FEMS microbiology reviews最新文献_第4页

Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity. 原核生物的表观遗传调控：DNA甲基转移酶活性的转录和表型结果。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag014

Sara Sharaf, Martina Cappelletti, Marco R Oggioni, Karolin Hijazi

{"title":"Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity.","authors":"Sara Sharaf, Martina Cappelletti, Marco R Oggioni, Karolin Hijazi","doi":"10.1093/femsre/fuag014","DOIUrl":"10.1093/femsre/fuag014","url":null,"abstract":"DNA methyltransferases (DNA MTases) are central epigenetic regulators in bacteria and archaea, with functions extending far beyond classical restriction-modification defence. Diverse MTase classes exist, including canonical and phase-variable restriction-modification systems, orphan MTases, and enzymes with currently undefined roles. MTase activity is associated with regulatory outcomes through both direct and indirect mechanisms. Methylation of promoters or regulatory regions can influence transcription, while broader methylome remodelling may affect genome-wide gene expression. These processes generate distinct epigenetic states associated with phenotypic variation. MTase-mediated regulation has been implicated in virulence, colonization, immune evasion, biofilm formation, motility, stress tolerance, metabolism, and antibiotic susceptibility. In archaea, MTase systems contribute to genome integrity and ecological specialization, highlighting shared epigenetic principles across domains of life. A major challenge is to move beyond descriptive methylome surveys and correlative analyses toward experimentally validated links between methylation and phenotype. This review synthesizes current understanding of prokaryotic DNA methylation, with primary emphasis on experimentally validated phenotypic outcomes. We also incorporate insights from omics-based studies where these provide context or generate testable hypotheses, while noting when evidence is based on inference rather than direct experimental validation, and include underrepresented archaeal systems.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-protein interfaces in chemotaxis receptor complexes and their role in signaling. 趋化受体复合物中的蛋白-蛋白界面及其在信号传导中的作用。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag015

Jessica J Allen, Gulalai Shah, Lynmarie K Thompson

{"title":"Protein-protein interfaces in chemotaxis receptor complexes and their role in signaling.","authors":"Jessica J Allen, Gulalai Shah, Lynmarie K Thompson","doi":"10.1093/femsre/fuag015","DOIUrl":"10.1093/femsre/fuag015","url":null,"abstract":"Chemotaxis receptor complexes sense chemical gradient in the cellular environment to direct swimming towards favorable environments. The core signaling units of these complexes are made up of two trimers-of-dimers of chemoreceptors, two CheW and a CheA dimer, which further assemble into large hexagonal signaling arrays. Structural and biochemical studies have provided important information on the architecture and interfaces of these complexes. However, the signaling pathway of these complexes that controls the kinase is not fully understood. In this review, we highlight the highest resolution models of this system and examine the current consensus on the protein-protein interfaces based on models and interface experiments. We also highlight differences observed between signaling states for the individual proteins and the protein interfaces that are proposed to be part of the signaling mechanism. Overall, we conclude that there is strong structural consensus for the protein interfaces but, despite some intriguing results, more information is needed to understand how the interfaces change between signaling states and the role they play in signaling. An animated Interactive 3D Complement (I3DC) is available in Proteopedia at https://proteopedia.org/w/Journal:FEMS_Microbiology_Reviews:1.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party. 从看门人到线粒体恶作剧：细菌外膜蛋白如何破坏宿主细胞派对。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuaf062

