FEBS Letters最新文献_第7页

Bebtelovimab-bound SARS-CoV-2 RBD mutants: resistance profiling and validation with escape mutations, clinical results, and viral genome sequences 与贝特罗单抗结合的SARS-CoV-2 RBD突变体：耐药性分析以及与逃逸突变、临床结果和病毒基因组序列的验证。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-06 DOI: 10.1002/1873-3468.14990

Khushboo Bhagat, Shweata Maurya, Amar Jeet Yadav, Timir Tripathi, Aditya K. Padhi

{"title":"Bebtelovimab-bound SARS-CoV-2 RBD mutants: resistance profiling and validation with escape mutations, clinical results, and viral genome sequences","authors":"Khushboo Bhagat, Shweata Maurya, Amar Jeet Yadav, Timir Tripathi, Aditya K. Padhi","doi":"10.1002/1873-3468.14990","DOIUrl":"10.1002/1873-3468.14990","url":null,"abstract":"The dynamic evolution of SARS-CoV-2 variants necessitates ongoing advancements in therapeutic strategies. Despite the promise of monoclonal antibody (mAb) therapies like bebtelovimab, concerns persist regarding resistance mutations, particularly single-to-multipoint mutations in the receptor-binding domain (RBD). Our study addresses this by employing interface-guided computational protein design to predict potential bebtelovimab-resistance mutations. Through extensive physicochemical analysis, mutational preferences, precision-recall metrics, protein–protein docking, and energetic analyses, combined with all-atom, and coarse-grained molecular dynamics (MD) simulations, we elucidated the structural-dynamics-binding features of the bebtelovimab–RBD complexes. Identification of susceptible RBD residues under positive selection pressure, coupled with validation against bebtelovimab-escape mutations, clinically reported resistance mutations, and viral genomic sequences enhances the translational significance of our findings and contributes to a better understanding of the resistance mechanisms of SARS-CoV-2.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation. 造血干细胞衰老与骨髓增生异常转化之间相互作用的去泛素酶。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-06 DOI: 10.1002/1873-3468.14991

Elisabetta Citterio, Antonella Ellena Ronchi

引用次数: 0

The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases 磷脂酰乙醇胺和磷脂酰丝氨酸的非酶氧化及其在炎症动态和疾病中的有趣作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-04 DOI: 10.1002/1873-3468.14992

Matilde Santos, Tânia Melo, Tatiana Maurício, Helena Ferreira, Pedro Domingues, Rosário Domingues

{"title":"The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases","authors":"Matilde Santos, Tânia Melo, Tatiana Maurício, Helena Ferreira, Pedro Domingues, Rosário Domingues","doi":"10.1002/1873-3468.14992","DOIUrl":"10.1002/1873-3468.14992","url":null,"abstract":"Phosphatidylethanolamine (PE) and phosphatidylserine (PS), along with phosphatidylcholine (PC), are key phospholipids (PL) in cell membranes and lipoproteins, prone to oxidative modifications. Their oxidized forms, OxPE and OxPS, play significant roles in inflammation and immune response. This review explores their structural oxidative changes under non-enzymatic conditions and their roles in physiological and pathological contexts, influencing inflammation, and immunity. Specific oxidations of PE and PS significantly alter their physicochemical properties, leading to enhanced biological functions, reduced activity, or inactivation. OxPE may show pro-inflammatory actions, similar to well-documented OxPC, while the OxPS pro-inflammatory effects are less noted. However, OxPS and OxPE have also shown an antagonistic effect against lipopolysaccharides (LPS), suggesting a protective role against exacerbated immune responses, similar to OxPC. Further research is needed to deepen our understanding of these less-studied OxPL classes. The role of OxPE and OxPS in disease pathogenesis remains largely unexplored, with limited studies linking them to Alzheimer's disease, diabetes, rheumatoid arthritis, traumatic brain injury, and skin inflammation. These findings highlight the potential of OxPE and OxPS as biomarkers for disease diagnosis, monitoring, and therapeutic targeting.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.14992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin resistance in nonobese type 2 diabetic Goto Kakizaki rats is associated with a proinflammatory T lymphocyte profile 非肥胖型 2 型糖尿病后藤柿崎大鼠的胰岛素抵抗与促炎性 T 淋巴细胞特征有关。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-08-02 DOI: 10.1002/1873-3468.14977

Tiago Bertola Lobato, Richelieau Manoel, Ana Carolina Gomes Pereira, Ilana Souza Correa, Patrícia Nancy Iser-Bem, Elvirah Samantha de Sousa Santos, Joice Naiara Bertaglia Pereira, Maria Janaína Leite de Araújo, João Carlos de Oliveira Borges, Janaina Ribeiro Barbosa Pauferro, Vinicius Leonardo Sousa Diniz, Maria Vitória Martins Scervino, Tamires Duarte Serdan, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Renata Gorjão

