FEMS microbiology reviews最新文献_第9页

Ruminococcus gnavus: friend or foe for human health. 反刍球菌：人类健康的朋友还是敌人？

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad014

Emmanuelle H Crost, Erika Coletto, Andrew Bell, Nathalie Juge

{"title":"Ruminococcus gnavus: friend or foe for human health.","authors":"Emmanuelle H Crost, Erika Coletto, Andrew Bell, Nathalie Juge","doi":"10.1093/femsre/fuad014","DOIUrl":"10.1093/femsre/fuad014","url":null,"abstract":"Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extraintestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterization of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonization of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9330615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microbiology of Power-to-X applications. Power-to-X应用的微生物学。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad013

Washington Logroño, Sabine Kleinsteuber, Jörg Kretzschmar, Falk Harnisch, Jo De Vrieze, Marcell Nikolausz

引用次数: 3

Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications. 人类肠道合成微生物群落(SynComs):设计、组装和应用

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad012

Pim T van Leeuwen, Stanley Brul, Jianbo Zhang, Meike T Wortel

{"title":"Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications.","authors":"Pim T van Leeuwen, Stanley Brul, Jianbo Zhang, Meike T Wortel","doi":"10.1093/femsre/fuad012","DOIUrl":"https://doi.org/10.1093/femsre/fuad012","url":null,"abstract":"The human gut harbors native microbial communities, forming a highly complex ecosystem. Synthetic microbial communities (SynComs) of the human gut are an assembly of microorganisms isolated from human mucosa or fecal samples. In recent decades, the ever-expanding culturing capacity and affordable sequencing, together with advanced computational modeling, started a ''golden age'' for harnessing the beneficial potential of SynComs to fight gastrointestinal disorders, such as infections and chronic inflammatory bowel diseases. As simplified and completely defined microbiota, SynComs offer a promising reductionist approach to understanding the multispecies and multikingdom interactions in the microbe-host-immune axis. However, there are still many challenges to overcome before we can precisely construct SynComs of designed function and efficacy that allow the translation of scientific findings to patients' treatments. Here, we discussed the strategies used to design, assemble, and test a SynCom, and address the significant challenges, which are of microbiological, engineering, and translational nature, that stand in the way of using SynComs as live bacterial therapeutics.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/6a/fuad012.PMC10062696.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9259978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs. mellellia -胞内细菌病原体感染模型:来龙去脉。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad011

Masanori Asai, Yanwen Li, Sandra M Newton, Brian D Robertson, Paul R Langford

{"title":"Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs.","authors":"Masanori Asai, Yanwen Li, Sandra M Newton, Brian D Robertson, Paul R Langford","doi":"10.1093/femsre/fuad011","DOIUrl":"https://doi.org/10.1093/femsre/fuad011","url":null,"abstract":"Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious disease models, due to ease of use and the presence of an innate immune system functionally similar to that of vertebrates. Here, we review G. mellonella-human intracellular bacteria pathogen infection models from the genera Burkholderia, Coxiella, Francisella, Listeria, and Mycobacterium. For all genera, G. mellonella use has increased understanding of host-bacterial interactive biology, particularly through studies comparing the virulence of closely related species and/or wild-type versus mutant pairs. In many cases, virulence in G. mellonella mirrors that found in mammalian infection models, although it is unclear whether the pathogenic mechanisms are the same. The use of G. mellonella larvae has speeded up in vivo efficacy and toxicity testing of novel antimicrobials to treat infections caused by intracellular bacteria: an area that will expand since the FDA no longer requires animal testing for licensure. Further use of G. mellonella-intracellular bacteria infection models will be driven by advances in G. mellonella genetics, imaging, metabolomics, proteomics, and transcriptomic methodologies, alongside the development and accessibility of reagents to quantify immune markers, all of which will be underpinned by a fully annotated genome.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Meat fermentation at a crossroads: where the age-old interplay of human, animal, and microbial diversity and contemporary markets meet. 肉类发酵在一个十字路口:在那里古老的相互作用的人类，动物和微生物多样性和当代市场相遇。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad016

Frédéric Leroy, Christina Charmpi, Luc De Vuyst

{"title":"Meat fermentation at a crossroads: where the age-old interplay of human, animal, and microbial diversity and contemporary markets meet.","authors":"Frédéric Leroy, Christina Charmpi, Luc De Vuyst","doi":"10.1093/femsre/fuad016","DOIUrl":"https://doi.org/10.1093/femsre/fuad016","url":null,"abstract":"Despite being part of the now often unfavourably perceived category of processed meats, fermented meats remain of substantial nutritional, economic, and cultural importance in today's foodscapes. This translates into a vast assortment of different products. Fermentation is driven by microorganisms (e.g. in fermented sausages), although the terminology is sometimes used to also designate products in which microbial contributions are less dominant and that depend primarily on the activity of endogenous meat enzymes (e.g. in raw hams). A summary is given of the main microbial groups that characterize various types of meat and, in particular, their fermented derivatives. Moreover, it is argued that producers of fermented meat products struggle to adapt to a contemporary dietary context of change. On the one hand, they wish to reassure consumers by reaffirming the position of fermented meat products as traditional strongholds. On the other hand, producers are trying to alleviate some of the perceived concerns through technological innovation, for instance related to the impact of processing on food safety and health. This review raises the point that these sometimes contradictory trends can affect the choice of meat type, ingredients, and processing parameters, and how these choices, in turn, can affect microbial diversity.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9422188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated molecular approaches for fermented food microbiome research. 发酵食品微生物组研究的综合分子方法。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad001