Paloma Osset-Trenor, Markus Proft, Amparo Pascual-Ahuir

{"title":"From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party.","authors":"Paloma Osset-Trenor, Markus Proft, Amparo Pascual-Ahuir","doi":"10.1093/femsre/fuaf062","DOIUrl":"10.1093/femsre/fuaf062","url":null,"abstract":"Gram-negative bacteria are equipped with a unique cell envelope structure that includes an outer membrane populated by diverse outer membrane proteins (OMPs). These OMPs are not only essential for bacterial survival, mediating critical functions such as nutrient transport, antibiotic resistance, and structural integrity, but they also play pivotal roles as virulence factors during host-pathogen interactions. Recent research highlights the ability of OMPs to manipulate host cellular processes, often targeting mitochondria to induce cell death or modulate immune responses. This review explores the multifunctional roles of bacterial OMPs, emphasizing their structural features, biogenesis, and pathogenic mechanisms. Furthermore, it delves into how bacterial OMPs exploit host cell machinery, particularly mitochondria, to promote infection, as well as their potential as targets for innovative antimicrobial strategies. Specifically, this review focuses on β-barrel OMPs that reach host mitochondria, detailing their delivery routes and mechanisms of organelle manipulation, while excluding non-β-barrel toxins and secretion-system effectors, to provide a defined perspective on mitochondria-targeting OMP virulence mechanisms.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12757748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring cooperation among social pathogens: a computational perspective. 探索社会病原体之间的合作：一个计算的视角。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag007

Andrea S Ramirez-Mata, Cameron Browne, Ryan S Doster, Marco Salemi, Brittany Rife Magalis

{"title":"Exploring cooperation among social pathogens: a computational perspective.","authors":"Andrea S Ramirez-Mata, Cameron Browne, Ryan S Doster, Marco Salemi, Brittany Rife Magalis","doi":"10.1093/femsre/fuag007","DOIUrl":"10.1093/femsre/fuag007","url":null,"abstract":"Once centered on animal social behavior, investigations into cooperation have expanded across the tree of life to include micro-organisms such as bacteria and viruses. Cooperative interactions are now understood to drive evolutionary dynamics within and between numerous microbial species and communities, including pathogen adaptation to and persistence in new hosts and environments. Identification and characterization of the underlying mechanisms of cooperation offer innovative opportunities for therapeutic interventions targeting difficult-to-treat pathogens through disruption of interactive networks. The current gold standards for evaluating micro-organismal cooperation often rely on assessing coordinated changes of phenotypic traits and the genetic and environmental factors that can affect them. Among these approaches, in vitro methods are labor-intensive, time-consuming, and often fail to replicate the natural microenvironment. Computational methods applied in vivo offer scalability and applicability but often require prior knowledge of metabolic pathways, restricting their use to bacterial systems. In contrast, sequence- and phylogeny-based frameworks can extend to viral datasets, though are typically con- strained by smaller sample sizes and incomplete annotations. Herein we focus on existing computational approaches used in identifying and/or characterizing cooperation and detail their advantages and limitations in shaping our understanding of cooperative pathogens.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From environmental signals to adaptive phenotypes: signal-responsive regulation and network logic of bacterial small RNAs. 从环境信号到适应性表型：细菌小rna的信号响应调节和网络逻辑。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag041

Zhengkai Yi, Xingning Xiao, Likou Zou, Congnan Cen, Xuping Shentu, Xiaoping Yu, Wen Wang

{"title":"From environmental signals to adaptive phenotypes: signal-responsive regulation and network logic of bacterial small RNAs.","authors":"Zhengkai Yi, Xingning Xiao, Likou Zou, Congnan Cen, Xuping Shentu, Xiaoping Yu, Wen Wang","doi":"10.1093/femsre/fuag041","DOIUrl":"10.1093/femsre/fuag041","url":null,"abstract":"Bacterial regulatory small RNAs (sRNAs) are integral components of posttranscriptional control, shaping environmental adaptation, metabolic homeostasis, and virulence. Advances in transcriptomics and RNA technologies have greatly expanded the repertoire of bacterial sRNAs and revealed their extensive roles in posttranscriptional regulatory networks. This review provides an updated framework for the biogenesis of bacterial sRNAs and their regulatory roles within posttranscriptional networks. Crucially, we describe the regulatory pathways controlling sRNA expression, including environmental signal sensing and regulation mediated by σ factors and transcription factors, to illustrate how sRNAs respond dynamically to changing conditions. Expanding beyond expression control, we further discuss the diverse roles of sRNA-mediated regulation in metabolic adaptation, stress responses, and bacterial virulence, emphasizing their importance in linking environmental changes to cellular phenotypes. Concurrently, we review current experimental and computational methods used for sRNA discovery and target identification. Overall, this review provides an integrated perspective on how bacterial sRNAs connect environmental sensing with adaptive cellular responses and highlights the broader significance of RNA-mediated regulation in bacterial physiology.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The natural history of a biocrust architect, the cyanobacterium Microcoleus vaginatus. 一个生物外壳建筑师的自然史，阴道微结肠蓝藻。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag033

