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YAP1 modulation of primary cilia-mediated ciliogenesis in 2D and 3D prostate cancer models. YAP1 在二维和三维前列腺癌模型中对原发性纤毛介导的纤毛生成的调节。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-18 DOI: 10.1002/1873-3468.15029
Yingbo Guo, Mathilde Dupart, Marie Irondelle, Pascal Peraldi, Frederic Bost, Nathalie M Mazure
{"title":"YAP1 modulation of primary cilia-mediated ciliogenesis in 2D and 3D prostate cancer models.","authors":"Yingbo Guo, Mathilde Dupart, Marie Irondelle, Pascal Peraldi, Frederic Bost, Nathalie M Mazure","doi":"10.1002/1873-3468.15029","DOIUrl":"https://doi.org/10.1002/1873-3468.15029","url":null,"abstract":"<p><p>The primary cilium, a non-motile organelle present in most human cells, plays a crucial role in detecting microenvironmental changes and regulating intracellular signaling. Its dysfunction is linked to various diseases, including cancer. We explored the role of ciliated cells in prostate cancer by using Gefitinib and Jasplakinolide compounds to induce ciliated cells in both normal and tumor-like prostate cell lines. We assessed GLI1 and IFT20 expression and investigated YAP1 protein's role, which is implicated in primary cilium regulation. Finally, we examined these compounds in 3D cell models, aiming to simulate in vivo conditions. Our study highlights YAP1 as a potential target for novel genetic models to understand the primary cilium's role in mediating resistance to anticancer treatments.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis. 视黄醛还原酶 DHRS3 的反馈调节是视黄酸平衡的关键因素。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-17 DOI: 10.1002/1873-3468.15038
Parisa Varshosaz, Catherine O'Connor, Alexander R Moise
{"title":"Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis.","authors":"Parisa Varshosaz, Catherine O'Connor, Alexander R Moise","doi":"10.1002/1873-3468.15038","DOIUrl":"https://doi.org/10.1002/1873-3468.15038","url":null,"abstract":"<p><p>Retinoic acid is crucial for vertebrate embryogenesis, influencing anterior-posterior patterning and organogenesis through its interaction with nuclear hormone receptors comprising heterodimers of retinoic acid receptors (RARα, β, or γ) and retinoid X receptors (RXRα, β, or γ). Tissue retinoic acid levels are tightly regulated since both its excess and deficiency are deleterious. Dehydrogenase/reductase 3 (DHRS3) plays a critical role in this regulation by converting retinaldehyde to retinol, preventing excessive retinoic acid formation. Mutations in DHRS3 can result in embryonic lethality and congenital defects. This study shows that mouse Dhrs3 expression is responsive to vitamin A status and is directly regulated by the RAR/RXR complex through cis-regulatory elements. This highlights a negative feedback mechanism that ensures retinoic acid homeostasis.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The autophagy initiation factor ATG13 mRNA is stabilized by the RNA-binding protein YBX3. 自噬启动因子 ATG13 mRNA 由 RNA 结合蛋白 YBX3 稳定。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-16 DOI: 10.1002/1873-3468.15035
Liva Pfuhler, Silina Awad, William Skipper, Jeremy Lavietes, Thomas Sah, Kayla Ho, Radha Ivanova, Amy Cooke
{"title":"The autophagy initiation factor ATG13 mRNA is stabilized by the RNA-binding protein YBX3.","authors":"Liva Pfuhler, Silina Awad, William Skipper, Jeremy Lavietes, Thomas Sah, Kayla Ho, Radha Ivanova, Amy Cooke","doi":"10.1002/1873-3468.15035","DOIUrl":"https://doi.org/10.1002/1873-3468.15035","url":null,"abstract":"<p><p>Autophagy, a highly conserved form of cellular recycling, is essential for cellular homeostasis. Its dysregulation has been linked to neurodegenerative diseases and various cancers, including breast cancer. We set out to determine if the RNA-binding protein (RBP) YBX3 regulates autophagy mRNAs, as previous findings suggest YBX3 depletion reduces distinct autophagy transcripts. We found that YBX3 interacts with and stabilizes the mRNA of the autophagy initiation factor ATG13 in HeLa, which in turn increases ATG13 protein expression. We have shown that this requires the 3' untranslated region (UTR) of ATG13 and occurs in other human cell lines, including HEK293, HepG2, and HCT116. Together, our data suggest a novel regulatory role for YBX3 of autophagy initiation through posttranscriptional control of ATG13 mRNA stability.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase. 半胱氨酸残基有助于拟南芥状态转换 7 激酶的调控。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-11 DOI: 10.1002/1873-3468.15032
Iskander M Ibrahim, Ji H Lee, Seth Weaver, Ronard Kwizera, Jeremy R Lohman, Sujith Puthiyaveetil
