FEBS Letters最新文献

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa. 环核苷酸信号作为视网膜色素变性的药物靶点。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-09 DOI: 10.1002/1873-3468.70107

Katri Vainionpää, Ahmed B Montaser, Henri Leinonen

{"title":"Cyclic nucleotide signaling as a drug target in retinitis pigmentosa.","authors":"Katri Vainionpää, Ahmed B Montaser, Henri Leinonen","doi":"10.1002/1873-3468.70107","DOIUrl":"https://doi.org/10.1002/1873-3468.70107","url":null,"abstract":"Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degenerative diseases caused by mutations in over 90 genes. The complexity of its genetic background and economic barriers limit the broad application of targeted gene therapies. Therefore, general pharmacological strategies to slow disease progression, regardless of the underlying mutation, are needed. Cyclic nucleotide second messengers, such as cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), are important for normal retinal function. This includes phototransduction, for which cGMP signaling is essential. Dysregulation of the cyclic nucleotide systems is associated with retinal degeneration, and the inhibition of cGMP or cAMP signaling has shown beneficial effects in several retinal degeneration disease models. Here, we propose these systems as drug targets for RP. Impact statement This perspective proposes targeting cyclic nucleotide signaling (cGMP and cAMP) as a mutation-independent therapeutic strategy for retinitis pigmentosa, offering broad potential for disease-modifying treatment potentially through drug repurposing and novel drug delivery systems.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Origin of life: β-sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks. 生命的起源：β-片淀粉样构象是早期地球上的原始功能聚合物及其在复杂动态网络出现中的作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-09 DOI: 10.1002/1873-3468.70112

Carl Peter J Maury

{"title":"Origin of life: β-sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks.","authors":"Carl Peter J Maury","doi":"10.1002/1873-3468.70112","DOIUrl":"https://doi.org/10.1002/1873-3468.70112","url":null,"abstract":"The origin of life has remained a conundrum. Among the origin-of-life hypotheses, the RNA world has gained wide popularity. It has, however, been difficult to explain the emergence of both stable and meaningful RNA under the presumably very harsh early Earth conditions, and it has been assumed that some other replicating system must have preceded the RNA world. The amyloid world hypothesis posits that the first functional polymers on the primitive Earth were structurally stable self-replicating β-sheet-based peptide amyloids. The amyloid hypothesis is examined in this perspective in light of new research results and highlights the role of dynamic interacting networks. The mechanisms of self-amplification and information transfer are discussed, as well as the catalytic, adaptive, and evolutionary properties of the cross-β-sheet ensembles. There is no contradiction between the amyloid and the RNA world hypotheses: In the harsh prebiotic environment, the β-sheet fibrillar networks provide a scaffold and initial protection for nucleobases and other prebiotic compounds, and the cooperative interactions of the β-sheet ensembles with nucleic acids, fatty acids, and natively folded proteins are in concert with the view of an early co-evolving amyloid-RNA-lipid-protein world.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies. 分析b细胞恶性肿瘤细胞外囊泡免疫相互作用的生物学和技术复杂性。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-04 DOI: 10.1002/1873-3468.70102

Daniel Bachurski, Michael Hallek

引用次数: 0

Mechanisms and kinetic assays of aminoacyl-tRNA synthetases. 氨基酰基- trna合成酶的机理和动力学分析。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-04 DOI: 10.1002/1873-3468.70098

Igor Zivkovic, Morana Dulic, Ita Gruic-Sovulj

引用次数: 0

EXPRESSION OF CONCERN: Inhibition of Endothelial Cell Migration by Cerivastatin, an HMG-CoA Reductase Inhibitor: Contribution to Its Anti-Angiogenic Effect. 关注表达：一种HMG-CoA还原酶抑制剂西伐他汀抑制内皮细胞迁移：有助于其抗血管生成作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-03 DOI: 10.1002/1873-3468.70103