Aaron M Walsh, John Leech, Curtis Huttenhower, Hue Delhomme-Nguyen, Fiona Crispie, Christian Chervaux, Paul D Cotter

{"title":"Integrated molecular approaches for fermented food microbiome research.","authors":"Aaron M Walsh, John Leech, Curtis Huttenhower, Hue Delhomme-Nguyen, Fiona Crispie, Christian Chervaux, Paul D Cotter","doi":"10.1093/femsre/fuad001","DOIUrl":"10.1093/femsre/fuad001","url":null,"abstract":"Molecular technologies, including high-throughput sequencing, have expanded our perception of the microbial world. Unprecedented insights into the composition and function of microbial communities have generated large interest, with numerous landmark studies published in recent years relating the important roles of microbiomes and the environment-especially diet and nutrition-in human, animal, and global health. As such, food microbiomes represent an important cross-over between the environment and host. This is especially true of fermented food microbiomes, which actively introduce microbial metabolites and, to a lesser extent, live microbes into the human gut. Here, we discuss the history of fermented foods, and examine how molecular approaches have advanced research of these fermented foods over the past decade. We highlight how various molecular approaches have helped us to understand the ways in which microbes shape the qualities of these products, and we summarize the impacts of consuming fermented foods on the gut. Finally, we explore how advances in bioinformatics could be leveraged to enhance our understanding of fermented foods. This review highlights how integrated molecular approaches are changing our understanding of the microbial communities associated with food fermentation, the creation of unique food products, and their influences on the human microbiome and health.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/9d/fuad001.PMC10002906.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9126431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporation, fate, and turnover of free fatty acids in cyanobacteria. 蓝藻中游离脂肪酸的合并，命运和周转。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad015

Amaranta Kahn, Paulo Oliveira, Marine Cuau, Pedro N Leão

引用次数: 0

Correction to: The cohesin complex of yeasts: sister chromatid cohesion and beyond. 修正:酵母的内聚复合体:姐妹染色单体内聚及其他。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad006

引用次数: 0

Four billion years of microbial terpenome evolution. 微生物萜烯素进化了40亿年。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad008

Yosuke Hoshino, Laura Villanueva

{"title":"Four billion years of microbial terpenome evolution.","authors":"Yosuke Hoshino, Laura Villanueva","doi":"10.1093/femsre/fuad008","DOIUrl":"https://doi.org/10.1093/femsre/fuad008","url":null,"abstract":"Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic compounds in nature and are involved in many membrane-associated cellular processes, including membrane organization, electron transport chain, cell signaling, and phototrophy. Terpenoids are ancient compounds with their origin presumably before the last universal common ancestor. However, Bacteria and Archaea are known to possess two distinct terpenoid repertoires and utilize terpenoids differently. Most notably, archaea constitute their cellular membrane solely made of terpenoid-based phospholipids, contrary to the bacterial membrane that consists of fatty acid-based phospholipids. Thus, the composition of ancestral membranes at the beginning of cellular life and the diversification of terpenoids in early life remain enigmatic. This review addresses these key issues through comprehensive phylogenomic analyses of extant terpenoid biosynthesis enzymes in Bacteria and Archaea. We aim to infer the basal components of terpenoid biosynthesis machinery that have an ancient origin before the divergence of the two domains and shed light on the deep evolutionary connection between terpenoid biochemistry and early life.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions. 珊瑚微生物组：了解珊瑚-微生物群相互作用的分子机制。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-03-10 DOI: 10.1093/femsre/fuad005

Amin R Mohamed, Michael A Ochsenkühn, Ahmed Kazlak, Ahmed Moustafa, Shady A Amin

{"title":"The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions.","authors":"Amin R Mohamed, Michael A Ochsenkühn, Ahmed Kazlak, Ahmed Moustafa, Shady A Amin","doi":"10.1093/femsre/fuad005","DOIUrl":"10.1093/femsre/fuad005","url":null,"abstract":"Corals live in a complex, multipartite symbiosis with diverse microbes across kingdoms, some of which are implicated in vital functions, such as those related to resilience against climate change. However, knowledge gaps and technical challenges limit our understanding of the nature and functional significance of complex symbiotic relationships within corals. Here, we provide an overview of the complexity of the coral microbiome focusing on taxonomic diversity and functions of well-studied and cryptic microbes. Mining the coral literature indicate that while corals collectively harbour a third of all marine bacterial phyla, known bacterial symbionts and antagonists of corals represent a minute fraction of this diversity and that these taxa cluster into select genera, suggesting selective evolutionary mechanisms enabled these bacteria to gain a niche within the holobiont. Recent advances in coral microbiome research aimed at leveraging microbiome manipulation to increase coral's fitness to help mitigate heat stress-related mortality are discussed. Then, insights into the potential mechanisms through which microbiota can communicate with and modify host responses are examined by describing known recognition patterns, potential microbially derived coral epigenome effector proteins and coral gene regulation. Finally, the power of omics tools used to study corals are highlighted with emphasis on an integrated host-microbiota multiomics framework to understand the underlying mechanisms during symbiosis and climate change-driven dysbiosis.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/45/fuad005.PMC10045912.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9258631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4