{"title":"Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase.","authors":"Iskander M Ibrahim, Ji H Lee, Seth Weaver, Ronard Kwizera, Jeremy R Lohman, Sujith Puthiyaveetil","doi":"10.1002/1873-3468.15032","DOIUrl":"https://doi.org/10.1002/1873-3468.15032","url":null,"abstract":"<p><p>State transitions are an acclimatory response by which plants, algae, and cyanobacteria counteract photosynthetic inefficiency caused by changes in incident light quality. In plants and green algae, state transition 7 (STN7/STT7) kinase promotes state 2 transition. Conserved cysteine residues are implicated in STN7/STT7 regulation, but the precise nature of their involvement remains unclear. Here, an analysis of the STN7 thiols in vitro and a determination of their midpoint redox potential indicate that the lumenal disulfide linkage is unlikely to be redox regulated while the stromal cysteines form a regulatory intramolecular disulfide. We further show that thioredoxin f1 (Trx-f1) reduces the STN7 stromal disulfide linkage as consistent with a Trx-f1-mediated inhibition of the kinase under high light.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asiatic acid impedes NSCLC progression by inhibiting COX-2 and modulating PI3K signaling. 积雪草酸通过抑制 COX-2 和调节 PI3K 信号传导来阻碍 NSCLC 的进展。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-11 DOI: 10.1002/1873-3468.15027
Jyoti Singh, Yusuf Hussain, Abha Meena, Rohit Anthony Sinha, Suaib Luqman
{"title":"Asiatic acid impedes NSCLC progression by inhibiting COX-2 and modulating PI3K signaling.","authors":"Jyoti Singh, Yusuf Hussain, Abha Meena, Rohit Anthony Sinha, Suaib Luqman","doi":"10.1002/1873-3468.15027","DOIUrl":"https://doi.org/10.1002/1873-3468.15027","url":null,"abstract":"<p><p>Non-small cell lung cancer comprises up to 85% of lung cancer cases and has a poor prognosis. At present, there are still no effective treatments for this illness. Evidence suggests that the prostaglandin [cyclooxygenase-2 (COX-2)] and leukotriene [lipoxygenase-5 (5-LOX)] pathways are involved in lung cancer carcinogenesis. Therefore, novel agents that target COX-2 and 5-LOX may have therapeutic potential. In the present study, we examined the role of asiatic acid (AA), a triterpenoid saponin, in targeting the protein kinases responsible for lung cancer proliferation and mobility. The experimental data revealed that AA inhibited the growth of lung cancer cells (> 50%) and it significantly impeded the proliferation of lung cancer cells by inhibiting COX-2, which results in downregulation of the phosphotidyl inositol-3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway, leading to an induction of cytotoxic autophagy-mediated apoptosis. Mechanistically, the expression of mitogen-activated protein kinase/extracellular signal-regulated kinase, hypoxia-inducible factor-1 and vascular endothelial growth factor is downregulated by AA, thereby reducing cell mobility and invasion. It also shows negative osmotic fragility on healthy human erythrocytes. It is concluded that AA may be a viable therapeutic drug for non-small cell lung cancer treatment, which opens new opportunities for synthesizing analogues.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The winner of the 2024 FEBS Letters Award—an interview with Rachel Flynn 2024 年 FEBS Letters 奖得主--专访瑞秋-弗林（Rachel Flynn）。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-07 DOI: 10.1002/1873-3468.15031
Rachel Litman Flynn, Duncan E. Wright
{"title":"The winner of the 2024 FEBS Letters Award—an interview with Rachel Flynn","authors":"Rachel Litman Flynn,&nbsp;Duncan E. Wright","doi":"10.1002/1873-3468.15031","DOIUrl":"10.1002/1873-3468.15031","url":null,"abstract":"<p>Since 2003, <i>FEBS Letters</i> has awarded an annual prize to the corresponding author of the best research paper published in the journal in the previous calendar year. The award-winning article is selected by a special committee formed by appointed members of the Editorial Board, plus one external member. The winner of the 2024 <i>FEBS Letters</i> Award is Professor Rachel Flynn of Boston University Chobanian &amp; Avedisian School of Medicine, for the outstanding paper “The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA.” In this interview, Rachel Flynn talks about her award-winning research.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting genome-wide tissue-specific enhancers via combinatorial transcription factor genomic occupancy analysis. 通过组合转录因子基因组占位分析预测全基因组组织特异性增强子
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-04 DOI: 10.1002/1873-3468.15030
Huma Shireen, Fatima Batool, Hizran Khatoon, Nazia Parveen, Noor Us Sehar, Irfan Hussain, Shahid Ali, Amir Ali Abbasi
{"title":"Predicting genome-wide tissue-specific enhancers via combinatorial transcription factor genomic occupancy analysis.","authors":"Huma Shireen, Fatima Batool, Hizran Khatoon, Nazia Parveen, Noor Us Sehar, Irfan Hussain, Shahid Ali, Amir Ali Abbasi","doi":"10.1002/1873-3468.15030","DOIUrl":"https://doi.org/10.1002/1873-3468.15030","url":null,"abstract":"<p><p>Enhancers are non-coding cis-regulatory elements crucial for transcriptional regulation. Mutations in enhancers can disrupt gene regulation, leading to disease phenotypes. Identifying enhancers and their tissue-specific activity is challenging due to their lack of stereotyped sequences. This study presents a sequence-based computational model that uses combinatorial transcription factor (TF) genomic occupancy to predict tissue-specific enhancers. Trained on diverse datasets, including ENCODE and Vista enhancer browser data, the model predicted 25 000 forebrain-specific cis-regulatory modules (CRMs) in the human genome. Validation using biochemical features, disease-associated SNPs, and in vivo zebrafish analysis confirmed its effectiveness. This model aids in predicting enhancers lacking well-characterized chromatin features, complementing experimental approaches in tissue-specific enhancer discovery.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming science communication through storytelling 通过讲故事改变科学传播。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-02 DOI: 10.1002/1873-3468.15026
