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Brain lipidomic profiles of sleep enhancement through co-administration of alprazolam and CGS21680.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-17 DOI: 10.1002/1873-3468.70009
Yi Zhang, Xingle Xia, Qian Jin, Guixiang Yang, Manzhu Cao, Xingxing Zong, Jingjing Shi, Chen Wang, Liqin Li
{"title":"Brain lipidomic profiles of sleep enhancement through co-administration of alprazolam and CGS21680.","authors":"Yi Zhang, Xingle Xia, Qian Jin, Guixiang Yang, Manzhu Cao, Xingxing Zong, Jingjing Shi, Chen Wang, Liqin Li","doi":"10.1002/1873-3468.70009","DOIUrl":"https://doi.org/10.1002/1873-3468.70009","url":null,"abstract":"<p><p>Alprazolam and CGS21680 are both drugs known for their sleep and sedation effects. The study aimed to utilize mass spectrometry imaging to assess the regulatory changes in brain lipids of mice by the sleep-enhancing effects of the co-administration of alprazolam and CGS21680. A seven-day continuous administration mouse model was established using alprazolam and CGS21680. Glycerophosphoinositols were elevated in nine regions, glycerophosphoglycerols rising in six brain regions, and glycerophosphoserines increasing in six regions. Other lipid classes exhibited reductions, with fatty acids decreasing in 10 regions, carnitines in seven regions, ceramides in nine regions, and diacylglycerols in 10 regions. The research provides valuable insights into sleep-related regulation pathways by delineating the regulation of various lipid biomarkers in multiple brain regions.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-14 DOI: 10.1002/1873-3468.70003
{"title":"Correction to: Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells","authors":"","doi":"10.1002/1873-3468.70003","DOIUrl":"10.1002/1873-3468.70003","url":null,"abstract":"<p>Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L and Chen S. Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells. <i>FEBS Lett</i> <b>592</b>, 1400–1411. https://doi.org/10.1002/1873-3468.13031</p><p>In the published article, the micrographs for the HS66 data in Fig. 2B were inadvertently duplicated in Fig. 2A. An amended version of Fig. 2 in which Fig. 2A has been corrected is shown below. This correction does not affect the conclusions of the study.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 4","pages":"595"},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-11 DOI: 10.1002/1873-3468.70008
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange
{"title":"Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp.","authors":"Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange","doi":"10.1002/1873-3468.70008","DOIUrl":"https://doi.org/10.1002/1873-3468.70008","url":null,"abstract":"<p><p>The alarmones (p)ppGpp play a critical role in chloroplasts by acting as signalling molecules that regulate gene expression, protein synthesis and chloroplast (cp) development, particularly in response to stress and nutrient availability. However, the underlying molecular mechanisms are still poorly understood. Here, we show that (p)ppGpp binds to the GTPase-containing NG domains of the chloroplast signal recognition particle (SRP) and its receptor, preventing their GTP-dependent association through a competitive mechanism. The structure of (cp)FtsY bound to ppGpp reveals that the alarmone employs the same binding mode as its GDP counterpart and hinders chloroplast SRP:FtsY complex formation via its pyrophosphate moiety. Consequently, (p)ppGpp also inhibits the mutual stimulation of the two GTPases present in the (cp)SRP54:FtsY complex. Taken together, our findings provide the first description of how the alarmones (p)ppGpp may regulate the SRP-dependent protein trafficking pathway in plants.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Umbilical cord mesenchymal stem cell-derived exosomes alleviate collagen-induced arthritis by balancing the population of Th17 and regulatory T cells
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-11 DOI: 10.1002/1873-3468.15104
{"title":"Correction to: Umbilical cord mesenchymal stem cell-derived exosomes alleviate collagen-induced arthritis by balancing the population of Th17 and regulatory T cells","authors":"","doi":"10.1002/1873-3468.15104","DOIUrl":"10.1002/1873-3468.15104","url":null,"abstract":"<p>Yanxia Fu, Jun Li, Ziyu Zhang, Fangli Ren, Yinyin Wang, Huihui Jia, Yihe Liu, Zhijie Chang. Umbilical cord mesenchymal stem cell-derived exosomes alleviate collagen-induced arthritis by balancing the population of Th17 and regulatory T cells. <i>FEBS Lett</i> <b>596</b>, 2668–2677. https://doi.org/10.1002/1873-3468.14460</p><p>In the original version of this article, Figs 2, 3, and 4 were presented in the wrong order. As such, the descriptions of the figures in the text did not match the referenced figures. Figure 2 in the originally published article should have been labelled as Fig. 4. Figure 3 in the originally published article should have been labelled as Fig. 2. Figure 4 in the originally published article should have been labelled as Fig. 3. The correctly numbered figures are shown below.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 4","pages":"592-594"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-10 DOI: 10.1002/1873-3468.70007
