process. This review summarizes the current knowledge on the numerous host cell receptors and their associated mycobacterial ligands or adhesins. It further discusses the downstream molecular and cellular events resulting from the engagement of the various receptor-mediated pathways, leading to either intracellular survival of mycobacteria or to activation of host immune defenses. The content presented herein on adhesins and host receptors may serve as a resource for those developing novel therapeutic approaches, e.g. in the design of antiadhesin molecules to prevent bacterial attachment and infection. The collection of mycobacterial surface molecules highlighted in this review may also provide potential new therapeutic targets, diagnostic markers, or vaccine candidates to combat these notoriously challenging and persistent pathogens.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Illuminating the oral microbiome and its host interactions: tools and approaches for molecular ecological studies. 阐明口腔微生物群及其与宿主的相互作用：分子生态学研究的工具和方法。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac052

Jens Kreth, Justin Merritt

引用次数: 3

New antiretroviral inhibitors and HIV-1 drug resistance: more focus on 90% HIV-1 isolates? 新的抗逆转录病毒抑制剂和HIV-1耐药性：更多关注90%的HIV-1分离株？

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac040

Emmanuel Ndashimye, Paul S Reyes, Eric J Arts

{"title":"New antiretroviral inhibitors and HIV-1 drug resistance: more focus on 90% HIV-1 isolates?","authors":"Emmanuel Ndashimye, Paul S Reyes, Eric J Arts","doi":"10.1093/femsre/fuac040","DOIUrl":"10.1093/femsre/fuac040","url":null,"abstract":"Combined HIV antiretroviral therapy (cART) has been effective except if drug resistance emerges. As cART has been rolled out in low-income countries, drug resistance has emerged at higher rates than observed in high income countries due to factors including initial use of these less tolerated cART regimens, intermittent disruptions in drug supply, and insufficient treatment monitoring. These socioeconomic factors impacting drug resistance are compounded by viral mechanistic differences by divergent HIV-1 non-B subtypes compared to HIV-1 subtype B that largely infects the high-income countries (just 10% of 37 million infected). This review compares the inhibition and resistance of diverse HIV-1 subtypes and strains to the various approved drugs as well as novel inhibitors in clinical trials. Initial sequence variations and differences in replicative fitness between HIV-1 subtypes pushes strains through different fitness landscapes to escape from drug selective pressure. The discussions here provide insight to patient care givers and policy makers on how best to use currently approved ART options and reduce the emergence of drug resistance in ∼33 million individuals infected with HIV-1 subtype A, C, D, G, and recombinants forms. Unfortunately, over 98% of the literature on cART resistance relates to HIV-1 subtype B.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841967/pdf/fuac040.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Regulatory and metabolic adaptations in the nitrogen assimilation of marine picocyanobacteria. 海洋picocyanobacteria氮同化的调节和代谢适应。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac043

J Díez, A López-Lozano, M A Domínguez-Martín, G Gómez-Baena, M C Muñoz-Marín, Y Melero-Rubio, J M García-Fernández

{"title":"Regulatory and metabolic adaptations in the nitrogen assimilation of marine picocyanobacteria.","authors":"J Díez, A López-Lozano, M A Domínguez-Martín, G Gómez-Baena, M C Muñoz-Marín, Y Melero-Rubio, J M García-Fernández","doi":"10.1093/femsre/fuac043","DOIUrl":"https://doi.org/10.1093/femsre/fuac043","url":null,"abstract":"Prochlorococcus and Synechococcus are the two most abundant photosynthetic organisms on Earth, with a strong influence on the biogeochemical carbon and nitrogen cycles. Early reports demonstrated the streamlining of regulatory mechanisms in nitrogen metabolism and the removal of genes not strictly essential. The availability of a large series of genomes, and the utilization of latest generation molecular techniques have allowed elucidating the main mechanisms developed by marine picocyanobacteria to adapt to the environments where they thrive, with a particular interest in the strains inhabiting oligotrophic oceans. Given that nitrogen is often limited in those environments, a series of studies have explored the strategies utilized by Prochlorococcus and Synechococcus to exploit the low concentrations of nitrogen-containing molecules available in large areas of the oceans. These strategies include the reduction in the GC and the cellular protein contents; the utilization of truncated proteins; a reduced average amount of N in the proteome; the development of metabolic mechanisms to perceive and utilize nanomolar nitrate concentrations; and the reduced responsiveness of key molecular regulatory systems such as NtcA to 2-oxoglutarate. These findings are in sharp contrast with the large body of knowledge obtained in freshwater cyanobacteria. We will outline the main discoveries, stressing their relevance to the ecological success of these important microorganisms.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10730570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

From the organismal to biosphere levels: environmental impacts on the amphibian microbiota. 从有机体到生物圈水平:环境对两栖动物微生物群的影响。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuad002

Obed Hernández-Gómez, Jessica Hua

{"title":"From the organismal to biosphere levels: environmental impacts on the amphibian microbiota.","authors":"Obed Hernández-Gómez, Jessica Hua","doi":"10.1093/femsre/fuad002","DOIUrl":"https://doi.org/10.1093/femsre/fuad002","url":null,"abstract":"This review summarizes the role of environmental factors on amphibian microbiotas at the organismal, population, community, ecosystem, and biosphere levels. At the organismal-level, tissue source, disease status, and experimental manipulations were the strongest predictors of variation in amphibian microbiotas. At the population-level, habitat quality, disease status, and ancestry were commonly documented as drivers of microbiota turnover. At the community-level, studies focused on how species' niche influence microbiota structure and function. At the ecosystem-level, abiotic and biotic reservoirs were important contributors to microbiota structure. At the biosphere-level, databases, sample banks, and seminatural experiments were commonly used to describe microbiota assembly mechanisms among temperate and tropical amphibians. Collectively, our review demonstrates that environmental factors can influence microbiotas through diverse mechanisms at all biological scales. Importantly, while environmental mechanisms occurring at each of the different scales can interact to shape microbiotas, the past 10 years of research have mostly been characterized by targeted approaches at individual scales. Looking forward, efforts considering how environmental factors at multiple organizational levels interact to shape microbiota diversity and function are paramount. Generating opportunities for meaningful cross-disciplinary interactions and supporting infrastructure for research that spans biological scales are imperative to addressing this gap.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9072098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In situ, in vivo, and in vitro approaches for studying AMR plasmid conjugation in the gut microbiome. 研究肠道微生物组中AMR质粒结合的原位、体内和体外方法。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac044

