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Investigation of oxidative-stress-induced axon beading using photo-oxidation 利用光氧化技术研究氧化应激诱导的轴突串珠。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-06-09 DOI: 10.1002/1873-3468.70074
Deepak Mehta, Pooja Joshi, Pramod Pullarkat
{"title":"Investigation of oxidative-stress-induced axon beading using photo-oxidation","authors":"Deepak Mehta,&nbsp;Pooja Joshi,&nbsp;Pramod Pullarkat","doi":"10.1002/1873-3468.70074","DOIUrl":"10.1002/1873-3468.70074","url":null,"abstract":"<p>Oxidative stress caused by excessive reactive oxygen species adversely affects cellular function. Here, we investigate axonal beading induced by the photo-oxidation of a membrane-based fluorescent dye. Our experiments show that, apart from using oxygen scavengers, chelation of free calcium, or stabilization of microtubules or actin filaments by pharmacological agents can mitigate oxidative-stress-induced beading. Furthermore, we take advantage of this light-induced oxidative stress to explore axonal responses to spatially confined perturbations. We demonstrate that low excitation causes localized, long-lasting axon beading, whereas high excitation leads to widespread degeneration and beading. Besides the results presented here, this light-based technique is a convenient tool for investigating local oxidative stress in tissues, such as brain slices or organoids.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 17","pages":"2491-2503"},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of single-cell transcriptomic profiles from Illumina and MGI Tech sequencing platforms 来自Illumina和MGI Tech测序平台的单细胞转录组谱验证。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-06-09 DOI: 10.1002/1873-3468.70087
Valerie Vandenbempt, Michael Roach, Monika Mohenska, Kellie Wise, Taopeng Wang, Kate Harvey, Kirk Jensen, Alexander Swarbrick, Jose M. Polo, Esteban N. Gurzov, Luciano G. Martelotto
{"title":"Validation of single-cell transcriptomic profiles from Illumina and MGI Tech sequencing platforms","authors":"Valerie Vandenbempt,&nbsp;Michael Roach,&nbsp;Monika Mohenska,&nbsp;Kellie Wise,&nbsp;Taopeng Wang,&nbsp;Kate Harvey,&nbsp;Kirk Jensen,&nbsp;Alexander Swarbrick,&nbsp;Jose M. Polo,&nbsp;Esteban N. Gurzov,&nbsp;Luciano G. Martelotto","doi":"10.1002/1873-3468.70087","DOIUrl":"10.1002/1873-3468.70087","url":null,"abstract":"<p>While Illumina is currently used for high-throughput short-read sequencing, MGI Tech have developed a similar sequencing method at a lower cost. Comparisons of the two platforms revealed that their accuracy, sensitivity, and reproducibility are very similar, but the impact of each on biological insights, particularly in heterogeneous samples, remains unknown. Illumina and MGI Tech were used to generate single-cell RNA-seq libraries from three human cancer samples. While unique platform-specific cells arise after additional cell quality controls, the chosen sequencing platform did not affect either clustering or gene expression analyses. In conclusion, MGI Tech delivers transcriptomic profiles similar to those of Illumina and can be confidently used for high-throughput applications.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 17","pages":"2533-2542"},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disruption of SETD3-mediated histidine-73 methylation by the BWCFF-associated β-actin G74S mutation bwcff相关β-肌动蛋白G74S突变破坏setd3介导的组氨酸-73甲基化。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-06-09 DOI: 10.1002/1873-3468.70088
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein
{"title":"Disruption of SETD3-mediated histidine-73 methylation by the BWCFF-associated β-actin G74S mutation","authors":"Anja Marquardt,&nbsp;Marcus S. Münchhoff,&nbsp;Jacqueline Krohn,&nbsp;Philip M. Palarz,&nbsp;Manuel H. Taft,&nbsp;Johannes N. Greve,&nbsp;Nataliya Di Donato,&nbsp;Falk F. R. Buettner,&nbsp;Dietmar J. Manstein","doi":"10.1002/1873-3468.70088","DOIUrl":"10.1002/1873-3468.70088","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <p>Histidine-73 methylation of β-actin by SETD3 modulates ATPase activity, filament assembly, and protein interactions. The pathogenic G74S mutation in cytoskeletal β-actin, associated with Baraitser–Winter cerebrofrontofacial syndrome (BWCFF), alters