FEMS microbiology reviews最新文献_第3页

The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections. 人类细胞外基质蛋白在确定金黄色葡萄球菌生物膜感染中的作用。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuae002

Mohini Bhattacharya, Alexander R Horswill

{"title":"The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections.","authors":"Mohini Bhattacharya, Alexander R Horswill","doi":"10.1093/femsre/fuae002","DOIUrl":"10.1093/femsre/fuae002","url":null,"abstract":"Twenty to forty one percent of the world's population is either transiently or permanently colonized by the Gram-positive bacterium, Staphylococcus aureus. In 2017, the CDC designated methicillin-resistant S. aureus (MRSA) as a serious threat, reporting ∼300 000 cases of MRSA-associated hospitalizations annually, resulting in over 19 000 deaths, surpassing that of HIV in the USA. S. aureus is a proficient biofilm-forming organism that rapidly acquires resistance to antibiotics, most commonly methicillin (MRSA). This review focuses on a large group of (>30) S. aureus adhesins, either surface-associated or secreted that are designed to specifically bind to 15 or more of the proteins that form key components of the human extracellular matrix (hECM). Importantly, this includes hECM proteins that are pivotal to the homeostasis of almost every tissue environment [collagen (skin), proteoglycans (lung), hemoglobin (blood), elastin, laminin, fibrinogen, fibronectin, and fibrin (multiple organs)]. These adhesins offer S. aureus the potential to establish an infection in every sterile tissue niche. These infections often endure repeated immune onslaught, developing into chronic, biofilm-associated conditions that are tolerant to ∼1000 times the clinically prescribed dose of antibiotics. Depending on the infection and the immune response, this allows S. aureus to seamlessly transition from colonizer to pathogen by subtly manipulating the host against itself while providing the time and stealth that it requires to establish and persist as a biofilm. This is a comprehensive discussion of the interaction between S. aureus biofilms and the hECM. We provide particular focus on the role of these interactions in pathogenesis and, consequently, the clinical implications for the prevention and treatment of S. aureus biofilm infections.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-talk between immunity and behavior: insights from entomopathogenic fungi and their insect hosts. 免疫与行为之间的相互影响：昆虫病原真菌及其昆虫宿主的启示。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuae003

Wei Zhang, Xuanyu Chen, Ioannis Eleftherianos, Amr Mohamed, Ashley Bastin, Nemat O Keyhani

{"title":"Cross-talk between immunity and behavior: insights from entomopathogenic fungi and their insect hosts.","authors":"Wei Zhang, Xuanyu Chen, Ioannis Eleftherianos, Amr Mohamed, Ashley Bastin, Nemat O Keyhani","doi":"10.1093/femsre/fuae003","DOIUrl":"10.1093/femsre/fuae003","url":null,"abstract":"Insects are one of the most successful animals in nature, and entomopathogenic fungi play a significant role in the natural epizootic control of insect populations in many ecosystems. The interaction between insects and entomopathogenic fungi has continuously coevolved over hundreds of millions of years. Many components of the insect innate immune responses against fungal infection are conserved across phyla. Additionally, behavioral responses, which include avoidance, grooming, and/or modulation of body temperature, have been recognized as important mechanisms for opposing fungal pathogens. In an effort to investigate possible cross-talk and mediating mechanisms between these fundamental biological processes, recent studies have integrated and/or explored immune and behavioral responses. Current information indicates that during discrete stages of fungal infection, several insect behavioral and immune responses are altered simultaneously, suggesting important connections between the two systems. This review synthesizes recent advances in our understanding of the physiological and molecular aspects influencing cross-talk between behavioral and innate immune antifungal reactions, including chemical perception and olfactory pathways.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Processing of stalled replication forks in Bacillus subtilis. 枯草芽孢杆菌中停滞复制叉的处理。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuad065

Begoña Carrasco, Rubén Torres, María Moreno-Del Álamo, Cristina Ramos, Silvia Ayora, Juan C Alonso

{"title":"Processing of stalled replication forks in Bacillus subtilis.","authors":"Begoña Carrasco, Rubén Torres, María Moreno-Del Álamo, Cristina Ramos, Silvia Ayora, Juan C Alonso","doi":"10.1093/femsre/fuad065","DOIUrl":"10.1093/femsre/fuad065","url":null,"abstract":"Accurate DNA replication and transcription elongation are crucial for preventing the accumulation of unreplicated DNA and genomic instability. Cells have evolved multiple mechanisms to deal with impaired replication fork progression, challenged by both intrinsic and extrinsic impediments. The bacterium Bacillus subtilis, which adopts multiple forms of differentiation and development, serves as an excellent model system for studying the pathways required to cope with replication stress to preserve genomic stability. This review focuses on the genetics, single molecule choreography, and biochemical properties of the proteins that act to circumvent the replicative arrest allowing the resumption of DNA synthesis. The RecA recombinase, its mediators (RecO, RecR, and RadA/Sms) and modulators (RecF, RecX, RarA, RecU, RecD2, and PcrA), repair licensing (DisA), fork remodelers (RuvAB, RecG, RecD2, RadA/Sms, and PriA), Holliday junction resolvase (RecU), nucleases (RnhC and DinG), and translesion synthesis DNA polymerases (PolY1 and PolY2) are key functions required to overcome a replication stress, provided that the fork does not collapse.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10804225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies. 连点成线：从单分子研究中了解 ParB 在染色体分离中的关键作用。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuad067

