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Outbreak of paediatric myocarditis associated with parvovirus B19 infection in Italy, January to October 2024.
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.48.2400746
Marco Poeta, Cristina Moracas, Francesca Ippolita Calò Carducci, Claudio Cafagno, Danilo Buonsenso, Marco Maglione, Sofia Sgubbi, Cecilia Liberati, Elisabetta Venturini, Giuseppe Limongelli, Felice Nunziata, Laura Petrarca, Claudia Mandato, Claudia Colomba, Alfredo Guarino
{"title":"Outbreak of paediatric myocarditis associated with parvovirus B19 infection in Italy, January to October 2024.","authors":"Marco Poeta, Cristina Moracas, Francesca Ippolita Calò Carducci, Claudio Cafagno, Danilo Buonsenso, Marco Maglione, Sofia Sgubbi, Cecilia Liberati, Elisabetta Venturini, Giuseppe Limongelli, Felice Nunziata, Laura Petrarca, Claudia Mandato, Claudia Colomba, Alfredo Guarino","doi":"10.2807/1560-7917.ES.2024.29.48.2400746","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400746","url":null,"abstract":"<p><p>Acute myocarditis has risen among paediatric patients in Italy, with 65 clinically suspected cases reported by 12 centres in 2024, 32 linked to parvovirus B19 (B19V) infection. In 11 cases, B19V was not ruled out despite a concurrent European outbreak. Twenty-nine children required intensive care; eight fatalities occurred. While effective for both severe B19V infection and myocarditis, intravenous immunoglobulins were given in only one-third of cases. These findings highlight the need for timely diagnosis, stronger surveillance, and standardised treatment protocols.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-reported hepatitis A and B vaccination coverage among men who have sex with men (MSM), associated factors and vaccination recommendations in 43 countries of the WHO European Region: results from the European MSM Internet Survey, EMIS-2017. 世卫组织欧洲地区 43 个国家的男男性行为者 (MSM) 自我报告的甲型肝炎和乙型肝炎疫苗接种覆盖率、相关因素和疫苗接种建议:欧洲 MSM 互联网调查 EMIS-2017 的结果。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.45.2400100
Michael Brandl, Axel J Schmidt, Ulrich Marcus, Erika Duffell, Ettore Severi, Antons Mozalevskis, Anda Kivite-Urtane, Matthias An der Heiden, Sandra Dudareva
{"title":"Self-reported hepatitis A and B vaccination coverage among men who have sex with men (MSM), associated factors and vaccination recommendations in 43 countries of the WHO European Region: results from the European MSM Internet Survey, EMIS-2017.","authors":"Michael Brandl, Axel J Schmidt, Ulrich Marcus, Erika Duffell, Ettore Severi, Antons Mozalevskis, Anda Kivite-Urtane, Matthias An der Heiden, Sandra Dudareva","doi":"10.2807/1560-7917.ES.2024.29.45.2400100","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400100","url":null,"abstract":"<p><p>BackgroundHepatitis A and B vaccinations are recommended for men who have sex with men (MSM), given their increased risk of infection. However, data on vaccination programmes are scarce.AimTo use information on vaccination recommendations and vaccine uptake among MSM in the WHO European Region to guide prevention.MethodsFrom a large pan-European MSM Internet Survey (EMIS-2017), we analysed data on self-reported hepatitis A and B vaccination status by age, education, financial coping, settlement size, outness (disclosure of sexual behaviour), migration history and diagnosis with hepatitis C or HIV, using multivariable logistic regression. Additionally, we collected information on national hepatitis A and B vaccination recommendations.ResultsWe present data of 113,884 MSM, median age 36 years (IQR: 27-47). Vaccination for hepatitis A and B was recommended and free for MSM in 7 and 18 of 43 countries, respectively. Of all respondents, 48% (n = 50,966) reported ever being vaccinated against hepatitis A, and 53% (n = 56,889) against hepatitis B. Odds for being vaccinated against hepatitis A increased with outness ('out to (almost) all' aOR: 1.78, 95% CI: 1.72-1.85 vs 'out to none') and were higher in countries where vaccination was recommended and free for MSM (aOR: 2.22, 95% CI: 1.29-3.82 vs 'no recommendation'). Results for hepatitis B were similar (outness: aOR: 1.81, 95% CI: 1.75-1.88 and MSM-specific vaccination recommendation: aOR: 2.44, 95% CI: 1.54-3.85).ConclusionLarge proportions of MSM in Europe remain vulnerable to hepatitis A and B, despite available vaccination. Implementation of MSM-specific vaccination recommendations and greater efforts to improve the societal climate for MSM are needed to address gaps in vaccine coverage.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Have your say in the Eurosurveillance evaluation survey.
