Single-cell insights into the role of T cells in B-cell malignancies.

Abstract

The intricate interplay between T cells and tumor cells in B-cell malignancies has garnered significant attention in recent years. Single-cell technologies have revolutionized our understanding of this dynamic relationship, offering unprecedented resolution and insights into cellular heterogeneity, signaling pathways, and immune interactions. This review synthesizes the recent findings that single-cell methodologies have elucidated on the roles of T cells in the pathogenesis, progression, and therapeutic response of B-cell malignancies. Key discoveries include the identification of previously unknown T-cell subsets and their functional states, as well as the mechanisms of immune evasion by malignant B cells. These insights pave the way for innovative therapeutic strategies aimed at harnessing the immune system to combat B-cell lymphomas.