Didem Naz Dioken, Ibrahim Ozgul, Ayse Elif Erson-Bensan
{"title":"癌症中被忽视的同工异构体的3'端。","authors":"Didem Naz Dioken, Ibrahim Ozgul, Ayse Elif Erson-Bensan","doi":"10.1002/1873-3468.70122","DOIUrl":null,"url":null,"abstract":"<p><p>The evolutionary expansion of 3' untranslated regions (3'UTRs), along with the incorporation of transposable elements and alternative polyadenylation (APA) sites, has introduced additional layers of gene expression control in eukaryotes. Consequently, 3'UTRs regulate the stability, translation, and localization of mRNAs by interacting with RNA-binding proteins and non-coding RNAs, thereby contributing to cell-type-specific and context-dependent gene expression. Mounting evidence highlights the importance of non-coding regions, particularly 3'UTRs, in normal physiology and disease states, including cancer. Genomic alterations and driver mutations in coding regions play a well-established role in cancer biology. Advances in long-read sequencing and 3'UTR-focused genome-/transcriptome-wide association studies (GWAS/TWAS) improve our understanding of transcriptome complexity and how mRNA isoforms with different 3'-ends may impact protein functions. This Review explores the regulatory roles of 3'UTRs, sources of 3'UTR isoform diversity, and implications in cancer, emphasizing the need for further research into their diagnostic and therapeutic potential. Impact statement This review highlights how alternative polyadenylation generates diverse mRNA 3'-end isoforms in cancer. Isoforms with distinct 3'UTRs are differentially regulated by microRNAs and RNA-binding proteins, while intronically polyadenylated isoforms can lead to C-terminally truncated proteins with altered functions.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The 3' end of the tale-neglected isoforms in cancer.\",\"authors\":\"Didem Naz Dioken, Ibrahim Ozgul, Ayse Elif Erson-Bensan\",\"doi\":\"10.1002/1873-3468.70122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The evolutionary expansion of 3' untranslated regions (3'UTRs), along with the incorporation of transposable elements and alternative polyadenylation (APA) sites, has introduced additional layers of gene expression control in eukaryotes. Consequently, 3'UTRs regulate the stability, translation, and localization of mRNAs by interacting with RNA-binding proteins and non-coding RNAs, thereby contributing to cell-type-specific and context-dependent gene expression. Mounting evidence highlights the importance of non-coding regions, particularly 3'UTRs, in normal physiology and disease states, including cancer. Genomic alterations and driver mutations in coding regions play a well-established role in cancer biology. Advances in long-read sequencing and 3'UTR-focused genome-/transcriptome-wide association studies (GWAS/TWAS) improve our understanding of transcriptome complexity and how mRNA isoforms with different 3'-ends may impact protein functions. This Review explores the regulatory roles of 3'UTRs, sources of 3'UTR isoform diversity, and implications in cancer, emphasizing the need for further research into their diagnostic and therapeutic potential. Impact statement This review highlights how alternative polyadenylation generates diverse mRNA 3'-end isoforms in cancer. Isoforms with distinct 3'UTRs are differentially regulated by microRNAs and RNA-binding proteins, while intronically polyadenylated isoforms can lead to C-terminally truncated proteins with altered functions.</p>\",\"PeriodicalId\":12142,\"journal\":{\"name\":\"FEBS Letters\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEBS Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1002/1873-3468.70122\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEBS Letters","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/1873-3468.70122","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
The 3' end of the tale-neglected isoforms in cancer.
The evolutionary expansion of 3' untranslated regions (3'UTRs), along with the incorporation of transposable elements and alternative polyadenylation (APA) sites, has introduced additional layers of gene expression control in eukaryotes. Consequently, 3'UTRs regulate the stability, translation, and localization of mRNAs by interacting with RNA-binding proteins and non-coding RNAs, thereby contributing to cell-type-specific and context-dependent gene expression. Mounting evidence highlights the importance of non-coding regions, particularly 3'UTRs, in normal physiology and disease states, including cancer. Genomic alterations and driver mutations in coding regions play a well-established role in cancer biology. Advances in long-read sequencing and 3'UTR-focused genome-/transcriptome-wide association studies (GWAS/TWAS) improve our understanding of transcriptome complexity and how mRNA isoforms with different 3'-ends may impact protein functions. This Review explores the regulatory roles of 3'UTRs, sources of 3'UTR isoform diversity, and implications in cancer, emphasizing the need for further research into their diagnostic and therapeutic potential. Impact statement This review highlights how alternative polyadenylation generates diverse mRNA 3'-end isoforms in cancer. Isoforms with distinct 3'UTRs are differentially regulated by microRNAs and RNA-binding proteins, while intronically polyadenylated isoforms can lead to C-terminally truncated proteins with altered functions.
期刊介绍:
FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.