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.48.2411289
{"title":"Have your say in the <i>Eurosurveillance</i> evaluation survey.","authors":"","doi":"10.2807/1560-7917.ES.2024.29.48.2411289","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2411289","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in-depth analysis of antimicrobial prescription quality in 10 non-university hospitals, in southwest Germany, 2021. 2021 年对德国西南部 10 家非大学医院抗菌药物处方质量的深入分析。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.46.2400156
Gesche Först, Roland Giesen, Geertje Fink, Matthias Sehlbrede, Nicole Wimmesberger, Rebekka Allen, Kerstin Meyer, Sabine Müller, Hanna Niese, Sina Polk, Barbara Reistle, Carolin Schuhmacher, Andreas von Ameln-Meyerhofer, Kim Winter, Dave Wirth, Winfried V Kern, Erik Farin-Glattacker, Siegbert Rieg
{"title":"An in-depth analysis of antimicrobial prescription quality in 10 non-university hospitals, in southwest Germany, 2021.","authors":"Gesche Först, Roland Giesen, Geertje Fink, Matthias Sehlbrede, Nicole Wimmesberger, Rebekka Allen, Kerstin Meyer, Sabine Müller, Hanna Niese, Sina Polk, Barbara Reistle, Carolin Schuhmacher, Andreas von Ameln-Meyerhofer, Kim Winter, Dave Wirth, Winfried V Kern, Erik Farin-Glattacker, Siegbert Rieg","doi":"10.2807/1560-7917.ES.2024.29.46.2400156","DOIUrl":"10.2807/1560-7917.ES.2024.29.46.2400156","url":null,"abstract":"<p><p>BackgroundNon-university hospitals are the major provider of inpatient care in Germany, serving 89% of acute care hospital beds. Although surveillance data on antimicrobial use in hospitals are widely available, data on prescription quality are rare.AimWe aimed to provide an in-depth analysis of antimicrobial prescribing patterns and quality in southwest German non-university hospitals.MethodsDuring 2021, we performed three point prevalence surveys (PPS) in 10 non-university hospitals, representing ca 10% of hospital beds in the federal state of Baden-Württemberg (11 million inhabitants). Demographic and clinical information were collected. We assessed the overall performance of 14 validated process quality indicators (QI) covering infection diagnostics, antimicrobial therapy and documentation.ResultsOf 8,560 patients analysed, 2,861 (33%) received at least one antimicrobial. Most (2,789, 80%) antimicrobial prescriptions were for therapeutic indications. Most frequently prescribed agents were beta-lactam/beta-lactamase inhibitors (1,120, 40%) in therapeutic and cefuroxime (269, 37%) in prophylactic indications. According to the World Health Organization's Access, Watch, Reserve classification, the Access-to-Watch ratio was 0.73. Overall adherence to QIs was low and varied substantially (27-93%), with documentation, possible streamlining and switching to oral therapy exhibiting the lowest fulfilment rates (< 50%).ConclusionThe results indicate a need to improve antimicrobial prescribing quality in non-university hospitals. The high prevalence of antimicrobial use in our setting underlines the demand for sustainable antimicrobial stewardship programmes in this sector. Our QI-based PPS approach can be used to identify key targets for future antimicrobial stewardship interventions. The results indicate a need for further legislation on antimicrobial stewardship.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 46","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Likelihood of HIV and recent bacterial sexually transmitted infections among transgender and non-binary individuals in 20 European countries, October 2023 to April 2024.
