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Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study. 在一项系统药理学研究中，虫草素通常会抑制生长因子信号转导。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-07 DOI: 10.1002/1873-3468.15046
Steven Lawrence, Jialiang Lin, Asma Khurshid, Wahyu Utami, Richa Singhania, Sadaf Ashraf, Graeme J Thorn, Irengbam Rocky Mangangcha, Keith Spriggs, Dong-Hyun Kim, David Barrett, Cornelia H de Moor
{"title":"Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study.","authors":"Steven Lawrence, Jialiang Lin, Asma Khurshid, Wahyu Utami, Richa Singhania, Sadaf Ashraf, Graeme J Thorn, Irengbam Rocky Mangangcha, Keith Spriggs, Dong-Hyun Kim, David Barrett, Cornelia H de Moor","doi":"10.1002/1873-3468.15046","DOIUrl":"https://doi.org/10.1002/1873-3468.15046","url":null,"abstract":"<p><p>Cordycepin (3' deoxyadenosine) has been widely researched as a potential cancer therapy, but many diverse mechanisms of action have been proposed. Here, we confirm that cordycepin triphosphate is likely to be the active metabolite of cordycepin and that it consistently represses growth factor-induced gene expression. Bioinformatic analysis, quantitative PCR and western blotting confirmed that cordycepin blocks the PI3K/AKT/mTOR and/or MEK/ERK pathways in six cell lines and that AMPK activation is not required. The effects of cordycepin on translation through mTOR pathway repression were detectable within 30 min, indicating a rapid process. These data therefore indicate that cordycepin has a universal mechanism of action, acting as cordycepin triphosphate on an as yet unknown target molecule involved in growth factor signalling.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of JNK ameliorates rod photoreceptor degeneration in a mouse model of retinitis pigmentosa. 抑制 JNK 可改善色素性视网膜炎小鼠模型中杆状光感受器的退化。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI: 10.1002/1873-3468.14978
Chunyan Liao, Shuai Chen, Xuxu Chen, Wanying Yi, Yingying Fan, Yuewen Chen, Tao Ye, Yu Chen
{"title":"Inhibition of JNK ameliorates rod photoreceptor degeneration in a mouse model of retinitis pigmentosa.","authors":"Chunyan Liao, Shuai Chen, Xuxu Chen, Wanying Yi, Yingying Fan, Yuewen Chen, Tao Ye, Yu Chen","doi":"10.1002/1873-3468.14978","DOIUrl":"10.1002/1873-3468.14978","url":null,"abstract":"<p><p>Retinitis pigmentosa (RP) is an inherited eye disease that causes progressive vision loss. Microglial activation and inflammation play essential roles in photoreceptor degeneration in RP, although the underlying mechanisms remain unclear. Here, we examined the progressive degeneration of photoreceptors in rd1 mice, a mouse model of RP. We investigated the molecular changes in various retinal cells in rd1 mice using single-cell RNA sequencing and found that potentiation of JNK signaling is associated with photoreceptor degeneration in RP. Moreover, inflammation-related molecules, which function downstream of JNK, are elevated in RP. Furthermore, inhibiting JNK alleviates microglial activation and rescues photoreceptor degeneration in rd1 mice. Thus, our findings suggest that targeting JNK is a promising approach for slowing RP progression.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The structural complexity of pyomelanin impacts UV shielding in Pseudomonas species with different lifestyles. 焦褐藻素的结构复杂性影响不同生活方式假单胞菌的紫外线屏蔽能力。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1002/1873-3468.15000
Mateo N Diaz Appella, Adriana Kolender, Oscar J Oppezzo, Nancy I López, Paula M Tribelli
