双组分系统在肠出血性大肠杆菌肠道信号传感和毒力调节中的关键作用。

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Hongmin Sun, Di Huang, Yu Pang, Jingnan Chen, Chenbo Kang, Mengjie Zhao, Bin Yang
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引用次数: 0

摘要

肠出血性大肠杆菌(EHEC)是一种食源性病原体,通过在大肠定植感染人类。到达大肠后,EHEC 会介导局部信号识别和毒力基因的转录调控,以高度特异性的方式促进粘附和定植。双组分系统(TCS)是 EHEC 用来将外部刺激与基因表达调控结合起来的重要策略,从而使 EHEC 能够快速适应不断变化的环境条件。近年来发表的越来越多的研究表明,EHEC 能感知人类肠道中存在的多种宿主和微生物群衍生信号,并通过多种 TCS 介导的信号转导途径协调毒力基因的表达,从而启动致病过程。在此,我们总结了 EHEC 在感染初期如何检测到广泛的肠道信号,并通过多种信号转导途径精确调控毒力基因的表达,其中特别强调了 TCS 的关键作用。这篇综述就 TCSs 在 EHEC 发病机制中的重要性提供了宝贵的见解,对开发抗 EHEC 感染的抗菌疗法具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Key roles of two-component systems in intestinal signal sensing and virulence regulation in enterohemorrhagic Escherichia coli.

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that infects humans by colonizing the large intestine. Upon reaching the large intestine, EHEC mediates local signal recognition and the transcriptional regulation of virulence genes to promote adherence and colonization in a highly site-specific manner. Two-component systems (TCSs) represent an important strategy used by EHEC to couple external stimuli with the regulation of gene expression, thereby allowing EHEC to rapidly adapt to changing environmental conditions. An increasing number of studies published in recent years have shown that EHEC senses a variety of host- and microbiota-derived signals present in the human intestinal tract and coordinates the expression of virulence genes via multiple TCS-mediated signal transduction pathways to initiate the disease-causing process. Here, we summarize how EHEC detects a wide range of intestinal signals and precisely regulates virulence gene expression through multiple signal transduction pathways during the initial stages of infection, with a particular emphasis on the key roles of TCSs. This review provides valuable insights into the importance of TCSs in EHEC pathogenesis, which has relevant implications for the development of antibacterial therapies against EHEC infection.

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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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