Eurosurveillance最新文献

{"title":"Multinational investigation of a <i>Salmonella</i> Umbilo outbreak reveals rocket salad and baby spinach as the likely infection vehicles, Europe, 2024.","authors":"Bettina M Rosner, Sandra Simon, Stine Nielsen, Sandra Köberl-Jelovcan, Pernille Gymoese, Dirk Werber, Anika Meinen, Michael Pietsch, Antje Flieger, Jennie Fischer, Marina C Lamparter, Felix Küffel, Fiona Költringer, Christian Kornschober, Luise Müller, Gerhard Falkenhorst, Sabine Maritschnik","doi":"10.2807/1560-7917.ES.2024.29.46.2400728","DOIUrl":"10.2807/1560-7917.ES.2024.29.46.2400728","url":null,"abstract":"<p><p>A food-borne outbreak with about 200 <i>Salmonella</i> Umbilo cases occurred mainly between July and September 2024 in several European countries. Collaborative work between outbreak teams in Germany, Austria and Denmark, including epidemiological and microbiological investigations, allowed to rapidly identify rocket salad as the likely infection vehicle. <i>Salmonella</i> Umbilo was detected in rocket salad, and later in baby spinach. The food isolates and clinical outbreak strain were genetically closely related. Both food items originated from the same company in Italy.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 46","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of the German public health service to the first imported mpox clade Ib case in Germany, October 2024.","authors":"Rosanne de Jong, Jennifer Schauer, Annelene Kossow, Sibylle Scharkus, Annette Jurke","doi":"10.2807/1560-7917.ES.2024.29.28.2400743","DOIUrl":"10.2807/1560-7917.ES.2024.29.28.2400743","url":null,"abstract":"<p><p>In October 2024, the first imported mpox clade Ib case was confirmed in Germany in an individual in their thirties returning from Rwanda. In this report we summarise the response from the public health service in North Rhine-Westphalia related to case management, contact tracing and institutional collaborations. Our findings highlight the importance of a coordinated public health response in the management of imported mpox cases and in preventing the transmission of mpox clade Ib in Germany and beyond.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Candida auris</i> fungaemia outbreak in a tertiary care academic hospital and emergence of a pan-echinocandin resistant isolate, Greece, 2021 to 2023.","authors":"Joseph Meletiadis, Maria Siopi, Bram Spruijtenburg, Panagiota-Christina Georgiou, Maria Kostoula, Sophia Vourli, Frantzeska Frantzeskaki, Elisabeth Paramythiotou, Jacques F Meis, Iraklis Tsangaris, Spyros Pournaras","doi":"10.2807/1560-7917.ES.2024.29.45.2400128","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400128","url":null,"abstract":"<p><p>After the start of the COVID-19 pandemic, a rapid rise in reported numbers and wide geographic spread of <i>Candida auris</i>-related invasive infections has been observed globally. However, the contemporary epidemiology of <i>C. auris</i> fungaemias in Greece remains unknown. An outbreak of <i>C. auris</i> bloodstream infections has been ongoing for almost 3 years in a Greek tertiary care academic hospital, with 89 <i>C. auris</i>-driven episodes appearing in five waves every 6-7 months following peaks in colonisation rates by 3-4 months. All isolates clustered in clade I and were genetically related, 84% were fluconazole-resistant and all were non-resistant to amphotericin B and echinocandins, except one pan-echinocandin-resistant isolate (<i>FKS1S639F</i> mutant) recovered from a patient on empiric therapy with anidulafungin. Notably, <i>C. auris</i> was in 2023 the most prevalent (34%) cause of candidaemia in our hospital. The accelerated and long-term transmission dynamics of <i>C. auris</i> fungaemia underscore the need for rigorous infection control measures, while antifungal stewardship is warranted to contain the selection of echinocandin-resistant isolates.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missed opportunities for early HIV diagnosis in Greece: The MORFEAS study, 2019 to 2021.","authors":"Sotirios Roussos, Nikos Pantazis, Konstantinos Protopapas, Anastasia Antoniadou, Antonios Papadopoulos, Giota Lourida, Vasileios Papastamopoulos, Maria Chini, Konstantinos Alexakis, Emmanouil Barbounakis, Diamantis Kofteridis, Lydia Leonidou, Markos Marangos, Vasileios Petrakis, Periklis Panagopoulos, Elpida Mastrogianni, Dimitrios Basoulis, Panagiota Palla, Nikolaos Sipsas, Varvara Vasalou, Vasileios Paparizos, Simeon Metallidis, Theofilos Chrysanthidis, Ioannis Katsarolis, Vana Sypsa, Mina Psichogiou","doi":"10.2807/1560-7917.ES.2024.29.48.2400138","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400138","url":null,"abstract":"<p><p>BackgroundLate HIV diagnosis (CD4+ T-cell count < 350 cells/μL, or with an AIDS-defining event) remains a persistent challenge in Greece, indicating potential missed opportunities (MOs) for earlier testing.AimTo determine the frequency of HIV indicator conditions (ICs) preceding diagnosis and to quantify MOs for earlier testing at a nationwide level in Greece.MethodsThis multicentre retrospective study analysed data on 823 antiretroviral therapy-naive adults (≥ 18 years) diagnosed with HIV during 2019-21. Medical records were reviewed to identify