FEBS Letters最新文献_第6页

The multifaceted significance of phosphoinositides in endocytic trafficking 磷酸肌苷在内吞运输中的多方面意义。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2026-01-07 DOI: 10.1002/1873-3468.70268

Chaoyi Xie, Anbing Shi

{"title":"The multifaceted significance of phosphoinositides in endocytic trafficking","authors":"Chaoyi Xie, Anbing Shi","doi":"10.1002/1873-3468.70268","DOIUrl":"10.1002/1873-3468.70268","url":null,"abstract":"Phosphoinositides, comprising less than 10% of membrane lipids, function as ‘lipid codes’ within cellular compartments through seven species formed by myo-inositol headgroup phosphorylation. This review examines their diverse roles in endocytic transport, encompassing endocytosis, endosomal sorting, degradation, and recycling, as well as specialized mechanisms, such as caveolin-mediated endocytosis. The review also investigates the involvement of specific kinases and phosphatases in these processes. Additionally, it discusses the impact of technological advancements, such as fluorescent biosensors, super-resolution microscopy, optogenetics, and synthetic biology, on elucidating phosphoinositide dynamics during endocytic trafficking. Perturbations in phosphoinositide metabolism have been associated with human diseases, including cancer and neurodegenerative disorders. Exploring these pathways may unveil potential therapeutic targets, with subsequent research focusing on their spatiotemporal regulation, tissue-specific metabolism, the synergistic effects of phosphoinositides with other lipids, and the incorporation of systems biology to bridge basic cell biology with translational medicine.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2490-2525"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expanding landscape of inositol phosphate signaling network in land plants 陆地植物肌醇磷酸信号网络的扩展景观。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-11-25 DOI: 10.1002/1873-3468.70236

Riya Ghosh, Ranjana Yadav, Naga Jyothi Pullagurla, Priyanshi Rana, Debabrata Laha

{"title":"The expanding landscape of inositol phosphate signaling network in land plants","authors":"Riya Ghosh, Ranjana Yadav, Naga Jyothi Pullagurla, Priyanshi Rana, Debabrata Laha","doi":"10.1002/1873-3468.70236","DOIUrl":"10.1002/1873-3468.70236","url":null,"abstract":"The emergence of land plants from aquatic habitat over half a billion years ago marked a pivotal moment in Earth's history, profoundly altering both soil composition and atmospheric chemistry. This remarkable evolutionary transition was accompanied by the establishment of multiple signaling pathways that facilitated plant adaptation to terrestrial environments. Among these, signaling pathways based on myo-inositol-derived cellular messengers have recently gained significant attention. Combinatorial attachment of phosphate to the myo-inositol (hereafter inositol) ring produces a large array of inositol phosphate (InsP) messengers that are involved in an ever-growing number of physiological processes in eukaryotes. Whether these messengers contributed to the emergence of land plants remains an open question. In this review, we explore recent advances in understanding the astonishing molecular diversity, biosynthesis and regulation of InsP molecules in plant cells, their integration into various physiological pathways, and the potential implications of InsP signaling pathways in the evolution of land plants.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2661-2678"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145603131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reciprocal control of viral infection and phosphoinositide dynamics 病毒感染与磷酸肌苷动力学的相互控制。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-10-13 DOI: 10.1002/1873-3468.70189

Marie Déborah Bancilhon, Bruno Mesmin

{"title":"Reciprocal control of viral infection and phosphoinositide dynamics","authors":"Marie Déborah Bancilhon, Bruno Mesmin","doi":"10.1002/1873-3468.70189","DOIUrl":"10.1002/1873-3468.70189","url":null,"abstract":"Phosphoinositides are scarce but dynamic lipids within the cell. They play crucial roles in regulating membrane dynamics and identity, intracellular trafficking, and signal transduction. These functions are coordinated through their distribution and turnover by phosphoinositide-kinases, phosphatases, and lipid-transfer proteins, which also act as key mediators in these processes. Viruses are obligate intracellular pathogens that have developed strategies to hijack the host cellular machinery, including lipid metabolic pathways, to support their replication. During viral infection, they take advantage of phosphoinositides to accomplish various steps of their cycle, such as entry, formation of replication organelles, assembly, and egress. Having such an important role in the viral cycle, targeting phosphoinositide metabolism has emerged as an interesting antiviral strategy over the years. This Review provides insight into the versatility of phosphoinositides during viral infection, presenting their involvement in the viral life cycle, their role as mediators of antiviral immunity, and their potential as a novel approach to antiviral development.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2526-2546"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inositol pyrophosphate kinases in health and disease 肌醇焦磷酸激酶在健康和疾病中的作用。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-10-23 DOI: 10.1002/1873-3468.70192

Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu

{"title":"Inositol pyrophosphate kinases in health and disease","authors":"Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu","doi":"10.1002/1873-3468.70192","DOIUrl":"10.1002/1873-3468.70192","url":null,"abstract":"Inositol phosphates (InsPs) are intracellular signaling molecules that are essential for life. Inositol pyrophosphates, a subset of inositol phosphates, are the end products of inositol phosphate metabolism. In mammalian cells, up to 90% of inositol pyrophosphates are 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5PP-InsP5), which is generated by inositol hexakisphosphate kinases (IP6Ks). 5PP-InsP5 can be further phosphorylated by diphosphoinositol pentakisphosphate kinases (PPIP5Ks) to generate 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate (InsP8). Unlike freely diffusible molecules, 5PP-InsP5 and InsP8 act locally at the sites where they are synthesized. Thus, individual IP6K and PPIP5K enzymes perform specific functions. Preclinical and clinical studies suggest that these molecules contribute to early life development, but mediate age-related diseases beyond adulthood. In this review, we summarize the functions and mechanisms of action of every individual IP6K and PPIP5K in both physiological processes and diseases and discuss the potential applications of these inositol pyrophosphate kinases as druggable targets for disease treatment.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2379-2396"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial organization of phosphoinositide signaling 磷酸肌肽信号的空间组织。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-11-17 DOI: 10.1002/1873-3468.70227

Siyu Lai, Wenbo Huang, Kangmin He

{"title":"Spatial organization of phosphoinositide signaling","authors":"Siyu Lai, Wenbo Huang, Kangmin He","doi":"10.1002/1873-3468.70227","DOIUrl":"10.1002/1873-3468.70227","url":null,"abstract":"Mammalian cells express seven distinct phosphoinositide species: PI(3)P, PI(4)P, PI(5)P, PI(3,4)P2, PI(3,5)P2, PI(4,5)P2, and PI(3,4,5)P3. With the rapid development of labeling, imaging, and manipulation tools, our understanding of the spatial distribution, functions, and regulation of these phosphoinositides has advanced significantly. Tightly regulated by lipid kinases, phosphatases, and lipid transfer proteins, each phosphoinositide exhibits a unique yet dynamic spatial distribution at both subcellular and suborganelle levels. This distinct spatial organization is critical for controlling membrane trafficking, defining organelle identity and function, mediating signal transduction, and supporting other essential cellular processes. Dysregulation of spatial phosphoinositide signaling has been linked to various human diseases. In this review, we provide a brief overview of current insights into the spatial organization of phosphoinositide signaling, highlighting its key roles in regulating membrane dynamics and signal transduction at the plasma membrane, endosomes and lysosomes, the Golgi apparatus, the ER, and the nucleus.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2451-2469"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphoinositides and inositol phosphates as molecular glues 磷酸肌苷和磷酸肌醇作为分子胶。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2026-06-19 DOI: 10.1002/1873-3468.70388

Aleshia Seaton-Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind

{"title":"Phosphoinositides and inositol phosphates as molecular glues","authors":"Aleshia Seaton-Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind","doi":"10.1002/1873-3468.70388","DOIUrl":"10.1002/1873-3468.70388","url":null,"abstract":"Inositol phosphates (IPs) and phosphoinositide lipids (PIPs) are regulatory molecules critical for a wide array of functions in eukaryotic cells. Membrane PIPs have clear functions in transient recruitment of signaling proteins to membranes, and IPs have been found locked in the core of proteins as structural cofactors. However, several recent studies have suggested IPs and PIPs can mediate protein–protein interactions at the interface between proteins, functioning as natural molecular glues. Here, we present recent structural biology describing how IPs and PIPs mediate these regulatory responses at protein interfaces. In addition, we describe protein–protein interactions mediated by IPs and PIPs, for which evidence supporting a natural molecular glue role is unclear or awaits further high-resolution structural analyses. Together, we put forth that PIPs and IPs have a historically under-appreciated role at protein–protein interfaces, requiring a more systematic, structural approach to elucidate.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2437-2450"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical methods and tools for studying inositol phosphates 磷酸肌醇的分析方法和工具。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-12-16 DOI: 10.1002/1873-3468.70246

