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RETRACTION: Role of the PDK1–PKB–GSK3 Pathway in Regulating Glycogen Synthase and Glucose Uptake in the Heart 回归：PDK1-PKB-GSK3 通路在调节心脏糖原合成酶和葡萄糖摄取中的作用。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-24 DOI: 10.1002/1873-3468.15044
{"title":"RETRACTION: Role of the PDK1–PKB–GSK3 Pathway in Regulating Glycogen Synthase and Glucose Uptake in the Heart","authors":"","doi":"10.1002/1873-3468.15044","DOIUrl":"10.1002/1873-3468.15044","url":null,"abstract":"<p><b>RETRACTION</b>: A. Mora, K. Sakamoto, E. J. McManus, and D. R. Alessi, “Role of the PDK1–PKB–GSK3 Pathway in Regulating Glycogen Synthase and Glucose Uptake in the Heart,” <i>FEBS Letters</i> 579, no. 17 (2005): 3632–3638, https://doi.org/10.1016/j.febslet.2005.05.040.</p><p>The above article, published online on 06 June 2005 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The journal was contacted by a representative of the research integrity group at the authors' institute, since an institutional investigation revealed inappropriate splicing and duplication of image sections within Fig. 2A, B and Fig. 3A. Consequently, the conclusions of the paper are substantially compromised, and the institute has recommended the paper to be retracted. The editors of the journal agree with the retraction based on the institutional investigation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"598 23","pages":"2939"},"PeriodicalIF":3.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substrate recognition by the 4-hydroxytryptamine kinase PsiK in psilocybin biosynthesis. 迷幻药生物合成过程中 4-羟色胺激酶 PsiK 的底物识别。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-24 DOI: 10.1002/1873-3468.15042
Kai Rogge, Tobias Johannes Wagner, Dirk Hoffmeister, Bernhard Rupp, Sebastiaan Werten
{"title":"Substrate recognition by the 4-hydroxytryptamine kinase PsiK in psilocybin biosynthesis.","authors":"Kai Rogge, Tobias Johannes Wagner, Dirk Hoffmeister, Bernhard Rupp, Sebastiaan Werten","doi":"10.1002/1873-3468.15042","DOIUrl":"https://doi.org/10.1002/1873-3468.15042","url":null,"abstract":"<p><p>Psilocybin, the natural hallucinogen from Psilocybe (magic) mushrooms, is a highly promising drug candidate for the treatment of depression and several other mental health conditions. Biosynthesis of psilocybin from the amino acid l-tryptophan involves four strictly sequential modifications. The third of these, ATP-dependent phosphorylation of the intermediate 4-hydroxytryptamine, is catalysed by PsiK. Here we present a crystallographic analysis and a structure-based mutagenesis study of this kinase, providing insight into its mode of substrate recognition. The results of our work will support future bioengineering efforts aimed at generating variants of psilocybin with enhanced therapeutic properties.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the sclerostin-LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin. 绘制硬骨蛋白-LRP4 结合界面图，确定硬骨蛋白环 1 和环 3 中的关键相互作用热点。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-23 DOI: 10.1002/1873-3468.15033
Svetlana Katchkovsky, Reut Meiri, Shiran Lacham-Hartman, Yaron Orenstein, Noam Levaot, Niv Papo
{"title":"Mapping the sclerostin-LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin.","authors":"Svetlana Katchkovsky, Reut Meiri, Shiran Lacham-Hartman, Yaron Orenstein, Noam Levaot, Niv Papo","doi":"10.1002/1873-3468.15033","DOIUrl":"https://doi.org/10.1002/1873-3468.15033","url":null,"abstract":"<p><p>The interaction of sclerostin (Scl) with the low-density lipoprotein receptor-related protein 4 (LRP4) leads to a marked reduction in bone formation by inhibiting the Wnt/β-catenin pathway. To characterize the Scl-LRP4 binding interface, we sorted a combinatorial library of Scl variants and isolated variants with reduced affinity to LRP4. We identified Scl single-mutation variants enriched during the sorting process and verified their reduction in affinity toward LRP4-a reduction that was not a result of changes in the variants' secondary structure or stability. We found that Scl positions K75 (loop 1) and V136 (loop 3) are critical hotspots for binding to LRP4. Our findings establish the foundation for targeting these hotspots for developing novel therapeutic strategies to promote bone formation.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and function of interferon lambda receptor 1 variants. 干扰素λ受体1变体的表达和功能。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-22 DOI: 10.1002/1873-3468.15041
Laura A Novotny, Eric G Meissner
{"title":"Expression and function of interferon lambda receptor 1 variants.","authors":"Laura A Novotny, Eric G Meissner","doi":"10.1002/1873-3468.15041","DOIUrl":"10.1002/1873-3468.15041","url":null,"abstract":"<p><p>Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solving the protein folding problem… 解决蛋白质折叠问题....
