FEMS microbiology reviews最新文献_第9页

Correction to: Biodiversity of microorganisms in the Baltic Sea: the power of novel methods in the identification of marine microbes. 更正：波罗的海微生物的生物多样性：鉴定海洋微生物的新方法的力量。

IF 12.3 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf002

引用次数: 0

A century of research on the Planctomycetota bacterial phylum, previously known as Planctomycetes. 一个世纪以来对plantomycetotta细菌门的研究，以前被称为plantomycetes。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf056

Olga Maria Lage, Ofélia Godinho, Rubén García-Domínguez, Lise Øvreås, Damien P Devos

{"title":"A century of research on the Planctomycetota bacterial phylum, previously known as Planctomycetes.","authors":"Olga Maria Lage, Ofélia Godinho, Rubén García-Domínguez, Lise Øvreås, Damien P Devos","doi":"10.1093/femsre/fuaf056","DOIUrl":"10.1093/femsre/fuaf056","url":null,"abstract":"One hundred years after planctomycetes were discovered and 50 years since the first isolate was successfully cultured, this bacterial phylum remains enigmatic in many ways. In the last few decades, a significant effort to characterize new isolates has resulted in >150 described species, allowing a more comprehensive analysis of their features. However, metagenomic studies reveal that a diverse group of planctomycetes has yet to be cultured and characterized, and that many biological surprises are yet to be revealed. This is the case for the recently discovered phagotrophic Candidatus Uabimicrobium, which challenges our understanding of the distinction between prokaryotes and eukaryotes. The unique biology of planctomycete cells, such as their ability to divide without the FtsZ protein, their complex structure and characteristic morphology, their relatively large genomes containing many genes with unknown function, and their variable metabolic capabilities, imposes significant barriers for researchers. Although ubiquitous, the precise ecological roles of planctomycetes in various environments are still not fully understood. However, their distinctive metabolism opens the door to a large number of potential biotechnological applications, which are beginning to be unveiled. In this article, we first review the historical milestones in planctomycetes research and describe the pioneers of the field. We then describe the controversies and their resolutions, we highlight the past discoveries and current interrogations related to planctomycetes, and discuss the ongoing challenges that hinder a comprehensive understanding of their biology. We end up with directions for exploring the biology and ecological roles of these fascinating organisms.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12673574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaginal Candida albicans infections: host-pathogen-microbiome interactions. 阴道白色念珠菌感染：宿主-病原体-微生物组相互作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf013

Marisa Valentine, Duncan Wilson, Mark S Gresnigt, Bernhard Hube

{"title":"Vaginal Candida albicans infections: host-pathogen-microbiome interactions.","authors":"Marisa Valentine, Duncan Wilson, Mark S Gresnigt, Bernhard Hube","doi":"10.1093/femsre/fuaf013","DOIUrl":"10.1093/femsre/fuaf013","url":null,"abstract":"Candida albicans is a fungus that colonizes the gut, oral, and vaginal mucosae of most humans without causing disease. However, under certain predisposing conditions this fungus can cause disease. Candida albicans has several factors and attributes that facilitate its commensal and pathogenic lifestyles including the transition from a yeast to a hyphal morphology, which is accompanied by the expression of virulence factors. These factors are central in candidiasis that can range from invasive to superficial. This review focuses on one example of a superficial disease, i.e. vulvovaginal candidiasis (VVC) that affects ~75% of women at least once with some experiencing four or more symptomatic infections per year (RVVC). During VVC, fungal factors trigger inflammation, which is maintained by a dysregulated innate immune response. This in turn leads to immunopathology and symptoms. Another unique characteristic of the vaginal niche, is its Lactobacillus-dominated microbiota with low species diversity that is believed to antagonize C. albicans pathogenicity. The importance of the interactions between C. albicans, the host, and vaginal microbiota during commensalism and (R)VVC is discussed in this review, which also addresses the application of this knowledge to identify novel treatment strategies and to study vaginal C. albicans infections.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"49 ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal shift assay to identify ligands for bacterial sensor proteins. 热移法鉴定细菌传感器蛋白的配体。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf033

Elizabet Monteagudo-Cascales, Mario Cano-Muñoz, Roberta Genova, Juan J Cabrera, Miguel A Matilla, Tino Krell

{"title":"Thermal shift assay to identify ligands for bacterial sensor proteins.","authors":"Elizabet Monteagudo-Cascales, Mario Cano-Muñoz, Roberta Genova, Juan J Cabrera, Miguel A Matilla, Tino Krell","doi":"10.1093/femsre/fuaf033","DOIUrl":"10.1093/femsre/fuaf033","url":null,"abstract":"Bacteria sense and respond to changing environmental conditions using a diverse range of receptors. Currently, the signals recognized by most receptors remain unknown, thereby limiting our understanding of their function. Since its introduction a decade ago, ligand screening by the thermal-shift assay has identified the signal molecules recognized by numerous receptors, solute-binding proteins, and transcriptional regulators. This progress is summarized in this review. Signal identification is facilitated by the fact that ligand-binding domains can be generated as individual soluble proteins that retain the signal-binding capabilities of the full-length proteins. Various issues relevant to the reliability of the thermal shift assay are discussed, including false-positive and false-negative results, the value of a protein pH screen prior to ligand screening, and the need to verify results with methods for the direct study of ligand binding, such as isothermal titration calorimetry. This review was inspired by the XVIII conference on Bacterial Locomotion and Signal Transduction (Cancun, January 2025), where several notable advances were reported based on the application of the thermal shift assay.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradation of synthetic organic pollutants: principles, progress, problems, and perspectives. 合成有机污染物的生物降解：原理、进展、问题与展望。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf043