{"title":"The structural complexity of pyomelanin impacts UV shielding in Pseudomonas species with different lifestyles.","authors":"Mateo N Diaz Appella, Adriana Kolender, Oscar J Oppezzo, Nancy I López, Paula M Tribelli","doi":"10.1002/1873-3468.15000","DOIUrl":"10.1002/1873-3468.15000","url":null,"abstract":"<p><p>Pyomelanin, a polymeric pigment in Pseudomonas, arises mainly from alterations in tyrosine degradation. The chemical structure of pyomelanin remains elusive due to its heterogeneous nature. Here, we report strain-specific differences in pyomelanin structural features across Pseudomonas using PAO1 and PA14 reference strains carrying mutations in hmgA (a gene involved in pyomelanin synthesis), a melanogenic P. aeruginosa clinical isolate (PAM), and a melanogenic P. extremaustralis (PexM). UV spectra showed dual peaks for PAO1 and PA14 mutants and single peaks for PAM and PexM. FTIR phenol : alcohol ratio changes and complex NMR spectra indicated non-linear polymers. UVC radiation survival increased with pyomelanin addition, correlating with pigment absorption attenuation. P. extremaustralis UVC survival varied with melanin source, with PAO1 pyomelanin being the most protective. These findings delineate structure-based pyomelanin subgroups, having distinct physiological effects.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities. 心肌细胞的分区调节肌酸激酶和腺苷酸激酶的活性。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.1002/1873-3468.14994
Rikke Birkedal, Jelena Branovets, Marko Vendelin
{"title":"Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities.","authors":"Rikke Birkedal, Jelena Branovets, Marko Vendelin","doi":"10.1002/1873-3468.14994","DOIUrl":"10.1002/1873-3468.14994","url":null,"abstract":"<p><p>Intracellular molecules are transported by motor proteins or move by diffusion resulting from random molecular motion. Cardiomyocytes are packed with structures that are crucial for function, but also confine the diffusional spaces, providing cells with a means to control diffusion. They form compartments in which local concentrations are different from the overall, average concentrations. For example, calcium and cyclic AMP are highly compartmentalized, allowing these versatile second messengers to send different signals depending on their location. In energetic compartmentalization, the ratios of AMP and ADP to ATP are different from the average ratios. This is important for the performance of ATPases fuelling cardiac excitation-contraction coupling and mechanical work. A recent study suggested that compartmentalization modulates the activity of creatine kinase and adenylate kinase in situ. This could have implications for energetic signaling through, for example, AMP-activated kinase. It highlights the importance of taking compartmentalization into account in our interpretation of cellular physiology and developing methods to assess local concentrations of AMP and ADP to enhance our understanding of compartmentalization in different cell types.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure. 剪接因子 hnRNPL 在不同物种中对心肌的调控是一致的，并在心力衰竭中发生改变。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI: 10.1002/1873-3468.15020
Isabelle Draper, Wanting Huang, Suchita Pande, Aaron Zou, Timothy D Calamaras, Richard H Choe, Ana Correia-Branco, Ariel L Mei, Howard H Chen, Hannah R Littel, Mekala Gunasekaran, Natalya M Wells, Christine C Bruels, Audrey L Daugherty, Matthew J Wolf, Peter B Kang, Vicky K Yang, Donna K Slonim, Mary C Wallingford, Robert M Blanton
{"title":"The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure.","authors":"Isabelle Draper, Wanting Huang, Suchita Pande, Aaron Zou, Timothy D Calamaras, Richard H Choe, Ana Correia-Branco, Ariel L Mei, Howard H Chen, Hannah R Littel, Mekala Gunasekaran, Natalya M Wells, Christine C Bruels, Audrey L Daugherty, Matthew J Wolf, Peter B Kang, Vicky K Yang, Donna K Slonim, Mary C Wallingford, Robert M Blanton","doi":"10.1002/1873-3468.15020","DOIUrl":"10.1002/1873-3468.15020","url":null,"abstract":"<p><p>Heart failure (HF) is highly prevalent. Mechanisms underlying HF remain incompletely understood. Splicing factors (SF), which control pre-mRNA alternative splicing, regulate cardiac structure and function. This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein-L (hnRNPL) in the failing heart. hnRNPL protein increased in left ventricular tissue from mice with transaortic constriction-induced HF and from HF patients. In left ventricular tissue, hnRNPL was detected predominantly in nuclei. Knockdown of the hnRNPL homolog Smooth in Drosophila induced cardiomyopathy. Computational analysis of predicted mouse and human hnRNPL binding sites suggested hnRNPL-mediated alternative splicing of tropomyosin, which was confirmed in C2C12 myoblasts. These findings identify hnRNPL as a sensor of cardiac dysfunction and suggest that disturbances of hnRNPL affect alternative splicing in HF.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjugative transfer of the IncN plasmid pKM101 is mediated by dynamic interactions between the TraK accessory factor and TraI relaxase. IncN质粒pKM101的共轭转移是由TraK附属因子和TraI松弛酶之间的动态相互作用介导的。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-09-08 DOI: 10.1002/1873-3468.15011
