FEMS microbiology reviews最新文献_第2页

Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift. 对抗原漂移至关重要的 H5 和 H7 禽流感病毒 HA 和 NA 表位。

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2024-05-08 DOI: 10.1093/femsre/fuae014

Jasmina M Luczo, Erica Spackman

{"title":"Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift.","authors":"Jasmina M Luczo, Erica Spackman","doi":"10.1093/femsre/fuae014","DOIUrl":"10.1093/femsre/fuae014","url":null,"abstract":"Avian influenza viruses evolve antigenically to evade host immunity. Two influenza A virus surface glycoproteins, the haemagglutinin and neuraminidase, are the major targets of host immunity and undergo antigenic drift in response to host pre-existing humoral and cellular immune responses. Specific sites have been identified as important epitopes in prominent subtypes such as H5 and H7, which are of animal and public health significance due to their panzootic and pandemic potential. The haemagglutinin is the immunodominant immunogen, it has been extensively studied, and the antigenic reactivity is closely monitored to ensure candidate vaccine viruses are protective. More recently, the neuraminidase has received increasing attention for its role as a protective immunogen. The neuraminidase is expressed at a lower abundance than the haemagglutinin on the virus surface but does elicit a robust antibody response. This review aims to compile the current information on haemagglutinin and neuraminidase epitopes and immune escape mutants of H5 and H7 highly pathogenic avian influenza viruses. Understanding the evolution of immune escape mutants and the location of epitopes is critical for identification of vaccine strains and development of broadly reactive vaccines that can be utilized in humans and animals.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140907908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diving into drug-screening: Zebrafish Embryos as an in vivo Platform for Antimicrobial Drug Discovery and Assessment 潜入药物筛选：斑马鱼胚胎作为抗菌药物发现和评估的体内平台

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-04-30 DOI: 10.1093/femsre/fuae011

Eva Habjan, Gina K Schouten, Alexander Speer, Peter van Ulsen, Wilbert Bitter

{"title":"Diving into drug-screening: Zebrafish Embryos as an in vivo Platform for Antimicrobial Drug Discovery and Assessment","authors":"Eva Habjan, Gina K Schouten, Alexander Speer, Peter van Ulsen, Wilbert Bitter","doi":"10.1093/femsre/fuae011","DOIUrl":"https://doi.org/10.1093/femsre/fuae011","url":null,"abstract":"The rise of multidrug-resistant bacteria underlines the need for innovative treatments, yet the introduction of new drugs has stagnated despite numerous antimicrobial discoveries. A major hurdle is a poor correlation between promising in vitro data and in vivo efficacy in animal models, which is essential for clinical development. Early in vivo testing is hindered by the expense and complexity of existing animal models. Therefore, there is a pressing need for cost-effective, rapid pre-clinical models with high translational value. To overcome these challenges, zebrafish embryos have emerged as an attractive model for infectious disease studies, offering advantages such as ethical alignment, rapid development, ease of maintenance, and genetic manipulability. The zebrafish embryo infection model, involving microinjection or immersion of pathogens and potential antibiotic hit compounds, provides a promising solution for early-stage drug screening. It offers a cost-effective and rapid means of assessing the efficacy, toxicity and mechanism of action of compounds in a whole-organism context. This review discusses the experimental design of this model, but also its benefits and challenges. Additionally, it highlights recently identified compounds in the zebrafish embryo infection model and discusses the relevance of the model in predicting the compound's clinical potential.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An opportunistic pathogen under stress: how group B streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive 压力下的机会性病原体：B 组链球菌如何应对细胞毒性反应物和金属离子失衡条件以求生存

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-04-27 DOI: 10.1093/femsre/fuae009

Kelvin G K Goh, Devika Desai, Ruby Thapa, Darren Prince, Dhruba Acharya, Matthew J Sullivan, Glen C Ulett

