FEBS Letters最新文献_第4页

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure-function relationships and relevance to human pathology. SLC7/SLC3家族的异二聚体氨基酸转运体（HAT）：结构-功能关系及其与人类病理的相关性

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-25 DOI: 10.1002/1873-3468.70464

Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri

{"title":"The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure-function relationships and relevance to human pathology.","authors":"Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri","doi":"10.1002/1873-3468.70464","DOIUrl":"https://doi.org/10.1002/1873-3468.70464","url":null,"abstract":"SLC transporters are the entry gates of nutrients required by intracellular enzymes to accomplish cell metabolism. SLCs include many amino acid transporters, which belong to different families and are characterized by redundancy, cross-specificity, and diverse transport mechanisms. Amino acid transporters are critical, as demonstrated by the onset of diseases caused by their altered expression, function, or localization. Despite their crucial roles, a systematic description of structure/function relationships of amino acid transporters is still far from being obtained. Among many SLCs specific toward amino acids, the heterodimeric transporters (HATs) of the SLC7 family, paired to proteins of the SLC3 family via a conserved disulfide, have emerged. Members A5 (LAT1), A6 (y+LAT2), A7 (y+LAT1), A8 (LAT2), A10 (ASC1), and A11 (xCT) are combined with SLC3A2; the members A9 (b0,+AT1) and A13 (AGT1) are combined with SLC3A1. Even though the members of the SLC3 family are classified as solute carriers (SLCs), they do not display transport capacity but are mainly involved in assisting the trafficking of the transport SLC7 subunits. An update of the structure/function relationships and relation to pathologies is reported.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing two nanobodies for SMAD4. 表征SMAD4的两个纳米体。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-24 DOI: 10.1002/1873-3468.70466

Miriam Condeminas, Carles Torner, Radoslaw Pluta, Lidia Ruiz, Marina R de Régil, Rameez J Khan, Joan Pous, Els Pardon, Jan Steyaert, Simon Fromm, Pau Martin-Malpartida, Maria J Macias

引用次数: 0

Structural and biochemical analysis of a B₁₂ superbinder. B12超粘接剂的结构与生化分析。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-23 DOI: 10.1002/1873-3468.70452

Jose M Martinez Felices, Jacob J Whittaker, Dirk J Slotboom, Albert Guskov

引用次数: 0

Invisible but not inaccessible-Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods. 不可见但并非不可接近-用溶液核磁共振和互补方法揭示由内在无序蛋白质形成的瞬态低聚物。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-22 DOI: 10.1002/1873-3468.70474

Martin D Gelenter, Ad Bax

引用次数: 0

BRCA1-mediated transcriptional repression of FABP3 - Implications for breast cancer progression and chemosensitivity. brca1介导的FABP3转录抑制对乳腺癌进展和化疗敏感性的影响。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-22 DOI: 10.1002/1873-3468.70469

Nilambra Dogra, Ambica Baru, Madhu Khullar, Tapas Mukhopadhyay

引用次数: 0

A context-dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma. eIF6在黑色素瘤获得性vemurafenib耐药中的环境依赖性调节作用。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-22 DOI: 10.1002/1873-3468.70467

George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi-Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos

引用次数: 0

The ubiquitin system in normal and infected germinal center B cells. 正常和感染生发中心B细胞中的泛素系统。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-21 DOI: 10.1002/1873-3468.70470

Destiny Davis, Lesly Mejia, Emily K Moser

{"title":"The ubiquitin system in normal and infected germinal center B cells.","authors":"Destiny Davis, Lesly Mejia, Emily K Moser","doi":"10.1002/1873-3468.70470","DOIUrl":"https://doi.org/10.1002/1873-3468.70470","url":null,"abstract":"The ubiquitin system is a highly regulated cellular mechanism that plays a central role in germinal center (GC) B cells, essential for protective humoral immunity and the site of gammaherpesvirus latency establishment. GC B cells undergo extraordinary levels of proliferation, DNA damage, and apoptosis prior to differentiating to long-lived memory or plasma cells, and ubiquitin pathways underpin these activities. Oncogenic gammaherpesviruses infect B cells and drive them through a GC activation program. Viral programs exploit ubiquitin biology to establish latency in GC B cells and persist for life in long-lived memory B cells, poised to drive lymphomagenesis over time. Here, we will first define how ubiquitin regulates normal GC B cells. Within this framework, we will describe how gammaherpesviruses interact with these mechanisms to establish latency, highlighting common and divergent mechanisms of GC control in infected and normal B cells. Further understanding ubiquitin mechanisms in GC B cells will aid the discovery of highly specific molecular circuits that regulate B-cell fate and function, with broad relevance to antiviral immunity and cancer biology.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic niche shaped by host factors influences disseminated cancer cell fate. 宿主因素形成的转移生态位影响播散性癌细胞的命运。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-21 DOI: 10.1002/1873-3468.70471

