Mechanisms of host adaptation by bacterial pathogens.

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Matthew F Barber, J Ross Fitzgerald
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引用次数: 0

Abstract

The emergence of new infectious diseases poses a major threat to humans, animals, and broader ecosystems. Defining factors that govern the ability of pathogens to adapt to new host species is therefore a crucial research imperative. Pathogenic bacteria are of particular concern, given dwindling treatment options amid the continued expansion of antimicrobial resistance. In this review, we summarize recent advancements in the understanding of bacterial host species adaptation, with an emphasis on pathogens of humans and related mammals. We focus particularly on molecular mechanisms underlying key steps of bacterial host adaptation including colonization, nutrient acquisition, and immune evasion, as well as suggest key areas for future investigation. By developing a greater understanding of the mechanisms of host adaptation in pathogenic bacteria, we may uncover new strategies to target these microbes for the treatment and prevention of infectious diseases in humans, animals, and the broader environment.

细菌病原体适应宿主的机制。
新传染病的出现对人类、动物和更广泛的生态系统构成了重大威胁。因此,确定制约病原体适应新宿主物种能力的因素是一项至关重要的研究任务。随着抗菌药耐药性的不断扩大,治疗方法也越来越少,因此致病细菌尤其令人担忧。在这篇综述中,我们总结了对细菌宿主物种适应性认识的最新进展,重点是人类和相关哺乳动物的病原体。我们特别关注细菌宿主适应的关键步骤(包括定殖、营养获取和免疫逃避)的分子机制,并提出了未来研究的关键领域。通过进一步了解致病细菌宿主适应的基本机制,我们可能会发现针对这些微生物的新策略,从而治疗和预防人类、动物和更广泛环境中的传染性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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