{"title":"An opportunistic pathogen under stress: how group B streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive","authors":"Kelvin G K Goh, Devika Desai, Ruby Thapa, Darren Prince, Dhruba Acharya, Matthew J Sullivan, Glen C Ulett","doi":"10.1093/femsre/fuae009","DOIUrl":"https://doi.org/10.1093/femsre/fuae009","url":null,"abstract":"Group B Streptococcus (GBS; also known as Streptococcus agalactiae) is an opportunistic bacterial pathogen that causes sepsis, meningitis, pneumonia and skin and soft tissue infections in neonates and healthy or immunocompromised adults. GBS is well-adapted to survive in humans due to a plethora of virulence mechanisms that afford responses to support bacterial survival in dynamic host environments. These mechanisms and responses include counteraction of cell death from exposure to excess metal ions that can cause mismetallation and cytotoxicity, and strategies to combat molecules such as reactive oxygen and nitrogen species that are generated as part of innate host defence. Cytotoxicity from reactive molecules can stem from damage to proteins, DNA, and membrane lipids, potentially leading to bacterial cell death inside phagocytic cells or within extracellular spaces within the host. Deciphering the ways in which GBS responds to the stress of cytotoxic reactive molecules within the host will benefit the development of novel therapeutic and preventative strategies to manage the burden of GBS disease. This review summarises knowledge of GBS carriage in humans and the mechanisms used by the bacteria to circumvent killing by these important elements of host immune defence: oxidative stress, nitrosative stress, and stress from metal ion intoxication/mismetallation.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Louis Pasteur, a child of the Jura, a man for the world 路易-巴斯德，一个汝拉的孩子，一个为世界而生的人

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-04-25 DOI: 10.1093/femsre/fuae010

Daniel Raichvarg, Tomasz Jagielski

{"title":"Louis Pasteur, a child of the Jura, a man for the world","authors":"Daniel Raichvarg, Tomasz Jagielski","doi":"10.1093/femsre/fuae010","DOIUrl":"https://doi.org/10.1093/femsre/fuae010","url":null,"abstract":"How did Louis Pasteur, born in a small town in the Jura—Dole, still little known to the world today, become a man of global recognition and fame? The answer to this question is guided by two pivotal considerations. First is Pasteur's relationship to the representation of reality. This relationship was seeded and steadily developed since his juvenile years through practicing different forms of artistic expression, the most famous of which were subtle pastels portraying Pasteur's parents and neighbors. This genuine attraction towards art gradually became «scientificized» at the same time, when new means of reproducing the reality were invented, such as photography. The second consideration, critical to understand the phenomenon of Pasteur's celebrity, is a strong linkage of his research with nature-based agricultural production. Here again, deeply rooted in his youth and home environment, permeated with the taste of wine and the smell of tanned leather, Pasteur's interests necessitated the processes of communication, not only at the scientific level, but also on a daily life basis, with numerous «social actors» at play (ferments, silkworms etc.). Throughout his work, Pasteur had to provide himself with the means to set up these interdisciplinarity and communication. The final result was the Pasteur Institute, or rather the Pasteur Institutes and the global Pasteur network.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic colonization by oral bacteria as an emerging theme in health and disease. 口腔细菌的异位定植是健康与疾病的一个新主题。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-04-22 DOI: 10.1093/femsre/fuae012

Carla Hernández-Cabanyero, Pascale Vonaesch

{"title":"Ectopic colonization by oral bacteria as an emerging theme in health and disease.","authors":"Carla Hernández-Cabanyero, Pascale Vonaesch","doi":"10.1093/femsre/fuae012","DOIUrl":"https://doi.org/10.1093/femsre/fuae012","url":null,"abstract":"The number of research papers published on the involvement of the oral microbiota in systemic diseases has grown exponentially over the last four years clearly demonstrating the growing interest in this field. Indeed, accumulating evidence highlights the central role of ectopic colonization by oral bacteria in numerous non-communicable diseases including inflammatory bowel diseases (IBDs), undernutrition, pre-term birth, neurological diseases, liver diseases, lung diseases, heart diseases or colonic cancer. There is thus much interest in understanding the molecular mechanisms that lead to the colonization and maintenance of ectopic oral bacteria. The aim of this review is to summarize and conceptualize the current knowledge about ectopic colonization by oral bacteria, highlight wherever possible the underlying molecular mechanisms and describe its implication in health and disease. The focus lies on the newly discovered molecular mechanisms, showcasing shared pathophysiological mechanisms across different body sites and syndromes and highlighting open questions in the field regarding the pathway from oral microbiota dysbiosis to non-communicable diseases.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models. 细菌性肺炎的体外模型：对广泛应用的复杂细胞培养模型的比较分析。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-03-01 DOI: 10.1093/femsre/fuae007