Ferran Garcia-Pichel

{"title":"The natural history of a biocrust architect, the cyanobacterium Microcoleus vaginatus.","authors":"Ferran Garcia-Pichel","doi":"10.1093/femsre/fuag033","DOIUrl":"10.1093/femsre/fuag033","url":null,"abstract":"The filamentous cyanobacterium Microcoleus vaginatus is a pioneer soil colonizer and the most important microorganism for the formation of cyanobacterial biological soil crusts (or biocrusts), biofilm-like communities developing on soil surfaces exposed to light that become prominent in arid and polar lands. Among the most abundant cyanobacteria by global biomass, it contributes significantly through its biocrust-building to the global terrestrial carbon and nitrogen cycles. Locally, it contributes to the fertility and stability against erosion of the soils it inhabits and has become an indispensable tool in arid soil restoration efforts. Despite its importance, it remains relatively understudied. Because most work has been descriptive and ecological in nature, the knowledge amassed could be called a natural history. We provide an integrative review of what is known about its biology, what is not, and what is hindering advancement. We touch on its evolutionary history and population genetics, its physiological, genetic (genomic), behavioral, and ecological capacities, including some that present apparent paradoxes. We also explore the consequential relationships it keeps with other microbes, both mutualistic and antagonistic. The different aspects are guided by a dual leitmotiv to facilitate the understanding of its ecological success and environmental impact, and to predict its fate in a changing world.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convergent symbioses: morphology, life history, and niche specialization in coral and lichen mutualisms. 趋同共生：珊瑚和地衣共生的形态、生活史和生态位特化。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag025

Rosa Celia Poquita-Du, Maren Ziegler, Imke Schmitt

{"title":"Convergent symbioses: morphology, life history, and niche specialization in coral and lichen mutualisms.","authors":"Rosa Celia Poquita-Du, Maren Ziegler, Imke Schmitt","doi":"10.1093/femsre/fuag025","DOIUrl":"10.1093/femsre/fuag025","url":null,"abstract":"Corals and lichens represent some of the most diverse mutualistic symbioses in the marine and terrestrial ecosystems. Their evolutionary success is partly attributed to their association with internal, photosynthetic symbionts, which provide carbon and enable colonization of a wide-range of habitats. Although corals and lichens occupy fundamentally different ecosystems and are phylogenetically unrelated-corals are animals associated with dinoflagellates, while lichens are fungi associated with green algae/cyanobacteria-they share surprisingly many morphological, ecological, and life history traits. Here, we juxtapose morphology, reproduction, dispersal, symbiont acquisition strategies, and symbiont diversity in coral and lichen mutualisms, focusing mainly on the host and associated photobiont partner. We highlight how shared traits lead to convergent mechanisms of niche specialization, including adaptation to abiotic conditions through the formation of environment-specific host-symbiont combinations. The comparison enhances our understanding of evolutionary forces shaping these symbioses and provides a framework for evaluating their adaptive potential in a changing world.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding dark septate endophyte symbiosis: a functional and ecological perspective. 解码暗隔内生菌共生：一个功能和生态的视角。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag035

