Eurosurveillance最新文献

{"title":"First nationwide point-prevalence survey on healthcare-associated infections and antibiotic use in long-term care facilities, Switzerland, September 2024.","authors":"Domenica Flury, Emmanouil Glampedakis, Nando Bloch, Celine Gardiol, Fabian Grässli, Simone Kessler, Jacqueline Kuhn, Tanja Kurdovsky, Stefan P Kuster, Vanja Piezzi, Matthias Schlegel, Simone Toppino, Philipp Kohler","doi":"10.2807/1560-7917.ES.2025.30.38.2500221","DOIUrl":"10.2807/1560-7917.ES.2025.30.38.2500221","url":null,"abstract":"<p><p>INTRODUCTIONData for healthcare-associated infections (HAI) and antibiotic use in long-term care facilities (LTCF) in Switzerland are lacking but are necessary to take actions.AIMWe aimed to estimate HAI prevalence and antibiotic use and to record existing structure and process indicators in the area of infection prevention/antibiotic use in Swiss LTCF.METHODSWe invited all Swiss LTCF for this PPS in September 2024 using the adapted Healthcare-Associated Infections in European Long-Term Care Facilities (HALT)-4 protocol. The proportion of residents with HAI and systemic antibiotic treatment was calculated for a representative sample, stratified by language region and size. We assessed resident-level and institutional risk factors for HAI in all participating institutions, using random-effects logistic regression.RESULTSWe included 94 LTCF (7,244 residents), whereof 49 LTCFs (3,375 residents) belonged to the representative sample. Median age of residents in the representative sample was 87 years (range: 36-107) and 2,334 (69.2%) were female. Prevalence of HAI was 2.2% (95% confidence interval (CI): 1.7-2.7); 2.7% (95% CI: 2.2-3.3) were receiving antibiotic treatment, with highest use in LTCF in French-speaking cantons (5.9%; 95% CI: 4.2-7.5). Urinary tract (46%) and respiratory infections (20%) were most common, aminopenicillins (26%) and nitrofurantoin (19%) the most commonly used antimicrobials. The strongest independent risk factor for HAI was presence of urinary catheters (adjusted odds ratio = 2.65; 95% CI: 1.71-4.11).DISCUSSIONPrevalence of HAI and antibiotic use in Swiss LTCFs were comparable to the European average from 2023/24. There are regional differences in antibiotic consumption. Urinary catheterisation, potentially modifiable, was the most important risk factor for HAI.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 38","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shotgun metagenomics on indoor air for surveillance of respiratory, enteric, and skin viruses in a Belgian daycare setting, January to December 2022.","authors":"Mustafa Karatas, Caspar Geenen, Els Keyaerts, Lore Budts, Joren Raymenants, Charlotte Eggers, Bastiaan Craessaerts, Emmanuel André, Jelle Matthijnssens","doi":"10.2807/1560-7917.ES.2025.30.38.2400711","DOIUrl":"10.2807/1560-7917.ES.2025.30.38.2400711","url":null,"abstract":"<p><p>BACKGROUNDHospital-based communicable disease surveillance may be costly during large outbreaks and often misses mild or asymptomatic infections. It can be enhanced by environmental surveillance, which monitors circulating pathogens, even from asymptomatic carriers.AIMWe investigated if tracking viruses in indoor air could be used for their surveillance in a community setting. We also tested the value of untargeted metagenomics to identify viruses in air samples.METHODSWeekly indoor air samples were collected with active air samplers from January until December 2022 from a daycare centre in Leuven, Belgium. Samples were analysed using respiratory and enteric quantitative (q)PCR panels, as well as with untargeted metagenomics, enabling both targeted and agnostic viral detections.RESULTSHuman-associated viruses were detected in 40 of 42 samples across the study period, with MW polyomavirus being most prevalent (33 samples). Respiratory agents such as rhinoviruses and RSV-B and enteric viruses including rotavirus A, astrovirus, and adenovirus appeared at epidemiologically expected times. Skin-associated viruses were also observed, notably Merkel cell polyomavirus and STL polyomavirus. Metagenomics enabled reconstructing multiple complete genomes, distinguishing viral subtypes and detecting copresence of closely related variants. Additionally, several animal, insect, fungal, and plant viruses were found, reflecting both indoor and outdoor environmental exposure.CONCLUSIONIndoor air monitoring, combined with untargeted metagenomics, demonstrates a potential to support virus surveillance. This approach can allow monitoring circulation of viruses in community settings, including those causing asymptomatic or mild infections. By enabling to reconstruct complete viral genomes, it allows detailed variant tracking, facilitating adapted public health responses.