FEBS Letters最新文献_第7页

Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila. 果蝇祖细胞衰老的发育调控形成了长期肠道稳态。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-11 DOI: 10.1002/1873-3468.70462

Shikha Malik, Atharva Anand Mahajan, Saraswathi J Pillai, Isha Shinde, Muhamad Shameem, Sumit Pande, Pratik Chandrani, Mandar M Inamdar, Rohan J Khadilkar

引用次数: 0

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers. 用火星探测器上的色谱柱对氯烷进行手性分离。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-08 DOI: 10.1002/1873-3468.70458

Asma Merzougui, Agnes Banreti, Armelle L Ernst, Guillaume Leseigneur, Uwe J Meierhenrich

引用次数: 0

Structural insights into the bioengineering of heme-containing enzymes. 含血红素酶的生物工程结构研究。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-03 DOI: 10.1002/1873-3468.70456

Epari Sai Santosh Kumar, Kshatresh Dutta Dubey

{"title":"Structural insights into the bioengineering of heme-containing enzymes.","authors":"Epari Sai Santosh Kumar, Kshatresh Dutta Dubey","doi":"10.1002/1873-3468.70456","DOIUrl":"https://doi.org/10.1002/1873-3468.70456","url":null,"abstract":"Heme-containing enzymes represent one of nature's most versatile catalytic platforms, capable of mediating a broad spectrum of redox and group-transfer reactions. This review provides a comprehensive overview of the structural and mechanistic principles that underpin the bioengineering of heme proteins for both natural and abiological transformations. Here, we discuss that the core of reactivity of such metalloenzymes is the iron-porphyrin cofactor, whose tunable oxidation and spin states enable the formation of diverse high-energy intermediates, including iron-oxo, carbene, and nitrene species. Using recent bioengineering applications, we also show that the catalytic behavior of these intermediates is not solely determined by intrinsic cofactor chemistry but is profoundly influenced by the surrounding protein scaffold. Key factors such as axial ligation, second coordination sphere interactions, hydrogen-bonding networks, and local electric fields collectively govern substrate binding, intermediate stabilization, and reaction selectivity. The review further discusses a few applications of de novo protein design and artificial metalloenzymes that provide unprecedented control over active-site architecture, allowing the creation of highly robust and tunable catalysts.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver organoids: modelling complexity in homeostasis and disease. 类肝器官：模拟体内平衡和疾病的复杂性。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-09-03 DOI: 10.1002/1873-3468.70432

Anna M Dowbaj, Meritxell Huch

引用次数: 0

From junk to function - How weak selection in eukaryotes builds new parts and drives genomic complexity. 从垃圾到功能——真核生物的弱选择如何构建新部分并驱动基因组复杂性。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-31 DOI: 10.1002/1873-3468.70455

Alexander F Palazzo, Yi Qiu

引用次数: 0

Phosphoproteomics identifies PAK2-associated developmental modules in mouse embryos. 磷酸化蛋白组学鉴定小鼠胚胎中pak2相关的发育模块。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-31 DOI: 10.1002/1873-3468.70454

Zheng Sun, Jie Yuan, Zhongsheng Sun, Yan Wang

引用次数: 0

Stress-induced trained immunity-A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease. 应激诱导的训练免疫——一个连接心理社会应激、动脉粥样硬化和心血管疾病的关键机制。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-29 DOI: 10.1002/1873-3468.70447

Dineke C W Touw, Saloua El Messaoudi, Willem J M Mulder, Mihai G Netea, George M Slavich, Niels P Riksen

{"title":"Stress-induced trained immunity-A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease.","authors":"Dineke C W Touw, Saloua El Messaoudi, Willem J M Mulder, Mihai G Netea, George M Slavich, Niels P Riksen","doi":"10.1002/1873-3468.70447","DOIUrl":"https://doi.org/10.1002/1873-3468.70447","url":null,"abstract":"Although chronic psychosocial stress is a well-established independent risk factor for cardiovascular disease (CVD), the underlying mechanisms linking stress to CVD remain incompletely understood. Here, we review clinical and preclinical research documenting how stress can activate innate immune cells. Based on these findings, we propose that trained innate immunity is one possible mechanism responsible for the lasting effects of stress on the innate immune system, and hence contributes to the association between stress and CVD. Trained immunity is defined as a persistent hyperinflammatory phenotype in innate immune cells, mediated by metabolic and epigenetic reprogramming of the bone marrow myeloid progenitor cells. As we describe herein, accumulating experimental evidence shows that chronic psychosocial stress can induce a maladaptive trained immunity program that accelerates atherosclerosis. By advancing our understanding of stress-induced trained immunity, we will move one step closer to designing new therapeutic, behavioral, and lifestyle strategies to counter maladaptive immune activation and reduce risk for CVD, one of the greatest causes of morbidity and mortality worldwide.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translophagy-A potential link between autophagy impairment and translational errors. 自噬损伤与翻译错误之间的潜在联系。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-27 DOI: 10.1002/1873-3468.70448