Sofia Appelgren, Pia Ädelroth
{"title":"Insertion of the Fe<sub>B</sub> cofactor in cNORs lacking metal inserting chaperones.","authors":"Sofia Appelgren, Pia Ädelroth","doi":"10.1002/1873-3468.70007","DOIUrl":"https://doi.org/10.1002/1873-3468.70007","url":null,"abstract":"<p><p>Cytochrome c-dependent nitric oxide reductase (cNOR) catalyzes the reduction of NO into nitrous oxide (N<sub>2</sub>O), a strong greenhouse gas released from denitrifying microorganisms. The cNOR active site holds an essential non-heme iron, Fe<sub>B</sub>, inserted using the chaperone complex NorQD. However, in Thermus thermophilus, the cNOR (TtcNOR) cluster lacks the norQD genes. Here we investigated Fe<sub>B</sub> insertion into TtcNOR and characterized and compared TtcNOR expressed in Escherichia coli to that natively produced. We show that Fe<sub>B</sub> is present in the natively produced TtcNOR only. Analysis of cNOR operon sequences suggests that a hydrophilic K-pathway analogue is present in cNORs that do not rely on NorQD for iron insertion. We discuss the implications of our data for the evolution of the NOR family.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The apo LETM1 F-EF-hand adopts a closed conformation that underlies a multi-modal sensory role in mitochondria.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-10 DOI: 10.1002/1873-3468.70006
Qi-Tong Lin, Danielle M Colussi, Peter B Stathopulos
{"title":"The apo LETM1 F-EF-hand adopts a closed conformation that underlies a multi-modal sensory role in mitochondria.","authors":"Qi-Tong Lin, Danielle M Colussi, Peter B Stathopulos","doi":"10.1002/1873-3468.70006","DOIUrl":"https://doi.org/10.1002/1873-3468.70006","url":null,"abstract":"<p><p>Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) plays a critical role in mitochondrial function, with haploinsufficiency linked to Wolf-Hirschhorn syndrome. Here, we present the solution NMR structure of the calcium (Ca<sup>2+</sup>)-depleted LETM1 EF-hand domain, revealing a closed conformation facilitated by a distinct F<sub>1</sub>-helix pivot rather than decreased interhelical angle. Further, we observe regiospecific unfolding in response to hot and cold denaturation and show H662 has a pKa in-line with physiological pH fluctuations. Finally, we demonstrate Ca<sup>2+</sup>-dependent transient interactions between the EF-hand and other LETM1 or GHITM protein domains. Collectively, our data reveal the apo-to-holo structural dynamics and mechanisms underlying the multi-modal sensing by the LETM1 EF-hand domain, highlighting its role as an adaptable regulatory element within the mitochondrial matrix.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated interactome, proteomic and functional analyses reveal molecular pathways driving L1TD1-induced aggressiveness in CNS embryonal tumor cells.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-06 DOI: 10.1002/1873-3468.70002
Thiago Giove Mitsugi, Matt Sherwood, Elisa Helena Farias Jandrey, Amanda Faria Assoni, Joseph Bell, Brandon Coke, Paul Skipp, Rob Ewing, Oswaldo Keith Okamoto
{"title":"Integrated interactome, proteomic and functional analyses reveal molecular pathways driving L1TD1-induced aggressiveness in CNS embryonal tumor cells.","authors":"Thiago Giove Mitsugi, Matt Sherwood, Elisa Helena Farias Jandrey, Amanda Faria Assoni, Joseph Bell, Brandon Coke, Paul Skipp, Rob Ewing, Oswaldo Keith Okamoto","doi":"10.1002/1873-3468.70002","DOIUrl":"https://doi.org/10.1002/1873-3468.70002","url":null,"abstract":"<p><p>L1TD1 is a pluripotency factor required for embryonic stem cell self-renewal; its expression has also been detected in solid tumors, including embryonal tumors of the central nervous system (CNS). Previously, we showed that L1TD1 expression correlates with metastasis formation and shorter overall survival of medulloblastoma patients. Here, we used affinity purification coupled to mass spectrometry to map the L1TD1 interactome, and global proteomics to assess proteins differentially regulated by L1TD1 expression in patient-derived embryonal CNS tumor cell lines. We identified novel L1TD1 interactors and differentially expressed proteins related to cell proliferation, death and motility. Finally, we demonstrated that L1TD1-overexpressing tumor cells have distinct cell morphology with enhanced filopodial formation, higher cell motility, greater proliferation capability, and reduced sensitivity to cisplatin treatment.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions.