Miloš Tišma, Jovana Kaljević, Stephan Gruber, Tung B K Le, Cees Dekker

{"title":"Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies.","authors":"Miloš Tišma, Jovana Kaljević, Stephan Gruber, Tung B K Le, Cees Dekker","doi":"10.1093/femsre/fuad067","DOIUrl":"10.1093/femsre/fuad067","url":null,"abstract":"Bacterial cells require DNA segregation machinery to properly distribute a genome to both daughter cells upon division. The most common system involved in chromosome and plasmid segregation in bacteria is the ParABS system. A core protein of this system - partition protein B (ParB) - regulates chromosome organization and chromosome segregation during the bacterial cell cycle. Over the past decades, research has greatly advanced our knowledge of the ParABS system. However, many intricate details of the mechanism of ParB proteins were only recently uncovered using in vitro single-molecule techniques. These approaches allowed the exploration of ParB proteins in precisely controlled environments, free from the complexities of the cellular milieu. This review covers the early developments of this field but emphasizes recent advances in our knowledge of the mechanistic understanding of ParB proteins as revealed by in vitro single-molecule methods. Furthermore, we provide an outlook on future endeavors in investigating ParB, ParB-like proteins, and their interaction partners.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploitation of microbial activities at low pH to enhance planetary health. 利用微生物在低pH下的活动来增强地球健康。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuad062

Merve Atasoy, Avelino Álvarez Ordóñez, Adam Cenian, Aleksandra Djukić-Vuković, Peter A Lund, Fatih Ozogul, Janja Trček, Carmit Ziv, Daniela De Biase

{"title":"Exploitation of microbial activities at low pH to enhance planetary health.","authors":"Merve Atasoy, Avelino Álvarez Ordóñez, Adam Cenian, Aleksandra Djukić-Vuković, Peter A Lund, Fatih Ozogul, Janja Trček, Carmit Ziv, Daniela De Biase","doi":"10.1093/femsre/fuad062","DOIUrl":"10.1093/femsre/fuad062","url":null,"abstract":"Awareness is growing that human health cannot be considered in isolation but is inextricably woven with the health of the environment in which we live. It is, however, under-recognized that the sustainability of human activities strongly relies on preserving the equilibrium of the microbial communities living in/on/around us. Microbial metabolic activities are instrumental for production, functionalization, processing, and preservation of food. For circular economy, microbial metabolism would be exploited to produce building blocks for the chemical industry, to achieve effective crop protection, agri-food waste revalorization, or biofuel production, as well as in bioremediation and bioaugmentation of contaminated areas. Low pH is undoubtedly a key physical-chemical parameter that needs to be considered for exploiting the powerful microbial metabolic arsenal. Deviation from optimal pH conditions has profound effects on shaping the microbial communities responsible for carrying out essential processes. Furthermore, novel strategies to combat contaminations and infections by pathogens rely on microbial-derived acidic molecules that suppress/inhibit their growth. Herein, we present the state-of-the-art of the knowledge on the impact of acidic pH in many applied areas and how this knowledge can guide us to use the immense arsenal of microbial metabolic activities for their more impactful exploitation in a Planetary Health perspective.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anelloviruses versus human immunity: how do we control these viruses? 阿奈洛韦病毒与人类免疫力：我们该如何控制这些病毒？

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2024-01-12 DOI: 10.1093/femsre/fuae005

Anne L Timmerman, Antonia L M Schönert, Lia van der Hoek

引用次数: 0

Root colonization by beneficial rhizobacteria 有益根瘤菌在根部定殖

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-12-14 DOI: 10.1093/femsre/fuad066

Yunpeng Liu, Zhihui Xu, Lin Chen, Weibing Xun, Xia Shu, Yu Chen, Xinli Sun, Zhengqi Wang, Yi Ren, Qirong Shen, Ruifu Zhang

引用次数: 0

Illuminating the oral microbiome and its host interactions: tools and approaches for molecular microbiology studies. 阐明口腔微生物组及其与宿主的相互作用：分子微生物学研究的工具和方法。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-11-01 DOI: 10.1093/femsre/fuac050