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.48.2400347
Haoyi Wang, Johann Kolstee, Jules L Casalini, Samira Hakim, Hanne Ml Zimmermann, Kai J Jonas
{"title":"Likelihood of HIV and recent bacterial sexually transmitted infections among transgender and non-binary individuals in 20 European countries, October 2023 to April 2024.","authors":"Haoyi Wang, Johann Kolstee, Jules L Casalini, Samira Hakim, Hanne Ml Zimmermann, Kai J Jonas","doi":"10.2807/1560-7917.ES.2024.29.48.2400347","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400347","url":null,"abstract":"<p><p>BackgroundGlobal data highlight the disproportionate burden of HIV and sexually transmitted infections (STIs) among transgender individuals. However, scant data exist for both transgender and non-binary individuals in European HIV/STI surveillance.AimTo assess self-reported prevalence of HIV and bacterial STIs (syphilis, gonorrhoea, chlamydia) in the past 6 months among transgender and non-binary individuals, comparing the likelihoods of recent STIs between groups.MethodsUsing data from the cross-sectional PROTECT survey conducted in 20 European countries from October 2023 to April 2024, we analysed a subset of 452 participants, 178 transgender and 274 non-binary individuals. Logistic regression was used to compare the risk of each recent bacterial STI, and Poisson regression to compare the risk of the number of recent STIs.ResultsAmong transgender individuals, 5 (2.8%) self-reported HIV infection, and recent STI prevalence was 6.7% for syphilis, 15.6% for gonorrhoea and 19.6% for chlamydia. For non-binary individuals, 15 (5.5%) self-reported HIV infection and recent STI prevalence was 15.0% for syphilis, 18.7% for gonorrhoea and 20.8% for chlamydia. Non-binary individuals had significantly higher risk for syphilis (aOR: 1.81; 95% CI: 1.01-4.05) and multiple recent STIs (aOR: 1.46; 95% CI: 1.11-1.91) compared with transgender individuals.ConclusionWhile both transgender and non-binary individuals showed high self-reported prevalence of HIV and bacterial STIs, non-binary individuals showed greater prevalence of STIs, particularly syphilis. Efforts aimed at HIV/STI prevention and surveillance should encourage inclusion of those who identify as non-binary and other gender-diverse individuals alongside transgender individuals to enhance the provision of tailored prevention and treatment services in Europe.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment uptake among notified cases of hepatitis C virus infection in Norway, 1990 to 2022: a registry-based study to monitor progress towards elimination. 1990年至2022年挪威丙型肝炎病毒感染通报病例的接受治疗情况:一项以登记为基础的研究,旨在监测消除丙型肝炎的进展情况。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.46.2400180
Robert Whittaker, Håvard Midgard, Olav Dalgard, Hilde Kløvstad
{"title":"Treatment uptake among notified cases of hepatitis C virus infection in Norway, 1990 to 2022: a registry-based study to monitor progress towards elimination.","authors":"Robert Whittaker, Håvard Midgard, Olav Dalgard, Hilde Kløvstad","doi":"10.2807/1560-7917.ES.2024.29.46.2400180","DOIUrl":"10.2807/1560-7917.ES.2024.29.46.2400180","url":null,"abstract":"<p><p>BackgroundHepatitis C virus (HCV) infection is targeted for elimination as a public health threat by 2030. The World Health Organization goal for treatment uptake is ≥ 80% among cases diagnosed with an active HCV infection (RNA- or core antigen-positive), maintained for 2 years.AimTo calculate treatment uptake, time from diagnosis to treatment start and complete treatment dispensation among notified cases of HCV infection in Norway.MethodWe linked national data on notified cases diagnosed from 1990-2022 to dispensed prescriptions for HCV treatment from January 2004-February 2023 and data on residence status at the end of 2022. We described treatment uptake by demographic and epidemiological characteristics. We calculated the median number of months from diagnosis to treatment start by year. For direct-acting antiviral treatment periods, complete dispensation was based on the treatment and number of defined daily doses.ResultsAmong 12,178 notified cases that had an active infection at diagnosis and were still resident, 10,091 (83%) had received treatment. Uptake among resident cases was > 80% in 2021 and 2022. The median number of months from diagnosis to treatment decreased over time to 3 (interquartile range: 1-5) among cases diagnosed in 2021 and 2022. From 2015-22, 89-93% of direct-acting antiviral treatment periods annually had complete treatment dispensed.ConclusionNorway has achieved the elimination goal for treatment uptake among notified cases diagnosed with an active HCV infection. This highlights the benefit of a strategy that includes unrestricted, simplified and integrated treatment options.