Correction to “Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression”

Abstract

Weining Yang, Albert J. Yee. Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression. FEBS Letters 2013; 587: 185-192. https://doi.org/10.1016/j.febslet.2012.11.023

In Fig. 3B of the published article, the two vector images (5x and 20x) are of the same vector sample 5 days after co-culture. The four V2 images (5x, 20x, 20x, 20x) are of the same V2 sample 5 days after co-culture. This was intentional, with the multiple images included to show readers more detail of the cell–cell interaction. This corrigendum has been published to amend the figure legend to make this clear. The amended figure legend is shown below.

Figure 3

Expression versican V2 promotes cell–cell interaction and tube-like structure formation. (A) V2- and vector-transfected cells were co-cultured with endothelial cells EOMA at a 1:1 ratio. After 5 days, the co-cultured cells were photographed. The V2 cells displayed higher capacities in interaction with EOMA cells than the control cells. As a result, there was closed contact between the V2 and EOMA cells compared with the control cells; (B) V2- and vector-transfected cells were co-cultured with YPEN endothelial cells at a ratio of 1:1. After 5 days, the co-cultured cells were photographed. The two vector images are of a single sample. The four V2 images (one at 5x magnification, and the other three at 20x magnification) are also of a single sample. YPEN cells could mix well with V2 expressing U87 cells, but not the control cells; (C) V2- and vector-transfected cells were mixed with YPEN cells and inoculated in Matrigel, followed by examination of tube formation. The YPEN cells formed complex tube-like structures when mixed with the V2 cells, but not with the control cells; (D) typical photographs of tube-like structures are shown; (E) V2- and vector-transfected cells were mixed with EOMA cells for tube formation assay. Similarly, the EOMA cells formed complex tube-like structures when mixed with the V2 cells, but not with the control cells.