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-20 DOI: 10.1002/1873-3468.15043
Roy D. Sleator
{"title":"Solving the protein folding problem…","authors":"Roy D. Sleator","doi":"10.1002/1873-3468.15043","DOIUrl":"10.1002/1873-3468.15043","url":null,"abstract":"<p>The protein folding problem was, to paraphrase Churchill, ‘<i>A riddle wrapped in a mystery inside an enigma’</i>. The <i>riddle</i>, in this context, was the folding code; what interactions at the amino acid level are driving the folding process? The <i>mystery</i> was the kinetic question (Levinthal's paradox); how does the folding process occur so quickly (typically in timescales ranging from μS to mS)? Finally, the <i>enigma</i> represents the computational problem of developing approaches to predict the final folded sate of a protein given only its amino acid sequence. Herein, I trace the path to solving this riddle wrapped in a mystery inside an enigma.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"598 23","pages":"2831-2835"},"PeriodicalIF":3.5,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis. 视黄醛还原酶 DHRS3 的反馈调节是视黄酸平衡的关键因素。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-17 DOI: 10.1002/1873-3468.15038
Parisa Varshosaz, Catherine O'Connor, Alexander R Moise
{"title":"Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis.","authors":"Parisa Varshosaz, Catherine O'Connor, Alexander R Moise","doi":"10.1002/1873-3468.15038","DOIUrl":"10.1002/1873-3468.15038","url":null,"abstract":"<p><p>Retinoic acid is crucial for vertebrate embryogenesis, influencing anterior-posterior patterning and organogenesis through its interaction with nuclear hormone receptors comprising heterodimers of retinoic acid receptors (RARα, β, or γ) and retinoid X receptors (RXRα, β, or γ). Tissue retinoic acid levels are tightly regulated since both its excess and deficiency are deleterious. Dehydrogenase/reductase 3 (DHRS3) plays a critical role in this regulation by converting retinaldehyde to retinol, preventing excessive retinoic acid formation. Mutations in DHRS3 can result in embryonic lethality and congenital defects. This study shows that mouse Dhrs3 expression is responsive to vitamin A status and is directly regulated by the RAR/RXR complex through cis-regulatory elements. This highlights a negative feedback mechanism that ensures retinoic acid homeostasis.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The autophagy initiation factor ATG13 mRNA is stabilized by the RNA-binding protein YBX3. 自噬启动因子 ATG13 mRNA 由 RNA 结合蛋白 YBX3 稳定。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-16 DOI: 10.1002/1873-3468.15035
Liva Pfuhler, Silina Awad, William Skipper, Jeremy Lavietes, Thomas Sah, Kayla Ho, Radha Ivanova, Amy Cooke
{"title":"The autophagy initiation factor ATG13 mRNA is stabilized by the RNA-binding protein YBX3.","authors":"Liva Pfuhler, Silina Awad, William Skipper, Jeremy Lavietes, Thomas Sah, Kayla Ho, Radha Ivanova, Amy Cooke","doi":"10.1002/1873-3468.15035","DOIUrl":"https://doi.org/10.1002/1873-3468.15035","url":null,"abstract":"<p><p>Autophagy, a highly conserved form of cellular recycling, is essential for cellular homeostasis. Its dysregulation has been linked to neurodegenerative diseases and various cancers, including breast cancer. We set out to determine if the RNA-binding protein (RBP) YBX3 regulates autophagy mRNAs, as previous findings suggest YBX3 depletion reduces distinct autophagy transcripts. We found that YBX3 interacts with and stabilizes the mRNA of the autophagy initiation factor ATG13 in HeLa, which in turn increases ATG13 protein expression. We have shown that this requires the 3' untranslated region (UTR) of ATG13 and occurs in other human cell lines, including HEK293, HepG2, and HCT116. Together, our data suggest a novel regulatory role for YBX3 of autophagy initiation through posttranscriptional control of ATG13 mRNA stability.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The publish or perish game: an interview with the inventor 出版或毁灭游戏：与发明者的访谈。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-15 DOI: 10.1002/1873-3468.15039