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 46","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic consumption patterns in older adults: a comparative study of people 65 years and older in and outside nursing homes, Belgium, 2016 to 2022. 老年人的抗生素消费模式:2016 年至 2022 年对比利时养老院内外 65 岁及以上老年人的比较研究。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.46.2400148
Moira Kelly, Marc de Falleur, El Maati Allaoui, Laura Bonacini, Boudewijn Catry, Katrien Latour, Lucy Catteau
{"title":"Antibiotic consumption patterns in older adults: a comparative study of people 65 years and older in and outside nursing homes, Belgium, 2016 to 2022.","authors":"Moira Kelly, Marc de Falleur, El Maati Allaoui, Laura Bonacini, Boudewijn Catry, Katrien Latour, Lucy Catteau","doi":"10.2807/1560-7917.ES.2024.29.46.2400148","DOIUrl":"10.2807/1560-7917.ES.2024.29.46.2400148","url":null,"abstract":"<p><p>BackgroundInappropriate antimicrobial consumption (AMC) drives the emergence of antimicrobial resistance. Institutionalised, older populations are associated with antimicrobial treatments of longer duration and broader spectrum than recommended, higher rates of multidrug-resistant infections and poorer outcomes for resistant infections. Yet systematic, national monitoring of AMC in nursing home (NH) residents is lacking.AimTo perform a retrospective analysis of antibiotic consumption in Belgian NHs, we compared analogous populations inside and outside NHs. We aimed to provide a blueprint for establishing surveillance of NH AMC, based on national reimbursement data.MethodsThe National Institute for Health and Disability Insurance supplied reimbursement AMC data for outpatients from 2016 to 2022. Data were classified by the Anatomical Therapeutic Chemical system, expressed as defined daily doses (DDD) and aggregated by prescription month, patient age, sex and residency inside/outside a NH. The number of ensured beneficiaries, aggregated by the same demographic variables, was collected from the Intermutualistic Agency. We compared the DDDs per 1,000 beneficiaries per day, along with secondary metrics for national and international targets for analogous populations inside and outside NHs.ResultsTotal antibiotic consumption decreased in both populations but remained twofold higher in NH residents. Proxy prescription quality metrics were consistently less favourable within NHs and diverged further during the COVID-19 pandemic. Distinct consumption patterns and greater seasonal fluctuations were observed in NH residents.ConclusionGiven the different infection risks and higher antibiotic consumption of NH residents, AMC surveillance and antimicrobial stewardship efforts targeting this fragile population are needed.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 46","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of circulating type 3 vaccine-derived polioviruses in French Guiana, May to August 2024. 2024 年 5 月至 8 月法属圭亚那 3 型疫苗衍生脊髓灰质炎病毒的检测。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.45.2400705
Stéphanie Raffestin, Ambre Tinard, Antoine Enfissi, Marie-Line Joffret, Timothée Lichtenstein, Sourakhata Tirera, Laura Zanetti, Marie Barrau, Francky Mubenga, Adrien Ortelli, Christophe N Peyrefitte, Anne Lavergne, Dominique Rousset, Maël Bessaud
