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Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit 志贺毒素a衍生肽通过与志贺毒素B亚基相互作用内化到Gb3受体承载细胞的鉴定。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-12 Epub Date: 2026-07-04 DOI: 10.1002/1873-3468.70403
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson
{"title":"Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit","authors":"Giulia Opassi,&nbsp;João C. Encarnação,&nbsp;Valeria Napolitano,&nbsp;Grzegorz Dubin,&nbsp;Grzegorz Popowicz,&nbsp;Karl Andersson,&nbsp;U. Helena Danielson","doi":"10.1002/1873-3468.70403","DOIUrl":"10.1002/1873-3468.70403","url":null,"abstract":"<p>Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug carriers. Using time-resolved biosensor-based assays we examined the interaction between a variety of STxA peptides (varying in length and end groups) and the cell receptor binding subunit (STxB). Peptides which bound STxB included the C-terminal α-helix protruding into the interior of STxB and the ß-strands binding to its surface. Specifically, the C-terminal 26-mer resulted in a stable complex in a physiologically relevant pH range for drug delivery. Real-time cell-binding analysis showed that the peptide-STxB complex binds to and is internalized by Gb3-overexpressing cancer cell lines with surface-exposed Gb3 receptors. It highlights STxA-derived peptides as potential as drug carriers.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 19","pages":"2961-2971"},"PeriodicalIF":3.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An epithelial GPR35 isoform supports tumor-associated transcriptional and metabolic phenotypes 上皮GPR35亚型支持肿瘤相关的转录和代谢表型。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-12 Epub Date: 2026-08-01 DOI: 10.1002/1873-3468.70423
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz
{"title":"An epithelial GPR35 isoform supports tumor-associated transcriptional and metabolic phenotypes","authors":"Jørgen D. Rønneberg,&nbsp;Martine Hjeltnes,&nbsp;Josephine Krieger,&nbsp;Joshua E. Elias,&nbsp;Maria Stensland,&nbsp;Kristian Holm,&nbsp;Xiaojun Jiang,&nbsp;Chuki Khangsar,&nbsp;Tuula A. Nyman,&nbsp;Arthur Kaser,&nbsp;Johannes R. Hov,&nbsp;Tom H. Karlsen,&nbsp;Nicole C. Kaneider,&nbsp;Frode L. Jahnsen,&nbsp;Georg Schneditz","doi":"10.1002/1873-3468.70423","DOIUrl":"10.1002/1873-3468.70423","url":null,"abstract":"<p>G protein-coupled receptor 35 (GPR35) has been implicated in cancer, but the functional roles of its isoforms remain unresolved. Here, we characterize GPR35-long, an N-terminally extended epithelial isoform selectively enriched in colorectal cancer and cholangiocarcinoma. Mass spectrometry and immunohistochemistry confirmed GPR35-long protein expression in tumor cells. Functional analyses revealed that GPR35-long supports tumor-associated transcriptional programs, enhances cellular ATP production, and exhibits increased constitutive and ligand-induced beta-arrestin signaling. These phenotypes were selectively suppressed by the inverse agonist CID-2745687, identifying GPR35-long as a functionally distinct isoform with selective pharmacological sensitivity in tumor cells.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 19","pages":"2876-2898"},"PeriodicalIF":3.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe-treated HepG2 cells. 抑制二肽基肽酶7损害llome处理的HepG2细胞的溶噬。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-08 DOI: 10.1002/1873-3468.70482
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji-Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong-Hyung Cho
{"title":"Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe-treated HepG2 cells.","authors":"Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji-Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong-Hyung Cho","doi":"10.1002/1873-3468.70482","DOIUrl":"https://doi.org/10.1002/1873-3468.70482","url":null,"abstract":"<p><p>Lysophagy selectively eliminates damaged lysosomes to preserve lysosomal homeostasis, but its regulatory mechanisms remain incompletely understood. Here, we identify dipeptidyl peptidase 7 (DPP7), a lysosomal serine protease, as a regulator of lysophagy. Inhibition or depletion of DPP7 impaired clearance of LLOMe-damaged lysosomes in HepG2 cells, as evidenced by sustained galectin-3 puncta and reduced lysophagic flux. DPP7 inhibition did not block TFEB activation; however, it markedly reduced ubiquitin accumulation on damaged lysosomes and attenuated the recruitment of SQSTM1 and LC3. This defect was accompanied by impaired lysosomal re-acidification and reduced maturation of cathepsin D and L. Together, our findings identify DPP7 as a novel modulator of ubiquitin-dependent lysophagy and reveal an unexpected role for a lysosomal peptidase in lysosomal quality control.