Justin Merritt, Jens Kreth

{"title":"Illuminating the oral microbiome and its host interactions: tools and approaches for molecular microbiology studies.","authors":"Justin Merritt, Jens Kreth","doi":"10.1093/femsre/fuac050","DOIUrl":"10.1093/femsre/fuac050","url":null,"abstract":"Advancements in DNA sequencing technologies within the last decade have stimulated an unprecedented interest in the human microbiome, largely due the broad diversity of human diseases found to correlate with microbiome dysbiosis. As a direct consequence of these studies, a vast number of understudied and uncharacterized microbes have been identified as potential drivers of mucosal health and disease. The looming challenge in the field is to transition these observations into defined molecular mechanistic studies of symbiosis and dysbiosis. In order to meet this challenge, many of these newly identified microbes will need to be adapted for use in experimental models. Consequently, this review presents a comprehensive overview of the molecular microbiology tools and techniques that have played crucial roles in genetic studies of the bacteria found within the human oral microbiota. Here, we will use specific examples from the oral microbiome literature to illustrate the biology supporting these techniques, why they are needed in the field, and how such technologies have been implemented. It is hoped that this information can serve as a useful reference guide to help catalyze molecular microbiology studies of the many new understudied and uncharacterized species identified at different mucosal sites in the body.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9346271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudomonas aeruginosa biofilm exopolysaccharides: assembly, function, and degradation. 铜绿假单胞菌生物膜胞外多糖：组装、功能和降解。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-11-01 DOI: 10.1093/femsre/fuad060

Andreea A Gheorghita, Daniel J Wozniak, Matthew R Parsek, P Lynne Howell

{"title":"Pseudomonas aeruginosa biofilm exopolysaccharides: assembly, function, and degradation.","authors":"Andreea A Gheorghita, Daniel J Wozniak, Matthew R Parsek, P Lynne Howell","doi":"10.1093/femsre/fuad060","DOIUrl":"10.1093/femsre/fuad060","url":null,"abstract":"The biofilm matrix is a fortress; sheltering bacteria in a protective and nourishing barrier that allows for growth and adaptation to various surroundings. A variety of different components are found within the matrix including water, lipids, proteins, extracellular DNA, RNA, membrane vesicles, phages, and exopolysaccharides. As part of its biofilm matrix, Pseudomonas aeruginosa is genetically capable of producing three chemically distinct exopolysaccharides - alginate, Pel, and Psl - each of which has a distinct role in biofilm formation and immune evasion during infection. The polymers are produced by highly conserved mechanisms of secretion, involving many proteins that span both the inner and outer bacterial membranes. Experimentally determined structures, predictive modelling of proteins whose structures are yet to be solved, and structural homology comparisons give us insight into the molecular mechanisms of these secretion systems, from polymer synthesis to modification and export. Here, we review recent advances that enhance our understanding of P. aeruginosa multiprotein exopolysaccharide biosynthetic complexes, and how the glycoside hydrolases/lyases within these systems have been commandeered for antimicrobial applications.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Alternaria pathogenesis in animals and plants. 链格孢病在动物和植物中的发病机制。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-11-01 DOI: 10.1093/femsre/fuad061

Chantal Fernandes, Arturo Casadevall, Teresa Gonçalves

{"title":"Mechanisms of Alternaria pathogenesis in animals and plants.","authors":"Chantal Fernandes, Arturo Casadevall, Teresa Gonçalves","doi":"10.1093/femsre/fuad061","DOIUrl":"10.1093/femsre/fuad061","url":null,"abstract":"Alternaria species are cosmopolitan fungi darkly pigmented by melanin that infect numerous plant species causing economically important agricultural spoilage of various food crops. Alternaria spp. also infect animals, being described as entomopathogenic fungi but also infecting warm-blooded animals, including humans. Their clinical importance in human health, as infection agents, lay in the growing number of immunocompromised patients. Moreover, Alternaria spp. are considered some of the most abundant and potent sources of airborne sensitizer allergens causing allergic respiratory diseases, as severe asthma. Among the numerous strategies deployed by Alternaria spp. to attack their hosts, the production of toxins, carrying critical concerns to public health as food contaminant, and the production of hydrolytic enzymes such as proteases, can be highlighted. Alternaria proteases also trigger allergic symptoms in individuals with fungal sensitization, acting as allergens and facilitating antigen access to the host subepithelium. Here, we review the current knowledge about the mechanisms of Alternaria pathogenesis in plants and animals, the strategies used by Alternaria to cope with the host defenses, and the involvement Alternaria allergens and mechanisms of sensitization.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0