{"title":"EXPRESSION OF CONCERN: Inhibition of Endothelial Cell Migration by Cerivastatin, an HMG-CoA Reductase Inhibitor: Contribution to Its Anti-Angiogenic Effect.","authors":"","doi":"10.1002/1873-3468.70103","DOIUrl":"https://doi.org/10.1002/1873-3468.70103","url":null,"abstract":"Expression of concern: L. Vincent , W. Chen , L. Hong , F. Mirshahi , Z. Mishal , T. Mirshahi-Khorassani , J.-P. Vannier , J. Soria , and C. Soria , \"Inhibition of Endothelial Cell Migration by Cerivastatin, an HMG-CoA Reductase Inhibitor: Contribution to Its Anti-Angiogenic Effect,\" FEBS Letters 495, no. 3 (2001): 159 -166, https://doi.org/10.1016/S0014-5793(01)02337-7. This Expression of Concern is for the above article, published online on 25 April 2001 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The Expression of Concern has been published due to concerns raised by a third party regarding duplicated and rotated image sections within Figure 2 (1A and 4A panels) representing different experimental conditions. A subsequent investigation by the journal team identified further duplications between the panels 1B and 4C of Figure 2. The authors and their institute were informed about the concerns but they remained unresponsive. In the absence of a satisfactory explanation and/or the original raw data, the journal team could not verify the authenticity of these figures and could not exclude that these concerns affect the related conclusions of the article. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Introgression of a Novel Salt-Tolerant L-Myo-Inositol 1-Phosphate Synthase from Porteresia Coarctata (Roxb.) Tateoka (PcINO1) Confers Salt Tolerance to Evolutionary Diverse Organisms. 关注的表达：一种新型耐盐l -肌醇1-磷酸合成酶从Coarctata Porteresia （Roxb.）中渗入Tateoka （PcINO1）赋予进化多样性生物耐盐性。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-02 DOI: 10.1002/1873-3468.70100

{"title":"EXPRESSION OF CONCERN: Introgression of a Novel Salt-Tolerant L-Myo-Inositol 1-Phosphate Synthase from Porteresia Coarctata (Roxb.) Tateoka (PcINO1) Confers Salt Tolerance to Evolutionary Diverse Organisms.","authors":"","doi":"10.1002/1873-3468.70100","DOIUrl":"https://doi.org/10.1002/1873-3468.70100","url":null,"abstract":"Expression of concern: A. Das-Chatterjee, L. Goswami, S. Maitra, K. G. Dastidar, S. Ray, and A. L. Majumder, \"Introgression of a Novel Salt-Tolerant L-Myo-Inositol 1-Phosphate Synthase from Porteresia Coarctata (Roxb.) Tateoka (PcINO1) Confers Salt Tolerance to Evolutionary Diverse Organisms,\" FEBS Letters 580, no. 16 (2006): 3980-3988, https://doi.org/10.1016/j.febslet.2006.06.033. This Expression of Concern is for the above article, published online on 21 June 2006 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The Expression of Concern has been published due to concerns raised by a third party regarding highly similar image sections between the 200 mM and 300 mM subpanels of Figure 1A. The authors and their institute were informed about the concerns but they remained unresponsive. In the absence of a satisfactory explanation and/or the original raw data, the journal team could not verify the authenticity of these figures and could not exclude that these concerns affect the related conclusions of the article. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intron-oriented HTLV-1 integration in an adult T-cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA. 内含子导向的HTLV-1整合在成人t细胞白血病/淋巴瘤细胞系中维持完整的ift81 mRNA的表达。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-01 DOI: 10.1002/1873-3468.70104

Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A Komano

引用次数: 0

Comprehensive analysis of mRNA 3' ends during early zebrafish development reveals dynamics of 3'UTR changes on a genome-wide scale. 对早期斑马鱼发育过程中mRNA 3‘末端的综合分析揭示了全基因组范围内3’ utr变化的动态。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2025-07-01 DOI: 10.1002/1873-3468.70106

Ludivine Fierro, Anna Ishii, Haruka Aoyama, Toshihiro Arae, Yukako Chiba, Tomoya Kotani

引用次数: 0

Single-cell insights into the role of T cells in B-cell malignancies. 单细胞观察T细胞在b细胞恶性肿瘤中的作用。