pre-diagnosis healthcare contacts (HCCs) and ICs justifying HIV testing. Univariable and multivariable logistic regression identified factors associated with ≥ 1 MO. A Bayesian model estimated the time from seroconversion to diagnosis.ResultsAmong 517 participants with HCC data, 249 had ≥ 1 HCC. Of these, 59.0% (147/249) were late presenters. These cases had 365 HCCs, and 191 (52.3%) were MOs for testing. The most common ICs were sexually transmitted infections (39.8%; 76/191) and fever (11.0%; 21/191). Non-Greek origin was associated with lower odds of experiencing ≥ 1 MO (adjusted odds ratio: 0.48; 95% CI: 0.22─1.02), while higher education increased odds of MOs for early HIV diagnosis. Median time from seroconversion to diagnosis was 3.2 years for the full sample and 3.7 years for those with HCC, with about half of the latter reporting MOs post-estimated seroconversion. Recognising MOs would have potentially spared approximately 1 year of delay in diagnosis.ConclusionMOs for earlier HIV diagnosis were prevalent in Greece. Leveraging IC-guided testing and addressing barriers could support earlier diagnosis and treatment, limiting adverse health outcomes and preventing transmission.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five years to 2030: reaching underserved populations is key to ending the AIDS epidemic in Europe.","authors":"Viviane Bremer, Anastasia Pharris","doi":"10.2807/1560-7917.ES.2024.29.48.2400778","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400778","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Antimicrobial resistance is invisible. I am not.'","authors":"Guido Werner, Muna Abu Sin","doi":"10.2807/1560-7917.ES.2024.29.47.2400762","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400762","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on antimicrobial resistance research priorities to focus development and implementation of antibacterial vaccines and monoclonal antibodies.","authors":"Nasreen Hassoun-Kheir, Mariana Guedes, Fabiana Arieti, Maria Diletta Pezzani, Beryl Primrose Gladstone, Julie V Robotham, Koen B Pouwels, Rhys Kingston, Yehuda Carmeli, Alessandro Cassini, Michele Cecchini, Francis Drobniewski, Isabel Frost, Jeroen Geurtsen, Andreas Kronenberg, Mila Nu Nu Htay, Mical Paul, Nuno Rocha-Pereira, Jesús Rodríguez-Baño, Luigia Scudeller, Andrew J Stewardson, Evelina Tacconelli, Stephan Harbarth, Venanzio Vella, Marlieke Ea de Kraker","doi":"10.2807/1560-7917.ES.2024.29.47.2400212","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400212","url":null,"abstract":"<p><p>To reduce antimicrobial resistance (AMR), pathogen-specific AMR burden data are crucial to guide target selection for research and development of vaccines and monoclonal antibodies (mAbs). We identified knowledge gaps through previously conducted systematic reviews, which informed a Delphi expert consultation on future AMR research priorities and harmonisation strategies to support data-driven decision-making. Consensus (≥80% agreement) on importance and feasibility of research topics was achieved in two rounds, involving 24 of 39 and 19 of 24 invited experts, respectively. Priority pathogens and resistance profiles for future research were identified: third generation cephalosporin-resistant <i>Klebsiella pneumoniae</i> and <i>Escherichia coli,</i> for bloodstream and urinary tract infections, respectively, and meticillin-resistant <i>Staphylococcus aureus</i> for surgical-site infections. Prioritised high-risk populations included surgical, haemato-oncological and transplant patients. Mortality and resource use were prioritised as health-economic outcomes. The importance of age-stratified data and inclusion of a non-infected comparator group were highlighted. This agenda provides guidance for future research to fill knowledge gaps and support data-driven selection of target pathogens and populations for new preventive and treatment strategies, specifically vaccines and mAbs, to effectively address the AMR burden in Europe. These research priorities are also relevant to improve the evidence base for future AMR burden estimates.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic epidemiological analysis of a single-centre polyclonal outbreak of <i>Serratia marcescens</i>, Belgium, 2022 to 2023.","authors":"Sam Van Goethem, Basil Britto Xavier, Youri Glupczynski, Matilda Berkell, Philippe Willems, Bruno Van Herendael, Katrien Hoet, Katleen Plaskie, Daan Van Brusselen, Herman Goossens, Surbhi Malhotra-Kumar","doi":"10.2807/1560-7917.ES.2024.29.48.2400144","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400144","url":null,"abstract":"<p><p><i>Serratia marcescens</i> is an opportunistic pathogen with a propensity to cause nosocomial outbreaks, particularly in neonatal intensive care units (NICUs). We present a sustained outbreak spanning over 18 months (1 January 2022-29 August 2023) in a NICU in Antwerp, Belgium, affecting 61 neonates, identified through samples taken for diagnostic purposes and by rectal screening. Ten neonates were infected: five with lower respiratory tract infection, four with conjunctivitis and one fatal case with sepsis. In a logistic regression analysis, nursing in an incubator was significantly associated with