Yue Huang, Yu Deng, Ke Yu, Bing Li, Tong Zhang

引用次数: 0

Insight into the environmental cues modulating the expression of bacterial toxin-antitoxin systems. 洞察环境线索调节细菌毒素-抗毒素系统的表达。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf007

Emeline Ostyn, Yoann Augagneur, Marie-Laure Pinel-Marie

{"title":"Insight into the environmental cues modulating the expression of bacterial toxin-antitoxin systems.","authors":"Emeline Ostyn, Yoann Augagneur, Marie-Laure Pinel-Marie","doi":"10.1093/femsre/fuaf007","DOIUrl":"10.1093/femsre/fuaf007","url":null,"abstract":"Bacteria require sophisticated sensing mechanisms to adjust their metabolism in response to stressful conditions and survive in hostile environments. Among them, toxin-antitoxin (TA) systems play a crucial role in bacterial adaptation to environmental challenges. TA systems are considered as stress-responsive elements, consisting of both toxin and antitoxin genes, typically organized in operons or encoded on complementary DNA strands. A decrease in the antitoxin-toxin ratio, often triggered by specific stress conditions, leads to toxin excess, disrupting essential cellular processes and inhibiting bacterial growth. These systems are categorized into eight types based on the nature of the antitoxin (RNA or protein) and the mode of action of toxin inhibition. While the well-established biological roles of TA systems include phage inhibition and the maintenance of genetic elements, the environmental cues regulating their expression remain insufficiently documented. In this review, we highlight the diversity and complexity of the environmental cues influencing TA systems expression. A comprehensive understanding of how these genetic modules are regulated could provide deeper insights into their functions and support the development of innovative antimicrobial strategies.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving spectrum of Pneumocystis host specificity, genetic diversity, and evolution. 肺囊虫宿主特异性、遗传多样性和进化的进化谱。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf006

Liang Ma, Christiane Weissenbacher-Lang, Alice Latinne, Spenser Babb-Biernacki, Barbara Blasi, Ousmane H Cissé, Joseph A Kovacs

{"title":"Evolving spectrum of Pneumocystis host specificity, genetic diversity, and evolution.","authors":"Liang Ma, Christiane Weissenbacher-Lang, Alice Latinne, Spenser Babb-Biernacki, Barbara Blasi, Ousmane H Cissé, Joseph A Kovacs","doi":"10.1093/femsre/fuaf006","DOIUrl":"10.1093/femsre/fuaf006","url":null,"abstract":"Following over a century's worth of research, our understanding of Pneumocystis has significantly expanded in various facets, spanning from its fundamental biology to its impacts on animal and human health. Its significance in public health has been underscored by its inclusion in the 2022 WHO fungal priority pathogens list. We present this review to summarize pivotal advancements in Pneumocystis epidemiology, host specificity, genetic diversity and evolution. Following a concise discussion of Pneumocystis species classification and divergence at the species and strain levels, we devoted the main focus to the following aspects: the epidemiological characteristics of Pneumocystis across nearly 260 mammal species, the increasing recognition of coinfection involving multiple Pneumocystis species in the same host species, the diminishing host specificity of Pneumocystis among closely related host species, and the intriguingly discordant evolution of certain Pneumocystis species with their host species. A comprehensive understanding of host specificity, genetic diversity, and evolution of Pneumocystis can provide important insights into pathogenic mechanisms and transmission modes. This, in turn, holds the potential to facilitate the development of innovative strategies for the prevention and control of Pneumocystis infection.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the LuxR solo, SdiA, in eavesdropping on foreign bacteria. LuxR独奏，SdiA，在窃听外来细菌中的作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf015

Andrew Schwieters, Brian M M Ahmer

引用次数: 0

The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance. 表型异质性对真菌致病性和耐药性的影响。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf001

Lukasz Kozubowski, Judith Berman

引用次数: 0

Pseudomonas aeruginosa as a model bacterium in antiphage defense research. 铜绿假单胞菌作为抗噬菌体防御研究的模式细菌。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2025-01-14 DOI: 10.1093/femsre/fuaf014

Hee-Won Bae, Shin-Yae Choi, Hyeong-Jun Ki, You-Hee Cho

{"title":"Pseudomonas aeruginosa as a model bacterium in antiphage defense research.","authors":"Hee-Won Bae, Shin-Yae Choi, Hyeong-Jun Ki, You-Hee Cho","doi":"10.1093/femsre/fuaf014","DOIUrl":"10.1093/femsre/fuaf014","url":null,"abstract":"Bacteriophages, or phages, depend on their bacterial hosts for proliferation, leading to a coevolutionary relationship characterized by on-going arms races, where bacteria evolve diverse antiphage defense systems. The development of in silico methods and high-throughput screening techniques has dramatically expanded our understanding of bacterial antiphage defense systems, enormously increasing the known repertoire of the distinct mechanisms across various bacterial species. These advances have revealed that bacterial antiphage defense systems exhibit a remarkable level of complexity, ranging from highly conserved to specialized mechanisms, underscoring the intricate nature of bacterial antiphage defense systems. In this review, we provide a concise snapshot of antiphage defense research highlighting two preponderantly commandeered approaches and classification of the known antiphage defense systems. A special focus is placed on the model bacterial pathogen, Pseudomonas aeruginosa in antiphage defense research. We explore the complexity and adaptability of these systems, which play crucial roles in genome evolution and adaptation of P. aeruginosa in response to an arsenal of diverse phage strains, emphasizing the importance of this organism as a key emerging model bacterium in recent antiphage defense research.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":"49 ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0