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Becoming the bull: Structural insights and engineering strategies for ultralong CDR-H3 paratopes from cattle. 成为公牛：牛的超长CDR-H3伞形结构洞察和工程策略。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-06 DOI: 10.1002/1873-3468.70475
Andreas Evers, Lukas Pekar, Enrico Guarnera, Hristo L Svilenov, Stefan Zielonka
{"title":"Becoming the bull: Structural insights and engineering strategies for ultralong CDR-H3 paratopes from cattle.","authors":"Andreas Evers, Lukas Pekar, Enrico Guarnera, Hristo L Svilenov, Stefan Zielonka","doi":"10.1002/1873-3468.70475","DOIUrl":"https://doi.org/10.1002/1873-3468.70475","url":null,"abstract":"<p><p>Cattle produce a subset of antibodies (Abs) with unique architecture. These immunoglobulins feature an ultralong CDR-H3 (uCDR-H3) composed of up to about 70 amino acids that protrudes from the scaffold and folds into a distinct stalk-and-knob structure. The knob is a disulfide-rich mini-domain that contains all paratope residues for antigen recognition. Due to their vast structural diversity and low molecular weight, cattle-derived knob paratopes have emerged as promising building blocks for engineering next-generation Abs. In this review, we discuss the structural features of uCDR-H3 Abs alongside engineering strategies of cattle-derived knob architectures, including stand-alone knob peptides and knob engraftments to generate bispecific antibodies (bsAbs).</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA-related functions of BRCA2 in transcription, replication, and genome stability. BRCA2在转录、复制和基因组稳定性中的rna相关功能。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-06 DOI: 10.1002/1873-3468.70461
Lucia Alvaro-Aranda, Sreerama Chaitanya Sridhara, Aura Carreira
{"title":"RNA-related functions of BRCA2 in transcription, replication, and genome stability.","authors":"Lucia Alvaro-Aranda, Sreerama Chaitanya Sridhara, Aura Carreira","doi":"10.1002/1873-3468.70461","DOIUrl":"https://doi.org/10.1002/1873-3468.70461","url":null,"abstract":"<p><p>BRCA2 is a central tumor suppressor protein best known for its roles in homologous recombination and replication fork stability. Increasing evidence, however, positions BRCA2 at the interface of transcription and replication, where it preserves genome stability under transcription-associated stress. BRCA2 regulates R-loop homeostasis, transcription-replication conflict resolution, and RNA polymerase II dynamics. Its loss leads to R-loop accumulation, transcriptional pausing, and elevated transcription-replication head-on collisions, particularly in highly transcribed regions. BRCA2 also promotes the processing of RNA-associated DNA lesions, preventing toxic intermediates during S phase. Through interactions with factors such as PAF1, PCAF, and DDX5, BRCA2 coordinates transcription, chromatin regulation, and DNA-RNA hybrid resolution, linking these processes to inflammatory and stress-responsive transcriptional programs, including NF-κB signaling. In this review, we focus on the emerging roles of BRCA2 in transcription-related pathways, including R-loop homeostasis, resolution of transcription-replication conflicts, RNA polymerase II dynamics, and broader transcriptional regulation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive oxygen species-induced lipid peroxidation mediates Wnt-dependent lipodystrophy and associated skin fibrosis. 活性氧诱导的脂质过氧化介导wnt依赖性脂肪营养不良和相关的皮肤纤维化。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-10-05 DOI: 10.1002/1873-3468.70479
Qiannan Ma, Suneeti R Madhavan, Emilia Sanz-Rios, Rachel Kim, Radhika P Atit