the adjacent phosphate sensor loop, disrupting SETD3-mediated methylation. Molecular docking indicates that SETD3 undergoes structural rearrangements to accommodate the mutant β-actin, leading to reduced catalytic efficiency. Enzymatic assays confirm slower turnover of mutant actin peptides, while mass spectrometry reveals decreased histidine-73 methylation in both recombinant mutant β-actin and patient-derived fibroblasts. This perturbance of SETD3-mediated methylation likely generates β-actin pools with distinct methylation states, varying across cell types and developmental stages, thereby impairing cytoskeletal dynamics and contributing to BWCFF pathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <div>\u0000 <div>\u0000 \u0000 <h3>Impact statement</h3>\u0000 <p>This study reveals that the BWCFF-linked G74S mutation in β-actin disrupts SETD3-mediated histidine-73 methylation, impairing a critical post-translational modification. It provides the first direct mechanistic link between a cytoskeletal actinopathy and altered methylation, highlighting potential targets for therapeutic intervention in β-actin-related developmental disorders.</p>\u0000 </div>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 17","pages":"2449-2462"},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor 螺旋结构域触发MmpL10寡聚化，这是海藻糖多聚酸前体的分枝杆菌转运体。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-06-04 DOI: 10.1002/1873-3468.70085
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai-Kee-Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise
{"title":"A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor","authors":"Julie Couston,&nbsp;Jérôme Feuillard,&nbsp;Aurélie Ancelin,&nbsp;Joséphine Lai-Kee-Him,&nbsp;Konstantin Brodolin,&nbsp;Christian Chalut,&nbsp;Pontus Gourdon,&nbsp;Mickaël Blaise","doi":"10.1002/1873-3468.70085","DOIUrl":"10.1002/1873-3468.70085","url":null,"abstract":"<p>The mycobacterial outer membrane is composed of unusual lipids and glycolipids. Some of these lipids are exported to the cell envelope by resistance-nodulation-division (RND) transporters called mycobacterial membrane protein large (MmpL). While the oligomeric state of most RND transporters is well established, MmpL assembly remains unclear. Here, we investigated MmpL10, the trehalose polyphleate transporter. Biochemical data suggest that MmpL10 forms a homotrimer and that its oligomerization is driven by a coiled-coil domain. Structural modeling and electron microscopy data reveal the presence of a tubular extension that spans the mycobacterial cell wall and reaches the mycomembrane. As most MmpL proteins possess this extension, oligomerization may be a common feature of this family of transporters, possibly involved in the transport of the MmpL cargo.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 12","pages":"1682-1697"},"PeriodicalIF":3.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells p -糖蛋白调节多重耐药CHO细胞质膜的流动性梯度。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-05-31 DOI: 10.1002/1873-3468.70083
Roger Busche, John R. Riordan, Burkhard Tümmler
{"title":"P-glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells","authors":"Roger Busche,&nbsp;John R. Riordan,&nbsp;Burkhard Tümmler","doi":"10.1002/1873-3468.70083","DOIUrl":"10.1002/1873-3468.70083","url":null,"abstract":"<p>Cryo-electron microscopy has yielded high-resolution structural data of the multidrug efflux transporter P-glycoprotein (ABCB1), but its direct and indirect interactions within the native membrane environment have remained largely unexplored. Here, we compared the fluidity gradients of plasma membranes of the drug-sensitive CHO cell line AuxB1 and its P-glycoprotein overexpressing derivative B30 by fluorescence anisotropy of embedded <i>n</i>-(9-anthroyloxy) fatty acid probes (<i>n</i> = 2, 7, 9, 12, 16) in the temperature range of 10–50 °C. The shape of the temperature profiles of probe mobility was comparable in AuxB1 and B30 membranes, but did not match. Overexpression of P-glycoprotein smoothened the transversal gradient of the out-of-plane mode of rotation of the probes, which may facilitate the partitioning of hydrophobic drugs into the membrane and thereby increase the speed of P-glycoprotein to pump the drug out of the cell.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 15","pages":"2167-2178"},"PeriodicalIF":3.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary interplay between viruses and R-loops. 病毒和r -环之间的进化相互作用。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-05-31 DOI: 10.1002/1873-3468.70086