Mykola V Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan-Herraz, Mustafa Khwaja, Max Brown, Gavin D Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I Korolchuk, Tetsushi Kataura

{"title":"Translophagy-A potential link between autophagy impairment and translational errors.","authors":"Mykola V Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan-Herraz, Mustafa Khwaja, Max Brown, Gavin D Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I Korolchuk, Tetsushi Kataura","doi":"10.1002/1873-3468.70448","DOIUrl":"https://doi.org/10.1002/1873-3468.70448","url":null,"abstract":"Maintenance of protein homeostasis requires coordination between protein synthesis and degradation, yet whether autophagy directly controls translational machinery remains unclear. Here we explored whether autophagy maintains translational fidelity. Proteomic analysis of ubiquitin-enriched fractions and p62-associated proteins in autophagy-deficient tissue confirmed previous studies identifying ribosomal proteins and RNA-binding factors among candidate autophagy cargo. Pharmacological or genetic impairment of autophagy increased translational errors, particularly during oxidative stress. Components of the translational machinery localised to LC3-positive autophagic structures and accumulated in human brain tissue affected by neurodegeneration. These findings support a hypothesis in which autophagy preserves protein synthesis quality by removing damaged translational machinery. We term this proposed mechanism translophagy, potentially linking autophagy dysfunction, oxidative stress and the aberrant proteins in neurodegenerative disease.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering peptides into antibodies-opportunities and strategies for therapeutic innovation. 工程多肽转化为抗体——治疗创新的机会和策略。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-26 DOI: 10.1002/1873-3468.70430

Jinling Wang, Ruslana Romaniuk, Hristo L Svilenov

{"title":"Engineering peptides into antibodies-opportunities and strategies for therapeutic innovation.","authors":"Jinling Wang, Ruslana Romaniuk, Hristo L Svilenov","doi":"10.1002/1873-3468.70430","DOIUrl":"https://doi.org/10.1002/1873-3468.70430","url":null,"abstract":"Peptides and antibodies occupy complementary therapeutic niches. Peptides offer compact size and high-affinity recognition of difficult targets, whereas antibodies provide exquisite specificity, long serum half-life, and effector functions. Here we review strategies that merge these modalities by engineering peptides into immunoglobulins and antibody fragments. We discuss peptide grafting into hypervariable and framework loops, terminal fusion to antibody chains, Fc-peptide fusion proteins, and bioconjugation approaches. Across these formats, we examine examples that illustrate the importance of insertion site, peptide topology, and linker design for folding, activity, and developability. We highlight how antibody fusion and conjugation with natural and engineered peptides can confer novel target binding, conditional activation, altered biodistribution, improved pharmacokinetics, or intracellular delivery, and we discuss how disulfide-rich and macrocyclic peptides have enriched the design space. Finally, we also point out key translational challenges, including manufacturability, stability, heterogeneity, and immunogenicity, and propose that advances in protein design and chemical bioconjugation will enable next-generation therapeutics at the interface of antibodies and peptides.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging experimental and computational methods for studying redox-regulated structural transitions. 新兴的实验和计算方法研究氧化还原调节的结构转变。

IF 3 4区生物学

FEBS Letters Pub Date : 2026-08-26 DOI: 10.1002/1873-3468.70443

Tasneem Rass, Dana Reichmann, Gábor Erdős

{"title":"Emerging experimental and computational methods for studying redox-regulated structural transitions.","authors":"Tasneem Rass, Dana Reichmann, Gábor Erdős","doi":"10.1002/1873-3468.70443","DOIUrl":"https://doi.org/10.1002/1873-3468.70443","url":null,"abstract":"Thiol-based redox switches utilize the unique nucleophilicity of cysteine and selenocysteine to dynamically link real-time cellular redox fluctuations to metabolic regulation and signaling pathways. Capturing the precise atomic-level thermodynamic and kinetic mechanisms driving these oxidative modifications has long been limited by the chemical instability of transient intermediates and the immense computational costs of classical molecular dynamics simulations. However, recent advancements in chemoselective small-molecule probes now allow for the high-purity trapping and enrichment of specific sulfenic and sulfinic acid states. In parallel, a paradigm shift toward machine learning, graph neural networks, and protein language models has bypassed traditional computational bottlenecks, enabling high-throughput, proteome-wide predictions of redox switches in seconds. Furthermore, emerging data reveal that these redox modifications do not merely alter well-structured proteins, but actively dictate conditional folding transitions and structural transformations within intrinsically disordered proteins and biomolecular condensates. Here, we provide a comparative overview of these dual experimental and computational advancements and highlight how the integration of generative diffusion models could facilitate the real-time simulation of conditional, multi-state structural ensembles across the redox proteome.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0