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 38","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and characterisation of Xpert CT/NG assay <i>Neisseria gonorrhoeae</i> diagnostic escape mutants, England, June 2025.","authors":"Melissa Jansen van Rensburg, Rachel Pitt-Kendall, Michelle Hincke, Penelope R Cliff, Jonathan Shaw, Katy Sinka, John Saunders, Helen Fifer, Sarah Alexander","doi":"10.2807/1560-7917.ES.2025.30.36.2500673","DOIUrl":"10.2807/1560-7917.ES.2025.30.36.2500673","url":null,"abstract":"<p><p>We report the timely detection of a strain of <i>Neisseria gonorrhoeae</i> which was confirmed as a diagnostic escape mutant on the Cepheid Xpert CT/NG assay in England in June 2025. The reason for assay failure was a likely recombination event with <i>Neisseria meningitidis</i>, which removed both assay target sites. Seven historical putative Xpert CT/NG assay diagnostic escape mutants were also identified following subsequent in silico screening of gonococcal genome collections, but currently there is no evidence of widespread circulation.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 36","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade of West Nile virus surveillance in the host and vector populations of Denmark, 2011 to 2023.","authors":"Ann Sofie Olesen, Charlotta Polacek, Anette Bøtner, René Bødker, Jesper Johannes Madsen, Kasper Thorup, Graham J Belsham, Thomas Bruun Rasmussen, Louise Lohse","doi":"10.2807/1560-7917.ES.2025.30.37.2400791","DOIUrl":"10.2807/1560-7917.ES.2025.30.37.2400791","url":null,"abstract":"<p><p>BACKGROUNDTo spot potential introductions of West Nile virus (WNV) into Denmark, a national surveillance programme for WNV was established in 2011. The relevance of this programme was underscored in the late 2010s, when WNV was detected in areas close to Denmark.AIMWe describe the Danish WNV surveillance programme and its findings in 2011-2023.METHODSThe surveillance programme monitors mosquitoes, which are WNV vectors, and some mammalian animals and birds, which are WNV hosts. Surveillance samples are also tested for the closely related Usutu virus (USUV), which, like WNV, is a flavivirus. During the study, WNV and USUV RNAs were sought in 62 bats (sampled in 2022-2023), 5,661 <i>Culex sp.</i> mosquitoes (2011-2023), 628 dead wild birds (2011-2014 and 2019-2023), and 492 live birds (2011-2012, 2022-2023). These 492 birds were from among 3,269 live long-distance migratory birds (sampled in 2011-2023) serologically tested for WNV and USUV antibodies. Additionally, 4,978 free-ranging poultry (2011-2023) and 236 horses (2011-2013) were tested serologically.RESULTSNeither WNV nor USUV RNA was detected in bats, mosquitoes, or birds, but anti-WNV specific antibodies were detected in migratory birds, one domestic chicken and one imported horse. For migratory birds, competitive ELISAs detected anti-flavivirus antibodies in 3.9% (128/3,269) of tested samples. Across 2011-2023, the annual flavivirus seroprevalence varied from 1-13%. Using virus neutralisation assays on selected samples, anti-WNV or anti-USUV specific antibodies were detected in 25 and 11 bird samples, respectively.CONCLUSIONSFindings demonstrate that the concern about virus incursion is well founded and support continued vigilance for WNV.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 37","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated cross-sectional surveys show a decreasing trend in <i>Borrelia burgdorferi</i> sensu lato seroprevalence over a 50-year period, Finland, 1966 to 2017.","authors":"Maija Lamppu, Tero Klemola, Eero Vesterinen, Timothée Dub, Annukka Pietikäinen, Jukka Hytönen","doi":"10.2807/1560-7917.ES.2025.30.36.2500171","DOIUrl":"10.2807/1560-7917.ES.2025.30.36.2500171","url":null,"abstract":"<p><p>BACKGROUNDLyme borreliosis (LB) caused by <i>Borrelia burgdorferi</i> sensu lato (Bbsl) spirochetes is the most common tick-borne infection in Europe and the incidence of LB has been increasing in many countries.AIMWe examined changes in Bbsl seroprevalence in Finland over the past 50 years.METHODSWe analysed samples collected from people aged ≥ 15 years in nationwide cross-sectional health surveys conducted over the years 1966-1972, 1978-1980, 2000-2001 and 2017. Samples were screened with an IgG ELISA assay and confirmed with an IgG bead immunoassay. We assessed factors associated with Bbsl seropositivity by generalised linear models.RESULTSSeroprevalence was highest in 1966-1972 (25.0%; 95% confidence interval (CI): 22.3-27.7%), while it was lower in 1978-1980 (16.6%; 95% CI: 14.3-18.9%), 2000-2001 (7.4%; 95% CI: 5.8-9.0%) and 2017 (3.4%; 95% CI: 2.3-4.5%). Male sex (p = 0.0014) and increasing age (p < 0.0001) were associated with higher seropositivity. The estimated probability of being seropositive was highest among residents from southern (least squares (LS) mean: 0.164; 95% CI: 0.139-0.192), central and eastern Finland (LS mean: 0.141; 95% CI: 0.116-0.170) and lowest in northern Finland (LS mean: 0.019; 95% CI: 0.014-0.028).CONCLUSIONOur results show a decrease in the seroprevalence in Finnish people over time. Reasons for this decrease are not clear but could be related to urbanisation, increased awareness, effective diagnostics and prompt antibiotic treatments. Overall, this study demonstrates how repeated serosurveys can help in revealing trends and identifying potential risk groups.