Gwennan Delyth Ward, Álvaro Ruiz-Tabas, Patricia Altea-Manzano

{"title":"Metastatic niche shaped by host factors influences disseminated cancer cell fate.","authors":"Gwennan Delyth Ward, Álvaro Ruiz-Tabas, Patricia Altea-Manzano","doi":"10.1002/1873-3468.70471","DOIUrl":"https://doi.org/10.1002/1873-3468.70471","url":null,"abstract":"Metastasis is responsible for the vast majority of cancer-related deaths, yet organ selectivity and the fate of disseminated cancer cells remain incompletely understood. While tumor-intrinsic programs have been extensively characterized, increasing evidence indicates that host-related extrinsic factors critically modulate the molecular and cellular landscape of metastatic niches. Aging, dietary habits, microbiome, physical activity, smoking, air pollution, and chronic stress may reshape systemic inflammation, immune surveillance, vascular permeability, stromal composition, extracellular matrix remodeling, and metabolic signaling in organs commonly targeted by metastasis, including bone, lung, liver, and brain. These host-dependent alterations influence disseminated cancer cell homing, extravasation, dormancy, and proliferative outgrowth by reprogramming tissue-resident and recruited cell populations, as well as niche-derived soluble and mechanical cues. In this review, we describe a framework in which metastasis is dynamically codetermined by tumor cell plasticity and host systemic state, contextualized by recent mechanistic insights into how lifestyle and physiological states rewire organ microenvironments to become either permissive or restrictive to metastatic colonization. Understanding these interactions may reveal actionable targets for metastasis prevention and highlight modifiable behaviors as biological determinants of organ susceptibility to metastatic disease.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Shewanella oneidensis Fic enzyme SoFic targets the switch-I region of EF-Tu for AMPylation. 希瓦氏菌Fic酶SoFic靶向EF-Tu的开关i区进行AMPylation。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-18 DOI: 10.1002/1873-3468.70457

Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht-Bucher, Aymelt Itzen

引用次数: 0

Prospecting the protein design landscape. 展望蛋白质设计前景。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-18 DOI: 10.1002/1873-3468.70459

Jakob R Riccabona, Katharina T Stonig, Jens Meiler, Clara T Schoeder, Monica L Fernández-Quintero

{"title":"Prospecting the protein design landscape.","authors":"Jakob R Riccabona, Katharina T Stonig, Jens Meiler, Clara T Schoeder, Monica L Fernández-Quintero","doi":"10.1002/1873-3468.70459","DOIUrl":"https://doi.org/10.1002/1873-3468.70459","url":null,"abstract":"Generative AI has driven remarkable breakthroughs in protein design, enabling the rapid, computationally guided creation of high-affinity binders against diverse targets. While remarkable experimental success has been demonstrated, the confidence metrics used to filter and evaluate designs remain optimized for static protein interfaces and can fail when applied to underrepresented or conformationally complex targets. In this review, we outline the current landscape of deep learning-driven protein design pipelines, discuss tailored applications in peptide, small molecule, binder, vaccine, and antibody design, and argue that the integration of ensemble-based methods represents a promising avenue for improving design success rates. Beyond single target binder design, we further highlight emerging strategies that expand the functional scope of designed proteins, including fold-switching scaffolds and molecular glues realized through engineered cyclic peptides, which enable context-dependent control of protein-protein interaction networks. Together, these advances position de novo protein design as a broadly applicable technology platform at the intersection of structural biology, biophysics, and molecular medicine.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0