FEMS microbiology reviews最新文献_第6页

Faecalibacterium: a bacterial genus with promising human health applications. 粪杆菌:一种具有良好人类健康应用前景的细菌属。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad039

Rebeca Martín, David Rios-Covian, Eugénie Huillet, Sandrine Auger, Sara Khazal, Luis G Bermúdez-Humarán, Harry Sokol, Jean-Marc Chatel, Philippe Langella

{"title":"Faecalibacterium: a bacterial genus with promising human health applications.","authors":"Rebeca Martín, David Rios-Covian, Eugénie Huillet, Sandrine Auger, Sara Khazal, Luis G Bermúdez-Humarán, Harry Sokol, Jean-Marc Chatel, Philippe Langella","doi":"10.1093/femsre/fuad039","DOIUrl":"https://doi.org/10.1093/femsre/fuad039","url":null,"abstract":"In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/6f/fuad039.PMC10410495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The role of glycoconjugates as receptors for insecticidal proteins. 糖缀合物作为杀虫蛋白受体的作用。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad026

Hannah L Best, Lainey J Williamson, Emily A Heath, Helen Waller-Evans, Emyr Lloyd-Evans, Colin Berry

{"title":"The role of glycoconjugates as receptors for insecticidal proteins.","authors":"Hannah L Best, Lainey J Williamson, Emily A Heath, Helen Waller-Evans, Emyr Lloyd-Evans, Colin Berry","doi":"10.1093/femsre/fuad026","DOIUrl":"https://doi.org/10.1093/femsre/fuad026","url":null,"abstract":"Bacillus thuringiensis (Bt) proteins are an environmentally safe and effective alternative to chemical pesticides and have been used as biopesticides, with great commercial success, for over 50 years. Global agricultural production is predicted to require a 70% increase until 2050 to provide for an increasing population. In addition to agriculture, Bt proteins are utilized to control human vectors of disease-namely mosquitoes-which account for >700 000 deaths annually. The evolution of resistance to Bt pesticial toxins threatens the progression of sustainable agriculture. Whilst Bt protein toxins are heavily utilized, the exact mechanisms behind receptor binding and toxicity are unknown. It is critical to gain a better understanding of these mechanisms in order to engineer novel toxin variants and to predict, and prevent, future resistance evolution. This review focuses on the role of carbohydrate binding in the toxicity of the most utilized group of Bt pesticidal proteins-three domain Cry (3D-Cry) toxins.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring probiotic effector molecules and their mode of action in gut-immune interactions. 探索益生菌效应分子及其在肠道免疫相互作用中的作用模式。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad046

Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im, Ho-Keun Kwon

{"title":"Exploring probiotic effector molecules and their mode of action in gut-immune interactions.","authors":"Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im, Ho-Keun Kwon","doi":"10.1093/femsre/fuad046","DOIUrl":"10.1093/femsre/fuad046","url":null,"abstract":"Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained significant attention for their potential therapeutic applications. The beneficial effects of probiotics are believed to stem from their ability to enhance intestinal barrier function, inhibit pathogens, increase beneficial gut microbes, and modulate immune responses. However, clinical studies investigating the effectiveness of probiotics have yielded conflicting results, potentially due to the wide variety of probiotic species and strains used, the challenges in controlling the desired number of live microorganisms, and the complex interactions between bioactive substances within probiotics. Bacterial cell wall components, known as effector molecules, play a crucial role in mediating the interaction between probiotics and host receptors, leading to the activation of signaling pathways that contribute to the health-promoting effects. Previous reviews have extensively covered different probiotic effector molecules, highlighting their impact on immune homeostasis. Understanding how each probiotic component modulates immune activity at the molecular level may enable the prediction of immunological outcomes in future clinical studies. In this review, we present a comprehensive overview of the structural and immunological features of probiotic effector molecules, focusing primarily on Lactobacillus and Bifidobacterium. We also discuss current gaps and limitations in the field and propose directions for future research to enhance our understanding of probiotic-mediated immunomodulation.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10173090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages. 发出信号：蛋白质磷酸化如何帮助芽孢杆菌穿越不同的生命阶段。

IF 10.1 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad044

Aakriti Gangwal, Nishant Kumar, Nitika Sangwan, Neha Dhasmana, Uma Dhawan, Andaleeb Sajid, Gunjan Arora, Yogendra Singh