Celia Kessler, Jingping Hou, Onalenna Neo, Michelle M C Buckner

{"title":"In situ, in vivo, and in vitro approaches for studying AMR plasmid conjugation in the gut microbiome.","authors":"Celia Kessler, Jingping Hou, Onalenna Neo, Michelle M C Buckner","doi":"10.1093/femsre/fuac044","DOIUrl":"https://doi.org/10.1093/femsre/fuac044","url":null,"abstract":"Antimicrobial resistance (AMR) is a global threat, with evolution and spread of resistance to frontline antibiotics outpacing the development of novel treatments. The spread of AMR is perpetuated by transfer of antimicrobial resistance genes (ARGs) between bacteria, notably those encoded by conjugative plasmids. The human gut microbiome is a known 'melting pot' for plasmid conjugation, with ARG transfer in this environment widely documented. There is a need to better understand the factors affecting the incidence of these transfer events, and to investigate methods of potentially counteracting the spread of ARGs. This review describes the use and potential of three approaches to studying conjugation in the human gut: observation of in situ events in hospitalized patients, modelling of the microbiome in vivo predominantly in rodent models, and the use of in vitro models of various complexities. Each has brought unique insights to our understanding of conjugation in the gut. The use and development of these systems, and combinations thereof, will be pivotal in better understanding the significance, prevalence, and manipulability of horizontal gene transfer in the gut microbiome.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9280190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases. 吞噬溶酶体病原体的常见免疫逃避机制:潜在的广谱治疗靶点。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac041

Angamuthu Selvapandiyan, Niti Puri, Pankaj Kumar, Anwar Alam, Nasreen Zafar Ehtesham, George Griffin, Seyed Ehtesham Hasnain

{"title":"Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases.","authors":"Angamuthu Selvapandiyan, Niti Puri, Pankaj Kumar, Anwar Alam, Nasreen Zafar Ehtesham, George Griffin, Seyed Ehtesham Hasnain","doi":"10.1093/femsre/fuac041","DOIUrl":"https://doi.org/10.1093/femsre/fuac041","url":null,"abstract":"The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to propagate and cause fatal diseases. The microbes overpower host immunity at various levels including during entry into host cells, phagosome formation, phagosome maturation, phagosome-lysosome fusion forming phagolysosomes, acidification of phagolysosomes, and at times after escape into the cytosol. Phagolysosome is the final organelle in the phagocyte with sophisticated mechanisms to degrade the pathogens. The immune evasion strategies by the pathogens include the arrest of host cell apoptosis, decrease in reactive oxygen species, the elevation of Th2 anti-inflammatory response, avoidance of autophagy and antigen cross-presentation pathways, and escape from phagolysosomal killing. Since the phagolysosome organelle in relation to infection/cure is seldom discussed in the literature, we summarize here the common host as well as pathogen targets manipulated or utilized by the pathogens established in phagosomes and phagolysosomes, to hijack the host immune system for their benefit. These common molecules or pathways can be broad-spectrum therapeutic targets for drug development for intervention against infectious diseases caused by different intracellular pathogens.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10785731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Zebrafish models of COVID-19. 斑马鱼COVID-19模型。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-01-16 DOI: 10.1093/femsre/fuac042

Sylwia D Tyrkalska, Sergio Candel, Annamaria Pedoto, Diana García-Moreno, Francisca Alcaraz-Pérez, Álvaro Sánchez-Ferrer, María L Cayuela, Victoriano Mulero

{"title":"Zebrafish models of COVID-19.","authors":"Sylwia D Tyrkalska, Sergio Candel, Annamaria Pedoto, Diana García-Moreno, Francisca Alcaraz-Pérez, Álvaro Sánchez-Ferrer, María L Cayuela, Victoriano Mulero","doi":"10.1093/femsre/fuac042","DOIUrl":"https://doi.org/10.1093/femsre/fuac042","url":null,"abstract":"Although COVID-19 has only recently appeared, research studies have already developed and implemented many animal models for deciphering the secrets of the disease and provided insights into the biology of SARS-CoV-2. However, there are several major factors that complicate the study of this virus in model organisms, such as the poor infectivity of clinical isolates of SARS-CoV-2 in some model species, and the absence of persistent infection, immunopathology, severe acute respiratory distress syndrome, and, in general, all the systemic complications which characterize COVID-19 clinically. Another important limitation is that SARS-CoV-2 mainly causes severe COVID-19 in older people with comorbidities, which represents a serious problem when attempting to use young and immunologically naïve laboratory animals in COVID-19 testing. We review here the main animal models developed so far to study COVID-19 and the unique advantages of the zebrafish model that may help to contribute to understand this disease, in particular to the identification and repurposing of drugs to treat COVID-19, to reveal the mechanism of action and side-effects of Spike-based vaccines, and to decipher the high susceptibility of aged people to COVID-19.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9295245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5