acquisition of <i>S. marcescens</i> (odds ratio (OR): 2.99; 95% confidence interval (CI): 1.14-8.25; p < 0.05). Whole genome sequencing-based multilocus sequence typing (wgMLST) and core genome single nucleotide polymorphism (cgSNP) analysis of isolates from clinical (n = 4), screening (n = 52) and environmental samples (n = 8), identified eight clusters and five singletons not associated with the clusters. Although outbreak measures were successful in containing further spread within the ward during sudden surges when > 4 cases per week were identified (peak events), several peaks with different clonal clusters occurred. The emergence of similar outbreaks in Belgian hospitals underscores the need of continuous surveillance and NICU-specific infection prevention and control (IPC) measures.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of invasive meningococcal disease, Japan, 2013 to 2023.","authors":"Miho Kobayashi, Hajime Kamiya, Munehisa Fukusumi, Hideyuki Takahashi, Yukihiro Akeda, Motoi Suzuki, Tomimasa Sunagawa","doi":"10.2807/1560-7917.ES.2024.29.46.2400136","DOIUrl":"10.2807/1560-7917.ES.2024.29.46.2400136","url":null,"abstract":"<p><p>BackgroundThe National Surveillance for Invasive Meningococcal Disease (IMD) initiative started in Japan in April 2013. Multiple international mass gathering events have since been held in Japan, and the COVID-19 pandemic has occurred.AimWe summarised 10 years of national surveillance data for IMD in Japan to describe epidemiological characteristics of IMD and evaluate the influence of mass gatherings and the COVID-19 pandemic on IMD.MethodsUpon diagnosis of IMD, patient information and specimens were collected and reported to local health centres. We analysed the epidemiology of IMD cases reported between 1 April 2013 and 31 March 2023.ResultsAmong 274 cases reported (median age: 55 years; 55% male), no outbreaks related to mass gathering events were identified. The annual reported incidence of IMD was 0.001-0.039 cases per 100,000 individuals between 2014 and 2022, with a notable decrease after 2020. The overall case fatality rate was 12% (33/274). The most frequent serogroups were Y and B (46 and 17%). Multilocus sequence typing revealed a predominance of clonal complex (cc) 23, followed by cc2057, while cc11 was detected in eight cases.ConclusionThe reported incidence of IMD in Japan is low compared with high-endemic countries and decreased further during the COVID-19 pandemic. This unique epidemiology of IMD in Japan lacks a clear explanation. However, distribution of meningococcal strains, such as predominance of serogroup Y, could be a contributing factor. Maintaining high-quality surveillance, including of serogroups and sequence types, is crucial to manage and prevent future IMD cases in Japan effectively.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 46","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral hepatitis knowledge and vaccination awareness among men who have sex with men (MSM) in 43 countries of the WHO European Region: results from the European MSM Internet Survey, EMIS-2017.","authors":"Sofia Burdi, Michael Brandl, Ulrich Marcus, Erika Duffell, Ettore Severi, Antons Mozalevskis, Kristi Rüütel, Achim Dörre, Axel J Schmidt, Sandra Dudareva","doi":"10.2807/1560-7917.ES.2024.29.45.2400099","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400099","url":null,"abstract":"<p><p>BackgroundRecent hepatitis A virus outbreaks in Europe affecting men who have sex with men (MSM) and ongoing hepatitis B virus transmission among MSM underscore the ongoing need for viral hepatitis prevention in this population.AimTo describe viral hepatitis knowledge and associated factors among MSM in the WHO European Region to inform targeted prevention.MethodsIn the European MSM Internet Survey (EMIS-2017), basic knowledge was defined as correctly identifying at least 4 of 5 statements about viral hepatitis and vaccination. We described basic knowledge by country. In a multilevel logistic regression model, we estimated adjusted odds ratios (aOR) with 95% confidence intervals (CI) for having basic knowledge and explanatory variables: sociodemographic characteristics, history of hepatitis C and/or HIV diagnosis, sexual orientation disclosure at last sexually transmitted infections (STI) test and outness.ResultsOf 113,884 participants across 43 WHO European Region countries, 68% demonstrated basic knowledge, ranging from 50% in Israel to 80% in the Netherlands. Basic knowledge was significantly associated with older age (≥ 40 years vs < 25 years, aOR: 2.9, 95% CI: 2.7-3.0), a history of hepatitis C and/or HIV diagnosis (aOR: 1.8, 95% CI: 1.7-1.9) and sexual orientation disclosure at last STI test (aOR: 1.3, 95% CI: 1.2-1.3), among other factors.ConclusionsWe found a knowledge disparity regarding viral hepatitis and hepatitis vaccination awareness among MSM across Europe, highlighting a need to address these gaps. A non-judgemental, accepting climate that allows individuals attending medical services to safely disclose their sexual orientation is fundamental to enable healthcare professionals to target information and preventative measures more effectively.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}