Laure Mahieu, Laurence Van Moll, Linda De Vooght, Peter Delputte, Paul Cos

{"title":"In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models.","authors":"Laure Mahieu, Laurence Van Moll, Linda De Vooght, Peter Delputte, Paul Cos","doi":"10.1093/femsre/fuae007","DOIUrl":"10.1093/femsre/fuae007","url":null,"abstract":"Bacterial pneumonia greatly contributes to the disease burden and mortality of lower respiratory tract infections among all age groups and risk profiles. Therefore, laboratory modelling of bacterial pneumonia remains important for elucidating the complex host-pathogen interactions and to determine drug efficacy and toxicity. In vitro cell culture enables for the creation of high-throughput, specific disease models in a tightly controlled environment. Advanced human cell culture models specifically, can bridge the research gap between the classical two-dimensional cell models and animal models. This review provides an overview of the current status of the development of complex cellular in vitro models to study bacterial pneumonia infections, with a focus on air-liquid interface models, spheroid, organoid, and lung-on-a-chip models. For the wide scale, comparative literature search, we selected six clinically highly relevant bacteria (Pseudomonas aeruginosa, Mycoplasma pneumoniae, Haemophilus influenzae, Mycobacterium tuberculosis, Streptococcus pneumoniae, and Staphylococcus aureus). We reviewed the cell lines that are commonly used, as well as trends and discrepancies in the methodology, ranging from cell infection parameters to assay read-outs. We also highlighted the importance of model validation and data transparency in guiding the research field towards more complex infection models.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10913945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life at the borderlands: microbiomes of interfaces critical to One Health. 边境地区的生命：对 "一体健康 "至关重要的界面微生物组。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-03-01 DOI: 10.1093/femsre/fuae008

Simon R Law, Falko Mathes, Amy M Paten, Pamela A Alexandre, Roshan Regmi, Cameron Reid, Azadeh Safarchi, Shaktivesh Shaktivesh, Yanan Wang, Annaleise Wilson, Scott A Rice, Vadakattu V S R Gupta

{"title":"Life at the borderlands: microbiomes of interfaces critical to One Health.","authors":"Simon R Law, Falko Mathes, Amy M Paten, Pamela A Alexandre, Roshan Regmi, Cameron Reid, Azadeh Safarchi, Shaktivesh Shaktivesh, Yanan Wang, Annaleise Wilson, Scott A Rice, Vadakattu V S R Gupta","doi":"10.1093/femsre/fuae008","DOIUrl":"10.1093/femsre/fuae008","url":null,"abstract":"Microbiomes are foundational components of the environment that provide essential services relating to food security, carbon sequestration, human health, and the overall well-being of ecosystems. Microbiota exert their effects primarily through complex interactions at interfaces with their plant, animal, and human hosts, as well as within the soil environment. This review aims to explore the ecological, evolutionary, and molecular processes governing the establishment and function of microbiome-host relationships, specifically at interfaces critical to One Health-a transdisciplinary framework that recognizes that the health outcomes of people, animals, plants, and the environment are tightly interconnected. Within the context of One Health, the core principles underpinning microbiome assembly will be discussed in detail, including biofilm formation, microbial recruitment strategies, mechanisms of microbial attachment, community succession, and the effect these processes have on host function and health. Finally, this review will catalogue recent advances in microbiology and microbial ecology methods that can be used to profile microbial interfaces, with particular attention to multi-omic, advanced imaging, and modelling approaches. These technologies are essential for delineating the general and specific principles governing microbiome assembly and functions, mapping microbial interconnectivity across varying spatial and temporal scales, and for the establishment of predictive frameworks that will guide the development of targeted microbiome-interventions to deliver One Health outcomes.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a rational approach to promoter engineering: understanding the complexity of transcription initiation in prokaryotes. 启动子工程的合理方法：了解原核生物转录启动的复杂性。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-03-01 DOI: 10.1093/femsre/fuae004