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi
{"title":"Evolutionary interplay between viruses and R-loops.","authors":"Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi","doi":"10.1002/1873-3468.70086","DOIUrl":"https://doi.org/10.1002/1873-3468.70086","url":null,"abstract":"<p><p>Viruses frequently interact with host transcriptional and epigenetic regulatory networks. A commonly overlooked element of these interactions is the formation of R-loops, three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single DNA strand. Accumulating evidence implicates R-loops in viral integration site preferences, the regulation of latent viral genomes, epigenetic silencing, and even the genesis of small interfering RNAs (siRNAs) that modulate mobile viral elements. This perspective presents the potential connections among viral genes, transposons, and R-loops; examines the roles of R-loops in viral pathogenesis, latency, and reactivation; explores how viruses harness or evade R-loop-associated responses; and highlights future research directions-from mapping R-loop hotspots to exploiting R-loop modulation for antiviral therapy.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a chemically induced dissociation system via phage surface-displayed nanobody screening 通过噬菌体表面显示纳米体筛选化学诱导解离系统的开发。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-05-31 DOI: 10.1002/1873-3468.70084
Zhizhuo Dai, Tianbin Yang, Wenqing Xu, Zhizhi Wang
{"title":"Development of a chemically induced dissociation system via phage surface-displayed nanobody screening","authors":"Zhizhuo Dai,&nbsp;Tianbin Yang,&nbsp;Wenqing Xu,&nbsp;Zhizhi Wang","doi":"10.1002/1873-3468.70084","DOIUrl":"10.1002/1873-3468.70084","url":null,"abstract":"<p>Chemical methods for controlling protein function posttranslationally in an inducible manner provide profound insights into cellular processes and are powerful tools in synthetic biology. Here, we utilized the phage display method to screen for a nanobody whose interaction with the hepatitis C virus protease NS3a can be disrupted by FDA-approved small-molecule drugs. By employing Grazoprevir as a chemical disruptor of the NS3a/nanobody interaction, we demonstrate that our chemically induced dissociation system (CIDiss) can effectively regulate protein–protein interaction in the endoplasmic reticulum in human cells. This CIDiss system offers a valuable tool for synthetic biology, with potential for enhanced safety in cell-based therapies.</p><p>\u0000 </p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 13","pages":"1935-1947"},"PeriodicalIF":3.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Sialic Acids Acquired by Pseudomonas aeruginosa Are Involved in Reduced Complement Deposition and Siglec Mediated Host-Cell Recognition 撤回：铜绿假单胞菌获得唾液酸参与补体沉积减少和Siglec介导的宿主细胞识别。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-05-27 DOI: 10.1002/1873-3468.70082
{"title":"RETRACTION: Sialic Acids Acquired by Pseudomonas aeruginosa Are Involved in Reduced Complement Deposition and Siglec Mediated Host-Cell Recognition","authors":"","doi":"10.1002/1873-3468.70082","DOIUrl":"10.1002/1873-3468.70082","url":null,"abstract":"<p><b>RETRACTION</b>: B. Khatua, A. Ghoshal, K. Bhattacharya, C. Mandal, B. Saha, P.R. Crocker, and C. Mandal, “Sialic Acids Acquired by Pseudomonas Aeruginosa Are Involved in Reduced Complement Deposition and Siglec Mediated Host-Cell Recognition,” <i>FEBS Letters</i> 584, no. 3 (2010): 555-561, https://doi.org/10.1016/j.febslet.2009.11.087.</p><p>The above article, published online on 27 November 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael Brunner; the Federation of European Biochemical Societies; and John Wiley &amp; Sons Ltd. UK. The retraction has been agreed due to concerns raised by a third party. Further investigation revealed the unattributed duplication of nearly all of the data presented in Figures 1 and 2 from Figures 2 and 3 from a now-retracted article by the same authors (DOI: 10.1128/IAI.01083-08). In addition, there is duplication of data within the MALDI-TOF-MS data in Figure 3b and within the flow cytometry-based binding assay data in Figure 5. These concerns undermine the journal's confidence in the results and conclusions presented. Therefore, the parties agree that the article must be retracted.