{"title":"Insulin resistance in nonobese type 2 diabetic Goto Kakizaki rats is associated with a proinflammatory T lymphocyte profile","authors":"Tiago Bertola Lobato, Richelieau Manoel, Ana Carolina Gomes Pereira, Ilana Souza Correa, Patrícia Nancy Iser-Bem, Elvirah Samantha de Sousa Santos, Joice Naiara Bertaglia Pereira, Maria Janaína Leite de Araújo, João Carlos de Oliveira Borges, Janaina Ribeiro Barbosa Pauferro, Vinicius Leonardo Sousa Diniz, Maria Vitória Martins Scervino, Tamires Duarte Serdan, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Renata Gorjão","doi":"10.1002/1873-3468.14977","DOIUrl":"10.1002/1873-3468.14977","url":null,"abstract":"Goto-Kakizaki (GK) rats develop a well-defined insulin resistance (IR) and type 2 diabetes mellitus (T2DM) without presenting obesity. The lymphocyte profile in nonobese diabetic conditions is not yet characterized. Therefore, GK rats were chosen to explore T lymphocyte (TL) dynamics at various stages (21, 60, and 120 days) compared to Wistar rats. GK rats exhibit progressive disruption of glucose regulation, with early glucose intolerance at 21 days and reduced insulin sensitivity at 60 days, confirming IR. Glucose transporter 1 (GLUT1) expression was consistently elevated in GK rats, suggesting heightened TL activation. T-regulatory lymphocyte markers diminished at 21 days. However, GK rats showed increased Th1 markers and reduced Gata-3 expression (crucial for Th2 cell differentiation) at 120 days. These findings underscore an early breakdown of anti-inflammatory mechanisms in GK rats, indicating a proinflammatory TL profile that may worsen chronic inflammation in T2DM.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene editing in liver diseases 肝脏疾病的基因编辑。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-30 DOI: 10.1002/1873-3468.14989

Laura Torella, Nerea Santana-Gonzalez, Nerea Zabaleta, Gloria Gonzalez Aseguinolaza

引用次数: 0

The COPII coat protein SEC24D is required for autophagosome closure in mammals. 哺乳动物的自噬体关闭需要 COPII 外壳蛋白 SEC24D。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-26 DOI: 10.1002/1873-3468.14983

Tianlong He, Cuicui Ji, Wenting Zhang, Xianghua Li, Yukun Liu, Xiaoli Wang, Haolin Zhang, Juan Wang

引用次数: 0

Topographical changes in extracellular matrix during skin fibrosis and recovery can be evaluated using automated image analysis algorithms. 皮肤纤维化和恢复过程中细胞外基质的地形变化可通过自动图像分析算法进行评估。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-25 DOI: 10.1002/1873-3468.14987

Rachel H Wyetzner, Ella X Segal, Anna R Jussila, Radhika P Atit

引用次数: 0

Age-associated myeloid malignancies - the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia. 与年龄相关的髓系恶性肿瘤--STAT3 和 STAT5 在骨髓增生异常综合征和急性髓系白血病中的作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-24 DOI: 10.1002/1873-3468.14985

Eirini Sofia Fasouli, Eleni Katsantoni

{"title":"Age-associated myeloid malignancies - the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia.","authors":"Eirini Sofia Fasouli, Eleni Katsantoni","doi":"10.1002/1873-3468.14985","DOIUrl":"https://doi.org/10.1002/1873-3468.14985","url":null,"abstract":"In the last few decades, the increasing human life expectancy has led to the inflation of the elderly population and consequently the escalation of age-related disorders. Biological aging has been associated with the accumulation of somatic mutations in the Hematopoietic Stem Cell (HSC) compartment, providing a fitness advantage to the HSCs leading to clonal hematopoiesis, that includes non-malignant and malignant conditions (i.e. Clonal Hematopoiesis of Indeterminate Potential, Myelodysplastic Syndrome and Acute Myeloid Leukemia). The Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a key player in both normal and malignant hematopoiesis. STATs, particularly STAT3 and STAT5, are greatly implicated in normal hematopoiesis, immunity, inflammation, leukemia, and aging. Here, the pleiotropic functions of JAK-STAT pathway in age-associated hematopoietic defects and of STAT3 and STAT5 in normal hematopoiesis, leukemia, and inflammaging are reviewed. Even though great progress has been made in deciphering the role of STATs, further research is required to provide a deeper understanding of the molecular mechanisms of leukemogenesis, as well as novel biomarkers and therapeutic targets for improved management of age-related disorders.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(Poly)phenols and brain health - beyond their antioxidant capacity. (多）酚与大脑健康--超越其抗氧化能力。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-23 DOI: 10.1002/1873-3468.14988

Thomas Hunt, Matthew G Pontifex, David Vauzour

{"title":"(Poly)phenols and brain health - beyond their antioxidant capacity.","authors":"Thomas Hunt, Matthew G Pontifex, David Vauzour","doi":"10.1002/1873-3468.14988","DOIUrl":"https://doi.org/10.1002/1873-3468.14988","url":null,"abstract":"(Poly)phenols are a group of naturally occurring phytochemicals present in high amounts in plant food and beverages with various structures and activities. The impact of (poly)phenols on brain function has gained significant attention due to the growing interest in the potential benefits of these dietary bioactive molecules for cognitive health and neuroprotection. This review will therefore summarise the current knowledge related to the impact of (poly)phenols on brain health presenting evidence from both epidemiological and clinical studies. Cellular and molecular mechanisms in relation to the observed effects will also be described, including their impact on the gut microbiota through the modulation of the gut-brain axis. Although (poly)phenols have the potential to modulate the gut-brain axis regulation and influence cognitive function and decline through their interactions with gut microbiota, anti-inflammatory and antioxidant properties, further research, including randomised controlled trials and mechanistic studies, is needed to better understand the underlying mechanisms and establish causal relationships between (poly)phenol intake and brain health.","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2-AG in the olfactory bulb and depressive-like behavior. 缺乏sEH磷酸酶活性的小鼠表现出嗅球中内源性大麻素2-AG水平的降低和类似抑郁的行为。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2024-07-21 DOI: 10.1002/1873-3468.14984

Ami Oguro, Yurino Kaga, Hideaki Sato, Taichi Fujiyama, Shinji Fujimoto, Saki Nagai, Makoto Matsuyama, Masatsugu Miyara, Yasuhiro Ishihara, Takeshi Yamazaki, Susumu Imaoka, Yaichiro Kotake

引用次数: 0