FEMS microbiology reviews最新文献_第9页

Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms. 缓解铜绿假单胞菌生物膜的新药物靶点的结构分析。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-09-05 DOI: 10.1093/femsre/fuad054

Moumita Ghosh, Shikha Raghav, Puja Ghosh, Swagatam Maity, Kavery Mohela, Deepti Jain

{"title":"Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms.","authors":"Moumita Ghosh, Shikha Raghav, Puja Ghosh, Swagatam Maity, Kavery Mohela, Deepti Jain","doi":"10.1093/femsre/fuad054","DOIUrl":"10.1093/femsre/fuad054","url":null,"abstract":"Pseudomonas aeruginosa is an opportunistic human pathogen responsible for acute and chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop into biofilms, which are sessile bacterial communities adhered to substratum and encapsulated in layers of self-produced exopolysaccharides. These biofilms provide enhanced protection from the host immune system and resilience towards antibiotics, which poses a challenge for treatment. Various strategies have been expended for combating biofilms, which involve inhibiting biofilm formation or promoting their dispersal. The current remediation approaches offer some hope for clinical usage, however, treatment and eradication of preformed biofilms is still a challenge. Thus, identifying novel targets and understanding the detailed mechanism of biofilm regulation becomes imperative. Structure-based drug discovery (SBDD) provides a powerful tool that exploits the knowledge of atomic resolution details of the targets to search for high affinity ligands. This review describes the available structural information on the putative target protein structures that can be utilized for high throughput in silico drug discovery against P. aeruginosa biofilms. Integrating available structural information on the target proteins in readily accessible format will accelerate the process of drug discovery.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41114972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Praemonitus praemunitus: can we forecast and prepare for future viral disease outbreaks? Praemonitus praemunitus：我们能预测和准备未来的病毒性疾病爆发吗？

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2023-09-05 DOI: 10.1093/femsre/fuad048

Zoe Sessions, Tesia Bobrowski, Holli-Joi Martin, Jon-Michael T Beasley, Aneri Kothari, Trevor Phares, Michael Li, Vinicius M Alves, Marcus T Scotti, Nathaniel J Moorman, Ralph Baric, Alexander Tropsha, Eugene N Muratov

{"title":"Praemonitus praemunitus: can we forecast and prepare for future viral disease outbreaks?","authors":"Zoe Sessions, Tesia Bobrowski, Holli-Joi Martin, Jon-Michael T Beasley, Aneri Kothari, Trevor Phares, Michael Li, Vinicius M Alves, Marcus T Scotti, Nathaniel J Moorman, Ralph Baric, Alexander Tropsha, Eugene N Muratov","doi":"10.1093/femsre/fuad048","DOIUrl":"10.1093/femsre/fuad048","url":null,"abstract":"Understanding the origins of past and present viral epidemics is critical in preparing for future outbreaks. Many viruses, including SARS-CoV-2, have led to significant consequences not only due to their virulence, but also because we were unprepared for their emergence. We need to learn from large amounts of data accumulated from well-studied, past pandemics and employ modern informatics and therapeutic development technologies to forecast future pandemics and help minimize their potential impacts. While acknowledging the complexity and difficulties associated with establishing reliable outbreak predictions, herein we provide a perspective on the regions of the world that are most likely to be impacted by future outbreaks. We specifically focus on viruses with epidemic potential, namely SARS-CoV-2, MERS-CoV, DENV, ZIKV, MAYV, LASV, noroviruses, influenza, Nipah virus, hantaviruses, Oropouche virus, MARV, and Ebola virus, which all require attention from both the public and scientific community to avoid societal catastrophes like COVID-19. Based on our literature review, data analysis, and outbreak simulations, we posit that these future viral epidemics are unavoidable, but that their societal impacts can be minimized by strategic investment into basic virology research, epidemiological studies of neglected viral diseases, and antiviral drug discovery.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas and light: triggers of c-di-GMP-mediated regulation. 气体和光：c-di-GMP介导的调节的触发因素。