{"title":"Detection of circulating type 3 vaccine-derived polioviruses in French Guiana, May to August 2024.","authors":"Stéphanie Raffestin, Ambre Tinard, Antoine Enfissi, Marie-Line Joffret, Timothée Lichtenstein, Sourakhata Tirera, Laura Zanetti, Marie Barrau, Francky Mubenga, Adrien Ortelli, Christophe N Peyrefitte, Anne Lavergne, Dominique Rousset, Maël Bessaud","doi":"10.2807/1560-7917.ES.2024.29.45.2400705","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400705","url":null,"abstract":"<p><p>Circulating type 3 vaccine-derived polioviruses (cVDPV3s) were detected in three wastewater samples collected in French Guiana from May through August 2024. As the oral polio vaccine is not used in French Guiana, this event involved an import either of cVDPV3s themselves or of a vaccine strain from which the cVDPV3s emerged in French Guiana. This highlights the importance of environmental surveillance for the detection of silent poliovirus circulation. Eliminating any pockets of cVDPVs is crucial for the polio eradication programme.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023. 2021 年 12 月至 2023 年 9 月,基因组监测发现罗马尼亚医院中产生新德里金属-beta-内酰胺酶-1 的普罗维登菌 stuartii 在地区间传播。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.47.2400587
Marius Linkevicius, Sandra Witteveen, Mariana Buzea, Mirela Flonta, Marina Indreas, Maria Nica, Edit Székely, Daniela Tălăpan, Olov Svartström, Erik Alm, Daniel Palm, Dominique L Monnet, Antoni Pa Hendrickx, Anke Kohlenberg, Gabriel Adrian Popescu
{"title":"Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing <i>Providencia stuartii</i> in hospitals, Romania, December 2021 to September 2023.","authors":"Marius Linkevicius, Sandra Witteveen, Mariana Buzea, Mirela Flonta, Marina Indreas, Maria Nica, Edit Székely, Daniela Tălăpan, Olov Svartström, Erik Alm, Daniel Palm, Dominique L Monnet, Antoni Pa Hendrickx, Anke Kohlenberg, Gabriel Adrian Popescu","doi":"10.2807/1560-7917.ES.2024.29.47.2400587","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400587","url":null,"abstract":"<p><p>BackgroundNew Delhi metallo-beta-lactamase (NDM)-producing <i>Providencia stuartii</i> has been reported from European Union/European Economic Area (EU/EEA) countries with increasing frequency. During 2018 to 2022, 355 cases of NDM-producing <i>P. stuartii</i> were detected in seven hospitals reporting on NDM-production in Enterobacterales in Romania.AimOur aim was to determine the extent of spread of NDM-producing <i>P. stuartii</i> in hospitals in Romania.MethodsWe analysed whole genome sequences and epidemiological data of 74 <i>P. stuartii</i> isolates collected in six hospitals from December 2021 to September 2023.ResultsWe identified four multi-hospital clusters including isolates detected over more than a year, indicating sustained spread of <i>bla</i> <sub>NDM-1</sub>-carrying <i>P. stuartii</i> within the healthcare system. These clusters consisted of isolates from up to four hospitals and three regions. Three multi-hospital clusters were caused by a specific multidrug-resistant <i>P. stuartii</i> sequence type 46 lineage carrying <i>bla</i> <sub>NDM-1</sub> and a large set of additional resistance markers. Investigation in an international context showed that this lineage had already been detected in nine countries (Bulgaria, France, Germany, Ireland, the Netherlands, Romania, Switzerland, United Kingdom, United States) since 2015.ConclusionOur results alert about the risk of carbapenem-resistant <i>P. stuartii</i> transmission in healthcare settings. Enhanced infection prevention and control measures should be instituted as soon as cases are detected in healthcare facilities. National surveillance systems in EU/EEA countries should, in addition to carbapenem-resistant and/or carbapenemase-producing <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i>, consider reporting carbapenem-resistant and/or carbapenemase-producing <i>P. stuartii</i> and other Enterobacterales where relevant.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agile, on-demand wastewater surveillance of virus infections to support pandemic and outbreak response in Rotterdam-Rijnmond, the Netherlands, 2020 to 2022. 2020 年至 2022 年,在荷兰鹿特丹-莱茵蒙德对病毒感染进行灵活、按需的废水监测,以支持大流行病和疫情的应对工作。
IF 9.9 2区 医学
Eurosurveillance Pub Date : 2024-11-01 DOI: 10.2807/1560-7917.ES.2024.29.47.2400055
Emma Besijn, Jane Whelan, Paul Bijkerk, Gregorius J Sips, Jeroen Langeveld, Ray W Izquierdo-Lara, Elvira van Baarle, Remy Schilperoort, Marion P G Koopmans, Miranda de Graaf, Gertjan Medema, Ewout Fanoy
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