癌症中被忽视的同工异构体的3'端。

IF 3 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Didem Naz Dioken, Ibrahim Ozgul, Ayse Elif Erson-Bensan
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引用次数: 0

摘要

3‘非翻译区(3’ utr)的进化扩展,以及转座元件和替代聚腺苷化(APA)位点的结合,在真核生物中引入了额外的基因表达控制层。因此,3' utr通过与rna结合蛋白和非编码rna相互作用来调节mrna的稳定性、翻译和定位,从而促进细胞类型特异性和上下文依赖性的基因表达。越来越多的证据强调了非编码区,特别是3' utr在正常生理和疾病状态(包括癌症)中的重要性。基因组改变和编码区的驱动突变在癌症生物学中起着公认的作用。长读测序和以3‘ utr为中心的全基因组/转录组关联研究(GWAS/TWAS)的进展提高了我们对转录组复杂性的理解,以及不同3’末端的mRNA异构体如何影响蛋白质功能。本文探讨了3'UTR的调控作用、3'UTR异构体多样性的来源及其在癌症中的意义,并强调需要进一步研究其诊断和治疗潜力。本综述强调了在癌症中选择性聚腺苷化如何产生不同的mRNA 3'端亚型。具有不同3' utr的同工异构体受microRNAs和rna结合蛋白的不同调控,而内含多腺苷化的同工异构体可导致c端截断的蛋白质功能改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The 3' end of the tale-neglected isoforms in cancer.

The evolutionary expansion of 3' untranslated regions (3'UTRs), along with the incorporation of transposable elements and alternative polyadenylation (APA) sites, has introduced additional layers of gene expression control in eukaryotes. Consequently, 3'UTRs regulate the stability, translation, and localization of mRNAs by interacting with RNA-binding proteins and non-coding RNAs, thereby contributing to cell-type-specific and context-dependent gene expression. Mounting evidence highlights the importance of non-coding regions, particularly 3'UTRs, in normal physiology and disease states, including cancer. Genomic alterations and driver mutations in coding regions play a well-established role in cancer biology. Advances in long-read sequencing and 3'UTR-focused genome-/transcriptome-wide association studies (GWAS/TWAS) improve our understanding of transcriptome complexity and how mRNA isoforms with different 3'-ends may impact protein functions. This Review explores the regulatory roles of 3'UTRs, sources of 3'UTR isoform diversity, and implications in cancer, emphasizing the need for further research into their diagnostic and therapeutic potential. Impact statement This review highlights how alternative polyadenylation generates diverse mRNA 3'-end isoforms in cancer. Isoforms with distinct 3'UTRs are differentially regulated by microRNAs and RNA-binding proteins, while intronically polyadenylated isoforms can lead to C-terminally truncated proteins with altered functions.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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