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad034

Zhaoqing Yu, Wei Zhang, He Yang, Shan-Ho Chou, Michael Y Galperin, Jin He

{"title":"Gas and light: triggers of c-di-GMP-mediated regulation.","authors":"Zhaoqing Yu, Wei Zhang, He Yang, Shan-Ho Chou, Michael Y Galperin, Jin He","doi":"10.1093/femsre/fuad034","DOIUrl":"10.1093/femsre/fuad034","url":null,"abstract":"The widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells depend, respectively, on diguanylate cyclases and c-di-GMP-specific phosphodiesterases. Since c-di-GMP metabolic enzymes (CMEs) are often fused to sensory domains, their activities are likely controlled by environmental signals, thereby altering cellular c-di-GMP levels and regulating bacterial adaptive behaviors. Previous studies on c-di-GMP-mediated regulation mainly focused on downstream signaling pathways, including the identification of CMEs, cellular c-di-GMP receptors, and c-di-GMP-regulated processes. The mechanisms of CME regulation by upstream signaling modules received less attention, resulting in a limited understanding of the c-di-GMP regulatory networks. We review here the diversity of sensory domains related to bacterial CME regulation. We specifically discuss those domains that are capable of sensing gaseous or light signals and the mechanisms they use for regulating cellular c-di-GMP levels. It is hoped that this review would help refine the complete c-di-GMP regulatory networks and improve our understanding of bacterial behaviors in changing environments. In practical terms, this may eventually provide a way to control c-di-GMP-mediated bacterial biofilm formation and pathogenesis in general.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"47 4","pages":""},"PeriodicalIF":10.1,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10291242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Faecalibacterium: a bacterial genus with promising human health applications. 粪杆菌:一种具有良好人类健康应用前景的细菌属。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad039

Rebeca Martín, David Rios-Covian, Eugénie Huillet, Sandrine Auger, Sara Khazal, Luis G Bermúdez-Humarán, Harry Sokol, Jean-Marc Chatel, Philippe Langella

{"title":"Faecalibacterium: a bacterial genus with promising human health applications.","authors":"Rebeca Martín, David Rios-Covian, Eugénie Huillet, Sandrine Auger, Sara Khazal, Luis G Bermúdez-Humarán, Harry Sokol, Jean-Marc Chatel, Philippe Langella","doi":"10.1093/femsre/fuad039","DOIUrl":"https://doi.org/10.1093/femsre/fuad039","url":null,"abstract":"In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"47 4","pages":""},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/6f/fuad039.PMC10410495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Exploring probiotic effector molecules and their mode of action in gut-immune interactions. 探索益生菌效应分子及其在肠道免疫相互作用中的作用模式。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad046

Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im, Ho-Keun Kwon

{"title":"Exploring probiotic effector molecules and their mode of action in gut-immune interactions.","authors":"Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im, Ho-Keun Kwon","doi":"10.1093/femsre/fuad046","DOIUrl":"10.1093/femsre/fuad046","url":null,"abstract":"Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained significant attention for their potential therapeutic applications. The beneficial effects of probiotics are believed to stem from their ability to enhance intestinal barrier function, inhibit pathogens, increase beneficial gut microbes, and modulate immune responses. However, clinical studies investigating the effectiveness of probiotics have yielded conflicting results, potentially due to the wide variety of probiotic species and strains used, the challenges in controlling the desired number of live microorganisms, and the complex interactions between bioactive substances within probiotics. Bacterial cell wall components, known as effector molecules, play a crucial role in mediating the interaction between probiotics and host receptors, leading to the activation of signaling pathways that contribute to the health-promoting effects. Previous reviews have extensively covered different probiotic effector molecules, highlighting their impact on immune homeostasis. Understanding how each probiotic component modulates immune activity at the molecular level may enable the prediction of immunological outcomes in future clinical studies. In this review, we present a comprehensive overview of the structural and immunological features of probiotic effector molecules, focusing primarily on Lactobacillus and Bifidobacterium. We also discuss current gaps and limitations in the field and propose directions for future research to enhance our understanding of probiotic-mediated immunomodulation.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"47 4","pages":""},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10173090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages. 发出信号：蛋白质磷酸化如何帮助芽孢杆菌穿越不同的生命阶段。

