研究微生物酸应激反应的方法:从分子到群体。

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Merve Atasoy, Simona Bartkova, Zeynep Çetecioğlu-Gürol, Nuno P Mira, Conor O'Byrne, Fernando Pérez-Rodríguez, Aricia Possas, Ott Scheler, Jana Sedláková-Kaduková, Mirka Sinčák, Matthias Steiger, Carmit Ziv, Peter A Lund
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引用次数: 0

摘要

对微生物如何检测和应对不同压力的研究由来已久,在产生基本生物学见解的同时,也对许多应用微生物领域具有重要意义,包括感染、食品和饮料制造以及工业和环境生物技术。有关酸胁迫的大量研究工作就很好地说明了这一点。为了了解低 pH 值对微生物生长和存活的影响,人们采用了许多不同的方法,从单细胞研究到大型异质种群研究,从分子或生物物理研究到计算研究,从易于理解的模式生物到定义不清的复杂微生物群。提高对这些方法的普遍认识大有裨益,因此本综述将举例说明用于研究耐酸性、耐酸性和酸胁迫反应的不同方法,以及这些方法可能带来的启示和使用中的一些问题。我们希望这能引起酸胁迫研究界内外的兴趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Methods for studying microbial acid stress responses: from molecules to populations.

The study of how micro-organisms detect and respond to different stresses has a long history of producing fundamental biological insights while being simultaneously of significance in many applied microbiological fields including infection, food and drink manufacture, and industrial and environmental biotechnology. This is well-illustrated by the large body of work on acid stress. Numerous different methods have been used to understand the impacts of low pH on growth and survival of micro-organisms, ranging from studies of single cells to large and heterogeneous populations, from the molecular or biophysical to the computational, and from well-understood model organisms to poorly defined and complex microbial consortia. Much is to be gained from an increased general awareness of these methods, and so the present review looks at examples of the different methods that have been used to study acid resistance, acid tolerance, and acid stress responses, and the insights they can lead to, as well as some of the problems involved in using them. We hope this will be of interest both within and well beyond the acid stress research community.

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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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