Keerthi Mandyam, Ari Jumpponen

{"title":"Decoding dark septate endophyte symbiosis: a functional and ecological perspective.","authors":"Keerthi Mandyam, Ari Jumpponen","doi":"10.1093/femsre/fuag035","DOIUrl":"10.1093/femsre/fuag035","url":null,"abstract":"Plant root microbial symbioses influence plant performance and ecosystem processes. Among these, dark septate endophyte (DSE) fungi are ubiquitous, non-mycorrhizal root endophytes with broad host ranges that facilitate nutrient acquisition, mitigate biotic and abiotic stress, and elicit positive, neutral, or negative plant growth responses depending on host and environmental context. Comparative genomic and transcriptomic analyses provide a robust framework for evaluating DSE lifestyles. Beyond their direct effects on plants, fungal endophytes contribute to soil microbiome networks, soil health, regenerative agriculture, and One Health. Integrating comparative genomics, transcriptomics, microbiome ecology, soil health, and agricultural studies, we present a systems-level synthesis of DSE biology that identifies key knowledge gaps and advances our understanding of DSE ecology and function. Comparative genomic, transcriptomic, and ecological evidence indicates that DSE share molecular and functional characteristics with ericoid mycorrhizal fungi, consistent with a hypothesized transition from saprotrophic toward specialized root-associated lifestyles. Their melanin production, extensive CAZyme repertoires, and broad ecological distribution suggest important roles in microbiome assembly, nutrient cycling, carbon dynamics, soil aggregation, and plant stress tolerance. We conclude by presenting an integrated framework linking plant-soil-fungus-environment interactions that defines core DSE competencies and highlights their importance for ecosystem functioning and sustainable agriculture.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type IV secretion systems: reconciling diversity through a unified nomenclature. IV型分泌系统：通过统一的命名法调和多样性。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuaf069

Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson, Nicolas Soler, Nathalie Leblond-Bourget, Badreddine Douzi

{"title":"Type IV secretion systems: reconciling diversity through a unified nomenclature.","authors":"Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson, Nicolas Soler, Nathalie Leblond-Bourget, Badreddine Douzi","doi":"10.1093/femsre/fuaf069","DOIUrl":"10.1093/femsre/fuaf069","url":null,"abstract":"Type IV secretion systems (T4SS) are versatile nanomachines responsible for the transfer of DNA and proteins across cell envelopes. From their ancestral role in conjugation, these systems have diversified into a superfamily with functions ranging from horizontal gene transfer to the delivery of toxins to eukaryotic and prokaryotic hosts. Recent structural and functional studies have uncovered unexpected architectural variations not only among Gram-negative systems but also between Gram-negative and Gram-positive systems. Despite this diversity, a conserved set of core proteins is maintained across the superfamily. To facilitate cross-system comparisons, we propose in this review a unified nomenclature for conserved T4SS subunits found in both Gram-negative and Gram-positive systems. We further highlight conserved and divergent mechanistic and architectural principles across bacterial lineages, and we discuss the diversity of emerging T4SSs whose unique structures and functions expand our understanding of this highly adaptable secretion superfamily.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molecular mechanisms of autophagy-virus interactions: from antiviral defense to viral counterstrategies. 自噬-病毒相互作用的分子机制：从抗病毒防御到病毒对抗策略。

IF 16.9 2区生物学

FEMS microbiology reviews Pub Date : 2026-01-02 DOI: 10.1093/femsre/fuag039

Yan-Mei Song, Xiao-Lan Gu, Bi-Feng Yuan, Xue-Jie Yu

{"title":"The molecular mechanisms of autophagy-virus interactions: from antiviral defense to viral counterstrategies.","authors":"Yan-Mei Song, Xiao-Lan Gu, Bi-Feng Yuan, Xue-Jie Yu","doi":"10.1093/femsre/fuag039","DOIUrl":"10.1093/femsre/fuag039","url":null,"abstract":"Autophagy is a highly conserved cellular degradative pathway in eukaryotes that exerts a dual regulatory role in the host antiviral defense. On the one hand, as an essential component of the host antiviral defense network, autophagy participates in the direct degradation of viral components, synergistically modulates innate immune signaling pathways including TLRs, RLRs, and cGAS-STING, and regulates adaptive immune responses such as MHC class I/II-mediated antigen presentation. On the other hand, diverse viruses have evolved sophisticated immune evasion mechanisms during long-term coevolution with the host. These viruses target key steps of autophagy, including initiation, membrane nucleation, elongation, maturation, and lysosomal fusion, to hijack or suppress the autophagic pathway and facilitate their replication. The regulation of autophagy by different viruses exhibits remarkable molecular specificity. In-depth dissection of these molecular mechanisms underlying autophagy-virus interactions will provide novel insights into the pathogenesis of viral diseases. This review systematically summarizes the core process of autophagy and its multiple regulatory mechanisms in antiviral immunity. We further highlight how viruses employ specific molecular strategies to target distinct stages of autophagy during infection, thereby hijacking the autophagic pathway to complete their replication cycles and pathogenic progression.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0