FEBS Letters最新文献_第3页

Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum. 来自真菌圆柱孢 Hebeloma cylindrosporum 的广底物谱 l- 氨基酸氧化酶 4 的晶体结构和酶工程。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-16 DOI: 10.1002/1873-3468.15002

Simon Koopmeiners, Dominic Gilzer, Christiane Widmann, Nils Berelsmann, Jens Sproß, Hartmut H Niemann, Gabriele Fischer von Mollard

引用次数: 0

T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy. 坐骨神经支配引起的骨骼肌萎缩增强了败血症中的 T 细胞免疫抑制。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-08 DOI: 10.1002/1873-3468.14999

Sumika Osa, Yuki Enoki, Daisuke Takahashi, Victor Tuan Giam Chuang, Kazuaki Taguchi, Kazuaki Matsumoto

{"title":"T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy.","authors":"Sumika Osa, Yuki Enoki, Daisuke Takahashi, Victor Tuan Giam Chuang, Kazuaki Taguchi, Kazuaki Matsumoto","doi":"10.1002/1873-3468.14999","DOIUrl":"https://doi.org/10.1002/1873-3468.14999","url":null,"abstract":"Skeletal muscle atrophy is a known risk factor for immunosuppressive conditions and for a poor prognosis in sepsis. However, its immunopathology has not been experimentally elucidated. This study investigated the effects of skeletal muscle atrophy on the immunopathology of sepsis. Male C57BL/6J mice were subjected to sciatic denervation (DN) and caecal ligation and puncture (CLP) to induce muscle atrophy or sepsis. The macrophages, myeloid-derived suppressor cells (MDSC), and T-cells in peritoneal and spleen were analysed using flow cytometry. DN-induced muscle atrophy did not affect macrophage and MDSC populations. In contrast, the percentage of cytotoxic T-lymphocyte-associated antigen (CTLA)-4+ CD4+ T-cells, programmed death (PD)-1+ CD8+ T-cells, regulatory T-cells, and the CTLA-4+ regulatory T-cells was statistically significantly higher in DN-CLP mice than in sham-CLP mice. Skeletal muscle atrophy before sepsis triggers excessive T cell immunosuppression, which may contribute to the exacerbation of sepsis under skeletal muscle atrophy.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hAtg8 protein GABARAP interacts with EGFR and supports its unique role during receptor trafficking hAtg8 蛋白 GABARAP 与表皮生长因子受体相互作用，支持其在受体迁移过程中发挥独特作用

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-08 DOI: 10.1002/1873-3468.14997

Alina Üffing, Oliver H. Weiergräber, Melanie Schwarten, Silke Hoffmann, Dieter Willbold

引用次数: 0

The dual nature of T_DC - bridging dendritic and T cells in immunity. 树突状细胞的双重性质--免疫中树突状细胞和 T 细胞的桥梁。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-08 DOI: 10.1002/1873-3468.14998

Maria Nelli, Mirela Kuka

引用次数: 0

Nrf2 as a regulator of energy metabolism and mitochondrial function Nrf2 是能量代谢和线粒体功能的调节器。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-08 DOI: 10.1002/1873-3468.14993

Alina Luchkova, Ana Mata, Susana Cadenas

引用次数: 0

Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities. 心肌细胞的分区调节肌酸激酶和腺苷酸激酶的活性。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-07 DOI: 10.1002/1873-3468.14994

Rikke Birkedal, Jelena Branovets, Marko Vendelin

{"title":"Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities.","authors":"Rikke Birkedal, Jelena Branovets, Marko Vendelin","doi":"10.1002/1873-3468.14994","DOIUrl":"https://doi.org/10.1002/1873-3468.14994","url":null,"abstract":"Intracellular molecules are transported by motor proteins or move by diffusion resulting from random molecular motion. Cardiomyocytes are packed with structures that are crucial for function, but also confine the diffusional spaces, providing cells with a means to control diffusion. They form compartments in which local concentrations are different from the overall, average concentrations. For example, calcium and cyclic AMP are highly compartmentalized, allowing these versatile second messengers to send different signals depending on their location. In energetic compartmentalization, the ratios of AMP and ADP to ATP are different from the average ratios. This is important for the performance of ATPases fuelling cardiac excitation-contraction coupling and mechanical work. A recent study suggested that compartmentalization modulates the activity of creatine kinase and adenylate kinase in situ. This could have implications for energetic signaling through, for example, AMP-activated kinase. It highlights the importance of taking compartmentalization into account in our interpretation of cellular physiology and developing methods to assess local concentrations of AMP and ADP to enhance our understanding of compartmentalization in different cell types.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress and aging: synergies for age related diseases 氧化应激与衰老：与年龄相关疾病的协同作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-07 DOI: 10.1002/1873-3468.14995

