FEBS LettersPub Date : 2024-12-13DOI: 10.1002/1873-3468.15076
{"title":"RETRACTION: Theaflavins retard human breast cancer cell migration by inhibiting NF-κB via p53-ROS cross-talk.","authors":"","doi":"10.1002/1873-3468.15076","DOIUrl":"https://doi.org/10.1002/1873-3468.15076","url":null,"abstract":"<p><strong>Retraction: </strong>A. Adhikary, S. Mohanty, L. Lahiry, D. S. Hossain, S. Chakraborty and T. Das, \"Theaflavins Retard Human Breast Cancer Cell Migration by Inhibiting NF-κB via p53-ROS Cross-talk,\" FEBS Letters 584, no. 1 (2010): 7-14, https://doi.org/10.1016/j.febslet.2009.10.081. The above article, published online on 31 October 2009 in Wiley Online Library (wileyonlinelibrary.com), has been published by agreement between the journal Editor-in-Chief, Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed due to partial duplication of micrographs observed in Figure 2C and the unexpected similarity of curves presented in 3C. Additionally, the blot against histone H1 in figure 4D (bottom-left panel) is a stretched duplication of the blot against alpha-actin in figure 3F (right-hand panel). Further, duplications have been observed between the MCF-7 p53 bands presented in Figures 1D and the p53 bands in Figure 3F; the alpha actin bands shown in Figure 3F and the Histone H1 bands in Figure 4D; and the alpha actin bands presented in Figures 3E and 4D. The authors provided some supporting data and an explanation, but the editors found them unsatisfactory. Due to the extent and nature of these concerns, the editors consider the results and conclusions of this article to be invalid. The authors disagree with the retraction.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suppression of amber stop codons impairs pathogenicity in Salmonella.","authors":"Zhihui Lyu, Cierra Wilson, Prajita Paul, Jiqiang Ling","doi":"10.1002/1873-3468.15075","DOIUrl":"10.1002/1873-3468.15075","url":null,"abstract":"<p><p>Translation terminates at UAG (amber), UGA (opal), and UAA (ochre) stop codons. In nature, readthrough of stop codons can be substantially enhanced by suppressor tRNAs. Stop-codon suppression also provides powerful tools in synthetic biology and disease treatment. How stop-codon suppression affects bacterial pathogenesis is poorly understood. Here, we show that suppression of UAG codons, but not UGA or UAA codons, attenuates expression of Salmonella Pathogenicity Island 1 (SPI-1) genes, which are required for virulence. Consistently, amber suppression abolishes Salmonella infection of macrophages. Systematic genetic and biochemical analyses further show that amber suppression decreases the activity, but not the level, of the master SPI-1 regulator HilD. Our work thus demonstrates an unexpected selectivity of stop codons in regulating Salmonella virulence.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-12DOI: 10.1002/1873-3468.15072
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T Haas
{"title":"The immunological interface: dendritic cells as key regulators in metabolic dysfunction-associated steatotic liver disease.","authors":"Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T Haas","doi":"10.1002/1873-3468.15072","DOIUrl":"https://doi.org/10.1002/1873-3468.15072","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) refers to a broad spectrum of conditions associating fat accumulation in the liver (steatosis) with varying degrees of inflammation (hepatitis) and fibrosis, which can progress to cirrhosis and potentially cancer (hepatocellular carcinoma). The first stages of these diseases are reversible and the immune system, together with metabolic factors (obesity, insulin resistance, Western diet, etc.), can influence the disease trajectory leading to progression or regression. Dendritic cells are professional antigen-presenting cells that constantly sense environmental stimuli and orchestrate immune responses. Herein, we discuss the existing literature on the heterogeneity of dendritic cell lineages, states, and functions, to provide a comprehensive overview of how liver dendritic cells influence the onset and evolution of MASLD.