Cara Deal, Lien De Wannemaeker, Marjan De Mey

{"title":"Towards a rational approach to promoter engineering: understanding the complexity of transcription initiation in prokaryotes.","authors":"Cara Deal, Lien De Wannemaeker, Marjan De Mey","doi":"10.1093/femsre/fuae004","DOIUrl":"10.1093/femsre/fuae004","url":null,"abstract":"Promoter sequences are important genetic control elements. Through their interaction with RNA polymerase they determine transcription strength and specificity, thereby regulating the first step in gene expression. Consequently, they can be targeted as elements to control predictability and tuneability of a genetic circuit, which is essential in applications such as the development of robust microbial cell factories. This review considers the promoter elements implicated in the three stages of transcription initiation, detailing the complex interplay of sequence-specific interactions that are involved, and highlighting that DNA sequence features beyond the core promoter elements work in a combinatorial manner to determine transcriptional strength. In particular, we emphasize that, aside from promoter recognition, transcription initiation is also defined by the kinetics of open complex formation and promoter escape, which are also known to be highly sequence specific. Significantly, we focus on how insights into these interactions can be manipulated to lay the foundation for a more rational approach to promoter engineering.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution and emergence of Mycobacterium tuberculosis. 结核分枝杆菌的进化和出现。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-03-01 DOI: 10.1093/femsre/fuae006

Mickael Orgeur, Camille Sous, Jan Madacki, Roland Brosch

{"title":"Evolution and emergence of Mycobacterium tuberculosis.","authors":"Mickael Orgeur, Camille Sous, Jan Madacki, Roland Brosch","doi":"10.1093/femsre/fuae006","DOIUrl":"10.1093/femsre/fuae006","url":null,"abstract":"Tuberculosis (TB) remains one of the deadliest infectious diseases in human history, prevailing even in the 21st century. The causative agents of TB are represented by a group of closely related bacteria belonging to the Mycobacterium tuberculosis complex (MTBC), which can be subdivided into several lineages of human- and animal-adapted strains, thought to have shared a last common ancestor emerged by clonal expansion from a pool of recombinogenic Mycobacterium canettii-like tubercle bacilli. A better understanding of how MTBC populations evolved from less virulent mycobacteria may allow for discovering improved TB control strategies and future epidemiologic trends. In this review, we highlight new insights into the evolution of mycobacteria at the genus level, describing different milestones in the evolution of mycobacteria, with a focus on the genomic events that have likely enabled the emergence and the dominance of the MTBC. We also review the recent literature describing the various MTBC lineages and highlight their particularities and differences with a focus on host preferences and geographic distribution. Finally, we discuss on putative mechanisms driving the evolution of tubercle bacilli and mycobacteria in general, by taking the mycobacteria-specific distributive conjugal transfer as an example.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments. 放射性废物微生物学：预测微生物在不断变化的极端环境中的生存和活动。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuae001

Simon P Gregory, Jessica R M Mackie, Megan J Barnett

{"title":"Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments.","authors":"Simon P Gregory, Jessica R M Mackie, Megan J Barnett","doi":"10.1093/femsre/fuae001","DOIUrl":"10.1093/femsre/fuae001","url":null,"abstract":"The potential for microbial activity to occur within the engineered barrier system (EBS) of a geological disposal facility (GDF) for radioactive waste is acknowledged by waste management organizations as it could affect many aspects of the safety functions of a GDF. Microorganisms within an EBS will be exposed to changing temperature, pH, radiation, salinity, saturation, and availability of nutrient and energy sources, which can limit microbial survival and activity. Some of the limiting conditions are incorporated into GDF designs for safety reasons, including the high pH of cementitious repositories, the limited pore space of bentonite-based repositories, or the high salinity of GDFs in evaporitic geologies. Other environmental conditions such as elevated radiation, temperature, and desiccation, arise as a result of the presence of high heat generating waste (HHGW). Here, we present a comprehensive review of how environmental conditions in the EBS may limit microbial activity, covering HHGW and lower heat generating waste (LHGW) in a range of geological environments. We present data from the literature on the currently recognized limits to life for each of the environmental conditions described above, and nutrient availability to establish the potential for life in these environments. Using examples where each variable has been modelled for a particular GDF, we outline the times and locations when that variable can be expected to limit microbial activity. Finally, we show how this information for multiple variables can be used to improve our understanding of the potential for microbial activity to occur within the EBS of a GDF and, more broadly, to understand microbial life in changing environments exposed to multiple extreme conditions.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0