Daniela F. Santos, Sónia Simão, Clévio Nóbrega, José Bragança, Pedro Castelo-Branco, Inês M. Araújo, ALFA Score Consortium

引用次数: 0

Bebtelovimab-bound SARS-CoV-2 RBD mutants: resistance profiling and validation with escape mutations, clinical results, and viral genome sequences. 与贝特罗单抗结合的SARS-CoV-2 RBD突变体：耐药性分析以及与逃逸突变、临床结果和病毒基因组序列的验证。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-06 DOI: 10.1002/1873-3468.14990

Khushboo Bhagat, Shweata Maurya, Amar Jeet Yadav, Timir Tripathi, Aditya K Padhi

{"title":"Bebtelovimab-bound SARS-CoV-2 RBD mutants: resistance profiling and validation with escape mutations, clinical results, and viral genome sequences.","authors":"Khushboo Bhagat, Shweata Maurya, Amar Jeet Yadav, Timir Tripathi, Aditya K Padhi","doi":"10.1002/1873-3468.14990","DOIUrl":"https://doi.org/10.1002/1873-3468.14990","url":null,"abstract":"The dynamic evolution of SARS-CoV-2 variants necessitates ongoing advancements in therapeutic strategies. Despite the promise of monoclonal antibody (mAb) therapies like bebtelovimab, concerns persist regarding resistance mutations, particularly single-to-multipoint mutations in the receptor-binding domain (RBD). Our study addresses this by employing interface-guided computational protein design to predict potential bebtelovimab-resistance mutations. Through extensive physicochemical analysis, mutational preferences, precision-recall metrics, protein-protein docking, and energetic analyses, combined with all-atom, and coarse-grained molecular dynamics (MD) simulations, we elucidated the structural-dynamics-binding features of the bebtelovimab-RBD complexes. Identification of susceptible RBD residues under positive selection pressure, coupled with validation against bebtelovimab-escape mutations, clinically reported resistance mutations, and viral genomic sequences enhances the translational significance of our findings and contributes to a better understanding of the resistance mechanisms of SARS-CoV-2.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation. 造血干细胞衰老与骨髓增生异常转化之间相互作用的去泛素酶。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-06 DOI: 10.1002/1873-3468.14991

Elisabetta Citterio, Antonella Ellena Ronchi

引用次数: 0

The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases 磷脂酰乙醇胺和磷脂酰丝氨酸的非酶氧化及其在炎症动态和疾病中的有趣作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-04 DOI: 10.1002/1873-3468.14992

Matilde Santos, Tânia Melo, Tatiana Maurício, Helena Ferreira, Pedro Domingues, Rosário Domingues

{"title":"The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases","authors":"Matilde Santos, Tânia Melo, Tatiana Maurício, Helena Ferreira, Pedro Domingues, Rosário Domingues","doi":"10.1002/1873-3468.14992","DOIUrl":"10.1002/1873-3468.14992","url":null,"abstract":"Phosphatidylethanolamine (PE) and phosphatidylserine (PS), along with phosphatidylcholine (PC), are key phospholipids (PL) in cell membranes and lipoproteins, prone to oxidative modifications. Their oxidized forms, OxPE and OxPS, play significant roles in inflammation and immune response. This review explores their structural oxidative changes under non-enzymatic conditions and their roles in physiological and pathological contexts, influencing inflammation, and immunity. Specific oxidations of PE and PS significantly alter their physicochemical properties, leading to enhanced biological functions, reduced activity, or inactivation. OxPE may show pro-inflammatory actions, similar to well-documented OxPC, while the OxPS pro-inflammatory effects are less noted. However, OxPS and OxPE have also shown an antagonistic effect against lipopolysaccharides (LPS), suggesting a protective role against exacerbated immune responses, similar to OxPC. Further research is needed to deepen our understanding of these less-studied OxPL classes. The role of OxPE and OxPS in disease pathogenesis remains largely unexplored, with limited studies linking them to Alzheimer's disease, diabetes, rheumatoid arthritis, traumatic brain injury, and skin inflammation. These findings highlight the potential of OxPE and OxPS as biomarkers for disease diagnosis, monitoring, and therapeutic targeting.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.14992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0