Yang Grace Li, Annika Breidenstein, Ronnie P-A Berntsson, Peter J Christie
{"title":"Conjugative transfer of the IncN plasmid pKM101 is mediated by dynamic interactions between the TraK accessory factor and TraI relaxase.","authors":"Yang Grace Li, Annika Breidenstein, Ronnie P-A Berntsson, Peter J Christie","doi":"10.1002/1873-3468.15011","DOIUrl":"10.1002/1873-3468.15011","url":null,"abstract":"<p><p>Conjugative dissemination of mobile genetic elements (MGEs) among bacteria is initiated by assembly of the relaxosome at the MGE's origin-of-transfer (oriT) sequence. A critical but poorly defined step of relaxosome assembly involves recruitment of the catalytic relaxase to its DNA strand-specific nicking site within oriT. Here, we present evidence by AlphaFold modeling, affinity pulldowns, and in vivo site-directed photocrosslinking that the TraK Ribbon-Helix-Helix DNA-binding protein recruits TraI to oriT through a dynamic interaction in which TraI's C-terminal unstructured domain (TraI<sub>CTD</sub>) wraps around TraK's C-proximal tetramerization domain. Upon relaxosome assembly, conformational changes disrupt this contact, and TraI<sub>CTD</sub> instead self-associates as a prerequisite for relaxase catalytic functions or substrate engagement with the transfer channel. These findings delineate key early-stage processing reactions required for conjugative dissemination of a model MGE.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural modeling and characterization of the Mycobacterium tuberculosis MmpL3 C-terminal domain. 结核分枝杆菌 MmpL3 C 端结构域的结构建模和特征描述。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1002/1873-3468.15007
Naomi Berkowitz, Allison MacMillan, Marit B Simmons, Ujwal Shinde, Georgiana E Purdy
{"title":"Structural modeling and characterization of the Mycobacterium tuberculosis MmpL3 C-terminal domain.","authors":"Naomi Berkowitz, Allison MacMillan, Marit B Simmons, Ujwal Shinde, Georgiana E Purdy","doi":"10.1002/1873-3468.15007","DOIUrl":"10.1002/1873-3468.15007","url":null,"abstract":"<p><p>The Mycobacterium tuberculosis (Mtb) cell envelope provides a protective barrier against the immune response and antibiotics. The mycobacterial membrane protein large (MmpL) family of proteins export cell envelope lipids and siderophores; therefore, these proteins are important for the basic biology and pathogenicity of Mtb. In particular, MmpL3 is essential and a known drug target. Despite interest in MmpL3, the structural data in the field are incomplete. Utilizing homology modeling, AlphaFold, and biophysical techniques, we characterized the cytoplasmic C-terminal domain (CTD) of MmpL3 to better understand its structure and function. Our in silico models of the MmpL11<sub>TB</sub> and MmpL3<sub>TB</sub> CTD reveal notable features including a long unstructured linker that connects the globular domain to the last transmembrane (TM) in each transporter, charged lysine and arginine residues facing the membrane, and a C-terminal alpha helix. Our predicted overall structure enables a better understanding of these transporters.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The publish or perish game: an interview with the inventor. 出版或毁灭游戏：与发明者的访谈。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI: 10.1002/1873-3468.15039
Daisy Y Shu, Vik Meadows, Roberto Mota Alvidrez, Max Bai