Giorgia Guglielmi, Emil Petersen, Laura Alvarez, Eva Zacharioudaki, Ana Morais, Esther Dorado-Ladera, Mari Kaunisto
{"title":"Transforming science communication through storytelling","authors":"Giorgia Guglielmi,&nbsp;Emil Petersen,&nbsp;Laura Alvarez,&nbsp;Eva Zacharioudaki,&nbsp;Ana Morais,&nbsp;Esther Dorado-Ladera,&nbsp;Mari Kaunisto","doi":"10.1002/1873-3468.15026","DOIUrl":"10.1002/1873-3468.15026","url":null,"abstract":"<p>Science communication is an important skill. It is easier for nonacademic audiences to remember stories that resonate with their imagination rather than facts and figures. To help early-career researchers develop their skills, the EU-LIFE Science Communications Working Group (SCWG) developed a training course based on the experience from previous workshops held at a research institute in Denmark. The stories crafted in the workshops proved impactful, with some integrated into broader campaigns and featured in science magazines. The initiative holds potential for transformative change, helping researchers promote their findings and increasing awareness of emerging research topics among the public. Recently, the initiative has been customized for a summer school aimed at medical doctors pursuing a PhD, marking a step forward in the SCWG's mission to equip researchers with essential communication skills.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-gonadal expression of piRNAs is widespread across Arthropoda. 在节肢动物中，piRNA 的非生殖腺表达非常普遍。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-02 DOI: 10.1002/1873-3468.15023
Takahisa Yamashita, Krystian Komenda, Rafał Miłodrowski, Dominik Robak, Szymon Szrajer, Tomasz Gaczorek, Guillem Ylla
{"title":"Non-gonadal expression of piRNAs is widespread across Arthropoda.","authors":"Takahisa Yamashita, Krystian Komenda, Rafał Miłodrowski, Dominik Robak, Szymon Szrajer, Tomasz Gaczorek, Guillem Ylla","doi":"10.1002/1873-3468.15023","DOIUrl":"https://doi.org/10.1002/1873-3468.15023","url":null,"abstract":"<p><p>PIWI-interacting RNAs (piRNAs) were discovered in the early 2000s and became known for their role in protecting the germline genome against mobile genetic elements. Successively, piRNAs were also detected in the somatic cells of gonads in multiple animal species. In recent years, piRNAs have been reported in non-gonadal tissues in various arthropods, contrary to the initial assumptions of piRNAs being exclusive to gonads. Here, we performed an extensive literature review, which revealed that reports on non-gonadal somatic piRNA expression are not limited to a few specific species. Instead, when multiple studies are considered collectively, it appears to be a widespread phenomenon across arthropods. Furthermore, we systematically analyzed 168 publicly available small RNA-seq datasets from diverse tissues in 17 species, which further supported the bibliographic reports that piRNAs are expressed across tissues and species in Arthropoda.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Selection for TRAIL Resistance Results in Melanoma Cells with High Proliferative Potential 回溯：选择 TRAIL 抗性会产生具有高增殖潜力的黑色素瘤细胞。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-09-27 DOI: 10.1002/1873-3468.15028
{"title":"RETRACTION: Selection for TRAIL Resistance Results in Melanoma Cells with High Proliferative Potential","authors":"","doi":"10.1002/1873-3468.15028","DOIUrl":"10.1002/1873-3468.15028","url":null,"abstract":"<p><b>RETRACTION</b>: J. J. Wu, X. D. Zhang, S. Gillespie, and P. Hersey, “Selection for TRAIL Resistance Results in Melanoma Cells with High Proliferative Potential,” <i>FEBS Letters</i> 579, no. 9 (2005): 1940–1944, https://doi.org/10.1016/j.febslet.2005.02.041.</p><p>The above article, published online on February 25, 2005, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplications of image sections within the article (Fig. 2A, 3A-C, 4A-B) depicting different experimental conditions. The authors were unable to provide a satisfactory explanation and due to the elapsed time the raw data was not available. Given the extent of the identified issues, the editors have lost confidence in the data presented and the article's conclusions can no longer be considered reliable.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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