{"title":"Reactive oxygen species-induced lipid peroxidation mediates Wnt-dependent lipodystrophy and associated skin fibrosis.","authors":"Qiannan Ma, Suneeti R Madhavan, Emilia Sanz-Rios, Rachel Kim, Radhika P Atit","doi":"10.1002/1873-3468.70479","DOIUrl":"https://doi.org/10.1002/1873-3468.70479","url":null,"abstract":"<p><p>Skin fibrosis is marked by extracellular matrix accumulation and dermal white adipose tissue (DWAT), resulting in tissue stiffening. We show that sustained Wnt activation in mature dermal adipocytes induces lipodystrophy and promotes fibrotic remodeling via oxidative stress. Meta-analysis of early systemic sclerosis skin transcriptomes reveals increased reactive oxygen species (ROS) production and lipid peroxidation. In cultured mouse dermal adipocytes, Wnt activation triggers a robust increase in ROS and lipid peroxidation, which is suppressed by scavengers. In vivo, Wnt activation elevates oxidative stress in DWAT, and N-acetyl-L-cysteine scavenger protects from DWAT lipodystrophy and dermal collagen accumulation. These findings identify a Wnt-ROS-lipid peroxidation axis as a key driver of lipodystrophy and skin fibrosis, highlighting a potential therapeutic target.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The planar cell polarity protein Vangl2 interacts with the PDZ-domains of Scribble but not with a unique PDZ-like domain in Inturned 平面细胞极性蛋白Vangl2与Scribble的pdz结构域相互作用，但不与inturn中独特的PDZ-like结构域相互作用。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-09-28 Epub Date: 2026-03-08 DOI: 10.1002/1873-3468.70319
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel
{"title":"The planar cell polarity protein Vangl2 interacts with the PDZ-domains of Scribble but not with a unique PDZ-like domain in Inturned","authors":"Stephan Wilmes,&nbsp;Jan Brysch,&nbsp;Carmen Gelze,&nbsp;Lilli Meier,&nbsp;Daniel Kümmel","doi":"10.1002/1873-3468.70319","DOIUrl":"10.1002/1873-3468.70319","url":null,"abstract":"<p>The proteins Inturned and Fuzzy are members of the tri-longin domain (TLD) RabGEF family and activate the GTPase Rab23 downstream of the core planar cell polarity (PCP) proteins Vangl2 and Prickle. To gain insight into the function of a predicted PDZ domain unique to Inturned among TLD proteins, we performed structural and biochemical characterisations. We show that this domain does not interact with membranes or Vangl2. Instead, we find a phosphorylation-dependent interaction between Vangl2 and a PDZ domain of the apical-basal polarity protein Scribble. A crystal structure of Intu-PDZ reveals a unique PDZ-like fold lacking an interaction site for PDZ-binding motifs. Our data provide new insight into the role of PDZ domains in coordinating cell polarity downstream of Vangl2.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 18","pages":"2765-2776"},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation 高渗应激诱导parp1介导的hpf1依赖性单核苷酸（adp -核糖基）化。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-09-28 Epub Date: 2026-03-31 DOI: 10.1002/1873-3468.70334
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky
{"title":"Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation","authors":"Anna Georgina Kopasz,&nbsp;Mihály Mérey,&nbsp;Rebeka Vásárhelyi,&nbsp;Ramóna Pék,&nbsp;Victor Imburchia,&nbsp;László Henn,&nbsp;Adrián Kószó,&nbsp;Nicholas D. Lakin,&nbsp;Ivan Ahel,&nbsp;Sébastien Huet,&nbsp;Ágnes Czibula,&nbsp;Gyula Timinszky","doi":"10.1002/1873-3468.70334","DOIUrl":"10.1002/1873-3468.70334","url":null,"abstract":"<p>While the downstream effectors of the hyperosmotic stress response are relatively well characterized, the primary molecular sensors responsible for initial stress detection remain poorly defined. In this study, we demonstrate that hyperosmotic stress triggers a rapid and transient mono(ADP-ribosyl)ation (MARylation). Beside MARylation, signs of acute genotoxicity are missing and CHK1 activation is observed only upon recovery from osmotic stress. Our data indicate that PARP1 catalyzes its own MARylation in an HPF1 co-factor dependent manner. Biochemical assays further demonstrate that the mono-ADP-ribose moiety is resistant to hydroxylamine treatment, which is a feature of HPF1-directed O-glycosidic bonds. Together, these findings support a model in which PARP1 acts as a sensor of chromatin structure changes induced by hyperosmotic stress leading to its autoMARylation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 18","pages":"2800-2813"},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discerning protein pools by selective staining with self-labeling tags 通过自我标记标签的选择性染色来识别蛋白质池。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-09-28 Epub Date: 2026-08-07 DOI: 10.1002/1873-3468.70425