{"title":"Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.","authors":"Aakriti Gangwal, Nishant Kumar, Nitika Sangwan, Neha Dhasmana, Uma Dhawan, Andaleeb Sajid, Gunjan Arora, Yogendra Singh","doi":"10.1093/femsre/fuad044","DOIUrl":"10.1093/femsre/fuad044","url":null,"abstract":"Protein phosphorylation is a universal mechanism regulating a wide range of cellular responses across all domains of life. The antagonistic activities of kinases and phosphatases can orchestrate the life cycle of an organism. The availability of bacterial genome sequences, particularly Bacillus species, followed by proteomics and functional studies have aided in the identification of putative protein kinases and protein phosphatases, and their downstream substrates. Several studies have established the role of phosphorylation in different physiological states of Bacillus species as they pass through various life stages such as sporulation, germination, and biofilm formation. The most common phosphorylation sites in Bacillus proteins are histidine, aspartate, tyrosine, serine, threonine, and arginine residues. Protein phosphorylation can alter protein activity, structural conformation, and protein-protein interactions, ultimately affecting the downstream pathways. In this review, we summarize the knowledge available in the field of Bacillus signaling, with a focus on the role of protein phosphorylation in its physiological processes.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriophage-host interactions in Streptococcus thermophilus and their impact on co-evolutionary processes. 嗜热链球菌中噬菌体-宿主相互作用及其对共同进化过程的影响。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad032

Katherine Lavelle, Brian McDonnell, Gerald Fitzgerald, Douwe van Sinderen, Jennifer Mahony

引用次数: 1

The never-ending battle between lactic acid bacteria and their phages. 乳酸菌和噬菌体之间永无休止的战斗。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad035

Cécile Philippe, Jeffrey K Cornuault, Alessandra G de Melo, Rachel Morin-Pelchat, Alice P Jolicoeur, Sylvain Moineau

引用次数: 1

Anti-infective activities of long-chain fatty acids against foodborne pathogens. 长链脂肪酸对食源性致病菌的抗感染活性。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad037

Caroline Borreby, Eva Maria Sternkopf Lillebæk, Birgitte H Kallipolitis

引用次数: 0

Drivers and consequences of bacteriophage host range. 噬菌体宿主的驱动因素和后果范围。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad038

D Holtappels, Poliane Alfenas-Zerbini, B Koskella

{"title":"Drivers and consequences of bacteriophage host range.","authors":"D Holtappels, Poliane Alfenas-Zerbini, B Koskella","doi":"10.1093/femsre/fuad038","DOIUrl":"https://doi.org/10.1093/femsre/fuad038","url":null,"abstract":"Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that they can infect. This \"host range\" depends on the genotypes and morphologies of the phage and the bacterial host, but also on the environment in which they are interacting. Understanding phage host range is critical to predicting the impacts of these parasites in their natural host communities and their utility as therapeutic agents, but is also key to predicting how phages evolve and in doing so drive evolutionary change in their host populations, including through movement of genes among unrelated bacterial genomes. Here, we explore the drivers of phage infection and host range from the molecular underpinnings of the phage-host interaction to the ecological context in which they occur. We further evaluate the importance of intrinsic, transient, and environmental drivers shaping phage infection and replication, and discuss how each influences host range over evolutionary time. The host range of phages has great consequences in phage-based application strategies, as well as natural community dynamics, and we therefore highlight both recent developments and key open questions in the field as phage-based therapeutics come back into focus.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quorum sensing architecture network in Escherichia coli virulence and pathogenesis. 群体感应结构网络在大肠杆菌毒力和发病机制中的作用。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad031

Celia Mayer, Anabela Borges, Saskia-Camille Flament-Simon, Manuel Simões

{"title":"Quorum sensing architecture network in Escherichia coli virulence and pathogenesis.","authors":"Celia Mayer, Anabela Borges, Saskia-Camille Flament-Simon, Manuel Simões","doi":"10.1093/femsre/fuad031","DOIUrl":"https://doi.org/10.1093/femsre/fuad031","url":null,"abstract":"Escherichia coli is a Gram-negative commensal bacterium of the normal microbiota of humans and animals. However, several E. coli strains are opportunistic pathogens responsible for severe bacterial infections, including gastrointestinal and urinary tract infections. Due to the emergence of multidrug-resistant serotypes that can cause a wide spectrum of diseases, E. coli is considered one of the most troublesome human pathogens worldwide. Therefore, a more thorough understanding of its virulence control mechanisms is essential for the development of new anti-pathogenic strategies. Numerous bacteria rely on a cell density-dependent communication system known as quorum sensing (QS) to regulate several bacterial functions, including the expression of virulence factors. The QS systems described for E. coli include the orphan SdiA regulator, an autoinducer-2 (AI-2), an autoinducer-3 (AI-3) system, and indole, which allow E. coli to establish different communication processes to sense and respond to the surrounding environment. This review aims to summarise the current knowledge of the global QS network in E. coli and its influence on virulence and pathogenesis. This understanding will help to improve anti-virulence strategies with the E. coli QS network in focus.","PeriodicalId":12201,"journal":{"name":"FEMS microbiology reviews","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Correction to: four billion years of microbial terpenome evolution. 修正为:40亿年的微生物萜烯素进化。

IF 11.3 2区生物学

FEMS microbiology reviews Pub Date : 2023-07-05 DOI: 10.1093/femsre/fuad027

引用次数: 0