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad044

Aakriti Gangwal, Nishant Kumar, Nitika Sangwan, Neha Dhasmana, Uma Dhawan, Andaleeb Sajid, Gunjan Arora, Yogendra Singh

{"title":"Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.","authors":"Aakriti Gangwal, Nishant Kumar, Nitika Sangwan, Neha Dhasmana, Uma Dhawan, Andaleeb Sajid, Gunjan Arora, Yogendra Singh","doi":"10.1093/femsre/fuad044","DOIUrl":"10.1093/femsre/fuad044","url":null,"abstract":"Protein phosphorylation is a universal mechanism regulating a wide range of cellular responses across all domains of life. The antagonistic activities of kinases and phosphatases can orchestrate the life cycle of an organism. The availability of bacterial genome sequences, particularly Bacillus species, followed by proteomics and functional studies have aided in the identification of putative protein kinases and protein phosphatases, and their downstream substrates. Several studies have established the role of phosphorylation in different physiological states of Bacillus species as they pass through various life stages such as sporulation, germination, and biofilm formation. The most common phosphorylation sites in Bacillus proteins are histidine, aspartate, tyrosine, serine, threonine, and arginine residues. Protein phosphorylation can alter protein activity, structural conformation, and protein-protein interactions, ultimately affecting the downstream pathways. In this review, we summarize the knowledge available in the field of Bacillus signaling, with a focus on the role of protein phosphorylation in its physiological processes.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"47 4","pages":""},"PeriodicalIF":10.1,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drivers and consequences of bacteriophage host range. 噬菌体宿主的驱动因素和后果范围。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad038

D Holtappels, Poliane Alfenas-Zerbini, B Koskella

{"title":"Drivers and consequences of bacteriophage host range.","authors":"D Holtappels, Poliane Alfenas-Zerbini, B Koskella","doi":"10.1093/femsre/fuad038","DOIUrl":"https://doi.org/10.1093/femsre/fuad038","url":null,"abstract":"Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that they can infect. This \"host range\" depends on the genotypes and morphologies of the phage and the bacterial host, but also on the environment in which they are interacting. Understanding phage host range is critical to predicting the impacts of these parasites in their natural host communities and their utility as therapeutic agents, but is also key to predicting how phages evolve and in doing so drive evolutionary change in their host populations, including through movement of genes among unrelated bacterial genomes. Here, we explore the drivers of phage infection and host range from the molecular underpinnings of the phage-host interaction to the ecological context in which they occur. We further evaluate the importance of intrinsic, transient, and environmental drivers shaping phage infection and replication, and discuss how each influences host range over evolutionary time. The host range of phages has great consequences in phage-based application strategies, as well as natural community dynamics, and we therefore highlight both recent developments and key open questions in the field as phage-based therapeutics come back into focus.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"47 4","pages":""},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bacteriophage-host interactions in Streptococcus thermophilus and their impact on co-evolutionary processes. 嗜热链球菌中噬菌体-宿主相互作用及其对共同进化过程的影响。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad032

Katherine Lavelle, Brian McDonnell, Gerald Fitzgerald, Douwe van Sinderen, Jennifer Mahony

引用次数: 1

The never-ending battle between lactic acid bacteria and their phages. 乳酸菌和噬菌体之间永无休止的战斗。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad035

Cécile Philippe, Jeffrey K Cornuault, Alessandra G de Melo, Rachel Morin-Pelchat, Alice P Jolicoeur, Sylvain Moineau

引用次数: 1

Anti-infective activities of long-chain fatty acids against foodborne pathogens. 长链脂肪酸对食源性致病菌的抗感染活性。