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-06 DOI: 10.1002/1873-3468.15105
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R Hall, Anton A Stepnov, Tom Z Emrich-Mills, Iván Ayuso-Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G H Eijsink
{"title":"Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions.","authors":"Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R Hall, Anton A Stepnov, Tom Z Emrich-Mills, Iván Ayuso-Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G H Eijsink","doi":"10.1002/1873-3468.15105","DOIUrl":"https://doi.org/10.1002/1873-3468.15105","url":null,"abstract":"<p><p>Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono-copper polysaccharide-degrading peroxygenases that engage in several on- and off-pathway redox reactions involving O<sub>2</sub> and H<sub>2</sub>O<sub>2</sub>. Herein, we show that the known metalloenzyme inhibitor cyanide inhibits reductive activation of LPMOs by binding to the LPMO-Cu(II) state and that the degree of inhibition depends on the concentrations of the polysaccharide substrate, the reductant and H<sub>2</sub>O<sub>2</sub>. Importantly, this analysis revealed differences between fungal NcAA9C and bacterial SmAA10A, which have different secondary copper coordination spheres. These differences were also highlighted by the observation that phosphate, a commonly used buffer ion, strongly inhibits NcAA9C while not affecting reactions with SmAA10A. The results provide insight into LPMO inhibition and catalysis and highlight pitfalls in the analysis thereof.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Lily Foundation: supporting patients, raising awareness and funding research into mitochondrial diseases
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-06 DOI: 10.1002/1873-3468.15107
Liz Curtis, Maria E. O'Hanlon, Katie Waller, Duncan E. Wright
{"title":"The Lily Foundation: supporting patients, raising awareness and funding research into mitochondrial diseases","authors":"Liz Curtis,&nbsp;Maria E. O'Hanlon,&nbsp;Katie Waller,&nbsp;Duncan E. Wright","doi":"10.1002/1873-3468.15107","DOIUrl":"10.1002/1873-3468.15107","url":null,"abstract":"<p>Primary mitochondrial diseases (‘mito’) are a group of genetically and phenotypically diverse disorders caused by defects in mitochondrial structure or function. Although they are individually rare, they collectively have an incidence of around 1 : 4300. Mitochondrial diseases can arise from mutations in either mitochondrial or nuclear genes, complicating genetic diagnosis. The Lily Foundation was founded by Liz Curtis in the UK in 2007 in order to raise awareness of mitochondrial diseases and to fund research into diagnosis and treatment. In this first of a new series on patient advocacy, <i>FEBS Letters</i> interviews Founder and CEO Liz Curtis MBE, Head of Patient Programmes Katie Waller and Research Manager Dr. Maria O'Hanlon on the aims, achievements and activities of the Lily Foundation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 4","pages":"459-465"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusion, belonging, and institutional climate – overlooked factors driving diverse STEM faculty turnover?
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2025-02-06 DOI: 10.1002/1873-3468.70005
Mali D. Doles, Joseph T. Cornelius, Jason D. Doles
{"title":"Inclusion, belonging, and institutional climate – overlooked factors driving diverse STEM faculty turnover?","authors":"Mali D. Doles,&nbsp;Joseph T. Cornelius,&nbsp;Jason D. Doles","doi":"10.1002/1873-3468.70005","DOIUrl":"10.1002/1873-3468.70005","url":null,"abstract":"<p>Faculty turnover at institutes of higher learning disrupts educational continuity, compromises scholarly activity, has negative impacts on learner experiences, and is costly. As such, understanding the reasons why faculty leave—especially in cases where they plan to stay in academia—is critically important with respect to designing and implementing informed retention initiatives. We conducted a survey of STEM faculty who recently switched institutions to gain insights into factors driving their decision to leave. Across all respondents, we found that factors relating to culture/climate were more important than factors relating to pay/compensation or position title. This relative prioritization was even more apparent among women faculty and faculty from disadvantaged backgrounds. We contextualize and discuss the implications of our findings and provide strategies for cultivating inclusive climates to promote faculty retention.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"599 6","pages":"791-798"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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