Masatoshi Ito, Shinichi Koguchi, Adolfo Saiardi, Eiichiro Nagata

{"title":"Analytical methods and tools for studying inositol phosphates","authors":"Masatoshi Ito, Shinichi Koguchi, Adolfo Saiardi, Eiichiro Nagata","doi":"10.1002/1873-3468.70246","DOIUrl":"10.1002/1873-3468.70246","url":null,"abstract":"Despite numerous studies, the biological and medical significance of inositol phosphates (InsPs) remains to be fully elucidated. One of the primary rate-limiting factors for InsP research is the difficulty in developing a method to specifically detect these molecules in complex biological matrices. Recent remarkable advancements in analytical chemistry such as nuclear magnetic resonance spectroscopy, mass spectrometry, and pertinent separation technologies have allowed the selective and sensitive differentiation of InsPs depending on the number and/or position of phosphate groups bound to the inositol ring. Thus, knowledge and experience of analytical chemistry have increasingly become a prerequisite for InsP studies. Establishing synthetic processes for functional InsPs and their analogs by organic chemists has also provided effective tools for quantitating their absolute abundances, as well as for investigating their molecular functions. This review briefly recapitulates the historical trajectory of the methodology applied to InsP research and highlights recently developed protocols using mass spectrometry coupled with liquid chromatography and capillary electrophoresis, in addition to a simple description of the chemical and chemoenzymatic synthesis of InsPs and their analogs.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2397-2419"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry-based approaches 磷酸肌苷的时空和定量分析-荧光探针和质谱为基础的方法。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-14 Epub Date: 2025-10-22 DOI: 10.1002/1873-3468.70200

Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki

{"title":"Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry-based approaches","authors":"Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki","doi":"10.1002/1873-3468.70200","DOIUrl":"10.1002/1873-3468.70200","url":null,"abstract":"Comprehensive understanding of phosphoinositide signaling requires both spatiotemporal visualization and precise quantitative analysis of individual lipid species. Phosphoinositides, a family of phosphorylated derivatives of phosphatidylinositol (PI), are structurally diverse lipid messengers that orchestrate a wide range of cellular functions, including membrane trafficking, cytoskeletal dynamics, and signal transduction. Due to their dynamic metabolism and compartment-specific localization, their analysis demands complementary strategies that integrate live-cell imaging with molecular quantification. In this review, we first summarize the development and application of fluorescence-based probes designed to monitor the distribution and dynamics of phosphoinositides in living cells, highlighting their specificity, targeting mechanisms, and limitations. We then provide an overview of recent advances in mass spectrometry-based methodologies that enable high-sensitivity, isomer-resolved quantification of phosphoinositides in biological specimens, including improvements in lipid extraction, derivatization, and chromatographic separation. Together, these dual approaches offer synergistic insights into the biochemical and cellular regulation of phosphoinositide signaling.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 17","pages":"2564-2578"},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial molecular machines and motors-Design and control of nanoscale motion. 人造分子机器和马达——纳米级运动的设计与控制。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-11 DOI: 10.1002/1873-3468.70463

Leonardo Andreoni, Alberto Credi

引用次数: 0

Structures of mycobacterial 3-methylcrotonyl-CoA carboxylase reveal carrier-domain translocation between catalytic sites. 分枝杆菌3-甲基丁基辅酶a羧化酶的结构揭示了催化位点之间载体结构域的易位。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-11 DOI: 10.1002/1873-3468.70453

Ajit Yadav, Bogdan I Florea, Sebastian Geibel

引用次数: 0