{"title":"The publish or perish game: an interview with the inventor.","authors":"Daisy Y Shu, Vik Meadows, Roberto Mota Alvidrez, Max Bai","doi":"10.1002/1873-3468.15039","DOIUrl":"10.1002/1873-3468.15039","url":null,"abstract":"<p><p>Many academics often have to face the pressure to constantly publish or quietly perish. The Publish or Perish Game™, a new tabletop game created by Max Bai, flips the script and offers a satirical reflection on the academic publishing process, turning the often-stressful endeavor into an entertainment experience. In this interview, Max Bai discusses the inspiration behind the game, the creative processes, and the broader impact he hopes the game will have on the academic community.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sphingosine-1-phosphate signalling in the heart: exploring emerging perspectives in cardiopathology. 心脏中的鞘氨醇-1-磷酸信号：探索心脏病理学的新视角。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI: 10.1002/1873-3468.14973
Franck Phan, Olivier Bourron, Fabienne Foufelle, Hervé Le Stunff, Eric Hajduch
{"title":"Sphingosine-1-phosphate signalling in the heart: exploring emerging perspectives in cardiopathology.","authors":"Franck Phan, Olivier Bourron, Fabienne Foufelle, Hervé Le Stunff, Eric Hajduch","doi":"10.1002/1873-3468.14973","DOIUrl":"10.1002/1873-3468.14973","url":null,"abstract":"<p><p>Cardiometabolic disorders contribute to the global burden of cardiovascular diseases. Emerging sphingolipid metabolites like sphingosine-1-phosphate (S1P) and its receptors, S1PRs, present a dynamic signalling axis significantly impacting cardiac homeostasis. S1P's intricate mechanisms extend to its transportation in the bloodstream by two specific carriers: high-density lipoprotein particles and albumin. This intricate transport system ensures the accessibility of S1P to distant target tissues, influencing several physiological processes critical for cardiovascular health. This review delves into the diverse functions of S1P and S1PRs in both physiological and pathophysiological conditions of the heart. Emphasis is placed on their diverse roles in modulating cardiac health, spanning from cardiac contractility, angiogenesis, inflammation, atherosclerosis and myocardial infarction. The intricate interplays involving S1P and its receptors are analysed concerning different cardiac cell types, shedding light on their respective roles in different heart diseases. We also review the therapeutic applications of targeting S1P/S1PRs in cardiac diseases, considering existing drugs like Fingolimod, as well as the prospects and challenges in developing novel therapies that selectively modulate S1PRs.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. 关注的问题：LLL12 是一种小分子，可抑制组成型 STAT3 和 IL-6 诱导的 STAT3 信号传导，并在人类多发性骨髓瘤细胞中显示出强大的生长抑制活性。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-11-01 Epub Date: 2024-10-11 DOI: 10.1002/1873-3468.15037
{"title":"EXPRESSION OF CONCERN: A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.","authors":"","doi":"10.1002/1873-3468.15037","DOIUrl":"10.1002/1873-3468.15037","url":null,"abstract":"<p><p>Expression of Concern: H. Wang, B. Wang, Q. Liao, H. An, W. Li, X. Jin, S. Cui, and L. Zhao, \"Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma,\" FEBS Letters 588, no. 3 (2014): 503-508. https://doi.org/10.1016/j.febslet.2013.12.016. This Expression of Concern is for the above article, published online on 24 December 2013, in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The Expression of Concern has been agreed due to concerns raised by a third party regarding the similarity of beta-actin blots in Fig. 3A between the HepG2 and the MHCC-97H lanes. The authors responded to an inquiry by the publisher and supplied what was labelled as original data. However, following an evaluation of the authors' response by FEBS and the editors, Wiley and the journal have determined that they are unable to verify if the files provided by the authors correspond to the research described in the article. The journal is issuing this Expression of Concern because the results of the experiment as presented cannot be confirmed. The authors do not agree with the expression of concern.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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