Kati Fischermanns, Johannes Broichhagen
{"title":"Discerning protein pools by selective staining with self-labeling tags","authors":"Kati Fischermanns,&nbsp;Johannes Broichhagen","doi":"10.1002/1873-3468.70425","DOIUrl":"10.1002/1873-3468.70425","url":null,"abstract":"<p>Transmembrane-spanning cell surface proteins undergo maturation from the site of synthesis in the endoplasmic reticulum to the plasma membrane, and may be endocytosed back into the cell. Microscopy allows the visual separation of such populations at the cell surface and in intracellular compartments and to monitor trafficking and dissect the relative abundance of such pools. Protein tags, like SNAP-tag, HTP, and FAST, combined with their respective (im)permeable ligands fused to fluorescent dyes, open up new possibilities to distinguish between intra- and extracellular protein pools. Introducing cleavable groups in dye-ligand molecules allows interrogation of endocytosed pools by stripping the remaining surface pools. Latest developments, for instance, fluorescence lifetime imaging microscopy and brightness demixing, give further opportunities in microscopy.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 18","pages":"2716-2728"},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stop paying predatory publishers of academic journals—A policy proposal to restore scientific integrity and transparency 停止向掠夺性的学术期刊出版商付费——一项旨在恢复科学诚信和透明度的政策建议。
IF 3 4区 生物学
FEBS Letters Pub Date : 2026-09-28 Epub Date: 2026-08-26 DOI: 10.1002/1873-3468.70451
Paul B. Rainey, Kenneth N. Timmis, Paul A. Williams, Zeynep Ceren Karahan, Purificación López-García, Max Chavarria, Chris Greening, Karen Steward, Cristina Silva Pereira, Rafael Giraldo, Willy Verstraete, Stipan Jonjić, Juan Luis Ramos, Olga Nunes, Antonio Ventosa, Rachel Armstrong, Angela Sessitsch, Eliora Ron, Hui Wang, Michael E. Hochberg, Brandon Berryhill, Bruce R. Levin
{"title":"Stop paying predatory publishers of academic journals—A policy proposal to restore scientific integrity and transparency","authors":"Paul B. Rainey,&nbsp;Kenneth N. Timmis,&nbsp;Paul A. Williams,&nbsp;Zeynep Ceren Karahan,&nbsp;Purificación López-García,&nbsp;Max Chavarria,&nbsp;Chris Greening,&nbsp;Karen Steward,&nbsp;Cristina Silva Pereira,&nbsp;Rafael Giraldo,&nbsp;Willy Verstraete,&nbsp;Stipan Jonjić,&nbsp;Juan Luis Ramos,&nbsp;Olga Nunes,&nbsp;Antonio Ventosa,&nbsp;Rachel Armstrong,&nbsp;Angela Sessitsch,&nbsp;Eliora Ron,&nbsp;Hui Wang,&nbsp;Michael E. Hochberg,&nbsp;Brandon Berryhill,&nbsp;Bruce R. Levin","doi":"10.1002/1873-3468.70451","DOIUrl":"10.1002/1873-3468.70451","url":null,"abstract":"<p>Scientific publishing is undergoing a systemic breakdown. Thousands of journals now collect article processing charges (APCs)—increasingly paid from public research funds—while providing minimal editorial oversight. This erodes standards, distorts incentives and threatens public trust in science. APC payments to six major publishers exceeded 8 billion dollars between 2019 and 2023, with almost no transparency over how these fees are set or spent. This cannot continue. We propose that public and institutional funds support journals—whether through APCs, subscriptions or bundled agreements—only where they are accredited against a transparent, enforceable quality standard. Implemented in stages and led by funding bodies and learned societies, such accreditation would narrow the space in which predatory journals operate without resorting to blacklists.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"600 18","pages":"2681-2685"},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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