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping the future of European health research: policy recommendations of the Biomedical Alliance in Europe for Framework Programme 10 and beyond 塑造欧洲卫生研究的未来：欧洲生物医学联盟为框架方案10及其以后提出的政策建议。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-05-27 DOI: 10.1002/1873-3468.70079
Wilfried Ellmeier, Marieke Meijer, Miriam Madrignani, Loredana Simulescu, Tom Hemming Karlsen, Elizabeth Macintyre, the members of the BioMed Alliance Health Research Committee
{"title":"Shaping the future of European health research: policy recommendations of the Biomedical Alliance in Europe for Framework Programme 10 and beyond","authors":"Wilfried Ellmeier,&nbsp;Marieke Meijer,&nbsp;Miriam Madrignani,&nbsp;Loredana Simulescu,&nbsp;Tom Hemming Karlsen,&nbsp;Elizabeth Macintyre,&nbsp;the members of the BioMed Alliance Health Research Committee","doi":"10.1002/1873-3468.70079","DOIUrl":"10.1002/1873-3468.70079","url":null,"abstract":"<p>As Europe charts its course for the next funding programme for research, Framework Programme 10 (FP10), the stakes have never been higher. In order to increase European competitiveness in research and innovation and generate better outcomes for patients, the Biomedical Alliance in Europe urges policymakers to embrace health and biomedical research as a strategic investment. We call for strong funding to support the translational health research value and innovation chain. We advocate for reducing the administrative burden in grant applications, and for simplification and harmonization of the regulatory framework. In addition, we call for strengthening of strategic leadership, coordination, collaboration and training. FP10 promises to transform European health research into a driver of societal well-being, economic growth and global leadership.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 12","pages":"1625-1633"},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms governing GPCR anterograde transport 控制GPCR顺行运输的机制。
IF 3 4区 生物学
FEBS Letters Pub Date : 2025-05-27 DOI: 10.1002/1873-3468.70081
Kevin Assoumou, Sofia Papadogkonaki, Itziar Muneta-Arrate, Miriam Stoeber
{"title":"Mechanisms governing GPCR anterograde transport","authors":"Kevin Assoumou,&nbsp;Sofia Papadogkonaki,&nbsp;Itziar Muneta-Arrate,&nbsp;Miriam Stoeber","doi":"10.1002/1873-3468.70081","DOIUrl":"10.1002/1873-3468.70081","url":null,"abstract":"<p>G protein-coupled receptors (GPCRs) constitute the largest family of human membrane proteins. GPCRs recognize diverse extracellular stimuli and activate intracellular signaling cascades that regulate key physiological processes such as neurotransmission and cardiovascular function. The controlled transport of nascent GPCRs from the endoplasmic reticulum (ER) <i>via</i> the Golgi apparatus to the cell surface critically determines the cellular responsiveness to incoming ligands. Here, we present a comprehensive overview of the cellular mechanisms and motif-driven interactions with regulatory proteins that orchestrate GPCR folding, post-translational modifications, and vesicular transport along the secretory pathway. We highlight signaling cues that can modulate the anterograde transport and specialized mechanisms that deliver biosynthetic GPCRs to dendrites and axons in neurons. Furthermore, we discuss that many disease-causing GPCR mutants exhibit aberrant intracellular retention, which can be rescued by pharmacological strategies that stabilize misfolded GPCRs. Finally, we highlight insights into the agonist-driven signaling of biosynthetic GPCRs in secretory organelles. This review covers the complex roles of anterograde transport in controlling GPCR function and emerging possibilities to target the underlying mechanisms in disease.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 17","pages":"2420-2438"},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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