Daisy Y. Shu, Vik Meadows, Roberto Mota Alvidrez, Max Bai
{"title":"The publish or perish game: an interview with the inventor","authors":"Daisy Y. Shu,&nbsp;Vik Meadows,&nbsp;Roberto Mota Alvidrez,&nbsp;Max Bai","doi":"10.1002/1873-3468.15039","DOIUrl":"10.1002/1873-3468.15039","url":null,"abstract":"<p>Many academics often have to face the pressure to constantly publish or quietly perish. The Publish or Perish Game™, a new tabletop game created by Max Bai, flips the script and offers a satirical reflection on the academic publishing process, turning the often-stressful endeavor into an entertainment experience. In this interview, Max Bai discusses the inspiration behind the game, the creative processes, and the broader impact he hopes the game will have on the academic community.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"598 21","pages":"2619-2622"},"PeriodicalIF":3.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase. 半胱氨酸残基有助于拟南芥状态转换 7 激酶的调控。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-11 DOI: 10.1002/1873-3468.15032
Iskander M Ibrahim, Ji H Lee, Seth Weaver, Ronard Kwizera, Jeremy R Lohman, Sujith Puthiyaveetil
{"title":"Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase.","authors":"Iskander M Ibrahim, Ji H Lee, Seth Weaver, Ronard Kwizera, Jeremy R Lohman, Sujith Puthiyaveetil","doi":"10.1002/1873-3468.15032","DOIUrl":"https://doi.org/10.1002/1873-3468.15032","url":null,"abstract":"<p><p>State transitions are an acclimatory response by which plants, algae, and cyanobacteria counteract photosynthetic inefficiency caused by changes in incident light quality. In plants and green algae, state transition 7 (STN7/STT7) kinase promotes state 2 transition. Conserved cysteine residues are implicated in STN7/STT7 regulation, but the precise nature of their involvement remains unclear. Here, an analysis of the STN7 thiols in vitro and a determination of their midpoint redox potential indicate that the lumenal disulfide linkage is unlikely to be redox regulated while the stromal cysteines form a regulatory intramolecular disulfide. We further show that thioredoxin f1 (Trx-f1) reduces the STN7 stromal disulfide linkage as consistent with a Trx-f1-mediated inhibition of the kinase under high light.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells 关注的问题：LLL12 是一种小分子，可抑制组成型 STAT3 和 IL-6 诱导的 STAT3 信号传导，并在人类多发性骨髓瘤细胞中显示出强大的生长抑制活性。
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2024-10-11 DOI: 10.1002/1873-3468.15037
{"title":"EXPRESSION OF CONCERN: A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells","authors":"","doi":"10.1002/1873-3468.15037","DOIUrl":"10.1002/1873-3468.15037","url":null,"abstract":"<p><b>Expression of Concern:</b> H. Wang, B. Wang, Q. Liao, H. An, W. Li, X. Jin, S. Cui, and L. Zhao, “Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma,” <i>FEBS Letters</i> 588, no. 3 (2014): 503–508. https://doi.org/10.1016/j.febslet.2013.12.016.</p><p>This Expression of Concern is for the above article, published online on 24 December 2013, in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief Michael Brunner; FEBS Press; and John Wiley and Sons Ltd. The Expression of Concern has been agreed due to concerns raised by a third party regarding the similarity of beta-actin blots in Fig. 3A between the HepG2 and the MHCC-97H lanes. The authors responded to an inquiry by the publisher and supplied what was labelled as original data. However, following an evaluation of the authors' response by FEBS and the editors, Wiley and the journal have determined that they are unable to verify if the files provided by the authors correspond to the research described in the article. The journal is issuing this Expression of Concern because the results of the experiment as presented cannot be confirmed. The authors do not agree with the expression of concern.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":"598 21","pages":"2748"},"PeriodicalIF":3.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.15037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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