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcriptional regulation of basophil-specific protease genes by C/EBPα, GATA2, TGF-β signaling, and epigenetic mechanisms.","authors":"Ryotaro Tojima, Kazuki Nagata, Naoto Ito, Kenta Ishii, Takahiro Arai, Tomoka Ito, Kazumi Kasakura, Chiharu Nishiyama","doi":"10.1002/1873-3468.15069","DOIUrl":"https://doi.org/10.1002/1873-3468.15069","url":null,"abstract":"<p><p>Basophils and mast cells (MCs) play an important role in immune responses against allergens and parasitic infection. To elucidate the mechanisms that determine the commitment between basophils and mast cell (MCs), transcription factors and epigenetic modifications regulating the gene expression of basophil-specific enzymes, Mcpt8 and Mcpt11, were analyzed using bone marrow-derived (BM) cells containing basophils and MCs. Knockdown (KD) and overexpression experiments revealed that the transcription factor C/EBPα positively regulated the gene expression of Mcpt8 and Prss34 (encoding Mcpt11). Cebpa, Mcpt8, and Prss34 mRNAs levels were upregulated by histone deacetylases and downregulated by DNA methyltransferases. Gata2 KD significantly reduced the mRNA levels of Mcpt8 and Prss34, while TGF-β treatment increased those of Mcpt8 and Prss34. These results show that basophil-specific protease genes were transactivated by C/EBPα, GATA2, and TGF-β signaling and modified with epigenetic regulation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-03DOI: 10.1002/1873-3468.15067
Matthew R Blackburn, Thao T Nguyen, Sophia E Patton, Jordan M Bartosiak, Michael R Sussman
{"title":"Covalent labeling of the Arabidopsis plasma membrane H<sup>+</sup>-ATPase reveals 3D conformational changes involving the C-terminal regulatory domain.","authors":"Matthew R Blackburn, Thao T Nguyen, Sophia E Patton, Jordan M Bartosiak, Michael R Sussman","doi":"10.1002/1873-3468.15067","DOIUrl":"https://doi.org/10.1002/1873-3468.15067","url":null,"abstract":"<p><p>The plasma membrane proton pump is the primary energy transducing, electrogenic ion pump of the plasma membrane in plants and fungi. Compared to its fungal counterpart, the plant plasma membrane proton pump's regulatory C-terminal domain (CTD) contains an additional regulatory segment that links multiple sensory pathways regulating plant cell length through phosphorylation and recruitment of regulatory 14-3-3 proteins. However, a complete structural model of a plant proton pump is lacking. Here, we performed covalent labeling with mass spectrometric analysis (CL-MS) on the Arabidopsis pump AHA2 to identify potential interactions between the CTD and the catalytic domains. Our results suggest that autoinhibition in the plant enzyme is much more structurally complex than in the fungal enzyme.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-01Epub Date: 2024-10-18DOI: 10.1002/1873-3468.15029
Yingbo Guo, Mathilde Dupart, Marie Irondelle, Pascal Peraldi, Frederic Bost, Nathalie M Mazure
{"title":"YAP1 modulation of primary cilia-mediated ciliogenesis in 2D and 3D prostate cancer models.","authors":"Yingbo Guo, Mathilde Dupart, Marie Irondelle, Pascal Peraldi, Frederic Bost, Nathalie M Mazure","doi":"10.1002/1873-3468.15029","DOIUrl":"10.1002/1873-3468.15029","url":null,"abstract":"<p><p>The primary cilium, a non-motile organelle present in most human cells, plays a crucial role in detecting microenvironmental changes and regulating intracellular signaling. Its dysfunction is linked to various diseases, including cancer. We explored the role of ciliated cells in prostate cancer by using Gefitinib and Jasplakinolide compounds to induce ciliated cells in both normal and tumor-like prostate cell lines. We assessed GLI1 and IFT20 expression and investigated YAP1 protein's role, which is implicated in primary cilium regulation. Finally, we examined these compounds in 3D cell models, aiming to simulate in vivo conditions. Our study highlights YAP1 as a potential target for novel genetic models to understand the primary cilium's role in mediating resistance to anticancer treatments.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":"3071-3086"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-01Epub Date: 2024-08-16DOI: 10.1002/1873-3468.15004
Sandra Cotino-Nájera, Enrique García-Villa, Samantha Cruz-Rosales, Patricio Gariglio, José Díaz-Chávez