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 36","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interseasonal outbreak of influenza A(H1N1)pdm09 related to a music festival, Denmark, August 2025.","authors":"Amanda Bolt Botnen, Hanne-Dorthe Emborg, Casper Thorup, Jesper Krog, Sofia Myrup Otero, Stine Nielsen, Bolette Søborg, Ramona Trebbien","doi":"10.2807/1560-7917.ES.2025.30.36.2500658","DOIUrl":"10.2807/1560-7917.ES.2025.30.36.2500658","url":null,"abstract":"<p><p>In week 33, 2025, the integrated respiratory virus surveillance at Statens Serum Institut, Denmark, detected an atypical sixfold increase in influenza A(H1N1)pdm09 cases. Rapid sequencing of viruses collected in week 33 identified a highly related cluster of 17 cases. Telephone interviews with patients belonging to this cluster revealed that they all had attended a large open-air music festival. This is the first time an influenza outbreak has been detected during the summer in Denmark related to a large gathering.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 36","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis screening among people who experience homelessness in Brno: a 20-year public health intervention, Czechia, 2005 to 2024.","authors":"Veronika Šponiar Ovesná, Renata Ciupek, Alena Holčíková, Hana Jirková","doi":"10.2807/1560-7917.ES.2025.30.37.2500119","DOIUrl":"10.2807/1560-7917.ES.2025.30.37.2500119","url":null,"abstract":"<p><p>INTRODUCTIONTuberculosis (TB) is curable and preventable, yet remains a health concern in vulnerable populations. Individuals experiencing homelessness are at increased risk owing to medical, environmental and social factors.AIMWe aimed to evaluate a 20-year TB screening programme in people experiencing homelessness in Brno, Czechia (2005-2024), and analyse additional TB diagnoses in this population made outside the project, to inform public health strategies for TB control in vulnerable groups in a low-incidence country.METHODSClinical examination and chest X-ray screening were offered to people without stable housing, incentivised by meal vouchers. Individuals with pathological findings underwent further diagnostic evaluation and treatment. Demographic and clinical data were collected. Additional TB diagnoses made in this population through other detection methods were analysed for comparison.RESULTSBetween 2005 and 2024, of 3,918 individuals approached, 2,664 participated in screening (average participation rate: 68.0%), and 18 were diagnosed with TB through the project. Another 132 individuals experiencing homelessness were diagnosed with TB through other pathways, yielding 150 diagnoses, representing 19.3% of TB notifications in Brno. The estimated TB incidence among people experiencing homelessness was 24.4 times higher than in the general population (95% confidence interval: 20.5-28.9). Despite a citywide decline in TB incidence, the proportion of TB diagnoses among people who experience homelessness increased over time.CONCLUSIONHomelessness is a risk factor for TB in low-incidence settings. This long-term screening initiative proved feasible and valuable, demonstrating how outreach-based screening can support early detection and contribute to TB prevention among socio-economically marginalised populations.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 37","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress towards HIV transmission elimination targets: model-based estimation of incidence and the extent of undiagnosed infection, Scotland, 1981 to 2022.","authors":"Scott A McDonald, Beth L Cullen, Lesley A Wallace, Alan Yeung, Rak Nandwani, Claudia Estcourt, Daniel Clutterbuck, Nicola Steedman, David Henderson, Kirsty Roy, Sharon J Hutchinson","doi":"10.2807/1560-7917.ES.2025.30.36.2500164","DOIUrl":"10.2807/1560-7917.ES.2025.30.36.2500164","url":null,"abstract":"<p><p>BACKGROUNDThe global goal to end the AIDS epidemic cannot be achieved without estimates of incidence and undiagnosed infection.AIMWe aimed to estimate the timing of HIV transmission events and the number of people unaware of their diagnosis in Scotland, by mode of acquisition and migrant status.METHODSSurveillance data from Scotland's national HIV diagnosis database (1981-2022) linked to death and migration data was entered into the HIV Platform tool of the European Centre for Disease Prevention and Control, to back-calculate HIV incidence while imputing missing data and adjusting for reporting delay.RESULTSWe estimated 8,235 HIV transmission events between 1980 and 2022 among people living in Scotland, with an 80% reduction from 2010 to 2021 (258 to 52 events). Excluding people diagnosed outside Scotland, we estimated 4,854 (95% confidence interval (CI): 4,637-5,080) people living with HIV at the end of 2021, of whom 8.2% (396/4,854) were undiagnosed. Stratified estimates of this proportion were 6.9% for gay, bisexual and other men who have sex with men, 7.0% for people who inject drugs, 12.6% and 12.4% for heterosexuals born and not-born in the United Kingdom (UK), respectively. Including people first diagnosed with HIV outside Scotland, the overall proportion undiagnosed was 6.1% (396/6,444).CONCLUSIONScotland is on track to meet the United Nations' diagnosis target of 95% by 2025, with the World Health Organization target of a 75% incidence reduction met since 2010. To reduce further transmission, expanded HIV testing and prevention services are necessary to better reach at-risk heterosexual individuals.