{"title":"The role of Lin28A and Lin28B in cancer beyond Let-7.","authors":"Sandra Cotino-Nájera, Enrique García-Villa, Samantha Cruz-Rosales, Patricio Gariglio, José Díaz-Chávez","doi":"10.1002/1873-3468.15004","DOIUrl":"10.1002/1873-3468.15004","url":null,"abstract":"<p><p>Lin28A and Lin28B are paralogous RNA-binding proteins that play fundamental roles in development and cancer by regulating the microRNA family of tumor suppressor Let-7. Although Lin28A and Lin28B share some functional similarities with Let-7 inhibitors, they also have distinct expression patterns and biological functions. Increasing evidence indicates that Lin28A and Lin28B differentially impact cancer stem cell properties, epithelial-mesenchymal transition, metabolic reprogramming, and other hallmarks of cancer. Therefore, it is important to understand the overexpression of Lin28A and Lin28B paralogs in specific cancer contexts. In this review, we summarize the main similarities and differences between Lin28A and Lin28B, their implications in different cellular processes, and their role in different types of cancer. In addition, we provide evidence of other specific targets of each lin28 paralog, as well as the lncRNAs and miRNAs that promote or inhibit its expression, and how this impacts cancer development and progression.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":"2963-2979"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-01Epub Date: 2024-11-28DOI: 10.1002/1873-3468.15065
Yussuf Ali
{"title":"Blueprints for the scientific society of the future: how FEBS and other scientific societies will have changed 60 years from now.","authors":"Yussuf Ali","doi":"10.1002/1873-3468.15065","DOIUrl":"10.1002/1873-3468.15065","url":null,"abstract":"<p><p>The Federation of European Biochemical Societies (FEBS) was founded in 1964 to bring together the scientific societies of Europe and neighbouring regions and to provide a platform for scientific exchange. Today, FEBS is an organisation of more than 30 000 members across 39 biochemistry and molecular biology societies that promotes excellence in the life sciences in Europe and beyond. To mark the 60<sup>th</sup> anniversary of FEBS, FEBS Letters celebrated with a writing contest focussed on participants' visions of scientific societies in the year 2084. Here, we present the winning essay, in which Yussuf Ali (Jagiellonian University, Poland) considers a future in which FEBS transcends not only geographical boundaries, but also interdisciplinary, technological and financial boundaries.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":"2946-2948"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-01DOI: 10.1002/1873-3468.15066
Duncan E Wright
{"title":"The FEBS 60th anniversary writing contest-blueprints for the scientific society of tomorrow.","authors":"Duncan E Wright","doi":"10.1002/1873-3468.15066","DOIUrl":"https://doi.org/10.1002/1873-3468.15066","url":null,"abstract":"<p><p>The Federation of European Biochemical Societies (FEBS) celebrated its 60th anniversary in 2024, and FEBS Letters marked the occasion with a writing contest on the future of scientific societies. This editorial introduces the winning article by Yussuf Ali and presents an overview of the predominant themes that emerged during the contest, which included AI, interdisciplinarity, diversity and sustainability.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"598 24","pages":"2943-2945"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2024-12-01Epub Date: 2024-10-20DOI: 10.1002/1873-3468.15034
Jin Lei, Xue-Wei Cao, Peng-Fei Li, Jian Zhao, Fu-Jun Wang
{"title":"Platycodin D reduces PD-L1 levels by inhibiting LXR-β activity and combines with nintedanib to enhance the tumor-killing effect of T cells.","authors":"Jin Lei, Xue-Wei Cao, Peng-Fei Li, Jian Zhao, Fu-Jun Wang","doi":"10.1002/1873-3468.15034","DOIUrl":"10.1002/1873-3468.15034","url":null,"abstract":"<p><p>Most tumors are resistant to programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) checkpoint inhibitors, which may be due to impaired antigen presentation resulting from the downregulation of major histocompatibility complex class I (MHC-I) expression on tumor cells. We observed that platycodin D (PD), polygalacin D, and platycodin D2, which are plant-derived triterpenoid saponins, significantly reduced PD-L1 levels. RNA sequencing and the PharmMapper database analysis identified liver X receptor β (LXR-β) as a potential PD target. Further studies showed that PD reduces PD-L1 levels by binding to LXR-β and inhibiting LXR-β activity. Coadministration of PD and nintedanib, known to upregulate MHC-I expression, enhanced tumor recognition and killing by T cells. This study provides new insights into PD applications and mechanisms.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":"3053-3070"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}