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 36","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes zoster incidence in adults aged ≥ 20 years in Finland, 2015 to 2023: a population-based register study.","authors":"Aapo Juutinen, Heini Salo, Toni Lehtonen, Tuija Leino","doi":"10.2807/1560-7917.ES.2025.30.35.2500077","DOIUrl":"10.2807/1560-7917.ES.2025.30.35.2500077","url":null,"abstract":"<p><p>BACKGROUNDHerpes zoster, also known as shingles, is a painful skin condition caused by varicella zoster virus. Information is lacking on incidence of herpes zoster in Finland.AIMTo estimate age-specific annual incidence of herpes zoster over 9 years with data from several nationwide health registers.METHODSIn a nationwide study, we compiled a dataset encompassing the entire Finnish population by linking data from multiple population-based registers for 2015-23. The dataset includes records from nearly all healthcare providers in Finland. Case definitions were based on ICD-10 codes B02 and G53.0, and ICPC-2 code S70. The dataset was supplemented with information on the purchase of prescribed antiviral medication.RESULTSIn total, 220,693 herpes zoster cases were identified during 2015-23 among adults aged ≥ 20 years. In 2023, when register coverage was best, age-specific annual incidence rates for the entire population varied from 3.8 to 12.2, increasing with age. Incidence was higher among females than males, and highest among elderly aged ≥ 85 years living at home without organised care. Cumulative incidence data from 2023 revealed that lifetime risk of developing herpes zoster by age 85 was 42%, and as high as 46% using the incidence among elderly living at home without organised care.CONCLUSIONHerpes zoster incidence varied by sex and age group, and appeared to be under-reported in institutional and organised care settings. Currently, there is no official decision on herpes zoster vaccination in Finland, despite favourable recommendations from the national expert group and the National Advisory Committee on Vaccination.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 35","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in hospital antibacterial consumption: a retrospective analysis of reimbursement data, Belgium 2017 to 2022.","authors":"Laura Bonacini, Julie Domen, Paul De Munter, Maya Hites, Diana Huis In't Veld, Antonelle Pardo, Johan Van Laethem, Dirk Vogelaers, Boudewijn Catry, Lucy Catteau","doi":"10.2807/1560-7917.ES.2025.30.35.2500088","DOIUrl":"10.2807/1560-7917.ES.2025.30.35.2500088","url":null,"abstract":"<p><p>BACKGROUNDThe COVID-19 pandemic has challenged efforts to optimise rational antibacterial use due to uncertainties in treatment protocols.AIMWe investigated the impact of COVID-19 on hospital antibacterial consumption in Belgium from 2017 to 2022, relative to the general and hospitalised population.METHODSWe analysed national reimbursement data using defined daily doses (DDD) and three metrics: DDD/1,000 inhabitants/day (DID), DDD/1,000 patient days (PD) and DDD/1,000 admissions. We performed linear regressions to analyse 6-year trends (2017-2022) and estimated predicted consumption from 2020 to 2022 using the compound annual growth rate from 2017 to 2019. To assess the impact of COVID-19, we compared observed and predicted relative changes in antibacterial consumption between 2019 (pre-pandemic) and 2020 (early pandemic) and between 2019 and 2022 (late pandemic).RESULTSFrom 2019 to 2020, hospital antibacterial consumption (anatomical therapeutic chemical (ATC) J01) decreased by 12% in DID but increased by 5% and 7% in DDD/1,000 PD and DDD/1,000 admissions, respectively. From 2017 to 2022, systemic antibacterials consumption declined significantly only when expressed in DID. Although all systemic antibacterial subclasses were used less than predicted between 2020 and 2022 when expressed in DID, hospital-based metrics showed higher consumption, except for macrolides and amphenicols. Broad-spectrum antibacterial consumption decreased from 2017 to 2022 when expressed in DID but fluctuated with hospital metrics, peaking in 2020, and exceeded forecasts.CONCLUSIONCOVID-19 altered trends in hospital antibacterial consumption, with contrasting patterns depending on the metric used, underline the importance of hospital-specific surveillance to support targeted stewardship and preparedness efforts.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 35","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}